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Volumn 3, Issue 1, 2012, Pages

Regulation of the mTOR-Rac1 axis in platelet function

Author keywords

Actin; Cytoskeleton; GEF; P Rex1; Rac1; Rapamycin; Rheb; S6K1; TIAM1; TSC2

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BCL 3; PROTEIN TYROSINE KINASE; RAC1 PROTEIN; RAC1 PROTEIN GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAPAMYCIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; S6 KINASE; S6 KINASE 1; UNCLASSIFIED DRUG; VAV PROTEIN; VAV1 PROTEIN;

EID: 84859029508     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.3.1.19137     Document Type: Article
Times cited : (15)

References (34)
  • 1
    • 70350435452 scopus 로고    scopus 로고
    • New insights into the haemostatic function of platelets
    • PMID: 19656155
    • Wei AH, Schoenwaelder SM, Andrews RK, Jackson SP. New insights into the haemostatic function of platelets. Br J Haematol 2009; 147:415-430; PMID: 19656155; http://dx.doi.org/10.1111/j.1365-2141.2009.07819.x
    • (2009) Br J Haematol , vol.147 , pp. 415-430
    • Wei, A.H.1    Schoenwaelder, S.M.2    Andrews, R.K.3    Jackson, S.P.4
  • 2
    • 78650415748 scopus 로고    scopus 로고
    • Signaling during platelet adhesion and activation
    • PMID: 21071698
    • Li Z, Delaney MK, O'Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 2010; 30:2341-2349; PMID: 21071698; http://dx.doi.org/10.1161/ATVBAHA.110.207522
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2341-2349
    • Li, Z.1    Delaney, M.K.2    O'Brien, K.A.3    Du, X.4
  • 3
    • 0033593667 scopus 로고    scopus 로고
    • Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
    • PMID:10037795
    • Klages B, Brandt U, Simon MI, Schultz G, Offermanns S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144:745-754; PMID:10037795; http://dx.doi.org/10.1083/jcb.144.4.745
    • (1999) J Cell Biol , vol.144 , pp. 745-754
    • Klages, B.1    Brandt, U.2    Simon, M.I.3    Schultz, G.4    Offermanns, S.5
  • 5
    • 84863011162 scopus 로고    scopus 로고
    • Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
    • In press. PMID:22045984
    • Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, et al. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 2011. In press. PMID:22045984; http://dx.doi.org/10.1182/blood-2011-08-372193
    • (2011) Blood
    • Pleines, I.1    Hagedorn, I.2    Gupta, S.3    May, F.4    Chakarova, L.5    van Hengel, J.6
  • 6
    • 28244479366 scopus 로고    scopus 로고
    • Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    • PMID:16195235
    • McCarty OJ, Larson MK, Auger JM, Kalia N, Atkinson BT, Pearce AC, et al. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem 2005; 280:39474-39484; PMID:16195235; http://dx.doi.org/10.1074/jbc.M504672200
    • (2005) J Biol Chem , vol.280 , pp. 39474-39484
    • McCarty, O.J.1    Larson, M.K.2    Auger, J.M.3    Kalia, N.4    Atkinson, B.T.5    Pearce, A.C.6
  • 7
    • 0037111633 scopus 로고    scopus 로고
    • Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
    • PMID:12411320
    • Pearce AC, Wilde JI, Doody GM, Best D, Inoue O, Vigorito E, et al. Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood 2002; 100:3561-3569; PMID:12411320; http://dx.doi.org/10.1182/blood.V100.10.3561
    • (2002) Blood , vol.100 , pp. 3561-3569
    • Pearce, A.C.1    Wilde, J.I.2    Doody, G.M.3    Best, D.4    Inoue, O.5    Vigorito, E.6
  • 8
    • 79960567744 scopus 로고    scopus 로고
    • Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation
    • PMID:21789221
    • Akbar H, Shang X, Perveen R, Berryman M, Funk K, Johnson JF, et al. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One 2011; 6:e22117; PMID:21789221; http://dx.doi.org/10.1371/journal.pone.0022117
    • (2011) PLoS One , vol.6
    • Akbar, H.1    Shang, X.2    Perveen, R.3    Berryman, M.4    Funk, K.5    Johnson, J.F.6
  • 9
    • 26444535506 scopus 로고    scopus 로고
    • GPVI and integrin alphaIIb beta3 signaling in platelets
    • PMID:16102042
    • Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost 2005; 3:1752-1762; PMID:16102042; http://dx.doi.org/10.1111/j.1538-7836.2005.01429.x
    • (2005) J Thromb Haemost , vol.3 , pp. 1752-1762
    • Watson, S.P.1    Auger, J.M.2    McCarty, O.J.3    Pearce, A.C.4
  • 10
    • 77953844482 scopus 로고    scopus 로고
    • MTOR signaling in cancer cell motility and tumor metastasis
    • PMID:20528734
    • Zhou H, Huang S. MTOR signaling in cancer cell motility and tumor metastasis. Crit Rev Eukaryot Gene Expr 2010; 20:1-16; PMID:20528734
    • (2010) Crit Rev Eukaryot Gene Expr , vol.20 , pp. 1-16
    • Zhou, H.1    Huang, S.2
  • 11
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • PMID:21157483
    • Zoncu R, Efeyan A, Sabatini DM. MTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID:21157483; http://dx.doi.org/10.1038/nrm3025
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 12
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: At the crossroads of besity, diabetes and cancer
    • PMID: 17452018
    • Dann SG, Selvaraj A, Thomas G. MTOR Complex1-S6K1 signaling: at the crossroads of besity, diabetes and cancer. Trends Mol Med 2007; 13:252-259; PMID: 17452018; http://dx.doi.org/10.1016/j.molmed.2007.04.002
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 13
    • 79953298958 scopus 로고    scopus 로고
    • Nextgeneration mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy
    • PMID:21490404
    • Wander SA, Hennessy BT, Slingerland JM. Nextgeneration mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest 2011; 121:1231-1241; PMID:21490404; http://dx.doi.org/10.1172/JCI44145
    • (2011) J Clin Invest , vol.121 , pp. 1231-1241
    • Wander, S.A.1    Hennessy, B.T.2    Slingerland, J.M.3
  • 15
    • 19344367393 scopus 로고    scopus 로고
    • Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
    • PMID: 15708965
    • Sakakibara K, Liu B, Hollenbeck S, Kent KC. Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am J Physiol Heart Circ Physiol 2005; 288:H2861-H2868; PMID: 15708965; http://dx.doi.org/10.1152/ajpheart.00561.2004
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Sakakibara, K.1    Liu, B.2    Hollenbeck, S.3    Kent, K.C.4
  • 16
    • 79957599658 scopus 로고    scopus 로고
    • P70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells
    • PMID:21258406
    • Ip CK, Cheung AN, Ngan HY, Wong AS. P70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene 2011; 30:2420-2432; PMID:21258406; http://dx.doi.org/10.1038/onc.2010.615
    • (2011) Oncogene , vol.30 , pp. 2420-2432
    • Ip, C.K.1    Cheung, A.N.2    Ngan, H.Y.3    Wong, A.S.4
  • 17
    • 79955486858 scopus 로고    scopus 로고
    • MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
    • PMID:21430067
    • Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, et al. MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 2011; 71:3246-3256; PMID:21430067; http://dx.doi.org/10.1158/0008-5472.CAN-10-4058
    • (2011) Cancer Res , vol.71 , pp. 3246-3256
    • Gulhati, P.1    Bowen, K.A.2    Liu, J.3    Stevens, P.D.4    Rychahou, P.G.5    Chen, M.6
  • 18
    • 0029890229 scopus 로고    scopus 로고
    • The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
    • PMID: 8653792
    • Chou MM, Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 1996; 85:573-583; PMID: 8653792; http://dx.doi.org/10.1016/S0092-8674(00)81257-X
    • (1996) Cell , vol.85 , pp. 573-583
    • Chou, M.M.1    Blenis, J.2
  • 19
    • 0031557653 scopus 로고    scopus 로고
    • Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase
    • PMID:9144421
    • Crouch MF. Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun 1997; 233: 193-199; PMID:9144421; http://dx.doi.org/10.1006/bbrc.1997.6419
    • (1997) Biochem Biophys Res Commun , vol.233 , pp. 193-199
    • Crouch, M.F.1
  • 20
    • 33847393035 scopus 로고    scopus 로고
    • MTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    • PMID:17110454
    • Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, et al. MTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 2007; 109:1975-1983; PMID:17110454; http://dx.doi.org/10.1182/blood-2006-08-042192
    • (2007) Blood , vol.109 , pp. 1975-1983
    • Weyrich, A.S.1    Denis, M.M.2    Schwertz, H.3    Tolley, N.D.4    Foulks, J.5    Spencer, E.6
  • 21
    • 0032510742 scopus 로고    scopus 로고
    • Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets
    • PMID:9576921
    • Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A 1998; 95:5556-5561; PMID:9576921; http://dx.doi.org/10.1073/pnas.95.10.5556
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5556-5561
    • Weyrich, A.S.1    Dixon, D.A.2    Pabla, R.3    Elstad, M.R.4    McIntyre, T.M.5    Prescott, S.M.6
  • 22
    • 36448956818 scopus 로고    scopus 로고
    • Preparation and characterization of rapamycin-loaded PLGA coating stent
    • PMID:17607513
    • Pan CJ, Tang JJ, Weng YJ, Wang J, Huang N. Preparation and characterization of rapamycin-loaded PLGA coating stent. J Mater Sci Mater Med 2007; 18:2193-2198; PMID:17607513; http://dx.doi.org/10.1007/s10856-007-3075-9
    • (2007) J Mater Sci Mater Med , vol.18 , pp. 2193-2198
    • Pan, C.J.1    Tang, J.J.2    Weng, Y.J.3    Wang, J.4    Huang, N.5
  • 23
    • 80052938277 scopus 로고    scopus 로고
    • S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation
    • PMID:21757621
    • Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood 2011; 118:3129-3136; PMID:21757621; http://dx.doi.org/10.1182/blood-2011-02-331579
    • (2011) Blood , vol.118 , pp. 3129-3136
    • Aslan, J.E.1    Tormoen, G.W.2    Loren, C.P.3    Pang, J.4    McCarty, O.J.5
  • 24
    • 0035160146 scopus 로고    scopus 로고
    • Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets
    • PMID:11204566
    • Rosenwald IB, Pechet L, Han A, Lu L, Pihan G, Woda B, et al. Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost 2001; 85:142-151; PMID:11204566
    • (2001) Thromb Haemost , vol.85 , pp. 142-151
    • Rosenwald, I.B.1    Pechet, L.2    Han, A.3    Lu, L.4    Pihan, G.5    Woda, B.6
  • 25
    • 0037805689 scopus 로고    scopus 로고
    • Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin
    • PMID:12531897
    • Buchsbaum RJ, Connolly BA, Feig LA. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. J Biol Chem 2003; 278:18833-18841; PMID:12531897; http://dx.doi.org/10.1074/jbc.M207876200
    • (2003) J Biol Chem , vol.278 , pp. 18833-18841
    • Buchsbaum, R.J.1    Connolly, B.A.2    Feig, L.A.3
  • 27
    • 78650235523 scopus 로고    scopus 로고
    • Identification of the Rac-GEF PRex1 as an essential mediator of ErbB signaling in breast cancer
    • PMID: 21172654
    • Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, et al. Identification of the Rac-GEF PRex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 2010; 40:877-892; PMID: 21172654; http://dx.doi.org/10.1016/j.molcel.2010.11.029
    • (2010) Mol Cell , vol.40 , pp. 877-892
    • Sosa, M.S.1    Lopez-Haber, C.2    Yang, C.3    Wang, H.4    Lemmon, M.A.5    Busillo, J.M.6
  • 28
    • 0037155727 scopus 로고    scopus 로고
    • P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guaninenucleotide exchange factor for Rac
    • PMID:11955434
    • Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guaninenucleotide exchange factor for Rac. Cell 2002; 108:809-821; PMID:11955434; http://dx.doi.org/10.1016/S0092-8674(02)00663-3
    • (2002) Cell , vol.108 , pp. 809-821
    • Welch, H.C.1    Coadwell, W.J.2    Ellson, C.D.3    Ferguson, G.J.4    Andrews, S.R.5    Erdjument-Bromage, H.6
  • 29
    • 80052175474 scopus 로고    scopus 로고
    • Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
    • PMID:21884615
    • Aslan JE, Spencer AM, Loren CP, Pang J, Welch HC, Greenberg DL, et al. Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets. J Mol Signal 2011; 6:11; PMID:21884615; http://dx.doi.org/10.1186/1750-2187-6-11
    • (2011) J Mol Signal , vol.6 , pp. 11
    • Aslan, J.E.1    Spencer, A.M.2    Loren, C.P.3    Pang, J.4    Welch, H.C.5    Greenberg, D.L.6
  • 30
    • 79953307234 scopus 로고    scopus 로고
    • Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
    • PMID: 21474067
    • Saci A, Cantley LC, Carpenter CL. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 2011; 42:50-61; PMID: 21474067; http://dx.doi.org/10.1016/j.molcel.2011.03.017
    • (2011) Mol Cell , vol.42 , pp. 50-61
    • Saci, A.1    Cantley, L.C.2    Carpenter, C.L.3
  • 31
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • PMID: 19383975
    • Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Sci Signal 2009; 2:pe24; PMID: 19383975; http://dx.doi.org/10.1126/scisignal.267pe24
    • (2009) Sci Signal , vol.2
    • Guertin, D.A.1    Sabatini, D.M.2
  • 32
    • 79960149722 scopus 로고    scopus 로고
    • MTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]
    • PMID:21592956
    • Moore SF, Hunter RW, Hers I. MTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. J Biol Chem 2011; 286:24553-24560; PMID:21592956; http://dx.doi.org/10.1074/jbc.M110.202341
    • (2011) J Biol Chem , vol.286 , pp. 24553-24560
    • Moore, S.F.1    Hunter, R.W.2    Hers, I.3
  • 33
    • 78649956469 scopus 로고    scopus 로고
    • MTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion
    • PMID:21145500
    • Liu L, Das S, Losert W, Parent CA. MTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell 2010; 19:845-857; PMID:21145500; http://dx.doi.org/10.1016/j.devcel.2010.11.004
    • (2010) Dev Cell , vol.19 , pp. 845-857
    • Liu, L.1    Das, S.2    Losert, W.3    Parent, C.A.4
  • 34
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • PMID:19143635
    • Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009; 37:217-222; PMID:19143635; http://dx.doi.org/10.1042/BST0370217
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2


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