메뉴 건너뛰기




Volumn 2, Issue 1, 2012, Pages

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

Author keywords

Fibrosis; Inflammation; Peroxisome proliferator activated receptor ; Proliferation; Signaling pathways

Indexed keywords

MUS;

EID: 84870946722     PISSN: None     EISSN: 20453701     Source Type: Journal    
DOI: 10.1186/2045-3701-2-34     Document Type: Article
Times cited : (66)

References (43)
  • 1
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • 10.1007/s10495-005-1055-4, 16151628
    • Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 2005, 10:927-939. 10.1007/s10495-005-1055-4, 16151628.
    • (2005) Apoptosis , vol.10 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 2
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • 10.1074/jbc.275.4.2247, 10644669
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000, 275:2247-2250. 10.1074/jbc.275.4.2247, 10644669.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 3
    • 0031819504 scopus 로고    scopus 로고
    • The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts
    • 10.1007/s004410051073, 9582401
    • Gressner AM. The cell biology of liver fibrogenesis - an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998, 292:447-452. 10.1007/s004410051073, 9582401.
    • (1998) Cell Tissue Res , vol.292 , pp. 447-452
    • Gressner, A.M.1
  • 4
    • 33644652740 scopus 로고    scopus 로고
    • Involvement of PPAR nuclear receptors in tissue injury and wound repair
    • 10.1172/JCI27958, 1386118, 16511592
    • Michalik L, Wahli W. Involvement of PPAR nuclear receptors in tissue injury and wound repair. The Journal of clinical investigation 2006, 116:598-606. 10.1172/JCI27958, 1386118, 16511592.
    • (2006) The Journal of clinical investigation , vol.116 , pp. 598-606
    • Michalik, L.1    Wahli, W.2
  • 5
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: nuclear control of metabolism
    • 10.1210/er.20.5.649, 10529898
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-688. 10.1210/er.20.5.649, 10529898.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 6
    • 0032524365 scopus 로고    scopus 로고
    • Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice
    • 10.1016/S0300-483X(98)00013-4, 9699788
    • Manautou JE, Silva VM, Hennig GE, Whiteley HE. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice. Toxicology 1998, 127:1-10. 10.1016/S0300-483X(98)00013-4, 9699788.
    • (1998) Toxicology , vol.127 , pp. 1-10
    • Manautou, J.E.1    Silva, V.M.2    Hennig, G.E.3    Whiteley, H.E.4
  • 8
    • 1842716887 scopus 로고    scopus 로고
    • Effects of PPARg agonist pioglitazone on rat hepatic fibrosis
    • Yuan GJ, Zhang ML, Gong ZJ. Effects of PPARg agonist pioglitazone on rat hepatic fibrosis. World J Gastroenterol 2004, 10:1047-1051.
    • (2004) World J Gastroenterol , vol.10 , pp. 1047-1051
    • Yuan, G.J.1    Zhang, M.L.2    Gong, Z.J.3
  • 9
    • 27144555677 scopus 로고    scopus 로고
    • Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta
    • 10.1093/carcin/bgi138, 15917308
    • Knight B, Yeap BB, Yeoh GC, Olynyk JK. Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta. Carcinogenesis 2005, 26:1782-1792. 10.1093/carcin/bgi138, 15917308.
    • (2005) Carcinogenesis , vol.26 , pp. 1782-1792
    • Knight, B.1    Yeap, B.B.2    Yeoh, G.C.3    Olynyk, J.K.4
  • 11
    • 0037596964 scopus 로고    scopus 로고
    • PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation
    • 10.1194/jlr.M200376-JLR200, 12576510
    • Hellemans K, Rombouts K, Quartier E, Dittie AS, Knorr A, Michalik L, Rogiers V, Schuit F, Wahli W, Geerts A. PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res 2003, 44:280-295. 10.1194/jlr.M200376-JLR200, 12576510.
    • (2003) J Lipid Res , vol.44 , pp. 280-295
    • Hellemans, K.1    Rombouts, K.2    Quartier, E.3    Dittie, A.S.4    Knorr, A.5    Michalik, L.6    Rogiers, V.7    Schuit, F.8    Wahli, W.9    Geerts, A.10
  • 12
    • 38649104434 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice
    • Shan W, Nicol CJ, Ito S, Bility MT, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. Peroxisome proliferator-activated receptor-beta/delta protects against chemically induced liver toxicity in mice. Hepatology 2008, 47:225-235.
    • (2008) Hepatology , vol.47 , pp. 225-235
    • Shan, W.1    Nicol, C.J.2    Ito, S.3    Bility, M.T.4    Kennett, M.J.5    Ward, J.M.6    Gonzalez, F.J.7    Peters, J.M.8
  • 13
    • 51849123779 scopus 로고    scopus 로고
    • Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression
    • Epub 2008 Jul 2012, 10.1093/toxsci/kfn142, 2527639, 18622026
    • Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci 2008, 105:418-428. Epub 2008 Jul 2012, 10.1093/toxsci/kfn142, 2527639, 18622026.
    • (2008) Toxicol Sci , vol.105 , pp. 418-428
    • Shan, W.1    Palkar, P.S.2    Murray, I.A.3    McDevitt, E.I.4    Kennett, M.J.5    Kang, B.H.6    Isom, H.C.7    Perdew, G.H.8    Gonzalez, F.J.9    Peters, J.M.10
  • 14
    • 67349255861 scopus 로고    scopus 로고
    • PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair
    • Epub 2009 Mar 1120, 10.1016/j.jhep.2009.01.021, 2680444, 19398227
    • Pang M, de la Monte SM, Longato L, Tong M, He J, Chaudhry R, Duan K, Ouh J, Wands JR. PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair. J Hepatol 2009, 50:1192-1201. Epub 2009 Mar 1120, 10.1016/j.jhep.2009.01.021, 2680444, 19398227.
    • (2009) J Hepatol , vol.50 , pp. 1192-1201
    • Pang, M.1    de la Monte, S.M.2    Longato, L.3    Tong, M.4    He, J.5    Chaudhry, R.6    Duan, K.7    Ouh, J.8    Wands, J.R.9
  • 16
    • 0037256608 scopus 로고    scopus 로고
    • Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    • 10.1080/713611034, 12708612
    • Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical reviews in toxicology 2003, 33:105-136. 10.1080/713611034, 12708612.
    • (2003) Critical reviews in toxicology , vol.33 , pp. 105-136
    • Weber, L.W.1    Boll, M.2    Stampfl, A.3
  • 17
    • 10844242987 scopus 로고    scopus 로고
    • Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
    • 10.1136/gut.2004.042127, 1774377, 15591520
    • Xu L, Hui AY, Albanis E, Arthur MJ, O'Byrne SM, Blaner WS, Mukherjee P, Friedman SL, Eng FJ. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis. Gut 2005, 54:142-151. 10.1136/gut.2004.042127, 1774377, 15591520.
    • (2005) Gut , vol.54 , pp. 142-151
    • Xu, L.1    Hui, A.Y.2    Albanis, E.3    Arthur, M.J.4    O'Byrne, S.M.5    Blaner, W.S.6    Mukherjee, P.7    Friedman, S.L.8    Eng, F.J.9
  • 18
    • 0037219276 scopus 로고    scopus 로고
    • Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
    • 10.1053/jhep.2003.50002, 12500193
    • Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman S, Gores GJ. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 2003, 37:87-95. 10.1053/jhep.2003.50002, 12500193.
    • (2003) Hepatology , vol.37 , pp. 87-95
    • Taimr, P.1    Higuchi, H.2    Kocova, E.3    Rippe, R.A.4    Friedman, S.5    Gores, G.J.6
  • 19
    • 0036731701 scopus 로고    scopus 로고
    • Mixed-lineage kinase control of JNK and p38 MAPK pathways
    • 10.1038/nrm906, 12209126
    • Gallo KA, Johnson GL. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol 2002, 3:663-672. 10.1038/nrm906, 12209126.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 663-672
    • Gallo, K.A.1    Johnson, G.L.2
  • 20
    • 3142741044 scopus 로고    scopus 로고
    • Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells
    • Epub 22004 Apr 29476, 10.1074/jbc.M313947200, 15069087
    • Kim KY, Kim BC, Xu Z, Kim SJ. Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. J Biol Chem 2004, 279:29478-29484. Epub 22004 Apr 29476, 10.1074/jbc.M313947200, 15069087.
    • (2004) J Biol Chem , vol.279 , pp. 29478-29484
    • Kim, K.Y.1    Kim, B.C.2    Xu, Z.3    Kim, S.J.4
  • 21
    • 4143098266 scopus 로고    scopus 로고
    • MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
    • Epub 2004 Jul 2018, 10.1038/ncb1152, 15258589
    • Chadee DN, Kyriakis JM. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nat Cell Biol 2004, 6:770-776. Epub 2004 Jul 2018, 10.1038/ncb1152, 15258589.
    • (2004) Nat Cell Biol , vol.6 , pp. 770-776
    • Chadee, D.N.1    Kyriakis, J.M.2
  • 22
    • 13944270624 scopus 로고    scopus 로고
    • A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation
    • Epub 2004 Oct 1219, 10.4161/cc.3.10.1187, 15467451
    • Chadee DN, Kyriakis JM. A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation. Cell Cycle 2004, 3:1227-1229. Epub 2004 Oct 1219, 10.4161/cc.3.10.1187, 15467451.
    • (2004) Cell Cycle , vol.3 , pp. 1227-1229
    • Chadee, D.N.1    Kyriakis, J.M.2
  • 24
    • 0034756576 scopus 로고    scopus 로고
    • TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells
    • 10.1053/jhep.2001.28790, 11679966
    • Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B, Brenner DA. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology 2001, 34:953-963. 10.1053/jhep.2001.28790, 11679966.
    • (2001) Hepatology , vol.34 , pp. 953-963
    • Schnabl, B.1    Bradham, C.A.2    Bennett, B.L.3    Manning, A.M.4    Stefanovic, B.5    Brenner, D.A.6
  • 25
    • 34249817142 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatic fibrogenesis
    • 10.1111/j.1440-1746.2006.04659.x, 17567474
    • Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 2007, 22:S79-84. 10.1111/j.1440-1746.2006.04659.x, 17567474.
    • (2007) J Gastroenterol Hepatol , vol.22
    • Parsons, C.J.1    Takashima, M.2    Rippe, R.A.3
  • 26
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • 10.1126/science.1072682, 12471242
    • Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912. 10.1126/science.1072682, 12471242.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 27
    • 0036771764 scopus 로고    scopus 로고
    • Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway
    • 10.1016/S1097-2765(02)00646-9, 12419217
    • Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002, 10:721-733. 10.1016/S1097-2765(02)00646-9, 12419217.
    • (2002) Mol Cell , vol.10 , pp. 721-733
    • Di-Poi, N.1    Tan, N.S.2    Michalik, L.3    Wahli, W.4    Desvergne, B.5
  • 28
    • 0037382326 scopus 로고    scopus 로고
    • Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation
    • 10.1023/A:1022857313917, 12741473
    • Ramm GA, Li L, Britton RS, O'Neill R, Bacon BR. Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation. Dig Dis Sci 2003, 48:790-796. 10.1023/A:1022857313917, 12741473.
    • (2003) Dig Dis Sci , vol.48 , pp. 790-796
    • Ramm, G.A.1    Li, L.2    Britton, R.S.3    O'Neill, R.4    Bacon, B.R.5
  • 29
    • 0036172218 scopus 로고    scopus 로고
    • Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: role of different intracellular signalling pathways
    • Di Sario A, Bendia E, Svegliati-Baroni G, Marzioni M, Ridolfi F, Trozzi L, Ugili L, Saccomanno S, Jezequel AM, Benedetti A. Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: role of different intracellular signalling pathways. J Hepatol 2002, 36:179-190.
    • (2002) J Hepatol , vol.36 , pp. 179-190
    • Di Sario, A.1    Bendia, E.2    Svegliati-Baroni, G.3    Marzioni, M.4    Ridolfi, F.5    Trozzi, L.6    Ugili, L.7    Saccomanno, S.8    Jezequel, A.M.9    Benedetti, A.10
  • 30
    • 0042167595 scopus 로고    scopus 로고
    • ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells
    • 10.1016/S1386-6346(03)00112-8, 12850696
    • Takahashi M, Matsui A, Inao M, Mochida S, Fujiwara K. ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells. Hepatol Res 2003, 26:232-236. 10.1016/S1386-6346(03)00112-8, 12850696.
    • (2003) Hepatol Res , vol.26 , pp. 232-236
    • Takahashi, M.1    Matsui, A.2    Inao, M.3    Mochida, S.4    Fujiwara, K.5
  • 31
    • 26044476621 scopus 로고    scopus 로고
    • High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase
    • 10.1111/j.1478-3231.2005.01130.x, 16162162
    • Sugimoto R, Enjoji M, Kohjima M, Tsuruta S, Fukushima M, Iwao M, Sonta T, Kotoh K, Inoguchi T, Nakamuta M. High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase. Liver Int 2005, 25:1018-1026. 10.1111/j.1478-3231.2005.01130.x, 16162162.
    • (2005) Liver Int , vol.25 , pp. 1018-1026
    • Sugimoto, R.1    Enjoji, M.2    Kohjima, M.3    Tsuruta, S.4    Fukushima, M.5    Iwao, M.6    Sonta, T.7    Kotoh, K.8    Inoguchi, T.9    Nakamuta, M.10
  • 32
    • 0028360492 scopus 로고
    • Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation
    • Casini A, Galli G, Salzano R, Ceni E, Franceschelli F, Rotella CM, Surrenti C. Acetaldehyde induces c-fos and c-jun proto-oncogenes in fat-storing cell cultures through protein kinase C activation. Alcohol Alcohol 1994, 29:303-314.
    • (1994) Alcohol Alcohol , vol.29 , pp. 303-314
    • Casini, A.1    Galli, G.2    Salzano, R.3    Ceni, E.4    Franceschelli, F.5    Rotella, C.M.6    Surrenti, C.7
  • 33
    • 0032986374 scopus 로고    scopus 로고
    • Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells
    • Anania FA, Womack L, Potter JJ, Mezey E. Acetaldehyde enhances murine alpha2(I) collagen promoter activity by Ca2+-independent protein kinase C activation in cultured rat hepatic stellate cells. Alcohol Clin Exp Res 1999, 23:279-284.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 279-284
    • Anania, F.A.1    Womack, L.2    Potter, J.J.3    Mezey, E.4
  • 34
    • 34547219895 scopus 로고    scopus 로고
    • Metabolic stress signaling mediated by mixed-lineage kinases
    • 10.1016/j.molcel.2007.07.008, 1986670, 17679097
    • Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed-lineage kinases. Mol Cell 2007, 27:498-508. 10.1016/j.molcel.2007.07.008, 1986670, 17679097.
    • (2007) Mol Cell , vol.27 , pp. 498-508
    • Jaeschke, A.1    Davis, R.J.2
  • 35
    • 0034992168 scopus 로고    scopus 로고
    • MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
    • 10.1101/gad.888501, 312702, 11390361
    • Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001, 15:1419-1426. 10.1101/gad.888501, 312702, 11390361.
    • (2001) Genes Dev , vol.15 , pp. 1419-1426
    • Tournier, C.1    Dong, C.2    Turner, T.K.3    Jones, S.N.4    Flavell, R.A.5    Davis, R.J.6
  • 36
    • 33645229806 scopus 로고    scopus 로고
    • Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
    • Epub 2006 Mar 4413, 10.1073/pnas.0510651103, 1450194, 16537381
    • Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci U S A 2006, 103:4463-4468. Epub 2006 Mar 4413, 10.1073/pnas.0510651103, 1450194, 16537381.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4463-4468
    • Chadee, D.N.1    Xu, D.2    Hung, G.3    Andalibi, A.4    Lim, D.J.5    Luo, Z.6    Gutmann, D.H.7    Kyriakis, J.M.8
  • 37
    • 0035149573 scopus 로고    scopus 로고
    • Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway
    • Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S, Horie T. Transforming growth Factor-beta1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-Jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 2001, 163:152-157.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 152-157
    • Hashimoto, S.1    Gon, Y.2    Takeshita, I.3    Matsumoto, K.4    Maruoka, S.5    Horie, T.6
  • 39
    • 0036988312 scopus 로고    scopus 로고
    • Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases
    • Saporito MS, Hudkins RL, Maroney AC. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog Med Chem 2002, 40:23-62.
    • (2002) Prog Med Chem , vol.40 , pp. 23-62
    • Saporito, M.S.1    Hudkins, R.L.2    Maroney, A.C.3
  • 41
    • 0031970019 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver retinoid content in alcoholic liver disease in humans
    • 10.1111/j.1530-0277.1998.tb03678.x, 9581658
    • Hautekeete ML, Dodeman I, Azais-Braesco V, Van den Berg K, Seynaeve C, Geerts A. Hepatic stellate cells and liver retinoid content in alcoholic liver disease in humans. Alcohol Clin Exp Res 1998, 22:494-500. 10.1111/j.1530-0277.1998.tb03678.x, 9581658.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 494-500
    • Hautekeete, M.L.1    Dodeman, I.2    Azais-Braesco, V.3    Van den Berg, K.4    Seynaeve, C.5    Geerts, A.6
  • 42
    • 33645802802 scopus 로고    scopus 로고
    • Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    • 10.1128/MCB.26.8.3266-3281.2006, 1446964, 16581799
    • Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol 2006, 26:3266-3281. 10.1128/MCB.26.8.3266-3281.2006, 1446964, 16581799.
    • (2006) Mol Cell Biol , vol.26 , pp. 3266-3281
    • Nadra, K.1    Anghel, S.I.2    Joye, E.3    Tan, N.S.4    Basu-Modak, S.5    Trono, D.6    Wahli, W.7    Desvergne, B.8
  • 43
    • 0043210428 scopus 로고    scopus 로고
    • Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference
    • 10.1128/JVI.77.16.8957-8951.2003, 167245, 12885912
    • Wiznerowicz M, Trono D. Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol 2003, 77:8957-8961. 10.1128/JVI.77.16.8957-8951.2003, 167245, 12885912.
    • (2003) J Virol , vol.77 , pp. 8957-8961
    • Wiznerowicz, M.1    Trono, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.