Clinical outcomes of occupational exposure to N,N-dimethylformamide: Perspectives from experimental toxicology

Safety and Health at Work

Volumn 2, Issue 2, 2011, Pages 97-104

  Kim, Tae Hyun ^a   Kim, Sang Geon ^a  

^a Seoul National University   (South Korea)

Author keywords

Cytochrome P 450 2E1; Dimethylformamide; Hepatotoxicity; Occupational exposure

Indexed keywords

EID: 84879028663     PISSN: 20937911     EISSN: 20937997     Source Type: Journal    
DOI: 10.5491/SHAW.2011.2.2.97     Document Type: Review

References (60)

1. American Conference of Govermental Industrial Hygienists (ACGIH). Documentation for DMF. Cincinnati (OH): ACGIH; 2001.
2. Lynch DW, Placke ME, Persing RL, Ryan MJ. Thirteen-week inhalation toxicity of N,N-dimethylformamide in F344/N rats and B6C3F1 mice. Toxicol Sci 2003;72:347-58.
3. Johnson W, Yagi K. CEH Report: Dimethylformamide. Menlo Park (CA): SRI Consulting; 2002.
4. Shieh DB, Chen CC, Shih TS, Tai HM, Wei YH, Chang HY. Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide. Chem Biol Interact 2007;165:211-9.
5. Lee SW, Kim TH, Kim JM. A study on the necessity in establishment of STEL of dimethylformamide (DMF) -on the focus of the exposure in synthetic Leather factories. J Korean Soc Occup Environ Hyg 2008;18:80-90.
6. Lee YJ. Annual reports on usage of chemical materials - Documentation for DMF. Incheon (Korea): Korea Occupational Safety & Health Agency (KOSHA); 2007. p. 72-3. Korean.
7. Scailteur V, Lauwerys RR. Dimethylformamide (DMF) hepatotoxicity. Toxicology 1987;43:231-8.
8. Potter HP. Dimethylformamide-induced abdominal pain and liver injury. Arch Environ Health 1973;27:340-1.
9. Craig DK, Weir RJ, Wagner W, Groth D. Subchronic inhalation toxicity of dimethylformamide in rats and mice. Drug Chem Toxicology 1984;7:551-71.
10. Kennedy GL Jr, Sherman H. Acute and subchronic toxicity of dimethylformamide and dimethylacetamide following various routes of administration. Drug Chem Toxicol 1986;9:147-70.
11. Redlich CA, Beckett WS, Sparer J, Barwick KW, Riely CA, Miller H, Sigal SL, Shalat SL, Cullen MR. Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med 1988;108:680-6.
12. Calvert GM, Fajen JM, Hills BW, Halperin WE. Testicular cancer, dimethylformamide, and leather tanneries. Lancet 1990;336:1253-4.
13. Hansen E, Meyer O. Embryotoxicity and teratogenicity study in rats dosed epicutaneously with dimethylformamide (DMF). J Appl Toxicol 1990;10:333-8.
14. Kang IC, Oh HM. Increased growth of human leukemic HL-60 cells by dimethyl sulfoxide and dimethylformamide. Korean J Immunol 1999;21:285-9.
15. Kim KH, Seoh JY. Phenotypic and functional differentiation of promyelocytic cell Line HL-60 by N-N-dimethylformamide. J Korean Pediatr Soc 1998;41:481-8.
16. Moorman WJ, Ahlers HW, Chapin RE, Daston GP, Foster PM, Kavlock RJ, Morawetz JS, Schnorr TM, Schrader SM. Prioritization of NTP reproductive toxicants for field studies. Reprod Toxicol 2000;14:293-301.
17. Kim KW, Choi BS, Kang SK, Moon YH. A study on the N-methylformamide excretion rate of workers at synthetic leather factories in Korea. Korean J Occup Environ Med 1999;11:106-12.
18. Lee SW, Kim TH, Kim JM, Kim JC. A valuation and improvement of industrial ventilation system of printing process in synthetic leather factory using dimethylformamide. J Korean Soc Occup Environ Hyg 2009;19:113-26.
19. Kang SK, Jang JY, Rhee KY, Chung HK. A study on the liver dysfunction due to dimethylformamide. Korean J Occup Environ Med 1991;3:58-64.
20. Kim SK, Lee SJ, Chung KC. A suspicious case of dimethylformamide induced fulminant hepatitis in synthetic leather workers. Korean J Occup Environ Med 1995;7:186-90.
21. Kim HR, Kim TW. Occupational hepatic disorders in Korea. J Korean Med Sci 2010;25(Suppl):S36-S40.
22. Joo MD, Sohn YD, Choi WI. A case of toxic hepatitis after the exposure of dimethylformamide. J Korean Soc Emerg Med 2006;17:515-18.
23. Roh JR, Sohn JG, Kim JH, Park SJ. A case of acute toxic hepatitis induced by brief exposure to Dimethylformamide. Korean J Occup Environ Med 2005;17:144-8.
24. Lee KY, Byeon JH, Song HR, Kim JH, Ko KW, Lee YH. Seasonal variations of the urinary N-Methylformamide concentration among workers at a synthetic leather factory. Korean J Occup Environ Med 2003;15:162-72.
25. Kim SA, Kim JS, Jeon HR, Jung SJ, Kim SW, Lee CY, Ham JO, Yoo JY, Choi TS, Goo HB, Cho MH, Woo KH. Surveillance of work-related diseases in Kumi. Korean J Occup Environ Med 2003;15:95-110.
26. Heo JH, lee KL, Han SG, Kim HJ, Pai YM, Whang YH, Kang PJ, Kim CH, Cho SL. A case of fulminant hepatitis due to dimethylformamide. Korean J Gastroenterol 1999;34:547-50.
27. Hantson P, Villa A, Galloy AC, Negri S, Esabon G, Lambiotte F, Haufroid V, Garnier R. Dimethylformamide metabolism following self-harm using a veterinary euthanasia product. Clin Toxicol (Phila) 2010;48:725-9.
28. Kennedy GL Jr. Biological effects of acetamide, formamide, and their mono and dimethyl derivatives: an update. Crit Rev Toxicol 2001;31:139-222.
29. Koh SB, Cha BS, Park JK, Chang SH, Chang SJ. The metabolism and liver toxicity of N,N-dimethylformamide in the isolated perfused rat liver. Yonsei Med J 2002;43:491-9.
30. Chung IS, Kim JG, Choi SK, Bae JY, Lee MY. Influencing factors that affect the biological monitoring of workers exposed to N,N-dimethylformamide in textile coating factories. J Prev Med Public Health 2006;39:171-6.
31. Chung HK, Kang SK, Rhee KY, Jang JY. Evaluation of biological metabolites among the workers exposed todimethylformanide. Korean J Occup Environ Med 1992;4:144-50.
32. Amato G, Grasso E, Longo V, Gervasi PG. Oxidation of N,N- dimethylformamide and N,N-diethylformamide by human liver microsomes and human recombinant P450s. Toxicol Lett 2001;124:11-9.
33. Scailteur V, Lauwerys R. In vivo metabolism of dimethylformamide and relationship to toxicity in the male rat. Arch Toxicol 1984;56:87-91.
34. Mráz J, Jheeta P, Gescher A, Hyland R, Thummel K, Threadgill MD. Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1. Chem Res Toxicol 1993;6:197-207.
35. Koh SB, Cha BS, Kang MG, Koh SY, Lee JW, Kwon SO. The metabolism and liver toxicity of N, N-dimethylformamide in the isolated perfused liver. Korean J Occup Environ Med 1997;9:217-29.
36. Lauwerys RR, Kivits A, Lhoir M, Rigolet P, Houbeau D, Buchet JP, Roels HA. Biological surveillance of workers exposed to dimethylformamide and the influence of skin protection on its percutaneous absorption. Int Arch Occup Environ Health 1980;45:189-203.
37. Wang JD, Lai MY, Chen JS, Lin JM, Chiang JR, Shiau SJ, Chang WS. Dimethylformamide-induced liver damage among synthetic leather workers. Arch Environ Health 1991;46:161-6.
38. Redlich CA, West AB, Fleming L, True LD, Cullen MR, Riely CA. Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylfor mamide. Gastroenterology 1990;99:748-57.
39. Nomiyama T, Nakashima H, Chen LL, Tanaka S, Miyauchi H, Yamauchi T, Sakurai H, Omae K. N,N-dimethylformamide: significance of dermal absorption and adjustment method for urinary N-methylformamide concentration as a biological exposure item. Int Arch Occup Environ Health 2001;74:224-8.
40. Mráz J, Nohová H. Percutaneous absorption of N,N-dimethylformamide in humans. Int Arch Occup Environ Health 1992;64:79-83.
41. Lyle WH, Spence TW, McKinneley WM, Duckers K. Dimethylformamide and alcohol intolerance. Br J Ind Med 1979;36:63-6.
42. Chivers CP. Disulfiram effect from inhalation of dimethylformamide. Lancet 1978;1:331.
43. Luo JC, Kuo HW, Cheng TJ, Chang MJ. Abnormal liver function associated with occupational exposure to dimethylformamide and hepatitis B virus. J Occup Environ Med 2001;43:474-82.
44. Massmann W. Toxicological investigations on dimethylformamide. Br J Ind Med 1956;13:51-4.
45. Kestell P, Threadgill MD, Gescher A, Gledhill AP, Shaw AJ, Farmer PB. An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides. J Pharmacol Exp Ther 1987;240:265-70.
46. Yang CS, Yoo JS, Ishizaki H, Hong JY. Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation. Drug Metab Rev 1990;22:147-59.
47. Hyland R, Gescher A, Thummel K, Schiller C, Jheeta P, Mynett K, Smith AW, Mráz J. Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1. Mol Pharmacol 1992;41:259-66.
48. Kim TH, Kim YW, Shin SM, Kim CW, Yu IJ, Kim SG. Synergistic hepatotoxicity of N,N-dimethylformamide with carbon tetrachloride in association with endoplasmic reticulum stress. Chem Biol Interact 2010;184:492-501.
49. Kelava T, Cavar I, Culo F. Influence of small doses of various drug vehicles on acetaminophen-induced liver injury. Can J Physiol Pharmacol 2010;88:960-7.
50. Nolan JP. The role of endotoxin in liver injury. Gastroenterology 1975;69:1346-56.
51. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005;115:2656-64.
52. Kaufman RJ, Scheuner D, Schröder M, Shen X, Lee K, Liu CY, Arnold SM. The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol 2002;3:411-21.
53. Arduíno DM, Esteves AR, Cardoso SM, Oliveira CR. Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem Int 2009;55:341-8.
54. Caro AA, Cederbaum AI. Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004;44:27-42.
55. Wang RS, Nakajima T, Honma T. Different change patterns of the isozymes of cytochrome P450 and glutathione S-transferases in chemically induced liver damage in rat. Ind Health 1999;37:440-8.
56. Koh SB, Cha BS, Kim KJ, Kang SK, Joung HS. Induction of hepatic microsomal cytochrome P450 by N,N-dimethylformamide in sprague-dawley rats. Korean J Prev Med 1999;32:88-94.
57. Dai Y, Cederbaum AI. Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line. J Pharmacol Exp Ther 1995;275:1614-22.
58. Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ. Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem 1986;261:16689-97.
59. Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal 2007;9:2277-93.
60. Scailteur V, Lauwerys R. In vivo and in vitro oxidative biotransformation of dimethylformamide in rat. Chem Biol Interact 1984;50:327-37.