Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

Arthritis Research and Therapy

Volumn 14, Issue 5, 2012, Pages

  Hardy, Rowan ^a   Juarez, Maria ^a   Naylor, Amy ^a   Tu, Jinwen ^b   Rabbitt, Elizabeth H ^a   Filer, Andrew ^a   Stewart, Paul M ^a   Buckley, Christopher D ^a,c   Raza, Karim ^a,c   Cooper, Mark S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ANZAC RESEARCH INSTITUTE   (Australia)

^c CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; DICKKOPF 1 PROTEIN; GLUCOCORTICOID; INTERLEUKIN 1BETA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN; DKK1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR;

ARTHRITIS; ARTICLE; CONTROLLED STUDY; CORTICOSTEROID METABOLISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; INFLAMMATORY ARTHRITIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; REAL TIME POLYMERASE CHAIN REACTION; WNT SIGNALING PATHWAY; ANKYLOSING SPONDYLITIS; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECTS; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; SIGNAL TRANSDUCTION; SYNOVIUM;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ARTHRITIS; CELLS, CULTURED; GLUCOCORTICOIDS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1BETA; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; SPONDYLITIS, ANKYLOSING; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA; WNT PROTEINS;

EID: 84867527586     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4065     Document Type: Article

References (23)

1. Herman S, Kronke G, Schett G. Molecular mechanisms of inflammatory bone damage: emerging targets for therapy. Trends in Molecular Medicine 2008, 14:245-253. 10.1016/j.molmed.2008.04.001, 18468489.
2. Hardy R, Cooper MS. Bone loss in inflammatory disorders. J Endocrinol 2009, 201:309-320. 10.1677/JOE-08-0568, 19443863.
3. Spector TD, Hall GM, McCloskey EV, Kanis JA. Risk of vertebral fracture in women with rheumatoid arthritis. BMJ 1993, 306:558. 10.1136/bmj.306.6877.558, 1677176, 8461772.
4. Raza K, Hardy R, Cooper MS. The 11beta-hydroxysteroid dehydrogenase enzymes-arbiters of the effects of glucocorticoids in synovium and bone. Rheumatology (Oxford) 2010, 49:2016-2023.
5. Cooper MS, Bujalska I, Rabbitt E, Walker EA, Bland R, Sheppard MC, Hewison M, Stewart PM. Modulation of 11β-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation. J Bone Miner Res 2001, 16:1037-1044. 10.1359/jbmr.2001.16.6.1037, 11393780.
6. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM. 11β-hydroxysteroid dehydrogenase type 1: A tissue-specific regulator of glucocorticoid response. Endocr Rev 2004, 25:831-866. 10.1210/er.2003-0031, 15466942.
7. Cooper MS, Stewart PM. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation. J Clin Endocrinol Metab 2009, 94:4645-4654. 10.1210/jc.2009-1412, 19837912.
8. Nordenstrom A, Marcus C, Axelson M, Wedell A, Ritzen EM. Failure of cortisone acetate treatment in congenital adrenal hyperplasia because of defective 11β-hydroxysteroid dehydrogenase reductase activity. J Clin Endocrinol Metab 1999, 84:1210-1213. 10.1210/jc.84.4.1210, 10199755.
9. Hardy RS, Filer A, Cooper MS, Parsonage G, Raza K, Hardie DL, Rabbitt EH, Stewart PM, Buckley CD, Hewison M. Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation. Arthritis Res Ther 2006, 8:R108. 10.1186/ar1993, 1779419, 16846535.
10. Hardy R, Rabbitt EH, Filer A, Emery P, Hewison M, Stewart PM, Gittoes NJ, Buckley CD, Raza K, Cooper MS. Local and systemic glucocorticoid metabolism in inflammatory arthritis. Ann Rheum Dis 2008, 67:1204-1210. 2564803, 18420938.
11. Kaur K, Hardy R, Ahasan MM, Eijken M, van Leeuwen JP, Filer A, Thomas AM, Raza K, Buckley CD, Stewart PM, Rabbitt EH, Hewison M, Cooper MS. Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss. Ann Rheum Dis 2010, 69:1185-1190. 10.1136/ard.2009.107466, 2927616, 19549618.
12. Ergang P, Leden P, Vagnerová K, Klusonová P, Miksik I, Jurcovicová J, Kment M, Pácha J. Local metabolism of glucocorticoids and its role in rat adjuvant arthritis. Mol Cell Endocrinol 2010, 323:155-160. 10.1016/j.mce.2010.03.003, 20226838.
13. Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der HD, Landewe R, Lacey D, Richards WG, Schett G. Dickkopf-1 is a master regulator of joint remodeling. Nature Medicine 2007, 13:156-163. 10.1038/nm1538, 17237793.
14. Wang FS, Ko JY, Yeh DW, Ke HC, Wu HL. Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss. Endocrinology 2008, 149:1793-1801. 10.1210/en.2007-0910, 18174290.
15. Cooper MS, Rabbitt EH, Goddard PE, Bartlett WA, Hewison M, Stewart PM. Osteoblastic 11β-hydroxysteroid dehydrogenase type 1 activity increases with age and glucocorticoid exposure. J Bone Miner Res 2002, 17:979-986. 10.1359/jbmr.2002.17.6.979, 12054173.
16. Wang SY, Liu YY, Ye H, Guo JP, Li R, Liu X, Li ZG. Circulating Dickkopf-1 is correlated with bone erosion and inflammation in rheumatoid arthritis. J Rheumatol 2011, 38:821-827. 10.3899/jrheum.100089, 21362762.
17. Rauch A, Seitz S, Baschant U, Schilling AF, Illing A, Stride B, Kirilov M, Mandic V, Takacz A, Schmidt-Ullrich R, Ostermay S, Schinke T, Spanbroek R, Zaiss MM, Angel PE, Lerner UH, David JP, Reichardt HM, Amling M, Schutz G, Tuckermann JP. Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab 2010, 11:517-531. 10.1016/j.cmet.2010.05.005, 20519123.
18. O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 2004, 145:1835-1841.
19. Cooper MS, Stewart PM. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003, 348:727-734. 10.1056/NEJMra020529, 12594318.
20. Coutinho AE, Gray M, Brownstein DG, Salter DM, Sawatzky DA, Clay S, Gilmour JS, Seckl JR, Savill JS, Chapman KE. 11beta-hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology 2012, 153:234-240. 10.1210/en.2011-1398, 3279737, 22067318.
21. Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, Kronke G, Schett G. Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis 2010, 69:592-597. 10.1136/ard.2008.102046, 19304568.
22. Appel H, Ruiz-Heiland G, Listing J, Zwerina J, Hermann M, Mueller R, Haibel H, Baraliakos X, Hempfing A, Rudwaleit M, Sieper J, Schett G. Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum 2010, 60:3257-3262.
23. Hwang JY, Lee SH, Kim GS, Koh JM, Go MJ, Kim YJ, Kim HC, Kim TH, Hong JM, Park EK, Lee JY, Kim SY. HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia. Bone 2009, 45:1098-1103. 10.1016/j.bone.2009.07.080, 19651257.