Triethylenetetramine prevents insulin aggregation and fragmentation during copper catalyzed oxidation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 84, Issue 3, 2013, Pages 464-471

  Torosantucci, Riccardo ^a   Weinbuch, Daniel ^a   Klem, Robin ^a   Jiskoot, Wim ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Aggregation; Antioxidant; Copper catalyzed oxidation; Fragmentation; Insulin; Monoclonal antibody

Indexed keywords

ASCORBIC ACID; COPPER; EDETIC ACID; GLUTATHIONE; IMMUNOGLOBULIN G1 ANTIBODY; INSULIN; RECOMBINANT HUMAN INSULIN; TRIENTINE;

ARTICLE; CATALYSIS; CIRCULAR DICHROISM; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; OXIDATION; PARTICLE SIZE; PROTEIN AGGREGATION; ROOM TEMPERATURE;

ANTIBODIES, MONOCLONAL; AREA UNDER CURVE; ASCORBIC ACID; BENZYLAMINES; CATALYSIS; CIRCULAR DICHROISM; COPPER; EDETIC ACID; GLUTATHIONE; HUMANS; IMMUNOGLOBULIN G; INSULIN; LIGHT; OXIDATION-REDUCTION; OXYGEN; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; TIME FACTORS; TRIENTINE;

EID: 84879092866     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.01.011     Document Type: Article

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