Sesquiterpene Lactones Downregulate G2/M Cell Cycle Regulator Proteins and Affect the Invasive Potential of Human Soft Tissue Sarcoma Cells

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Lohberger, Birgit ^a   Rinner, Beate ^a   Stuendl, Nicole ^a   Kaltenegger, Heike ^a   Steinecker Frohnwieser, Bibiane ^b   Bernhart, Eva ^a   Rad, Ehsan Bonyadi ^a   Weinberg, Annelie Martina ^a   Leithner, Andreas ^a   Bauer, Rudolf ^c   Kretschmer, Nadine ^c  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COSTUNOLIDE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DEHYDROCOSTUS LACTONE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; SESQUITERPENE LACTONE DERIVATIVE;

ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN SW 872; CELL STRAIN SW 982; CELL STRAIN TE 671; CONTROLLED STUDY; DAUGHTER CELL; DOSE RESPONSE; DRUG ISOLATION; DRUG MECHANISM; EXTRACELLULAR MATRIX; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LIPOSARCOMA; M PHASE CELL CYCLE CHECKPOINT; METASTASIS; METASTASIS POTENTIAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SARCOMA CELL; SOFT TISSUE SARCOMA; SYNOVIAL SARCOMA; TUMOR INVASION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLLAGENASES; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LACTONES; NEOPLASM INVASIVENESS; SARCOMA; SESQUITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84879150243     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066300     Document Type: Article

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