Glucocorticoid receptors modulate mitochondrial function: A novel mechanism for neuroprotection

Communicative and Integrative Biology

Volumn 2, Issue 4, 2009, Pages 350-352

  Du, Jing ^a   McEwen, Bruce ^b   Manji, Husseini K ^c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Bcl 2; Glucocorticoid; Mitochondria; Mood disorders; Neuroprotection; Nuclear receptor; Plasticity; Steroid

Indexed keywords

EID: 69249128380     PISSN: None     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.2.4.8554     Document Type: Article

References (28)

1. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 2008; 583:174-85.
2. McEwen BS, Milner TA. Hippocampal formation: shedding light on the influence of sex and stress on the brain. Brain Res Rev 2007; 55:343-55.
3. Croxtall JD, van Hal PT, Choudhury Q, Gilroy DW, Flower RJ. Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells. Br J Pharmacol 2002; 135:511-9.
4. Sionov RV, Kfir S, Zafrir E, Cohen O, Zilberman Y, Yefenof E. Glucocorticoid-induced apoptosis revisited: a novel role for glucocorticoid receptor translocation to the mitochondria. Cell Cycle 2006; 5:1017-26.
5. Koufali MM, Moutsatsou P, Sekeris CE, Breen KC. The dynamic localization of the glucocorticoid receptor in rat C6 glioma cell mitochondria. Mol Cell Endocrinol 2003; 209:51-60.
6. Moutsatsou P, Psarra AM, Tsiapara A, Paraskevakou H, Davaris P, Sekeris CE. Localization of the glucocorticoid receptor in rat brain mitochondria. Arch Biochem Biophys 2001; 386:69-78.
7. Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C, et al. Dynamic regulation of mitochondrial function by glucocorticoids. Proc Natl Acad Sci USA 2009; In press.
8. Filipovic D, Gavrilovic L, Dronjak S, Radojcic MB. Brain glucocorticoid receptor and heat shock protein 70 levels in rats exposed to acute, chronic or combined stress. Neuropsychobiology 2005; 51:107-14.
9. Pratt WB, Morishima Y, Murphy M, Harrell M. Chaperoning of glucocorticoid receptors. Handb Exp Pharmacol 2006; 111-38.
10. Cato AC, Mink S. BAG-1 family of cochaperones in the modulation of nuclear receptor action. J Steroid Biochem Mol Biol 2001; 78:379-88.
11. Cvoro A, Dundjerski J, Trajkovic D, Matic G. Association of the rat liver glucocorticoid receptor with Hsp90 and Hsp70 upon whole body hyperthermic stress. J Steroid Biochem Mol Biol 1998; 67:319-25.
12. Dittmar KD, Demady DR, Stancato LF, Krishna P, Pratt WB. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. J Biol Chem 1997; 272:21213-20.
13. Lee J, Sharma S, Kim J, Ferrante RJ, Ryu H. Mitochondrial nuclear receptors and transcription factors: who's minding the cell? J Neurosci Res 2008; 86:961-71.
14. Wattenberg BW, Clark D, Brock S. An artificial mitochondrial tail signal/anchor sequence confirms a requirement for moderate hydrophobicity for targeting. Biosci Rep 2007; 27:385-401.
15. Demonacos C, Djordjevic-Markovic R, Tsawdaroglou N, Sekeris CE. The mitochondrion as a primary site of action of glucocorticoids: the interaction of the glucocorticoid receptor with mitochondrial DNA sequences showing partial similarity to the nuclear glucocorticoid responsive elements. J Steroid Biochem Mol Biol 1995; 55:43-55.
16. Nilsen J, Brinton RD. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drug Targets CNS Neurol Disord 2004; 3:297-313.
17. Zhou R, Gray NA, Yuan P, Li X, Chen J, Chen G, et al. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. J Neurosci 2005; 25:4493-502.
18. Maeng S, Hunsberger JG, Pearson B, Yuan P, Wang Y, Wei Y, et al. BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. Proc Nat Acad Sci USA 2008; 105:8766-71.
19. Gottlieb RA. Role of mitochondria in apoptosis. Crit Rev Eukaryot Gene Expr 2000; 10:231-9.
20. Daniel PT, Schulze-Osthoff K, Belka C, Guner D. Guardians of cell death: the Bcl-2 family proteins. Essays Biochem 2003; 39:73-88.
21. Armstrong JS. Mitochondria: a target for cancer therapy. Br J Pharmacol 2006; 147:239-48.
22. 2+-mediated mitochondrial dysfunction and the protective effects of Bcl-2. Ann N Y Acad Sci 1999; 893:19-32.
23. 2+-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells. J Biol Chem 2003; 278:38686-92.
24. Psarra AM, Sekeris CE. Steroid and thyroid hormone receptors in mitochondria. IUBMB Life 2008; 60:210-23.
25. Groc L, Choquet D, Chaouloff F. The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation. Nat Neurosci 2008; 11:868-70.
26. Liu F, Day M, Muniz LC, Bitran D, Arias R, Revilla-Sanchez R, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci 2008; 11:334-43.
27. Srivastava DP, Woolfrey KM, Jones KA, Shum CY, Lash LL, Swanson GT, Penzes P. Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity. Proc Natl Acad Sci USA 2008; 105:14650-5.
28. Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol Neurobiol 2005; 32:173-202.