-
1
-
-
70350435452
-
New insights into the haemostatic function of platelets
-
PMID: 19656155
-
Wei AH, Schoenwaelder SM, Andrews RK, Jackson SP. New insights into the haemostatic function of platelets. Br J Haematol 2009; 147:415-430; PMID: 19656155; http://dx.doi.org/10.1111/j.1365-2141.2009.07819.x
-
(2009)
Br J Haematol
, vol.147
, pp. 415-430
-
-
Wei, A.H.1
Schoenwaelder, S.M.2
Andrews, R.K.3
Jackson, S.P.4
-
2
-
-
78650415748
-
Signaling during platelet adhesion and activation
-
PMID: 21071698
-
Li Z, Delaney MK, O'Brien KA, Du X. Signaling during platelet adhesion and activation. Arterioscler Thromb Vasc Biol 2010; 30:2341-2349; PMID: 21071698; http://dx.doi.org/10.1161/ATVBAHA.110.207522
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 2341-2349
-
-
Li, Z.1
Delaney, M.K.2
O'Brien, K.A.3
Du, X.4
-
3
-
-
0033593667
-
Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets
-
PMID:10037795
-
Klages B, Brandt U, Simon MI, Schultz G, Offermanns S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999; 144:745-754; PMID:10037795; http://dx.doi.org/10.1083/jcb.144.4.745
-
(1999)
J Cell Biol
, vol.144
, pp. 745-754
-
-
Klages, B.1
Brandt, U.2
Simon, M.I.3
Schultz, G.4
Offermanns, S.5
-
4
-
-
0037177816
-
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear
-
PMID: 11830597
-
Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, et al. RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem 2002; 277:14738-14746; PMID: 11830597
-
(2002)
J Biol Chem
, vol.277
, pp. 14738-14746
-
-
Schoenwaelder, S.M.1
Hughan, S.C.2
Boniface, K.3
Fernando, S.4
Holdsworth, M.5
Thompson, P.E.6
-
5
-
-
84863011162
-
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
-
In press. PMID:22045984
-
Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, et al. Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 2011. In press. PMID:22045984; http://dx.doi.org/10.1182/blood-2011-08-372193
-
(2011)
Blood
-
-
Pleines, I.1
Hagedorn, I.2
Gupta, S.3
May, F.4
Chakarova, L.5
van Hengel, J.6
-
6
-
-
28244479366
-
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
-
PMID:16195235
-
McCarty OJ, Larson MK, Auger JM, Kalia N, Atkinson BT, Pearce AC, et al. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem 2005; 280:39474-39484; PMID:16195235; http://dx.doi.org/10.1074/jbc.M504672200
-
(2005)
J Biol Chem
, vol.280
, pp. 39474-39484
-
-
McCarty, O.J.1
Larson, M.K.2
Auger, J.M.3
Kalia, N.4
Atkinson, B.T.5
Pearce, A.C.6
-
7
-
-
0037111633
-
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
-
PMID:12411320
-
Pearce AC, Wilde JI, Doody GM, Best D, Inoue O, Vigorito E, et al. Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood 2002; 100:3561-3569; PMID:12411320; http://dx.doi.org/10.1182/blood.V100.10.3561
-
(2002)
Blood
, vol.100
, pp. 3561-3569
-
-
Pearce, A.C.1
Wilde, J.I.2
Doody, G.M.3
Best, D.4
Inoue, O.5
Vigorito, E.6
-
8
-
-
79960567744
-
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation
-
PMID:21789221
-
Akbar H, Shang X, Perveen R, Berryman M, Funk K, Johnson JF, et al. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PLoS One 2011; 6:e22117; PMID:21789221; http://dx.doi.org/10.1371/journal.pone.0022117
-
(2011)
PLoS One
, vol.6
-
-
Akbar, H.1
Shang, X.2
Perveen, R.3
Berryman, M.4
Funk, K.5
Johnson, J.F.6
-
9
-
-
26444535506
-
GPVI and integrin alphaIIb beta3 signaling in platelets
-
PMID:16102042
-
Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets. J Thromb Haemost 2005; 3:1752-1762; PMID:16102042; http://dx.doi.org/10.1111/j.1538-7836.2005.01429.x
-
(2005)
J Thromb Haemost
, vol.3
, pp. 1752-1762
-
-
Watson, S.P.1
Auger, J.M.2
McCarty, O.J.3
Pearce, A.C.4
-
10
-
-
77953844482
-
MTOR signaling in cancer cell motility and tumor metastasis
-
PMID:20528734
-
Zhou H, Huang S. MTOR signaling in cancer cell motility and tumor metastasis. Crit Rev Eukaryot Gene Expr 2010; 20:1-16; PMID:20528734
-
(2010)
Crit Rev Eukaryot Gene Expr
, vol.20
, pp. 1-16
-
-
Zhou, H.1
Huang, S.2
-
11
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
PMID:21157483
-
Zoncu R, Efeyan A, Sabatini DM. MTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID:21157483; http://dx.doi.org/10.1038/nrm3025
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
12
-
-
34249679614
-
MTOR Complex1-S6K1 signaling: At the crossroads of besity, diabetes and cancer
-
PMID: 17452018
-
Dann SG, Selvaraj A, Thomas G. MTOR Complex1-S6K1 signaling: at the crossroads of besity, diabetes and cancer. Trends Mol Med 2007; 13:252-259; PMID: 17452018; http://dx.doi.org/10.1016/j.molmed.2007.04.002
-
(2007)
Trends Mol Med
, vol.13
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
13
-
-
79953298958
-
Nextgeneration mTOR inhibitors in clinical oncology: How pathway complexity informs therapeutic strategy
-
PMID:21490404
-
Wander SA, Hennessy BT, Slingerland JM. Nextgeneration mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy. J Clin Invest 2011; 121:1231-1241; PMID:21490404; http://dx.doi.org/10.1172/JCI44145
-
(2011)
J Clin Invest
, vol.121
, pp. 1231-1241
-
-
Wander, S.A.1
Hennessy, B.T.2
Slingerland, J.M.3
-
15
-
-
19344367393
-
Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin
-
PMID: 15708965
-
Sakakibara K, Liu B, Hollenbeck S, Kent KC. Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of rapamycin. Am J Physiol Heart Circ Physiol 2005; 288:H2861-H2868; PMID: 15708965; http://dx.doi.org/10.1152/ajpheart.00561.2004
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Sakakibara, K.1
Liu, B.2
Hollenbeck, S.3
Kent, K.C.4
-
16
-
-
79957599658
-
P70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells
-
PMID:21258406
-
Ip CK, Cheung AN, Ngan HY, Wong AS. P70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene 2011; 30:2420-2432; PMID:21258406; http://dx.doi.org/10.1038/onc.2010.615
-
(2011)
Oncogene
, vol.30
, pp. 2420-2432
-
-
Ip, C.K.1
Cheung, A.N.2
Ngan, H.Y.3
Wong, A.S.4
-
17
-
-
79955486858
-
MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
-
PMID:21430067
-
Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, et al. MTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res 2011; 71:3246-3256; PMID:21430067; http://dx.doi.org/10.1158/0008-5472.CAN-10-4058
-
(2011)
Cancer Res
, vol.71
, pp. 3246-3256
-
-
Gulhati, P.1
Bowen, K.A.2
Liu, J.3
Stevens, P.D.4
Rychahou, P.G.5
Chen, M.6
-
18
-
-
0029890229
-
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
-
PMID: 8653792
-
Chou MM, Blenis J. The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell 1996; 85:573-583; PMID: 8653792; http://dx.doi.org/10.1016/S0092-8674(00)81257-X
-
(1996)
Cell
, vol.85
, pp. 573-583
-
-
Chou, M.M.1
Blenis, J.2
-
19
-
-
0031557653
-
Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase
-
PMID:9144421
-
Crouch MF. Regulation of thrombin-induced stress fibre formation in Swiss 3T3 cells by the 70-kDa S6 kinase. Biochem Biophys Res Commun 1997; 233: 193-199; PMID:9144421; http://dx.doi.org/10.1006/bbrc.1997.6419
-
(1997)
Biochem Biophys Res Commun
, vol.233
, pp. 193-199
-
-
Crouch, M.F.1
-
20
-
-
33847393035
-
MTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
-
PMID:17110454
-
Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, et al. MTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 2007; 109:1975-1983; PMID:17110454; http://dx.doi.org/10.1182/blood-2006-08-042192
-
(2007)
Blood
, vol.109
, pp. 1975-1983
-
-
Weyrich, A.S.1
Denis, M.M.2
Schwertz, H.3
Tolley, N.D.4
Foulks, J.5
Spencer, E.6
-
21
-
-
0032510742
-
Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets
-
PMID:9576921
-
Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A 1998; 95:5556-5561; PMID:9576921; http://dx.doi.org/10.1073/pnas.95.10.5556
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 5556-5561
-
-
Weyrich, A.S.1
Dixon, D.A.2
Pabla, R.3
Elstad, M.R.4
McIntyre, T.M.5
Prescott, S.M.6
-
22
-
-
36448956818
-
Preparation and characterization of rapamycin-loaded PLGA coating stent
-
PMID:17607513
-
Pan CJ, Tang JJ, Weng YJ, Wang J, Huang N. Preparation and characterization of rapamycin-loaded PLGA coating stent. J Mater Sci Mater Med 2007; 18:2193-2198; PMID:17607513; http://dx.doi.org/10.1007/s10856-007-3075-9
-
(2007)
J Mater Sci Mater Med
, vol.18
, pp. 2193-2198
-
-
Pan, C.J.1
Tang, J.J.2
Weng, Y.J.3
Wang, J.4
Huang, N.5
-
23
-
-
80052938277
-
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation
-
PMID:21757621
-
Aslan JE, Tormoen GW, Loren CP, Pang J, McCarty OJ. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood 2011; 118:3129-3136; PMID:21757621; http://dx.doi.org/10.1182/blood-2011-02-331579
-
(2011)
Blood
, vol.118
, pp. 3129-3136
-
-
Aslan, J.E.1
Tormoen, G.W.2
Loren, C.P.3
Pang, J.4
McCarty, O.J.5
-
24
-
-
0035160146
-
Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets
-
PMID:11204566
-
Rosenwald IB, Pechet L, Han A, Lu L, Pihan G, Woda B, et al. Expression of translation initiation factors elF-4E and elF-2alpha and a potential physiologic role of continuous protein synthesis in human platelets. Thromb Haemost 2001; 85:142-151; PMID:11204566
-
(2001)
Thromb Haemost
, vol.85
, pp. 142-151
-
-
Rosenwald, I.B.1
Pechet, L.2
Han, A.3
Lu, L.4
Pihan, G.5
Woda, B.6
-
25
-
-
0037805689
-
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin
-
PMID:12531897
-
Buchsbaum RJ, Connolly BA, Feig LA. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. J Biol Chem 2003; 278:18833-18841; PMID:12531897; http://dx.doi.org/10.1074/jbc.M207876200
-
(2003)
J Biol Chem
, vol.278
, pp. 18833-18841
-
-
Buchsbaum, R.J.1
Connolly, B.A.2
Feig, L.A.3
-
26
-
-
34548151890
-
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
-
PMID:17565979
-
Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, et al. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem 2007; 282:23708-23715; PMID:17565979; http://dx.doi.org/10.1074/jbc.M703771200
-
(2007)
J Biol Chem
, vol.282
, pp. 23708-23715
-
-
Hernández-Negrete, I.1
Carretero-Ortega, J.2
Rosenfeldt, H.3
Hernández-García, R.4
Calderón-Salinas, J.V.5
Reyes-Cruz, G.6
-
27
-
-
78650235523
-
Identification of the Rac-GEF PRex1 as an essential mediator of ErbB signaling in breast cancer
-
PMID: 21172654
-
Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, et al. Identification of the Rac-GEF PRex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 2010; 40:877-892; PMID: 21172654; http://dx.doi.org/10.1016/j.molcel.2010.11.029
-
(2010)
Mol Cell
, vol.40
, pp. 877-892
-
-
Sosa, M.S.1
Lopez-Haber, C.2
Yang, C.3
Wang, H.4
Lemmon, M.A.5
Busillo, J.M.6
-
28
-
-
0037155727
-
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guaninenucleotide exchange factor for Rac
-
PMID:11955434
-
Welch HC, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guaninenucleotide exchange factor for Rac. Cell 2002; 108:809-821; PMID:11955434; http://dx.doi.org/10.1016/S0092-8674(02)00663-3
-
(2002)
Cell
, vol.108
, pp. 809-821
-
-
Welch, H.C.1
Coadwell, W.J.2
Ellson, C.D.3
Ferguson, G.J.4
Andrews, S.R.5
Erdjument-Bromage, H.6
-
29
-
-
80052175474
-
Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
-
PMID:21884615
-
Aslan JE, Spencer AM, Loren CP, Pang J, Welch HC, Greenberg DL, et al. Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets. J Mol Signal 2011; 6:11; PMID:21884615; http://dx.doi.org/10.1186/1750-2187-6-11
-
(2011)
J Mol Signal
, vol.6
, pp. 11
-
-
Aslan, J.E.1
Spencer, A.M.2
Loren, C.P.3
Pang, J.4
Welch, H.C.5
Greenberg, D.L.6
-
30
-
-
79953307234
-
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
-
PMID: 21474067
-
Saci A, Cantley LC, Carpenter CL. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell 2011; 42:50-61; PMID: 21474067; http://dx.doi.org/10.1016/j.molcel.2011.03.017
-
(2011)
Mol Cell
, vol.42
, pp. 50-61
-
-
Saci, A.1
Cantley, L.C.2
Carpenter, C.L.3
-
31
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
PMID: 19383975
-
Guertin DA, Sabatini DM. The pharmacology of mTOR inhibition. Sci Signal 2009; 2:pe24; PMID: 19383975; http://dx.doi.org/10.1126/scisignal.267pe24
-
(2009)
Sci Signal
, vol.2
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
32
-
-
79960149722
-
MTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]
-
PMID:21592956
-
Moore SF, Hunter RW, Hers I. MTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected]. J Biol Chem 2011; 286:24553-24560; PMID:21592956; http://dx.doi.org/10.1074/jbc.M110.202341
-
(2011)
J Biol Chem
, vol.286
, pp. 24553-24560
-
-
Moore, S.F.1
Hunter, R.W.2
Hers, I.3
-
33
-
-
78649956469
-
MTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion
-
PMID:21145500
-
Liu L, Das S, Losert W, Parent CA. MTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell 2010; 19:845-857; PMID:21145500; http://dx.doi.org/10.1016/j.devcel.2010.11.004
-
(2010)
Dev Cell
, vol.19
, pp. 845-857
-
-
Liu, L.1
Das, S.2
Losert, W.3
Parent, C.A.4
-
34
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
PMID:19143635
-
Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009; 37:217-222; PMID:19143635; http://dx.doi.org/10.1042/BST0370217
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
|