Targeting 11β-hydroxysteroid dehydrogenases: A novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease

Current Opinion in Pharmacology

Volumn 13, Issue 3, 2013, Pages 440-444

  Hardy, Rowan S ^a   Seibel, Markus J ^b   Cooper, Mark S ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ANZAC RESEARCH INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR; ANTIDIABETIC AGENT; CARBENOXOLONE; CORTICOSTEROID; DICKKOPF 1 PROTEIN; ENZYME INHIBITOR; GLUCOCORTICOID; HEMOGLOBIN A1C; INCB 13739; MK 0736; MK 0916; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DKK1; PLACEBO; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; BONE DENSITY; BONE DISEASE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE SEVERITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FRACTURE; HUMAN; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OSSIFICATION; OSTEOBLAST; OSTEOCYTE; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; GLUCOCORTICOIDS; HUMANS; METABOLIC SYNDROME X; OSTEOPOROSIS; RHEUMATIC DISEASES;

EID: 84879094549     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.03.003     Document Type: Review

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