Effect of hypercholesterolemia on myocardial necrosis and apoptosis in the setting of ischemia-reperfusion

Circulation

Volumn 120, Issue SUPPL. 1, 2009, Pages

  Osipov, Robert M ^a,d   Bianchi, Cesario ^a,d   Feng, Jun ^a,d   Clements, Richard T ^a,d   Liu, Yuhong ^a,d   Robich, Michael P ^a,d   Glazer, Hilary P ^a,d   Sodha, Neel R ^b,d   Sellke, Frank W ^a,c,d  

^a Division of Cardiothoracic Surgery   (United States)

^b Department of Surgery ^*

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; Hypercholesterolemia; Ischemia; Myocardial infarction; Risk factors

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; LIPID; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART MUSCLE REPERFUSION; HYPERCHOLESTEROLEMIA; INFLAMMATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SWINE; ANIMAL; BLOOD; CORONARY BLOOD VESSEL; HEART INFARCTION; HEART MUSCLE; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; METABOLISM; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; APOPTOSIS; CORONARY VESSELS; HEMODYNAMICS; HYPERCHOLESTEROLEMIA; LIPIDS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NECROSIS; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASE; SWINE; VENTRICULAR FIBRILLATION;

EID: 66849089854     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.842724     Document Type: Article

References (36)

1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet. 1997; 349:1498-1504.
2. 2. Corti R, Fuster V, Badimon JJ, Hutter R, Fayad ZA. New understanding of atherosclerosis (clinically and experimentally) with evolving MRI technology in vivo. Ann N Y Acad Sci. 2001;947:181-195; discussion 195-1188 (Pubitemid 34059913)
3. 3. Ballantyne CM, Olsson AG, Cook TJ, Mercuri MF, Pedersen TR, Kjekshus J. Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation. 2001;104:3046-3051. (Pubitemid 34014055)
4. 4. Prasad K, Kalra J. Experimental atherosclerosis and oxygen free radicals. Angiology. 1989;40:835-843. (Pubitemid 19218070)
5. Liu HR, Tao L, Gao E, Qu Y, Lau WB, Lopez BL, Christopher TA, Koch. W, Yue TL, Ma XL. Rosiglitazone inhibits hypercholesterolaemiainduced myeloperoxidase upregulation-a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc Res. 2009;81: 344-352.
6. 6. Prasan AM, McCarron HC, Zhang Y, Jeremy RW. Myocardial release of nitric oxide during ischaemia and reperfusion: effects of L-arginine and hypercholesterolaemia. Heart Lung Circ. 2007;16:274-281. (Pubitemid 47010472)
7. 7. Golino P, Maroko PR, Carew TE. The effect of acute hypercholesterolemia on myocardial infarct size and the no-reflow phenomenon during coronary occlusion-reperfusion. Circulation. 1987;75:292-298. (Pubitemid 17234570)
8. Wang TD, Chen WJ, Su SS, Lo SC, Lin WW, Lee YT. Increased cardiomyocyte apoptosis following ischemia and reperfusion in dietinduced hypercholesterolemia: relation to Bcl-2 and Bax proteins and caspase-3 activity. Lipids. 2002;37:385-394.
9. 9. Wang S, El-Deiry WS. TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 2003;22:8628-8633. (Pubitemid 38019198)
10. 10. Thim T, Bentzon JF, Kristiansen SB, Simonsen U, Andersen HL, Wassermann K, Falk E. Size of myocardial infarction induced by ischaemia/ reperfusion, is unaltered in rats with metabolic syndrome. Clin Sci (Lond). 2006;110:665-671. (Pubitemid 43844736)
11. Zhao JL, Yang YJ, You SJ, Cui CJ, Gao RL. Different effects of postconditioning on myocardial no-reflow in the normal and hypercholesterolemic mini-swines. Microvasc Res. 2007;73:137-142.
12. 12. Toyoda Y, Di Gregorio V, Parker RA, Levitsky S, McCully JD. Antistunning and anti-infarct effects of adenosine-enhanced ischemic preconditioning. Circulation. 2000;102:111326-111331. (Pubitemid 30819423)
13. Sodha NR, Clements RT, Feng J, Liu Y, Bianchi C, Horvath EM, Szabo C, Sellke FW. The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury. Eur J Cardiothorac Surg. 2008;33:906-913.
14. 14. Mannheim D, Versari D, Daghini E, Gossl M, Galili O, Chade A, Rajkumar VS, Ritman EL, Lerman LO, Lerman A. Impaired myocardial perfusion, reserve in experimental hypercholesterolemia is independent of myocardial neovascularization. Am J Physiol Heart Circ Physiol. 2007; 292:H2449-H2458. (Pubitemid 47084628)
15. 15. Nag SS, Daniel GW, Bullano MF, Kamal-Bahl S, Sajjan SG, Hu H, Alexander C. LDL-C goal attainment among patients newly diagnosed, with coronary heart disease or diabetes in a commercial HMO. J Manag Care Pharm, 2007;13:652-663. (Pubitemid 350065234)
16. 16. Galinanes M, Fowler AG. Role of clinical pathologies in myocardial injury following ischaemia and reperfusion. Cardiovasc Res. 2004;61: 512-521. (Pubitemid 38210156)
17. Inagi R. Oxidative stress in cardiovascular disease: a new avenue toward future therapeutic approaches. Recent Patents Cardiovasc Drug Discov. 2006;1:151-159.
18. Rosa CE, Bianchini A, Monserrat JM. Antioxidant responses of Laeonereis acuta (Polychaeta) after exposure to hydrogen peroxide. Braz J Med Biol Res. 2008;41:117-121.
19. 19. Zhang Y, Shi G, Zheng J, Tang Z, Gao P, Lv Y, Guo F, Jia Q. The protective effects of N-n-butyl haloperidol iodide on myocardial ischemia-reperfusion injury in rats by inhibiting Egr-1 overexpression. Cell Physiol Biochem. 2007;20:639-648. (Pubitemid 47340624)
20. Labarthe F, Gelinas R, Des Rosiers C. Medium-chain fatty acids as metabolic therapy in cardiac disease. Cardiovasc Drugs Ther. 2008;22: 97-106.
21. 21. Osborne JA, Lento PH, Siegfried MR, Stahl GL, Fusman B, Lefer AM. Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment. J Clin Invest. 1989;83:465-473. (Pubitemid 19061165)
22. 22. Hoshida S, Yamashita N, Otsu K, Kuzuya T, Hon M. Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol. 2000;278:H256-H262. (Pubitemid 30101878)
23. 23. Kawashima S, Yokoyama M. Dysfunction, of endothelial nitric oxide synthase and atherosclerosis. Arterioscler Thromb Vase Biol, 2004;24: 998-1005. (Pubitemid 38737823)
24. 24. Piana RN, Shafique T, Dai HB, Sellke FW. Epicardial and endocardial coronary microvascular responses: effects of ischemia-reperfusion. J Cardiovasc Pharmacol. 1994;23:539-546. (Pubitemid 24100137)
25. 25. Besse S, Bulteau AL, Boucher F, Riou B, Swynghedauw B, de Leiris J. Antioxidant treatment prevents cardiac protein, oxidation after ischemiareperfusion and improves myocardial function and coronary perfusion in senescent hearts. J Physiol Pharmacol, 2006;57:541-552. (Pubitemid 46096104)
26. 26. Onody A, Csonka C, Giricz Z, Ferdinandy P. Hyperlipidemia induced by a cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts. Cardiovasc Res. 2003;58:663-670. (Pubitemid 36694452)
27. Schulz R, Wambolt R. Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury. Cardiovasc Res. 1995;30:432-439.
28. 28. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840-844. (Pubitemid 30943820)
29. 29. Sodha NR, Boodhwani M, Ramlawi B, Clements RT, Mieno S, Feng J, Xu SH, Bianchi C, Sellke FW. Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia. J Card Surg. 2008;23:312-320. (Pubitemid 351852564)
30. 30. Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS. Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization. Am. J Physiol Heart Circ Physiol. 2007;293:H1107-H1114. (Pubitemid 47254211)
31. 31. Okamura T, Miura T, Takemura G, Fujiwara H, Iwamoto H, Kawamura S, Kimura M, Ikeda Y, Iwatate M, Matsuzaki M. Effect of caspase inhibitors on myocardial infarct size and myocyte DNA fragmentation in the ischemia-reperfused rat heart. Cardiovasc Res. 2000; 45:642-650. (Pubitemid 30047130)
32. 32. Gustafsson AB, Gottlieb RA. Bcl-2 family members and apoptosis, taken to heart. Am J Physiol Cell Physiol. 2007;292:C45-C51. (Pubitemid 46115120)
33. 33. Zhao ZQ, Nakamura M, Wang NP, Wilcox JN, Shearer S, Ronson RS, Guyton RA, Vinten-Johansen J. Reperfusion induces myocardial apoptotic cell death. Cardiovasc Res. 2000;45:651-660. (Pubitemid 30047131)
34. 34. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemiareperfusion injury in mouse heart. Circulation. 2000;101:660-667. (Pubitemid 30094738)
35. Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD. Protein, kinase G transmits the cardioprotective signal from, cytosol to mitochondria. Circ Res. 2005;97:329-336.
36. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 2008;88: 581-609.