Exploring DOXP-reductoisomerase binding limits using phosphonated N-aryl and N-heteroarylcarboxamides as DXR inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4332-4341

  Bodill, Taryn ^a   Conibear, Anne C ^a   Mutorwa, Marius K M ^a   Goble, Jessica L ^a   Blatch, Gregory L ^a,b   Lobb, Kevin A ^a   Klein, Rosalyn ^a   Kaye, Perry T ^a  

^a RHODES UNIVERSITY   (South Africa)

^b VICTORIA UNIVERSITY   (Australia)

Author keywords

Anti malarial; DOXP reductoisomerase; Enzyme inhibitors; In silico docking; Phosphonates; Saturation transfer difference NMR

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; AMIDE; FOSMIDOMYCIN; ISOMERASE; N ARYLCARBOXAMIDE DERIVATIVE; N HETEROARYLCARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ESCHERICHIA COLI; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM;

ALDOSE-KETOSE ISOMERASES; AMIDES; BINDING SITES; CARBAMATES; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING;

PLASMODIUM FALCIPARUM;

EID: 84879006654     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.04.076     Document Type: Article

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