PPARα-dependent activation of cell cycle control and DNA repair genes in hepatic nonparenchymal cells

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 404-410

  Qu, Aijuan ^a   Shah, Yatrik M ^a,b   Matsubara, Tsutomu ^a   Yang, Qian ^a   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Carcinogenesis; DNA damage repair; Hepatomegaly; Peroxisome proliferators; PPAR

Indexed keywords

CHECKPOINT KINASE 1; MINICHROMOSOME MAINTENANCE PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; POLYPEPTIDE; PROTEIN PRKDC; RAD51 PROTEIN; UNCLASSIFIED DRUG; PEROXISOME PROLIFERATOR; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPAIR; GENE ACTIVATION; GENE INDUCTION; HEPATOMEGALY; LIVER CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ANIMAL; CELL CYCLE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DNA DAMAGE; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; KUPFFER CELL; LIVER; LONGEVITY; METABOLISM; MOUSE MUTANT; ORGAN SIZE; PATHOLOGY;

MUS; MUS MUSCULUS; RODENTIA;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GENE EXPRESSION PROFILING; HEPATOCYTES; HEPATOMEGALY; KUPFFER CELLS; LIVER; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; ORGAN SIZE; PEROXISOME PROLIFERATORS; PPAR ALPHA; PYRIMIDINES;

EID: 78549248181     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq259     Document Type: Article

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