Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 3, 2011, Pages 1321-1327

  Bodill, Taryn ^a   Conibear, Anne C ^a   Blatch, Gregory L ^a   Lobb, Kevin A ^a   Kaye, Perry T ^a  

^a RHODES UNIVERSITY   (South Africa)

Author keywords

Anti malarial; DOXP reductoisomerase; Enzyme inhibitors; In silico docking; Phosphonates; Saturation Transfer Difference NMR

Indexed keywords

DIETHYL 2 [(1,3 THIAZOL 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; DIETHYL 2 [(5 ACETYL 4 METHYL 1,3 THIAZOL 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; DIETHYL 2 [(FURAN 2 YLMETHYL)CARBAMOYL]ETHYLPHOSPHONATE; DIETHYL 2 [(ISOXAZOL 3 YL)CARBAMOYL]ETHYLPHOSPHONATE; DIETHYL 2 [(PYRIDIN 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; DISODIUM 2 [(1,3 THIAZOL 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; DISODIUM 2 [(5 ACETYL 4 METHYL 1,3 THIAZOL 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; DISODIUM 2 [(FURAN 2 YLMETHYL)CARBAMOYL]ETHYLPHOSPHONATE; DISODIUM 2 [(ISOXAZOL 3 YL)CARBAMOYL]ETHYLPHOSPHONATE; DISODIUM 2 [(PYRIDIN 2 YL)CARBAMOYL]ETHYLPHOSPHONATE; FOSMIDOMYCIN; ISOMERASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; COMPUTER SIMULATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME BINDING; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ALDOSE-KETOSE ISOMERASES; ANTIMALARIALS; COMPUTER SIMULATION; DRUG DESIGN; FOSFOMYCIN; FURANS; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; OXIDOREDUCTASES; PHOSPHONIC ACIDS; PROTEIN BINDING;

EID: 79551481493     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.062     Document Type: Article

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