T cell receptor gene polymorphisms associated with anti-insulin, autoimmune T cells in diabetes-prone NOD mice

Journal of Autoimmunity

Volumn 10, Issue 3, 1997, Pages 317-321

  Simone, Eric A ^a   Yu, Liping ^a   Wegmann, Dale R ^a   Eisenbarth, George S ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Alpha chain; Autoimmunity; Insulin; Type I diabetes

Indexed keywords

INSULIN ANTIBODY;

ALPHA CHAIN; ANALYTIC METHOD; ANIMAL CELL; AUTOIMMUNITY; CELL SPECIFICITY; CONFERENCE PAPER; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA LIBRARY; DNA POLYMORPHISM; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR GENE; T LYMPHOCYTE ACTIVATION;

EID: 0031170925     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1997.0134     Document Type: Conference Paper

References (29)

1. Vardi P., Ziegler A.G., Matthews J.H., Dib S., Keller R.J., Ricker A.T., Wolfsdorf J.I., Herskowitz R.D., Rabizadeh A., Eisenbarth G.S., Soeldner J.S. Concentration of insulin autoantibodies at onset of Type I diabetes: inverse log-linear correlation with age. Diabetes Care. 11:1988;736-739.
2. Wegmann D.R., Gill R.G., Norbury-Glaser M., Schloot N., Daniel D. Analysis of the spontaneous T cell response to insulin in NOD mice. J. Autoimmun. 7:1994;833-843.
3. Wegmann D., Norbury-Glaser M., Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol. 24:1994;1853-1857.
4. Daniel D., Wegmann D.R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. U.S.A. 93:1996;956-960.
5. Daniel D., Gill R.G., Schloot N., Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25:1995;1056-1062.
6. Chluba J., Steeg C., Becker A., Wekerle H., Epplen J.G. T cell receptor B chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol. 19:1989;279-284.
7. Urban J.L., Kumar V., Kono D.H., Gomez C., Ando D.G., Sercarz E.E., Hood L. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raised possibilities for antibody therapy. Cell. 54:1988;577-592.
8. Acha-Orbea H., Mitchell D.J., Timmermann L., Wraith D.C., Tausch G.S., Waldor M.K., Zamvil S.S., McDevitt H.O., Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell. 54:1988;263-273.
9. Clark L., Heber-Katz E., Rostami A. Shared T-cell receptor gene usage in experimental allergic neuritis and encephalomyelitis. Ann. Neurol. 31:1992;587-592.
10. Gregerson D.S., Fling S.P., Merryman C.F., Zhang X., Li X., Heber-Katz E. Conserved T cell receptor V gene usage by uveitogenic T cells. Clin. Immunol. Immunopathol. 58:1991;154-161.
11. Osman G.E., Toda M., Kanagawa O., Hood L.E. Characterization of the T cell receptor repertoire causing collagen arthritis in mice. J. Exp. Med. 177:1993;387-395.
12. Sarukhan A., Gombert J.M., Olivi M., Bach J.F., Carnaud C., Garchon H.J. Anchored polymerase chain reaction based analysis of the V beta repertoire in the non-obese diabetic (NOD) mouse. Eur. J. Immunol. 84:1994;1750-1756.
13. Sarukhan A., Bedossa P., Garchon H., Bach J., Carnaud C. Molecular analysis of TCR junctional variability in individual infiltrated islets of non-obese diabetic mice: evidence for the constitution of largely autonomous T cell foci within the same pancreas. Int. Immunol. 7:1994;139-146.
14. Candeias S., Katz J., Benoist C., Mathis D., Haskins K. Islet-specific T cell clones from non-obese diabetic mice express heterogenous T cell receptors. Proc. Natl. Acad. Sci. U.S.A. 88:1991;6167-6170.
15. Nakano N., Kikutani H., Nishimoto H., Kishimoto T. T cell receptor V gene usage of islet B cell-reactive T cells is not restricted in non-obese diabetic mice. J. Exp. Med. 173:1991;1091-1097.
16. Shizuru J.A., Taylor-Edwards C., Livingstone A., Fathman C.G. Genetic dissection of T cell receptor V beta gene requirements for spontaneous murine diabetes. J. Exp. Med. 174:1991;633-638.
17. McDuffie M. Diabetes in NOD mice does not require T lymphocytes expressing V beta 8 or V beta 5. Diabetes. 40:1991;1555-1559.
18. Lipes M.A., Rosenzweig A., Tan K.N., Tanigawa G., Ladd D., Seidman J.G., Eisenbarth G.S. Progression to diabetes in nonobese diabetic (NOD) mice with transgenic T cell receptors. Science. 259:1993;1165-1169.
19. Simone E., Daniel D., Schloot N., Kawasaki E., Gottlieb P., Babu S., Wegmann D., Eisenbarth G.S. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc. Nat. Acad. Sci. U.S.A. 94:1997;2518-2521.
20. Arden B., Kotz J.L., Siu G., Hood L.E. Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor. Nature. 316:1985;783-787.
21. Arden B., Clark S.P., Kabelitz D. Mouse T-cell receptor variable gene segment families. Immunogenetics. 42:1995;501-530.
22. Smith L.R., Plaza A., Singer P.A., Theofilopoulos A.N. Coding sequence polymorphisms among VB T cell receptor genes. J. Immunol. 144:1990;3234-3237.
23. Lund T., Shaikh S., Hattori M., Makino S. Analysis of the T cell receptor (TcR) regions in the NOD, NON and CTS mouse strains define the new TcR Va haplotypes and new deletions in the TcR VB region. Eur. J. Immunol. 22:1992;871-874.
24. Chou H.S., Behlke M.A., Godambe S.A., Russell J.H., Brooks C.G., Loh D.Y. T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments. EMBO J. 5:1986;2149-2155.
25. Dattamajumdar A.K., Li S.W., Jacobson D.P., Ladiges W., Hood L.E., Osman G.E. Characterization of the mouse Tcra-V22 gene subfamily. Immunogenetics. 44:1996;432-440.
26. Jovin-Marche E., Hue I., Marche P.N., Liebe-Gris C., Marolleau J., Malissen B., Cazenave P. Genomic organization of the mouse T cell receptor V alpha family. EMBO J. 9:1990;2141-2150.
27. Jameson S.C., Nakajima P.B., Brooks J.L., Heath W., Kanagawa O., Gascoigne N.R.J. The T cell receptor Va11 gene family: analysis of allelic sequence polymorphism and demonstration of Ja region-dependent recognition by allele-specific antibodies. J. Immunol. 147:1991;3185-3193.
28. Vessey S.J.R., Bell J.K., Jakobsen B.K. A functionally significant allelic polymorphism in a T cell receptor VB gene segment. Eur. J. Immunol. 26:1996;1660-1663.
29. Morahan G., McClive P., Huang D., Little P., Baxter A. Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity. Proc. Natl. Acad. Sci U.S.A. 91:1994;5898-5902.