Microinjection of the melanin-concentrating hormone into the lateral basal forebrain increases REM sleep and reduces wakefulness in the rat

Life Sciences

Volumn 90, Issue 23-24, 2012, Pages 895-899

  Lagos, Patricia ^a   Monti, Jaime M ^a   Jantos, Héctor ^a   Torterolo, Pablo ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

Author keywords

Acetylcholine; Basal forebrain; Melanin concentrating hormone; Nucleus of the horizontal limb of the diagonal band of Broca; REM sleep; Wakefulness

Indexed keywords

MELANIN CONCENTRATING HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIAGONAL BAND OF BROCA; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; FOREBRAIN; LIGHT DARK CYCLE; MALE; NONHUMAN; RAT; REM SLEEP; SLEEP TIME; SLOW WAVE SLEEP; WAKEFULNESS;

ACETYLCHOLINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; HYPOTHALAMIC HORMONES; MALE; MELANINS; MICROINJECTIONS; PITUITARY HORMONES; PROSENCEPHALON; RATS; RATS, WISTAR; SLEEP, REM; WAKEFULNESS;

RATTUS; RATTUS NORVEGICUS;

EID: 84862015700     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.04.019     Document Type: Article

References (30)

1. Ahnaou A, Drinkenburg W, Bouwknecht JA, Alcazar J, Steckler T, Dautzenberg FM. Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep-wake architecture. Eur J Pharmacol 2008;579:177-88.
2. Bittencourt JC, Presse F, Arias C, Peto C, Vaughan JL, Nahon W, et al. The melaninconcentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992;319:218-45.
3. Bittencourt JC, Elias CF. Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers. Brain Res 1998;805:1-19. (Pubitemid 29005118)
4. Deurveilheur S, Semba K. Basal forebrain regulation of cortical activity and sleep-wake states: roles of cholinergic and non-cholinergic neurons. Sleep Biol Rhythms 2011;9(Suppl. 1):65-70.
5. Elias CF, Sita LV, Zambon BK, Oliveira ER, Vasconcelos LA, Bittencourt JC. Melanin-concentrating hormone projections to areas involved in somatomotor responses. J Chem Neuroanat 2008;35:188-201.
6. Forray C. The M.C.H. receptor family: feeding brain disorders? Curr Opin Pharmacol 2003;3:85-9. (Pubitemid 36131332)
7. Freund TF, Gulyas AI. GABAergic interneurons containing calbindin D28K or somatostatin are major targets of GABAergic basal forebrain afferents in the rat neocortex. J Comp Neurol 1991;314:187-99.
8. Gao XB, van den Pol N. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol 2001;1:237-52.
9. Harthoorn LF, Sane A, Nethe M, Van Heerikhuize JJ. Multi-transcriptional profiling of melanine-concentrating hormone and orexin-containing neurons. Cell Mol Neurobiol 2005;25:1209-23. (Pubitemid 43037034)
10. Hassani OK, Lee MG, Jones BE. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A 2009;106:2418-22.
11. Hervieu GJ, Cluderay JE, Harrison D, Meakin J, Maycox P, Nasir S, et al. The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat. Eur J Neurosci 2000;12:1194-216. (Pubitemid 30224225)
12. Jones BE. From waking to sleeping: neuronal and chemical substrates. TIPS 2005;26:578-86. (Pubitemid 41505226)
13. Lagos P, Torterolo P, Jantos H, Chase MH, Monti JM. Effects on sleep of melaninconcentrating hormone (MCH) microinjections into the dorsal raphe nucleus. Brain Res 2009;1265:103-10.
14. Lagos P, Torterolo P, Jantos H, Monti JM. Immunoneutralization of melaninconcentrating hormone (MCH) in the dorsal raphe nucleus: effects on sleep and wakefulness. Brain Res 2011;1269:112-8.
15. Lee M, Hassani O, Alonso A, Jones BE. Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep. J Neurosci 2005;25:4365-9. (Pubitemid 40628780)
16. McCarley RW. Neurobiology of REM and NREM sleep. Sleep Med 2007;8:302-30. (Pubitemid 46706357)
17. McKenna JT, Chen L, McCarley RW. Neuronal models of REM-sleep control: evolving concepts. In: Mallick BN, Pandi-Perumal SR, McCarley RW, Morrison AR, editors. REM sleep: regulation and function. Cambridge: Cambridge University Press; 2011. p. 285-99.
18. Monti JM, Jantos H, Catenaccio V, Xavier S. Blockade of the NMDA and AMPA/kainate receptors in the dorsal raphe nucleus prevents the 5-HT3 receptor agonist mchlorphenylbiguanide-induced suppression of REM sleep in the rat. Prog Neuropsychopharmacol Biol Psychiat 2011;35:1341-8.
19. Paxinos G, Watson C. The rat brain. New York: Academic Press; 2005.
20. Peyron C, Sapin E, Leger L, Luppi PH, Fort P. Role of the melanin-concentrating hormone neuropeptide in sleep regulation. Pepetides 2009;30:2052-9.
21. Rodrigo-Angulo M, Heredero S, Rodríguez-Veiga E, Reinoso-Suárez F. GABAergic and non-GABAergic thalamic, hypothalamic and basal forebrain projections to the ventral oral pontine reticular nucleus: their implication in REM sleep regulation. Brain Res 2008;1210:116-25.
22. Saito Y, Cheng M, Leslie FM, Civelli O. Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain. J Comp Neurol 2001;435:26-40. (Pubitemid 32448720)
23. Semba K. Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance. Behav Brain Res 2000;115:117-41.
24. Semba K. Preoptic and basal forebrain modulation of REM sleep. In: Mallick BN, Pandi-Perumal SR, McCarley R, Morrison AR, editors. REM sleep: regulation and function. Cambridge: Cambridge University Press; 2011. p. 99-109.
25. Skofitsch G, Jacobowitz DM, Zamir N. Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain. Brain Res Bull 1985;15:635-49. (Pubitemid 16149275)
26. Torterolo P, Sampogna S, Morales FR, Chase MH. MCH-containing neurons in the hypothalamus of the cat: searching for a role in the control of sleep and wakefulness. Brain Res 2006;1119:101-14. (Pubitemid 44647231)
27. Torterolo P, Sampogna S, Chase MH. MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep. Brain Res 2009;1268:76-87.
28. Torterolo P, Lagos P, Monti JM. Melanin-concentrating hormone: a new sleep factor? Frontier Neurol 2011;2:1-12.
29. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Léger L, et al. A role of melaninconcentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 2003;4:19-28.
30. Willie JT, Sinton CM, Maratos-Flier E, Yanagisawa M. Abnormal response of melaninconcentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience 2008;156:819-29.