-
1
-
-
33847637080
-
Is there really good news about pandemic diabetic nephropathy?
-
Friedman, E. A., Friedman, A. L., Is there really good news about pandemic diabetic nephropathy? Nephrol. Dia. Transplant. 2007, 22, 681-683.
-
(2007)
Nephrol. Dia. Transplant.
, vol.22
, pp. 681-683
-
-
Friedman, E.A.1
Friedman, A.L.2
-
2
-
-
33644783770
-
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
-
DOI 10.2337/diabetes.55.1.225
-
Susztak, K., Raff, A. C., Schiffer, M., Bottinger, E. P., Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006, 55, 225-233. (Pubitemid 43343319)
-
(2006)
Diabetes
, vol.55
, Issue.1
, pp. 225-233
-
-
Susztak, K.1
Raff, A.C.2
Schiffer, M.3
Bottinger, E.P.4
-
3
-
-
10744221885
-
Alterations in the Renal Elastin-Elastase System in Type 1 Diabetic Nephropathy Identified by Proteomic Analysis
-
DOI 10.1097/01.ASN.0000115334.65095.9B
-
Thongboonkerd, V., Barati, M. T., McLeish, K. R., Benarafa, C. et al., Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis. J. Am. Soc. Nephrol. 2004, 15, 650-662. (Pubitemid 38294795)
-
(2004)
Journal of the American Society of Nephrology
, vol.15
, Issue.3
, pp. 650-662
-
-
Thongboonkerd, V.1
Barati, M.T.2
McLeish, K.R.3
Benarafa, C.4
Remold-O'Donnell, E.5
Zheng, S.6
Rovin, B.H.7
Pierce, W.M.8
Epstein, P.N.9
Klein, J.B.10
-
4
-
-
21244443761
-
Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes
-
DOI 10.1152/physiolgenomics.00231.2004
-
Knoll, K. E., Pietrusz, J. L., Liang, M., Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes. Physiol. Genomics 2005, 21, 222-229. (Pubitemid 40898482)
-
(2005)
Physiological Genomics
, vol.21
, pp. 222-229
-
-
Knoll, K.E.1
Pietrusz, J.L.2
Liang, M.3
-
5
-
-
0043268708
-
Microarray analysis of gene expression in the kidneys of new- And post-onset diabetic NOD mice
-
Wilson, K. H. S., Eckenrode, S. E., Li, Q.-Z., Ruan, Q. G. et al., Microarray analysis of gene expression in the kidneys of new- and post-onset diabetic NOD mice. Diabetes 2003, 52, 2151-2159.
-
(2003)
Diabetes
, vol.52
, pp. 2151-2159
-
-
Wilson, K.H.S.1
Eckenrode, S.E.2
Li, Q.-Z.3
Ruan, Q.G.4
-
6
-
-
33845890016
-
An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells
-
DOI 10.1080/13813450601093518, PII T271KU6G52582300
-
Cheng, D. W., Jiang, Y., Shalev, A., Kowluru, R. et al., An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells. Arch. Physiol. Biochem. 2006, 112, 189-218. (Pubitemid 46018362)
-
(2006)
Archives of Physiology and Biochemistry
, vol.112
, Issue.4-5
, pp. 189-218
-
-
Cheng, D.W.1
Jiang, Y.2
Shalev, A.3
Kowluru, R.4
Crook, E.D.5
Singh, L.P.6
-
7
-
-
0037586884
-
Structural and functional consequences of streptozotocin-induced diabetes on the kidney
-
Sharma, K., Han, D. C., Mogyorosi, A., Ziyadeh, F. N. (Eds.), McNeill J. H. (Ed.), CRC, Boca Raton, FL
-
Sharma, K., Han, D. C., Mogyorosi, A., Ziyadeh, F. N. (Eds.), Structural and functional consequences of streptozotocin-induced diabetes on the kidney. In: McNeill J. H. (Ed.), Experimental Models of Diabetes, CRC, Boca Raton, FL 1999, pp. 39-62.
-
(1999)
Experimental Models of Diabetes
, pp. 39-62
-
-
-
8
-
-
0035745203
-
The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats
-
DOI 10.1023/A:1016398200087
-
Liu, D., Razzaque, M. S., Cheng, M., Taguchi, T., The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats. Histochem. J. 2001, 33, 621-628. (Pubitemid 34852230)
-
(2001)
Histochemical Journal
, vol.33
, Issue.11-12
, pp. 621-628
-
-
Liu, D.1
Razzaque, M.S.2
Cheng, M.3
Taguchi, T.4
-
9
-
-
34248216953
-
Rodent models of streptozotocin-induced diabetic nephropathy
-
Tesch, G. H., Allen, T. J., Rodent models of streptozotocin-induced diabetic nephropathy. Nephrol. 2007, 12, 261-266.
-
(2007)
Nephrol.
, vol.12
, pp. 261-266
-
-
Tesch, G.H.1
Allen, T.J.2
-
10
-
-
33751081836
-
Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
-
DOI 10.1124/mol.106.028605
-
Gong, D., Lu, J., Chen, X., Choong, S. Y. et al., Molecular changes evoked by triethylenetetramine (TETA) of extracellular matrix in the heart and aorta of diabetic rats. Mol. Pharmacol. 2006, 70, 2045-2051. (Pubitemid 44771920)
-
(2006)
Molecular Pharmacology
, vol.70
, Issue.6
, pp. 2045-2051
-
-
Gong, D.1
Lu, J.2
Chen, X.3
Choong, S.Y.4
Zhang, S.5
Chan, Y.-K.6
Glyn-Jones, S.7
Gamble, G.D.8
Phillips, A.R.J.9
Cooper, G.J.S.10
-
11
-
-
49249098236
-
A copper (II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes
-
Gong, D., Lu, J., Chen, X., Reddy, S. et al., A copper (II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes. Diabetologia 2008, 51, 1741-1751.
-
(2008)
Diabetologia
, vol.51
, pp. 1741-1751
-
-
Gong, D.1
Lu, J.2
Chen, X.3
Reddy, S.4
-
12
-
-
36248931071
-
Effect of long-term type 1 diabetes on renal sodium and water transporters in rats
-
DOI 10.1159/000109967
-
Vidotti, D. B., Arnoni, C. P., Maquigussa, E., Boim, M. A., Effect of long-term type 1 diabetes on renal sodium and water transporters in rats. Am. J. Nephrol. 2008, 28, 107-114. (Pubitemid 350126500)
-
(2008)
American Journal of Nephrology
, vol.28
, Issue.1
, pp. 107-114
-
-
Vidotti, D.B.1
Arnoni, C.P.2
Maquigussa, E.3
Boim, M.A.4
-
13
-
-
33646522149
-
Roles of aquaporins in kidney revealed by transgenic mice
-
Verman, A. S., Roles of aquaporins in kidney revealed by transgenic mice. Semin. Nephrology 2006, 26, 200-208.
-
(2006)
Semin. Nephrology
, vol.26
, pp. 200-208
-
-
Verman, A.S.1
-
14
-
-
57649192743
-
Reduced calmodulin expression accelerates transient outward potassium current inactivation in diabetic rat heart
-
Gallego, M., Fernandez, D., Ahyayauch, H., Casis, E., Casis, O., Reduced calmodulin expression accelerates transient outward potassium current inactivation in diabetic rat heart. Cell. Physio. Biochem. 2008, 22, 625-634.
-
(2008)
Cell. Physio. Biochem.
, vol.22
, pp. 625-634
-
-
Gallego, M.1
Fernandez, D.2
Ahyayauch, H.3
Casis, E.4
Casis, O.5
-
15
-
-
10044242226
-
Sodium benzoate attenuates d-serine induced nephrotoxicity in the rat
-
DOI 10.1016/j.tox.2004.08.008, PII S0300483X0400469X
-
Williams, R. E., Lock, E. A., Sodium benzoate attenuates D-serine-induced nephrotoxicity in the rat. Toxicology 2005, 207, 35-48. (Pubitemid 39601684)
-
(2005)
Toxicology
, vol.207
, Issue.1
, pp. 35-48
-
-
Williams, R.E.1
Lock, E.A.2
-
16
-
-
0024316939
-
Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal beta-oxidation
-
DOI 10.1016/0006-2952(89)90528-5
-
Thomas, H., Schladt, L., Knehr, M., Oesch, F., Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal beta-oxidation. Biochem. Pharmacol. 1989, 38, 4291-4297. (Pubitemid 20009029)
-
(1989)
Biochemical Pharmacology
, vol.38
, Issue.23
, pp. 4291-4297
-
-
Thomas, H.1
Schladt, L.2
Knehr, M.3
Oesch, F.4
-
17
-
-
0034534288
-
Eicosanoid regulation of the renal vasculature
-
Imig, J. D., Eicosanoid regulation of the renal vasculature. Am. J. Physiol. Renal Physiol. 2000, 279, F965-F981.
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.279
-
-
Imig, J.D.1
-
18
-
-
60549106716
-
Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats
-
Olearczyk, J. J., Quigley, J. E., Mitchell, B. C., Yamamoto, T. et al., Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clin. Sci. 2009, 116, 61-70.
-
(2009)
Clin. Sci.
, vol.116
, pp. 61-70
-
-
Olearczyk, J.J.1
Quigley, J.E.2
Mitchell, B.C.3
Yamamoto, T.4
-
19
-
-
42649126674
-
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension
-
DOI 10.2741/2942
-
Li, J., Carroll, M. A., Chander, P. N., Falck, J. R. et al., Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension. Front. Biosci. 2008, 13, 3480-3487. (Pubitemid 351594697)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.9
, pp. 3480-3487
-
-
Li, J.1
Carroll, M.A.2
Chander, P.N.3
Falck, J.R.4
Sangras, B.5
Stier Jr., C.T.6
-
20
-
-
33644654633
-
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension
-
Imig, J. D., Zhao, X., Zaharis, C. Z., Olearczyk, J. J. et al., An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 2005, 46, 975-981.
-
(2005)
Hypertension
, vol.46
, pp. 975-981
-
-
Imig, J.D.1
Zhao, X.2
Zaharis, C.Z.3
Olearczyk, J.J.4
-
21
-
-
34748841342
-
Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator
-
Jullig, M., Chen, X., Hickey, A. J., Crossman, C. et al., Reversal of diabetes-evoked changes in mitochondrial protein expression of cardiac left ventricle by treatment with a copper(II)-selective chelator. Proteomics Clin. Appl. 2007, 1, 387-399.
-
(2007)
Proteomics Clin. Appl.
, vol.1
, pp. 387-399
-
-
Jullig, M.1
Chen, X.2
Hickey, A.J.3
Crossman, C.4
-
22
-
-
38149124113
-
Characterization of proteomic changes in cardiac mitochondria in streptozotocin-diabetic rats using iTRAQ isobaric tags
-
Jullig, M., Hickey, A. J., Middleditch, M. J., Crossman, D. J., Cooper, G. J. S., Characterization of proteomic changes in cardiac mitochondria in streptozotocin-diabetic rats using iTRAQ isobaric tags. Proteomics Clin. Appl. 2007, 1, 565-576.
-
(2007)
Proteomics Clin. Appl.
, vol.1
, pp. 565-576
-
-
Jullig, M.1
Hickey, A.J.2
Middleditch, M.J.3
Crossman, D.J.4
Cooper, G.J.S.5
-
23
-
-
0242413155
-
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: Implications on decreased myocardial protection in diabetic cardiomyopathy
-
DOI 10.1074/jbc.M304498200
-
Shan, Y. X., Yang, T. L., Mestril, R., Wang, P. H., HSP10 and HSP60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy. J. Biol. Chem. 2003, 278, 45492-45498. (Pubitemid 37432688)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.46
, pp. 45492-45498
-
-
Shan, Y.-X.1
Yang, T.-L.2
Mestril, R.3
Wang, P.H.4
-
24
-
-
12144284874
-
Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium
-
Chen, H. S., Shan, Y. X., Yang, T. L., Lin, H. D. et al., Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium. Diabetes 2005, 54, 175-181.
-
(2005)
Diabetes
, vol.54
, pp. 175-181
-
-
Chen, H.S.1
Shan, Y.X.2
Yang, T.L.3
Lin, H.D.4
-
25
-
-
43349090939
-
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes
-
DOI 10.1111/j.1365-2249.2008.03656.x
-
Huurman, V. A., van der Meide, P. E., Duinkerken, G., Willemen, S. et al., Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes. Clin. Exp. Immunol. 2008, 152, 488-497. (Pubitemid 351661507)
-
(2008)
Clinical and Experimental Immunology
, vol.152
, Issue.3
, pp. 488-497
-
-
Huurman, V.A.L.1
Van Der Meide, P.E.2
Duinkerken, G.3
Willemen, S.4
Cohen, I.R.5
Elias, D.6
Roep, B.O.7
-
26
-
-
20044363264
-
The hyperglycemia-induced inflammatory response in adipocytes: The role of reactive oxygen species
-
DOI 10.1074/jbc.M411863200
-
Lin, Y., Berg, A. H., Iyengar, P., Lam, T. K. et al., The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 2005, 280, 4617-4626. (Pubitemid 40288630)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.6
, pp. 4617-4626
-
-
Lin, Y.1
Berg, A.H.2
Iyengar, P.3
Lam, T.K.T.4
Giacca, A.5
Combs, T.P.6
Rajala, M.W.7
Du, X.8
Rollman, B.9
Li, W.10
Hawkins, M.11
Barzilai, N.12
Rhodes, C.J.13
Fantus, I.G.14
Brownlee, M.15
Scherer, P.E.16
-
27
-
-
33645474281
-
Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production
-
Zhang, Y., Wada, J., Hashimoto, I., Eguchi, J. et al., Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. J. Am. Soc. Nephrol. 2006, 17, 1090-1101.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1090-1101
-
-
Zhang, Y.1
Wada, J.2
Hashimoto, I.3
Eguchi, J.4
-
28
-
-
55249118568
-
Role of reactive oxygen species in the pathogenesis of diabetic nephropathy
-
Ha, H., Hwang, I. A., Park, J. H., Lee, H. B., Role of reactive oxygen species in the pathogenesis of diabetic nephropathy. Diabetes Res. Clin. Practice 2008, 82, S42-S45.
-
(2008)
Diabetes Res. Clin. Practice
, vol.82
-
-
Ha, H.1
Hwang, I.A.2
Park, J.H.3
Lee, H.B.4
-
29
-
-
0028306071
-
Immunohistochemical localization of collagen VI in diabetic glomeruli
-
Nerlich, A. G., Schleicher, E. D., Wiest, I., Specks, U., Timpl, R., Immunohistochemical localization of collagen VI in diabetic glomeruli. Kidney Int. 1994, 45, 1648-1656. (Pubitemid 24207500)
-
(1994)
Kidney International
, vol.45
, Issue.6
, pp. 1648-1656
-
-
Nerlich, A.G.1
Schleicher, E.D.2
Wiest, I.3
Specks, U.4
Timpl, R.5
-
30
-
-
0025017859
-
Occurrence of type VI collagen in extracellular matrix of renal glomeruli and its increase in diabetes
-
Mohan, P. S., Carter, W. G., Spiro, R. G., Occurrence of type VI collagen in extracellular matrix of renal glomeruli and its increase in diabetes. Diabetes 1990, 39, 31-37.
-
(1990)
Diabetes
, vol.39
, pp. 31-37
-
-
Mohan, P.S.1
Carter, W.G.2
Spiro, R.G.3
-
31
-
-
0033635915
-
Progeria kidney has abnormal mesangial collagen distribution
-
Delahunt, B., Stehbens,W. E., Gilbert-Barness, E., Shozawa, T., Ruger, B. M., Progeria kidney has abnormal mesangial collagen distribution. Pediatr. Nephrol. 2000, 15, 279-285.
-
(2000)
Pediatr. Nephrol.
, vol.15
, pp. 279-285
-
-
Delahunt, B.1
Stehbens, W.E.2
Gilbert-Barness, E.3
Shozawa, T.4
Ruger, B.M.5
-
32
-
-
0029445123
-
Morphology of basement membrane and associated matrix proteins in normal and pathological tissues
-
Nerlich, A., Morphology of basement membrane and associated matrix proteins in normal and pathological tissues. Veroffentlichungen aus der Pathologie 1995, 145, 1-139.
-
(1995)
Veroffentlichungen Aus der Pathologie
, vol.145
, pp. 1-139
-
-
Nerlich, A.1
-
33
-
-
0030457613
-
Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): Implications for Alport syndrome
-
Miner, J. H., Sanes, J. R., Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome. J. Cell Biol. 1996, 135, 1403-1413.
-
(1996)
J. Cell Biol.
, vol.135
, pp. 1403-1413
-
-
Miner, J.H.1
Sanes, J.R.2
-
34
-
-
10944263493
-
High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells
-
DOI 10.1111/j.1523-1755.2005.00058.x
-
Mishra, R., Emancipator, S. N., Kern, T., Simonson, M. S., High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int. 2005, 67, 82-93. (Pubitemid 40019229)
-
(2005)
Kidney International
, vol.67
, Issue.1
, pp. 82-93
-
-
Mishra, R.1
Emancipator, S.N.2
Kern, T.3
Simonson, M.S.4
-
35
-
-
35848951893
-
Apoptosis in the kidneys of patients with type II diabetic nephropathy
-
DOI 10.1038/sj.ki.5002531, PII 5002531
-
Verzola, D., Gandolfo, M. T., Ferrario, F., Rastaldi, M. P. et al., Apoptosis in the kidneys of patients with type II diabetic nephropathy. Kidney Int. 2007, 72, 1262-1272. (Pubitemid 350059668)
-
(2007)
Kidney International
, vol.72
, Issue.10
, pp. 1262-1272
-
-
Verzola, D.1
Gandolfo, M.T.2
Ferrario, F.3
Rastaldi, M.P.4
Villaggio, B.5
Gianiorio, F.6
Giannoni, M.7
Rimoldi, L.8
Lauria, F.9
Miji, M.10
Deferrari, G.11
Garibotto, G.12
-
36
-
-
33645823657
-
The expression level of the voltage-dependent anion channel controls life and death of the cell
-
Abu-Hamad, S., Sivan, S., Shoshan-Barmatz, V., The expression level of the voltage-dependent anion channel controls life and death of the cell. Proc. Natl. Acad. Sci. USA 2006, 103, 5787-5792.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 5787-5792
-
-
Abu-Hamad, S.1
Sivan, S.2
Shoshan-Barmatz, V.3
-
37
-
-
0042316795
-
Quantitative protein profiling in heart mitochondria from diabetic rats
-
DOI 10.1074/jbc.M303139200
-
Turko, I. V., Murad, F., Quantitative protein profiling in heart mitochondria from diabetic rats. J. Biol. Chem. 2003, 278, 35844-35849. (Pubitemid 37102363)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.37
, pp. 35844-35849
-
-
Turko, I.V.1
Murad, F.2
-
38
-
-
4344702433
-
Regeneration of the heart in diabetes by selective copper chelation
-
Cooper, G. J., Phillips, A. R., Choong, S. Y., Leonard, B. L. et al., Regeneration of the heart in diabetes by selective copper chelation. Diabetes 2004, 53, 2501-2508.
-
(2004)
Diabetes
, vol.53
, pp. 2501-2508
-
-
Cooper, G.J.1
Phillips, A.R.2
Choong, S.Y.3
Leonard, B.L.4
-
39
-
-
61449239980
-
A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type-2 diabetic patients
-
Cooper, G. J., Young, A. A., Gamble, G. D., Occleshaw, C. J. et al., A copper(II)-selective chelator ameliorates left-ventricular hypertrophy in type-2 diabetic patients. Diabetologia 2009, 52, 715-722.
-
(2009)
Diabetologia
, vol.52
, pp. 715-722
-
-
Cooper, G.J.1
Young, A.A.2
Gamble, G.D.3
Occleshaw, C.J.4
-
40
-
-
20944436062
-
Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: Quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals
-
Cooper, G. J., Chan, Y. K., Dissanayake, A. M., Leahy, F. E. et al., Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals. Diabetes 2005, 54, 1468-1476.
-
(2005)
Diabetes
, vol.54
, pp. 1468-1476
-
-
Cooper, G.J.1
Chan, Y.K.2
Dissanayake, A.M.3
Leahy, F.E.4
|