Benzimidazole-2-one: A novel anchoring principle for antagonizing p53-Mdm2

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 3982-3995

  Wang, Wei ^a,b   Cao, Haiping ^a   Wolf, Siglinde ^c   Camacho Horvitz, Miguel S ^d   Holak, Tad A ^c,e   Dömling, Alexander ^a,f  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d Taylor Allderdice High School   (United States)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

ANCHOR; Multicomponent reaction; p53 mdm2; Protein protein interaction; Selectivity; Tryptophan; Ugi

Indexed keywords

2 (2 OXO 2,3 DIHYDRO 1H BENZO[D]IMIDAZOL 1 YL)ACETAMIDE; ACETAMIDE DERIVATIVE; BENZIMIDAZOL 2 ONE; BENZIMIDAZOLE DERIVATIVE; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CYCLIZATION; FLUORESCENCE POLARIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROTEIN INTERACTION; REACTION ANALYSIS;

BENZIMIDAZOLES; DRUG DESIGN; MODELS, MOLECULAR; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84879022305     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.020     Document Type: Article

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