The metabolism and liver toxicity of N,N-dimethylformamide in the isolated perfused rat liver

Yonsei Medical Journal

Volumn 43, Issue 4, 2002, Pages 491-499

  Koh, Sang Baek ^a   Cha, Bong Suk ^a   Park, Jong Ku ^a   Chang, Soung Hoon ^a   Chang, Sei Jin ^a,b  

^a Yonsei University Wonju College of Medicine   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

Cytochrome p 450; Hepatotoxicity; N methylformamide isolated perfused rat liver; NN dimethylformamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; LACTATE DEHYDROGENASE; N,N DIMETHYLFORMAMIDE; OXYGEN; PROADIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; GAS CHROMATOGRAPHY; ISOLATED LIVER; LIVER PERFUSION; LIVER TOXICITY; MALE; NONHUMAN; OXYGEN CONSUMPTION; RAT; TIME; TOXICOKINETICS; TOXICOLOGY;

EID: 0036672404     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2002.43.4.491     Document Type: Article

References (31)

1. Absorption, metabolism and elimination of N,N-dimethylformamide in humans
2. Toxicology of dimethylformamide
3. Toxicokinetics of dimethyl-acetamide (DMAC) in rat isolated perfused liver
4. The inhalation toxicity of dimethylformamide (DMF)
5. Liver disease associated with occupational exposure to the solvent dimethylformamide
6. Differences between rodents and humans in the metabolic toxification of N,N-dimethylformamide
7. Dimethylformamide induced liver damage among synthetic leather workers
8. Germ cell tumors of the testicle among aircraft repairmen
9. TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents & biological exposure indices
10. Study on in vivo and in vitro metabolism of dimethylformamide in male and female rats
11. The Metabolism of dimethylformamide and dimethylacetamide
12. Studies of the metabolism of dimethylformamide in mice
13. Effect of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats
14. Investigation of the mechanistic basis of N, N-dimethylformamide toxicity. Metabolism of N, N-dimethylformamide and its denaturated isotopomers by cytochrome p-450 2E1
15. Hepatotoxicity and P-450 2E1 dependent metabolic oxidation of N, N dimethylformamide in rat and mice
16. The acute toxicity of dimethylamide in several animal species
17. Biological monitoring of workers exposed to N, N-dimethylformamide by determination of the urinary metabolites, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl) cysteine
18. Toxicological investigation on dimethylformamide
19. History of isolated liver perfusion and some still unsolved problem
20. The Isolated Perfused Rat Liver; Conceptual and Practical Considerations
21. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: Approved recommendation (1985) on IFCC methods measurement of catalytic concentration of enzymes. IFCC method aminotransferase
22. International Federation of Clinical Chemistry (ITCC) Scientific Committee, Analytical Section: Approved recommendation (1985) on IFCC methods measurement of catalytic concentration of enzymes. IFCC method for alanine transferase
23. Biological monitoring of workers exposed to N, N-dimethylformamide I. Method of analysis
24. Metabolism studies of N,N-dimethylformamide. II. Studies in persons
25. An investigation of the mechanisms of hepatotoxicity of the antitumor agent N-methylformamide in the rat
26. The formation and metabolism of N-hydroxymethyl compounds. IV. Cytotoxicity and antitumor activity of N-hydroxymethyl formamide, a putative metabolite of N-methylformamide
27. An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides
28. Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl) glutathione and S-(N-methylcabamoyl)-cysteine, two electrophilic S-linked conjugates of methylisocyanate
29. Metabolism and hepatotoxicity of N,N-dimethylformamide, N,N-hydroxymethyl-N-Methylformamide, and N-methylformamide in the rat
30. Mixed function oxidation in perfused rat liver The Effect of aminopyrine on oxygen uptake