Nontoxic and neuroprotective β-naphthotacrines for alzheimer's disease

Chemical Research in Toxicology

Volumn 26, Issue 6, 2013, Pages 986-992

  Esquivias Pérez, Mario ^a   Maalej, Emna ^b   Romero, Alejandro ^c   Chabchoub, Fakher ^b   Samadi, Abdelouahid ^d   Marco Contelles, José ^c,d   Oset Gasque, María Jesús ^a,c  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b University of Sfax   (Tunisia)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

14 (3,4 DIMETHOXYPHENYL) 10,11,12,14 TETRAHYDRO 9H BENZO[5,6]CHROMENO[2,3 B]QUINOLIN 13 AMINE; BETA NAPHTHOTACRINE DERIVATIVE; CHOLINESTERASE INHIBITOR; OLIGOMYCIN; ROTENONE; TACRINE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE; CHOLINESTERASE; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL STRAIN HEPG2; CELL VIABILITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; LIVER TOXICITY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; ANALOGS AND DERIVATIVES; BRAIN CORTEX; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEPG2 CELL LINE; METABOLISM; NERVE CELL; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

RATTUS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; CELL SURVIVAL; CEREBRAL CORTEX; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HUMANS; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84879127155     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx400138s     Document Type: Article

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