Hypothalamic and amygdalar cell lines differ markedly in mitochondrial rather than nuclear encoded gene expression

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Dalwadi, Dhwanil A ^a   Uht, Rosalie M ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Amygdala; Cytochrome b; Cytochrome c oxidase; Glucocorticoids; Hypothalamus; Mitochondria; Mitochondrial genes; NADH dehydrogenase; Oxidative phosphorylation; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CYTOCHROME B; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE 1; CYTOCHROME C OXIDASE 2; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE) 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ARTICLE; CELL LINE; GENE DOSAGE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC REGULATION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MICROARRAY ANALYSIS; MITOCHONDRIAL GENE; MITOCHONDRIAL GENOME; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMYGDALA; ANIMALS; CELL LINE; CELL NUCLEUS; CHROMATIN; CORTICOTROPIN-RELEASING HORMONE; HUMANS; HYPOTHALAMUS; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

MAMMALIA;

EID: 84879077173     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-413     Document Type: Article

References (23)

1. Majzoub JA. Corticotropin-releasing hormone physiology. Eur J Endocrinol 2006, 155:S71-S76.
2. Van Bockstaele EJ, Colago EE, Valentino RJ. Amygdaloid corticotropin-releasing factor targets locus coeruleus dendrites: substrate for the co-ordination of emotional and cognitive limbs of the stress response. J Neuroendocrinol 1998, 10:743-757.
3. Reyes BA, Valentino RJ, Xu G, Van Bockstaele EJ. Hypothalamic projections to locus coeruleus neurons in rat brain. Eur J Neurosci 2005, 22:93-106. 10.1111/j.1460-9568.2005.04197.x, 16029199.
4. Makino S, Shibasaki T, Yamauchi N, Nishioka T, Mimoto T, Wakabayashi I, Gold PW, Hashimoto K. Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat. Brain Res 1999, 850:136-143. 10.1016/S0006-8993(99)02114-9, 10629757.
5. de Kloet ER, Joels M, Holsboer F. Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005, 6:463-475. 10.1038/nrn1683, 15891777.
6. Kasckow JW, Aguilera G, Mulchahey JJ, Sheriff S, Herma JP. In vitro regulation of corticotropin-releasing hormone. Life Sci 2003, 73:769-781. 10.1016/S0024-3205(03)00409-0, 12801598.
7. Kasckow J, Mulchahey JJ, Aguilera G, Pisarska M, Nikodemova M, Chen HC, Herman JP, Murphy EK, Liu Y, Rizvi TA, Dautzenberg FM, Sheriff S. Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH Receptor signalling in an immortalized hypothalamic cell line. J Neuroendocrinol 2003, 15:521-529. 10.1046/j.1365-2826.2003.01026.x, 12694378.
8. Mulchahey JJ, Regmi A, Sheriff S, Balasubramaniam A, Kasckow JW. Coordinate and divergent regulation of corticotropin-releasing factor (CRF) and CRF-binding protein expression in a immortalized amygdalar neuronal cell line. Endocrinology 1999, 140:251-259. 10.1210/en.140.1.251, 9886832.
9. Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009, 4:44-57.
10. Huang DW, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 2009, 37:1-13. 10.1093/nar/gkn923, 2615629, 19033363.
11. Jensen LJ, Kuhn M, Stark M, Chaffrson S, Creevey C, Miller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, von Mering C. STRING 8 --a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 2009, 37:D412-D416. 10.1093/nar/gkn760, 2686466, 18940858.
12. Manoli I, Alesci S, Blackman MR, Su YA, Rennert OM, Chrousos GP. Mitochondria as key components of the stress response. Trends Endocrinol Metab 2007, 18:190-198. 10.1016/j.tem.2007.04.004, 17500006.
13. Veltri KL, Espiritu M, Singh G. Distinct genomic copy number in mitochondria of different mammalian organs. J Cell Physiol 1990, 143:160-164. 10.1002/jcp.1041430122, 2318903.
14. Fuke S, Kubota-Sakashita M, Kasahara T, Shigeyoshi Y, Kato T. Regional variation in mitochondrial DNA copy number in mouse brain. Biochimica et Biophysica Acta - Bioenergetics 2011, 1807:270-274. 10.1016/j.bbabio.2010.11.016, 23806663.
15. Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science 1990, 249:1266-1272. 10.1126/science.2119054, 2119054.
16. Aguilera G, Liu Y. The molecular physiology of CRH neurons. Front Neuroendocrinol 2012, 33:67-84. 10.1016/j.yfrne.2011.08.002, 21871477.
17. Du J, McEwen B, Manji HK. Glucocorticoids receptors modulate mitochondrial function: A novel mechanism for neuroprotection. Communicative and Integrative Biology 2009, 2:350-352. 10.4161/cib.2.4.8554, 2734045, 19721888.
18. Kimberg VD, Loud VA, Wiener J. Cortisone-induced alterations in mitochondrial function and structure. J Cell Biol 1968, 37:63-79. 10.1083/jcb.37.1.63, 2107393, 5645846.
19. Wakat DK, Haynes RC. Glucocorticoid-stimulated utilization of substrates in hepatic mitochondria. Arch Biochem Biophys 1977, 184:561-571. 10.1016/0003-9861(77)90466-0, 596886.
20. Martin A, Titheragde AM. Stimulation of mitochondrial pyruvate metabolism and citrulline synthesis by dexamethasone. Biochem J 1984, 222:379-387. 1144189, 6433898.
21. Psarra AMG, Sekeris CE. Glucocorticoids induce mitochondrial gene transcription in HepG2 cells Role of mitochondrial glucocorticoid receptor. Biochim Biophys Acta 1813, 2011:1814-1821.
22. Demonacos C, Djordjevic-Markovic R, Tsawdaroglou N, Sekeris CE. The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements. J Steroid Biochem Mol Biol 1995, 55:43-55. 10.1016/0960-0760(95)00159-W, 7577720.
23. Berdanier CD. Mitochondrial gene expression: influence of nutrients and hormones. Exp Biol Med 2006, 231:1593-1601.