Activation of PAK1/2 during the shedding of platelet microvesicles

Blood Coagulation and Fibrinolysis

Volumn 20, Issue 1, 2009, Pages 63-70

  Crespin, Malvina ^a,b,c   Vidal, Catherine ^a,b   Picard, Françoise ^b,c   Lacombe, Catherine ^a,b,c   Fontenay, Michaëla ^a,b,c  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c université Paris Cité   (France)

Author keywords

Microvesicles; P21 activated kinase; Platelet

Indexed keywords

CALCIMYCIN; CALPEPTIN; CLOSTRIDIUM DIFFICILE TOXIN B; COLLAGEN; P21 ACTIVATED KINASE 1; P21 ACTIVATED KINASE 2; PROTEIN CDC42; RAC1 PROTEIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ACTIN POLYMERIZATION; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; FILOPODIUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LAMELLIPODIUM; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THROMBOCYTE; THROMBOCYTE SHAPE; THROMBOCYTE SHEDDING;

ACTINS; BACTERIAL TOXINS; BLOOD PLATELETS; ENZYME ACTIVATION; HUMANS; MICROFILAMENTS; P21-ACTIVATED KINASES; REFERENCE VALUES;

EID: 58849159111     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32831bc310     Document Type: Article

References (43)

1. Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89:1121 - 1132.
2. Del Conde I, Shrimpton CN, Thiagarajan P, López JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005; 106: 1604-1611.
3. Hrachovinova I, Cambien B, Hafezi-Moghadam A, Kappelmayer J, Camphausen RT, Widom A, et al. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Sar Med 2003; 9: 1020-1025.
4. Diamant M, Nieuwland R, Pablo RF, Sturk A, Smit JW, Radder JK. Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus. Circulation 2002; 106: 2442-2447.
5. Mallat Z, Hugel B, Ohan J, Lesèche G, Freyssinet JM, Tedgui A. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation 1999; 99: 348-353.
6. Shet AS, Aras O, Gupta K, Hass MJ, Rausch DJ, Saba N, et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Stood 2003; 102:2678-2683.
7. Aras O, Shet A, Bach RR, Hysjulien JL, Slungaard A, Hebbel RP, et al. Induction of microparticle - and cell-associated intravascular tissue factor in human endotoxemia. Blood 2004; 103: 4545-4553.
8. Warkentin TE, Hayward CP, Boshkov LK, Santos AV, Sheppard JA, Bode AP, Kelton JG. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 1994; 84: 3691 -3699.
9. vanWijk MJ, vanBavel E, Sturk A, Nieuwland R. Microparticles in cardiovascular diseases. Cardiovasc Res 2003; 59: 277-287.
10. Bretelle F, Sabatier F, Desprez D, Camoin L, Grunebaum L, Combes V, et al. Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complication by preeclampsia or intrauterine growth restriction. Thromb Haemost 2003; 89: 486-492.
11. van den Goor JM, van den Brink A, Nieuwland R, van Oeveren W, Rutten PM, Tepaske R, et al. Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation. J Thorac Cardiovasc Surg 2003; 126: 1101 -1106.
12. Ogura H, Kawasaki T, Tanaka H, Koh T, Tanaka R, Ozeki Y, et al. Activated platelets enhance microparticle formation and platelet-leukocyte interaction in severe trauma and sepsis. J Trauma 2001; 50: 801 -809.
13. Pfister SL. Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery. Hypertension 2004; 43: 428-433.
14. Janiszewski M, Do Carmo AO, Pedro MA, Silva E, Knobel E, Laurindo FR. Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: a novel vascular redox pathway. Crit Care Med 2004; 32: 818-825.
15. Xiao H, Jepkorir CJ, Harvey K, Remick DG. Thrombin-induced platelet microparticles improved the aggregability of cryopreserved platelets. Cryobiology 2002; 44: 179-188.
16. Hughes M, Hayward CP, Warkentin TE, Horsewood P, Chomeyko KA, Kelton JG. Morphological analysis of microparticle generation in heparininduced thrombocytopenia. Blood 2000; 96: 188-194.
17. Pasquet J-M, Dachary-Prigent J, Nurden AT. Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagen. Biochem J 1998; 333: 591-599.
18. Yano Y, Kambayashi J, Shiba E, Sakon M, Oiki E, Fukuda K, et al. The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membrane. Biochem J 1994; 299: 303-308.
19. Fox JE, Austin CD, Reynolds CC, Steffen PK. Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets. J Biol Chem 1991; 266:13289-13295.
20. Pasquet JM, Toti F, Nurden AT, Dachary-Prigent J. Procoagulant activity and active calpain in platelet-derived microparticles. Thromb Res 1996; 82: 509-522.
21. Bachelot-Loza C, Badol P, Brohard-Bohn B, Fraiz N, Cano E, Rendu F. Differential regulation of platelet aggregation and aminophospholipid exposure by calpain. Br J Haematol 2006; 133:419-426.
22. O'Connell DJ, Rozenvayn N, Flaumenhaft R. Phosphatidylinositol 4,5-bisphosphate regulates activation-induced platelet microparticle formation. Biochemistry 2005; 44: 6361 -6370.
23. Fox JE, Austin CD, Boyles JK, Steffen PK. Role of the membrane cytoskeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane. J Cell Biol 1990; 111: 483-493.
24. Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995; 81: 53-62.
25. Teo M, Manser E, Lim L. Identification and molecular cloning of a p21cdc42/rac1-activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J Biol Chem 1995; 270: 26690-26697.
26. Azim AC, Barkalow K, Chou J, Hartwig JH. Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood 2000; 95: 959-964.
27. Vidal C, Geny B, Melle J, Jandrot-Perrus M, Fontenay-Roupie M. Cdc42/Rac1 - dependent activation of the p21 -activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood 2002; 100: 4462-4469.
28. Huang C, Tandon NN, Greco NJ, Ni Y, Wang T, Zhan X. Proteolysis of platelet cortactin by calpain. J Biol Chem 1997; 272: 19248-19252.
29. Basse F, Gaffet P, Bienvenue A. Correlation between inhibition of cytoskeleton proteolysis and antivesiculation effect of calpeptin during A23187-induced activation of human platelets: are vesicles shed by filopod fragmentation? Biochim Biophys Acta 1994; 1190: 217-224.
30. Richard J-F, Petit L, Gibert M, Marvaud JC, Bouchaud C, Popoff MR. Bacterial toxins modifying the actin cytoskeleton. Int Microbiol 1999; 2:185-194.
31. Plenchette S, Moutet M, Benguella M, N'Gondara JP, Guigner F, Coffe C, et al. Early increase in DcR2 expression and late activation of caspases in the platelet storage lesion. Leukemia 2001; 15:1572-1581.
32. Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood 1999; 94: 1683-1692.
33. Jin M, Drwal G, Bourgeois T, Saltz J, Wu HM. Distinct proteome features of plasma microparticles. Proteomics 2005; 5: 1940-1952.
34. Suzuki-lnoue K, Yatomi Y, Asazuma N, Kainoh M, Tanaka T, Satoh K, Ozaki Y. Rac, a small guanosine triphosphate-binding protein, and p21 -activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1). Blood 2001; 98: 3708-3716.
35. Gratacap MC, Payrastre B, Viala C, Mauco G, Plantavid M, Chap H. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets. J Biol Chem 1998; 273:24314-24321.
36. Soulet C, Gendreau S, Missy K, Benard V, Plantavid M, Payrastre B. Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets. FEBS Lett 2001; 507: 253-258.
37. Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling. J Cell Biol1999; 145: 851-863.
38. Meriane M, Mary S, Comunale F, Vignal E, Fort P, Gauthier-Rouviére C. Cdc42Hs and Rac1 GTPases induce the collapse of the vimentin intermediate filament network. J Biol Chem 2000; 275:33046-33052.
39. Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIM-kinase by PAK1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Wat Cell Biol 1999; 1: 253-259.
40. Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP, Kumar R. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 2002; 4: 681 -690.
41. Lee SH, Eom M, Lee SJ, Kim S, Park HJ, Park D. BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling. J Biol Chem 2001; 276:25066- 25072.
42. Paul BZS, Daniel JL, Kunapuli SP. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. J Biol Chem 1999; 274: 28293-28300.
43. 2+ entry: role of actin cytoskeleton. J Biol Chem 2001; 276: 5134-5139.