-
1
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
DOI 10.1126/science.1086907
-
Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301: 1374-1377. (Pubitemid 37075812)
-
(2003)
Science
, vol.301
, Issue.5638
, pp. 1374-1377
-
-
Wardemann, H.1
Yurasov, S.2
Schaefer, A.3
Young, J.W.4
Meffre, E.5
Nussenzweig, M.C.6
-
2
-
-
15444365480
-
Defective B cell tolerance checkpoints in systemic lupus erythematosus
-
DOI 10.1084/jem.20042251
-
Yurasov, S., H. Wardemann, J. Hammersen, M. Tsuiji, E. Meffre, V. Pascual, and M. C. Nussenzweig. 2005. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J. Exp. Med. 201: 703-711. (Pubitemid 40395116)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.5
, pp. 703-711
-
-
Yurasov, S.1
Wardemann, H.2
Hammersen, J.3
Tsuiji, M.4
Meffre, E.5
Pascual, V.6
Nussenzweig, M.C.7
-
3
-
-
19344374510
-
Impaired early B cell tolerance in patients with rheumatoid arthritis
-
DOI 10.1084/jem.20042321
-
Samuels, J., Y. S. Ng, C. Coupillaud, D. Paget, and E. Meffre. 2005. Impaired early B cell tolerance in patients with rheumatoid arthritis. J. Exp. Med. 201: 1659-1667. (Pubitemid 40721009)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.10
, pp. 1659-1667
-
-
Samuels, J.1
Ng, Y.-S.2
Coupillaud, C.3
Paget, D.4
Meffre, E.5
-
4
-
-
80052376347
-
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
-
Menard, L., D. Saadoun, I. Isnardi, Y. S. Ng, G. Meyers, C. Massad, C. Price, C. Abraham, R. Motaghedi, J. H. Buckner, et al. 2011. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans. J. Clin. Invest. 121: 3635-3644.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 3635-3644
-
-
Menard, L.1
Saadoun, D.2
Isnardi, I.3
Ng, Y.S.4
Meyers, G.5
Massad, C.6
Price, C.7
Abraham, C.8
Motaghedi, R.9
Buckner, J.H.10
-
5
-
-
2942652985
-
Receptor editing is the main mechanism of B cell tolerance toward membrane antigens
-
DOI 10.1038/ni1076
-
Halverson, R., R. M. Torres, and R. Pelanda. 2004. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat. Immunol. 5: 645-650. (Pubitemid 38811890)
-
(2004)
Nature Immunology
, vol.5
, Issue.6
, pp. 645-650
-
-
Halverson, R.1
Torres, R.M.2
Pelanda, R.3
-
6
-
-
62849091467
-
Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
-
Pereira, J. P., J. An, Y. Xu, Y. Huang, and J. G. Cyster. 2009. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat. Immunol. 10: 403-411.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 403-411
-
-
Pereira, J.P.1
An, J.2
Xu, Y.3
Huang, Y.4
Cyster, J.G.5
-
7
-
-
77749245824
-
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development
-
Donovan, E. E., R. Pelanda, and R. M. Torres. 2010. S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development. Eur. J. Immunol. 40: 688-698.
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 688-698
-
-
Donovan, E.E.1
Pelanda, R.2
Torres, R.M.3
-
8
-
-
0021019885
-
Insulin antibodies in insulin-dependent diabetics before insulin treatment
-
Palmer, J. P., C. M. Asplin, P. Clemons, K. Lyen, O. Tatpati, P. K. Raghu, and T. L. Paquette. 1983. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337-1339. (Pubitemid 14204704)
-
(1983)
Science
, vol.222
, Issue.4630
, pp. 1337-1339
-
-
Palmer, J.P.1
Asplin, C.M.2
Clemons, P.3
-
9
-
-
0034652317
-
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
-
DOI 10.1073/pnas.040556697
-
Yu, L., D. T. Robles, N. Abiru, P. Kaur, M. Rewers, K. Kelemen, and G. S. Eisenbarth. 2000. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc. Natl. Acad. Sci. USA 97: 1701-1706. (Pubitemid 30118506)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1701-1706
-
-
Yu, L.1
Robles, D.T.2
Abiru, N.3
Kaur, P.4
Rewers, M.5
Kelemen, K.6
Eisenbarth, G.S.7
-
10
-
-
80051979794
-
Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: Diabetes autoimmunity study in the young
-
Steck, A. K., K. Johnson, K. J. Barriga, D. Miao, L. Yu, J. C. Hutton, G. S. Eisenbarth, and M. J. Rewers. 2011. Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young. Diabetes Care 34: 1397-1399.
-
(2011)
Diabetes Care
, vol.34
, pp. 1397-1399
-
-
Steck, A.K.1
Johnson, K.2
Barriga, K.J.3
Miao, D.4
Yu, L.5
Hutton, J.C.6
Eisenbarth, G.S.7
Rewers, M.J.8
-
11
-
-
18744366947
-
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
-
DOI 10.1038/nature03523
-
Nakayama, M., N. Abiru, H. Moriyama, N. Babaya, E. Liu, D. Miao, L. Yu, D. R. Wegmann, J. C. Hutton, J. F. Elliott, and G. S. Eisenbarth. 2005. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435: 220-223. (Pubitemid 40685949)
-
(2005)
Nature
, vol.435
, Issue.7039
, pp. 220-223
-
-
Nakayama, M.1
Abiru, N.2
Moriyama, H.3
Babaya, N.4
Liu, E.5
Miao, D.6
Yu, L.7
Wegmann, D.R.8
Hutton, J.C.9
Elliott, J.F.10
Eisenbarth, G.S.11
-
12
-
-
0035889964
-
Cutting edge: B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice
-
Hulbert, C., B. Riseili, M. Rojas, and J. W. Thomas. 2001. B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J. Immunol. 167: 5535-5538. (Pubitemid 33062740)
-
(2001)
Journal of Immunology
, vol.167
, Issue.10
, pp. 5535-5538
-
-
Hulbert, C.1
Riseili, B.2
Rojas, M.3
Thomas, J.W.4
-
13
-
-
84864390309
-
Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes
-
Henry, R. A., P. L. Kendall, and J. W. Thomas. 2012. Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes. Diabetes 61: 2037-2044.
-
(2012)
Diabetes
, vol.61
, pp. 2037-2044
-
-
Henry, R.A.1
Kendall, P.L.2
Thomas, J.W.3
-
14
-
-
0028064578
-
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
-
DOI 10.1038/371389a0
-
Cyster, J. G., S. B. Hartley, and C. C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371: 389-395. (Pubitemid 24302553)
-
(1994)
Nature
, vol.371
, Issue.6496
, pp. 389-395
-
-
Cyster, J.G.1
Hartley, S.B.2
Goodnow, C.C.3
-
15
-
-
0032955190
-
Follicular exclusion and rapid elimination of hen egg lysozyme autoantigen-binding B cells are dependent on competitor B cells, but not on T cells
-
Schmidt, K. N., and J. G. Cyster. 1999. Follicular exclusion and rapid elimination of hen egg lysozyme autoantigen-binding B cells are dependent on competitor B cells, but not on T cells. J. Immunol. 162: 284-291. (Pubitemid 29018931)
-
(1999)
Journal of Immunology
, vol.162
, Issue.1
, pp. 284-291
-
-
Schmidt, K.N.1
Cyster, J.G.2
-
16
-
-
23244448606
-
Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice
-
Woodward, E. J., and J. W. Thomas. 2005. Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice. J. Immunol. 175: 1073-1079. (Pubitemid 41094993)
-
(2005)
Journal of Immunology
, vol.175
, Issue.2
, pp. 1073-1079
-
-
Woodward, E.J.1
Thomas, J.W.2
-
17
-
-
0035284755
-
Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen
-
Rojas, M., C. Hulbert, and J. W. Thomas. 2001. Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J. Immunol. 166: 3194-3200. (Pubitemid 33117317)
-
(2001)
Journal of Immunology
, vol.166
, Issue.5
, pp. 3194-3200
-
-
Rojas, M.1
Hulbert, C.2
Thomas, J.W.3
-
18
-
-
0021150335
-
Binding of insulin to its receptor impairs recognition by monoclonal anti-insulin antibodies
-
Taylor, S. I., J. A. Schroer, B. Marcus-Samuels, A. McElduff, and T. P. Bender. 1984. Binding of insulin to its receptor impairs recognition by monoclonal antiinsulin antibodies. Diabetes 33: 778-784. (Pubitemid 14053519)
-
(1984)
Diabetes
, vol.33
, Issue.8
, pp. 778-784
-
-
Taylor, S.I.1
Schroer, J.A.2
Marcus-Samuels, B.3
-
19
-
-
0031227790
-
T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin
-
Thomas, J. W., P. M. Kralick, and U. K. Ewulonu. 1997. T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin. J. Immunol. 159: 2334-2341. (Pubitemid 127681025)
-
(1997)
Journal of Immunology
, vol.159
, Issue.5
, pp. 2334-2341
-
-
Thomas, J.W.1
Kralick, P.M.2
Ewulonu, U.K.3
-
20
-
-
0025193410
-
V(H) and V(L) gene usage by murine IgG antibodies that bind autologous insulin
-
Ewulonu, U. K., L. J. Nell, and J. W. Thomas. 1990. VH and VL gene usage by murine IgG antibodies that bind autologous insulin. J. Immunol. 144: 3091-3098. (Pubitemid 20149485)
-
(1990)
Journal of Immunology
, vol.144
, Issue.8
, pp. 3091-3098
-
-
Ewulonu, U.K.1
Nell, L.J.2
Thomas, J.W.3
-
21
-
-
0020510712
-
Mapping epitopes on the insulin molecule using monoclonal antibodies
-
Schroer, J. A., T. Bender, R. J. Feldmann, and K. J. Kim. 1983. Mapping epitopes on the insulin molecule using monoclonal antibodies. Eur. J. Immunol. 13: 693-700. (Pubitemid 13012564)
-
(1983)
European Journal of Immunology
, vol.13
, Issue.9
, pp. 693-700
-
-
Schroer, J.A.1
Bender, T.2
Feldmann, R.J.3
Jin, K.K.4
-
22
-
-
0028969406
-
VH gene structure predicts a large potential anti-insulin repertoire
-
Mitchell, H. C., and J. W. Thomas. 1995. VH gene structure predicts a large potential anti-insulin repertoire. Mol. Immunol. 32: 311-321.
-
(1995)
Mol. Immunol.
, vol.32
, pp. 311-321
-
-
Mitchell, H.C.1
Thomas, J.W.2
-
24
-
-
77955885712
-
Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains
-
Henry, R. A., P. L. Kendall, E. J. Woodward, C. Hulbert, and J. W. Thomas. 2010. Vkappa polymorphisms in NOD mice are spread throughout the entire immunoglobulin kappa locus and are shared by other autoimmune strains. Immunogenetics 62: 507-520.
-
(2010)
Immunogenetics
, vol.62
, pp. 507-520
-
-
Henry, R.A.1
Kendall, P.L.2
Woodward, E.J.3
Hulbert, C.4
Thomas, J.W.5
-
25
-
-
77954232248
-
Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene
-
Kendall, P. L., D. J. Moore, C. Hulbert, K. L. Hoek, W. N. Khan, and J. W. Thomas. 2009. Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. J. Immunol. 183: 6403-6412.
-
(2009)
J. Immunol.
, vol.183
, pp. 6403-6412
-
-
Kendall, P.L.1
Moore, D.J.2
Hulbert, C.3
Hoek, K.L.4
Khan, W.N.5
Thomas, J.W.6
-
26
-
-
65449159750
-
Functional silencing is initiated and maintained in immature anti-insulin B cells
-
Henry, R. A., C. A. Acevedo-Suárez, and J. W. Thomas. 2009. Functional silencing is initiated and maintained in immature anti-insulin B cells. J. Immunol. 182: 3432-3439.
-
(2009)
J. Immunol.
, vol.182
, pp. 3432-3439
-
-
Henry, R.A.1
Acevedo-Suárez, C.A.2
Thomas, J.W.3
-
27
-
-
7244227849
-
+ stage
-
DOI 10.1002/eji.200425400
-
Milne, C. D., H. E. Fleming, and C. J. Paige. 2004. IL-7 does not prevent pro-B/pre-B cell maturation to the immature/sIgM(+) stage. Eur. J. Immunol. 34: 2647-2655. (Pubitemid 39430141)
-
(2004)
European Journal of Immunology
, vol.34
, Issue.10
, pp. 2647-2655
-
-
Milne, C.D.1
Fleming, H.E.2
Paige, C.J.3
-
28
-
-
0021253902
-
125I anti-IgM antibody
-
Osmond, D. G., and S. J. Batten. 1984. Genesis of B lymphocytes in the bone marrow: extravascular and intravascular localization of surface IgM-bearing cells in mouse bone marrow detected by electron-microscope radioautography after in vivo perfusion of 125I anti-IgM antibody. Am. J. Anat. 170: 349-365. (Pubitemid 14095965)
-
(1984)
American Journal of Anatomy
, vol.170
, Issue.3
, pp. 349-365
-
-
Osmond, D.G.1
Batten, S.J.2
-
29
-
-
0006879543
-
Physiologic action of insulin
-
M. Ellenberg and H. Rifkin, eds. Medical Examination Publishing, New Hyde Park, NY
-
Felig, P. 1983. Physiologic action of insulin. In Diabetes Mellitus: Theory and Practice. M. Ellenberg and H. Rifkin, eds. Medical Examination Publishing, New Hyde Park, NY, p. 77-88.
-
(1983)
Diabetes Mellitus: Theory and Practice
, pp. 77-88
-
-
Felig, P.1
-
30
-
-
11844260763
-
Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes
-
Acevedo-Suárez, C. A., C. Hulbert, E. J. Woodward, and J. W. Thomas. 2005. Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes. J. Immunol. 174: 827-833. (Pubitemid 40094278)
-
(2005)
Journal of Immunology
, vol.174
, Issue.2
, pp. 827-833
-
-
Acevedo-Suarez, C.A.1
Hulbert, C.2
Woodward, E.J.3
Thomas, J.W.4
-
31
-
-
34247617232
-
Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes
-
Kendall, P. L., G. Yu, E. J. Woodward, and J. W. Thomas. 2007. Tertiary lymphoid structures in the pancreas promote selection of B lymphocytes in autoimmune diabetes. J. Immunol. 178: 5643-5651. (Pubitemid 46674360)
-
(2007)
Journal of Immunology
, vol.178
, Issue.9
, pp. 5643-5651
-
-
Kendall, P.L.1
Yu, G.2
Woodward, E.J.3
Thomas, J.W.4
-
32
-
-
84874885423
-
Tolerant anti-insulin B Cells are effective APCs
-
Kendall, P. L., J. B. Case, A. M. Sullivan, J. S. Holderness, S. K. Wells, E. Liu, and J. W. Thomas. 2013. Tolerant anti-insulin B Cells are effective APCs. J. Immunol. 190: 2519-2526.
-
(2013)
J. Immunol.
, vol.190
, pp. 2519-2526
-
-
Kendall, P.L.1
Case, J.B.2
Sullivan, A.M.3
Holderness, J.S.4
Wells, S.K.5
Liu, E.6
Thomas, J.W.7
-
33
-
-
0029010646
-
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice
-
Healey, D., P. Ozegbe, S. Arden, P. Chandler, J. Hutton, and A. Cooke. 1995. In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95: 2979-2985.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2979-2985
-
-
Healey, D.1
Ozegbe, P.2
Arden, S.3
Chandler, P.4
Hutton, J.5
Cooke, A.6
-
34
-
-
0029036567
-
Interferon expression in the pancreases of patients with type I diabetes
-
Huang, X., J. Yuang, A. Goddard, A. Foulis, R. F. James, A. Lernmark, R. Pujol- Borrell, A. Rabinovitch, N. Somoza, and T. A. Stewart. 1995. Interferon expression in the pancreases of patients with type I diabetes. Diabetes 44: 658-664.
-
(1995)
Diabetes
, vol.44
, pp. 658-664
-
-
Huang, X.1
Yuang, J.2
Goddard, A.3
Foulis, A.4
James, R.F.5
Lernmark, A.6
Pujol- Borrell, R.7
Rabinovitch, A.8
Somoza, N.9
Stewart, T.A.10
-
35
-
-
84960989501
-
Influenza: The new acquayantance
-
Francis, T., Jr. 1953. Influenza: the new acquayantance. Ann. Intern. Med. 39: 203-221.
-
(1953)
Ann. Intern. Med.
, vol.39
, pp. 203-221
-
-
Francis Jr., T.1
-
36
-
-
33744924210
-
Cutting edge: Impaired transitional B cell production and selection in the nonobese diabetic mouse
-
Quinn, W. J., III, N. Noorchashm, J. E. Crowley, A. J. Reed, H. Noorchashm, A. Naji, and M. P. Cancro. 2006. Cutting edge: impaired transitional B cell production and selection in the nonobese diabetic mouse. J. Immunol. 176: 7159-7164. (Pubitemid 43849016)
-
(2006)
Journal of Immunology
, vol.176
, Issue.12
, pp. 7159-7164
-
-
Quinn III, W.J.1
Noorchashm, N.2
Crowley, J.E.3
Reed, A.J.4
Noorchashm, H.5
Naji, A.6
Cancro, M.P.7
-
37
-
-
59649105484
-
RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes
-
Panigrahi, A. K., N. G. Goodman, R. A. Eisenberg, M. R. Rickels, A. Naji, and E. T. Luning Prak. 2008. RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes. J. Exp. Med. 205: 2985-2994.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2985-2994
-
-
Panigrahi, A.K.1
Goodman, N.G.2
Eisenberg, R.A.3
Rickels, M.R.4
Naji, A.5
Luning Prak, E.T.6
-
38
-
-
0031136693
-
Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice
-
Tikhomirov OYu, and J W. Thomas. 1997. Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice. J. Immunol. 158: 4292-4300.
-
(1997)
J. Immunol.
, vol.158
, pp. 4292-4300
-
-
Tikhomirov, O.Yu.1
Thomas, J.W.2
-
39
-
-
0036883945
-
The natural autoantibody repertoire of nonobese diabetic mice is highly active
-
Thomas, J. W., P. L. Kendall, and H. G. Mitchell. 2002. The natural autoantibody repertoire of nonobese diabetic mice is highly active. J. Immunol. 169: 6617-6624. (Pubitemid 36903516)
-
(2002)
Journal of Immunology
, vol.169
, Issue.11
, pp. 6617-6624
-
-
Thomas, J.W.1
Kendall, P.L.2
Mitchell, H.G.3
-
40
-
-
0030962478
-
T cell receptor restriction of diabetogenic autoimmune NOD T cells
-
DOI 10.1073/pnas.94.6.2518
-
Simone, E., D. Daniel, N. Schloot, P. Gottlieb, S. Babu, E. Kawasaki, D. Wegmann, and G. S. Eisenbarth. 1997. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc. Natl. Acad. Sci. USA 94: 2518-2521. (Pubitemid 27136907)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.6
, pp. 2518-2521
-
-
Simone, E.1
Daniel, D.2
Schloot, N.3
Gottlieb, P.4
Babu, S.5
Kawasaki, E.6
Wegmann, D.7
Eisenbarth, G.S.8
-
41
-
-
0031170925
-
T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice
-
DOI 10.1006/jaut.1997.0134
-
Simone, E. A., L. Yu, D. R. Wegmann, and G. S. Eisenbarth. 1997. T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice. J. Autoimmun. 10: 317-321. (Pubitemid 27286540)
-
(1997)
Journal of Autoimmunity
, vol.10
, Issue.3
, pp. 317-321
-
-
Simone, E.A.1
Yu, L.2
Wegmann, D.R.3
Eisenbarth, G.S.4
|