The 11β-hydroxysteroid dehydrogenase enzymes-arbiters of the effects of glucocorticoids in synovium and bone

Rheumatology

Volumn 49, Issue 11, 2010, Pages 2016-2023

  Raza, Karim ^a   Hardy, Rowan ^a   Cooper, Mark S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

11 hydroxysteroid dehydrogenase 1; 11 hydroxysteroid dehydrogenase 2; Bone; Fibroblast; Macrophage; Osteoblast; Osteoporosis; Rheumatoid arthritis; Steroid; Synovitis

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTICOTROPIN RELEASING FACTOR; CORTISONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LEUKOCYTE ELASTASE; MIFEPRISTONE; PREDNISONE; TRANSCORTIN;

ADRENAL INSUFFICIENCY; ARTHRITIS; BIOTRANSFORMATION; BONE; DRUG EFFECT; DRUG METABOLISM; DRUG SENSITIVITY; ENDOCRINE FUNCTION TEST; ENDOTHELIUM; ENZYME ACTIVITY; ENZYME REGULATION; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RHEUMATIC DISEASE; RHEUMATOLOGY; STEROID METABOLISM; STEROID THERAPY; SYNOVIUM; METABOLISM; RHEUMATOID ARTHRITIS;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ARTHRITIS, RHEUMATOID; BONE AND BONES; GLUCOCORTICOIDS; HUMANS; SYNOVIAL MEMBRANE;

EID: 78649337885     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keq212     Document Type: Review

References (41)

1. Wilson H, Fairbanks R, Scialabba D, McEwan C, Ziff M. Metabolites of hydrocortisone and cortisone in synovial fluid in rheumatoid arthritis. J Clin Endocrinol Metab 1956; 16:86-113.
2. Panayi GS. Hormonal control of rheumatoid inflammation. Br Med Bull 1995;51:462-71.
3. Sternberg EM, Hill JM, Chrousos GP et al. Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats. Proc Natl Acad Sci USA 1989;86:2374-8.
4. Jessop DS, Harbuz MS. A defect in cortisol production in rheumatoid arthritis: why are we still looking? Rheumatology 2005;44:1097-100.
5. Sternberg EM, Silverman MN, Cizza G. The neuroendocrine system and rheumatoid arthritis: insights from anti-tumor necrosis factor-alpha therapy. J Rheumatol 2007;34:1443-5.
6. Eijsbouts AM, van den Hoogen FH, Laan RF, Hermus AR, Sweep CG, van de Putte LB. Hypothalamic-pituitary-adrenal axis activity in patients with rheumatoid arthritis. Clin Exp Rheumatol 2005;23: 658-64.
7. Straub RH, Paimela L, Peltomaa R, Scholmerich J, Leirisalo-Repo M. Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. Arthritis Rheum 2002;46:654-62.
8. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003;348:727-34.
9. Cooper MS, Stewart PM. Adrenal insufficiency in critical illness. J Intensive Care Med 2007;22:348-62.
10. Hammond GL, Smith CL, Paterson NA, Sibbald WJ. A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. J Clin Endocrinol Metab 1990;71: 34-9.
11. Cooper MS. Sensitivity of bone to glucocorticoids. Clin Sci 2004;107:111-23.
12. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N Engl J Med 2005;353:1711-23.
13. Cooper MS, Stewart PM. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. J Clin Endocrinol Metab 2009;94: 4645-54.
14. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 1988;242: 583-5.
15. Tomlinson JW, Draper N, Mackie J et al. Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion. J Clin Endocrinol Metab 2002;87:57-62.
16. Kotelevtsev Y, Holmes MC, Burchell A et al. 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 1997;94:14924-9.
17. Hermanowski-Vosatka A, Balkovec JM, Cheng K et al. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 2005;202:517-27.
18. Cooper M, Stewart PM. The syndrome of apparent mineralocorticoid excess. Q J Med 1998;91:453-5.
19. Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR. Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age. Lancet 1987;2:821-4.
20. Bailey E, Greaves MS, Murphy D, West HF. Corticosteroid metabolism and rheumatoid arthritis. Ann Rheum Dis 1966;25:516-24.
21. Murphy D, West HF. Catabolism and interconversion of cortisol and cortisone in human synovial tissue in vitro. Ann Rheum Dis 1969;28:637-43.
22. Schmidt M, Weidler C, Naumann H, Anders S, Scholmerich J, Straub RH. Reduced capacity for the reactivation of glucocorticoids in rheumatoid arthritis synovial cells: possible role of the sympathetic nervous system? Arthritis Rheum 2005;52:1711-20.
23. Ferguson SE, Pallikaros Z, Michael AE, Cooke BA. The effects of different culture media, glucose, pyridine nucleotides and adenosine on the activity of 11beta-hydroxysteroid dehydrogenase in rat Leydig cells. Mol Cell Endocrinol 1999;158:37-44.
24. Hardy R, Rabbitt EH, Filer A et al. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis 2008;67:1204-10.
25. Olsen N, Sokka T, Seehorn CL et al. A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis 2004;63: 1387-92.
26. Haas CS, Creighton CJ, Pi X et al. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. Arthritis Rheum 2006;54:2047-60.
27. Hardy RS, Filer A, Cooper MS et al. Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation. Arthritis Res Ther 2006;8:R108.
28. Kaur K, Hardy R, Ahasan MM et al. Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. Ann Rheum Dis 2010;69:1185-90.
29. Boland E. Clinical comparison of the newer anti-inflammatory corticosteroids. Ann Rheum Dis 1962; 21:176-87.
30. Rabbitt E, Lavery GG, Walker EA, Cooper MS, Stewart PM, Hewison M. Pre-receptor regulation of glucocorticoid action by 11β-hydroxysteroid dehydrogenase: a novel determinant of cell proliferation. FASEB J 2002;16:36-44.
31. Sliwinska-Stanczyk P, Pazdur J, Ziolkowska M, Jaworski J, Kaminska-Tchorzewska E, Lacki JK. The effect of methylprednisolone on proliferation of PBMCs obtained from steroid-sensitive and steroid-resistant rheumatoid arthritis patients. Scand J Rheumatol 2007;36: 167-71.
32. Kirwan JR. Glucocorticoid resistance in patients with rheumatoid arthritis. Scand J Rheumatol 2007;36: 165-6.
33. Cooper MS, Walker EA, Bland R, Fraser WD, Hewison M, Stewart PM. Expression and functional consequences of 11β-hydroxysteroid dehydrogenase activity in human bone. Bone 2000;27:375-81.
34. Eijken M, Hewison M, Cooper MS et al. 11β-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol 2005;19:621-31.
35. Cooper MS, Bujalska I, Rabbitt E et al. Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proin-flammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 2001;16:1037-44.
36. Cooper MS, Rabbitt EH, Goddard PE, Bartlett WA, Hewison M, Stewart PM. Osteoblastic 11β-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure. J Bone Miner Res 2002;17: 979-86.
37. Weinstein RS, Wan C, Liu Q et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell 2010;9: 147-61.
38. Cooper MS, Syddall HE, Fall CH et al. Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study. Clin Endocrinol 2005;62:692-7.
39. Cooper MS, Blumsohn A, Goddard PE et al. 11β-hydroxysteroid dehydrogenase type 1 activity predicts the effects of glucocorticoids on bone. J Clin Endocrinol Metab 2003;88:3874-7.
40. Buttgereit F, Zhou H, Kalak R et al. Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo. Arthritis Rheum 2009;60: 1998-2007.
41. Boyle CD, Kowalski TJ. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: a review of recent patents. Expert Opin Ther Pat 2009;19:801-25.