Optogenetic stimulation of MCH neurons increases sleep

Journal of Neuroscience

Volumn 33, Issue 25, 2013, Pages 10257-10263

  Konadhode, Roda Rani ^b   Pelluru, Dheeraj ^b   Blanco Centurion, Carlos ^b   Zayachkivsky, Andrew ^c   Liu, Meng ^b   Uhde, Thomas ^b   Glen, W Bailey ^b   van den Pol, Anthony N ^c   Mulholland, Patrick J ^b   Shiromani, Priyattam J ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNELRHODOPSIN 2; MELANIN CONCENTRATING HORMONE; RHODOPSIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DELTA RHYTHM; ELECTROMYOGRAPHY; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL STIMULATION; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; REM SLEEP; SLEEP; SLEEP INDUCTION; SLEEP WAKING CYCLE; VIRAL GENE DELIVERY SYSTEM;

EID: 84879147540     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1225-13.2013     Document Type: Article

References (23)

1. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450:420-424. CrossReff Medline
2. Adamantidis A, Salvert D, Goutagny R, Lakaye B, Gervasoni D, Grisar T, Luppi PH, Fort P (2008) Sleep architecture of the melanin concentrating hormone receptor 1-knockout mice. Eur J Neurosci 27: 1793-1800. CrossReff Medline
3. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan J, Nahon JL, Vale W, Sawchenko PE (1992) The melanin-concentrating hormone system of the rat brain: an immune and hybridization histochemical characterization. J Comp Neurol 319:218-245. CrossReff Medline
4. Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM (2013) Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat Commun 4:1547. CrossReff Medline
5. Borbély AA (1982) A two process model of sleep regulation. Hum Neuro biol 1:195-204. Medline
6. Burdakov D, Gerasimenko O, Verkhratsky A (2005) Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 25:2429-2433. CrossReff Medline
7. Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L (2010) Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci 13:1526-1533. CrossReff Medline
8. Del Cid-Pellitero E, Jones BE (2012) Immunohistochemical evidence for synaptic release of GABA from melanin-concentrating hormone containing varicosities in the locus coeruleus. Neuroscience 223:269-276. CrossReff Medline
9. Elias CF, Lee CE, Kelly JF, Ahima RS, Kuhar M, Saper CB, Elmquist JK (2001) Characterization of CART neurons in the rat and human hypothalamus. J Comp Neurol 432:1-19. CrossReff Medline
10. Gao XB, van den Pol AN (2001) Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol 533:237-252. CrossReff Medline
11. Hassani OK, Lee MG, Jones BE (2009) Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A 106:2418-2422. CrossReff Medline
12. Jones BE (2011) Neurobiology of waking and sleeping. Handb Clin Neurol 98:131-149. CrossReff Medline
13. Lagos P, Torterolo P, Jantos H, Chase MH, Monti JM (2009) Effects on sleep of melanin-concentrating hormone (MCH) microinjections into the dorsal raphe nucleus. Brain Res 1265:103-110. CrossReff Medline
14. Lagos P, Monti JM, Jantos H, Torterolo P (2012) Microinjection of the melanin-concentrating hormone into the lateral basal forebrain increases REM sleep and reduces wakefulness in the rat. Life Sci 90:895-899. CrossReff Medline
15. Liu M, Blanco-Centurion C, Konadhode R, Begum S, Pelluru D, Gerashchenko D, Sakurai T, Yanagisawa M, van den Pol AN, Shiromani PJ (2011) Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci 31:6028-6040. CrossReff Medline
16. Lu J, Shiromani P, Saper CB (1999) Retinal input to the sleep-active ventro-lateral preoptic nucleus in the rat. Neuroscience 93:209-214. CrossReff Medline
17. Sasaki K, Suzuki M, Mieda M, Tsujino N, Roth B, Sakurai T (2011) Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS One 6:e20360. CrossReff Medline
18. Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ven-trolateral preoptic neurons during sleep. Science 271:216-219. CrossReff Medline
19. Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillation in the sleeping and aroused brain. Science 262:679-685. CrossReff Medline
20. Tsunematsu T, Kilduff TS, Boyden ES, Takahashi S, Tominaga M, Yamanaka A (2011) Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci 31:10529-10539. CrossReff Medline
21. van den Pol AN, Acuna-Goycolea C, Clark KR, Ghosh PK (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 42:635-652. CrossReff Medline
22. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, Boissard R, Salin P, Peyron C, Luppi PH (2003) A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 4:19. CrossReff Medline
23. Willie JT, Sinton CM, Maratos-Flier E, Yanagisawa M (2008) Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience 156:819-829 CrossReff Medline