Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

Journal of Molecular Medicine

Volumn 91, Issue 5, 2013, Pages 625-636

  Cucchiarini, Magali ^a   Orth, Patrick ^a   Madry, Henning ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Articular cartilage defects; Gene transfer; rAAV; Rabbits; SOX9

Indexed keywords

TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BIOLOGICAL ACTIVITY; CARTILAGE CELL; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FEMALE; GENE CASSETTE; GENE EXPRESSION; GENE TARGETING; HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; KNEE INJURY; MESENCHYMAL STEM CELL; NONHUMAN; TISSUE DIFFERENTIATION; TISSUE REPAIR; TRANSGENE;

ANIMALS; BETA CATENIN; CARTILAGE, ARTICULAR; CELL DIFFERENTIATION; CHONDROCYTES; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DEPENDOVIRUS; FEMALE; GENE EXPRESSION REGULATION; GENETIC THERAPY; GENETIC VECTORS; HYPERTROPHY; LAC OPERON; MESENCHYMAL STROMAL CELLS; RABBITS; SIGNAL TRANSDUCTION; SOX9 TRANSCRIPTION FACTOR; TRANSGENES; WOUND HEALING;

EID: 84879086601     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0978-9     Document Type: Article

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