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Volumn 19, Issue 11, 2013, Pages 3008-3018

Effects of early chemotherapeutic treatment on learning in adolescent mice: Implications for cognitive impairment and remediation in childhood cancer survivors

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; METHOTREXATE; SODIUM CHLORIDE;

EID: 84878995269     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-3764     Document Type: Article
Times cited : (22)

References (54)
  • 1
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • DOI 10.1056/NEJMra052603
    • Pui C, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166-78. (Pubitemid 43076714)
    • (2006) New England Journal of Medicine , vol.354 , Issue.2 , pp. 166-178
    • Pui, C.-H.1    Evans, W.E.2
  • 2
    • 33748442495 scopus 로고    scopus 로고
    • Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate
    • DOI 10.1200/JCO.2006.05.9055
    • Spiegler BJ, Kennedy K, Maze R, Greenberg ML, Weitzman S, Hitzler JK, et al. Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate. J Clin Oncol 2006;24:3858-64. (Pubitemid 46630732)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.24 , pp. 3858-3864
    • Spiegler, B.J.1    Kennedy, K.2    Maze, R.3    Greenberg, M.L.4    Weitzman, S.5    Hitzler, J.K.6    Nathan, P.C.7
  • 3
    • 36849056160 scopus 로고    scopus 로고
    • Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: Findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01
    • DOI 10.1200/JCO.2007.10.8464
    • Waber DP, Turek J, Catania L, Stevenson K, Robaey P, Romero I, et al. Neuropsychological outcomes from a randomized trial of triple intrathecal chemotherapy compared with 18 gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber cancer institute ALL consortium protocol 95-01. J Clin Oncol 2007;25:4914-21. (Pubitemid 350220422)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.31 , pp. 4914-4921
    • Waber, D.P.1    Turek, J.2    Catania, L.3    Stevenson, K.4    Robaey, P.5    Romero, I.6    Adams, H.7    Alyman, C.8    Jandet-Brunet, C.9    Neuberg, D.S.10    Sallan, S.E.11    Silverman, L.B.12
  • 4
    • 51649089891 scopus 로고    scopus 로고
    • Screening for neurocognitive impairment in pediatric cancer long-term survivors
    • Krull KR, Okcu MF, Potter B, Jain N, Dreyer Z, Kamdar K, et al. Screening for neurocognitive impairment in pediatric cancer long-term survivors. J Clin Oncol 2008;26:4138-43.
    • (2008) J Clin Oncol , vol.26 , pp. 4138-4143
    • Krull, K.R.1    Okcu, M.F.2    Potter, B.3    Jain, N.4    Dreyer, Z.5    Kamdar, K.6
  • 5
    • 62449193931 scopus 로고    scopus 로고
    • Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: A critical review of the literature
    • Buizer AI, de Sonneville LMJ, Veerman AJP. Effects of chemotherapy on neurocognitive function in children with acute lymphoblastic leukemia: a critical review of the literature. Pediatr Blood Cancer 2009;52:447-54.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 447-454
    • Buizer, A.I.1    De Sonneville, L.M.J.2    Veerman, A.J.P.3
  • 6
    • 78649512896 scopus 로고    scopus 로고
    • Impact of acute lymphoblastic leukemia therapy on attention and working memory in children
    • Reddick WE, Conklin HM. Impact of acute lymphoblastic leukemia therapy on attention and working memory in children. Expert Rev Hematol 2010;3:655-9.
    • (2010) Expert Rev Hematol , vol.3 , pp. 655-659
    • Reddick, W.E.1    Conklin, H.M.2
  • 7
    • 78649903193 scopus 로고    scopus 로고
    • Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research
    • Seigers R, Fardell JE. Neurobiological basis of chemotherapy-induced cognitive impairment: a review of rodent research. Neurosci Biobehav Rev 2011;35:729-41.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 729-741
    • Seigers, R.1    Fardell, J.E.2
  • 8
    • 72149134895 scopus 로고    scopus 로고
    • Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats
    • Li Y, Vijayanathan V, Gulinello ME, Cole PD. Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats. Pharmacol Biochem Behav 2010;94:454-63.
    • (2010) Pharmacol Biochem Behav , vol.94 , pp. 454-463
    • Li, Y.1    Vijayanathan, V.2    Gulinello, M.E.3    Cole, P.D.4
  • 9
    • 0020965485 scopus 로고
    • An animal model to detect learning deficits following treatment of the immature brain. Studies using radiation and methotrexate
    • Yadin E, Bruno L, Micalizzi M, Rorke L, D'Angio G. An animal model to detect learning deficits following treatment of the immature brain. Childs Brain 1983;10:273-80. (Pubitemid 13002068)
    • (1983) Child's Brain , vol.10 , Issue.4 , pp. 273-280
    • Yadin, E.1    Bruno, L.2    Micalizzi, M.3
  • 11
    • 0028078887 scopus 로고
    • Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia
    • Mullenix PJ, Kernan WJ, Schunior A, Howes A, Waber DP, Sallan SE, et al. Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia. Pediatr Res 1994;35:171-8. (Pubitemid 24039144)
    • (1994) Pediatric Research , vol.35 , Issue.2 , pp. 171-178
    • Mullenix, P.J.1    Kernan, W.J.2    Schunior, A.3    Howes, A.4    Waber, D.P.5    Sallan, S.E.6    Tarbell, N.J.7
  • 12
  • 14
    • 0037262627 scopus 로고    scopus 로고
    • Biochemical and clinical aspects of methotrexate neurotoxicity
    • DOI 10.1159/000069773
    • Vezmar S,Becker A,BodeU, Jaehde U. Biochemicalandclinical aspects of methotrexate neurotoxicity. Chemotherapy 2003;49:92-104. (Pubitemid 36469805)
    • (2003) Chemotherapy , vol.49 , Issue.1-2 , pp. 92-104
    • Vezmar, S.1    Becker, A.2    Bode, U.3    Jaehde, U.4
  • 16
    • 74849097394 scopus 로고    scopus 로고
    • Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor
    • Seigers R, Pourtau L, Schagen SB, van Dam FS, Koolhaas JM, Konsman JP, et al. Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor. Brain Res Bull 2010;81:472-6.
    • (2010) Brain Res Bull , vol.81 , pp. 472-476
    • Seigers, R.1    Pourtau, L.2    Schagen, S.B.3    Van Dam, F.S.4    Koolhaas, J.M.5    Konsman, J.P.6
  • 18
    • 48149092284 scopus 로고    scopus 로고
    • Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory
    • Berl
    • Foley JJ, Raffa RB, Walker EA. Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory. Psychopharmacology (Berl) 2008;199:527-38.
    • (2008) Psychopharmacology , vol.199 , pp. 527-538
    • Foley, J.J.1    Raffa, R.B.2    Walker, E.A.3
  • 19
    • 33846991965 scopus 로고    scopus 로고
    • CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo
    • Dietrich J, Han R, Yang Y, Mayer-Proschel M, Noble M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol 2006;5:22.
    • (2006) J Biol , vol.5 , pp. 22
    • Dietrich, J.1    Han, R.2    Yang, Y.3    Mayer-Proschel, M.4    Noble, M.5
  • 20
    • 54549093727 scopus 로고    scopus 로고
    • Cytosine arabinoside treatment impairs the remote spatial memory function and induces dendritic retraction in the anterior cingulate cortex of rats
    • Li CQ, Liu D, Huang L, Wang H, Zhang JY, Luo XG. Cytosine arabinoside treatment impairs the remote spatial memory function and induces dendritic retraction in the anterior cingulate cortex of rats. Brain Res Bull 2008;77:237-40.
    • (2008) Brain Res Bull , vol.77 , pp. 237-240
    • Li, C.Q.1    Liu, D.2    Huang, L.3    Wang, H.4    Zhang, J.Y.5    Luo, X.G.6
  • 21
    • 0032702933 scopus 로고    scopus 로고
    • Toxic leukoencephalopathy
    • Filley CM. Toxic leukoencephalopathy. Clin Neuropharmacol 1999;22:249-60. (Pubitemid 29506393)
    • (1999) Clinical Neuropharmacology , vol.22 , Issue.5 , pp. 249-260
    • Filley, C.M.1
  • 22
    • 0036739780 scopus 로고    scopus 로고
    • Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro
    • Akutsu M, Furukawa Y, Tsunoda S, Izumi T, Ohmine K, Kano Y. Schedule-dependent synergism and antagonism between methotrexate and cytarabine against human leukemia cell lines in vitro . Leukemia 2002;16:1808-17.
    • (2002) Leukemia , vol.16 , pp. 1808-1817
    • Akutsu, M.1    Furukawa, Y.2    Tsunoda, S.3    Izumi, T.4    Ohmine, K.5    Kano, Y.6
  • 23
    • 0031597454 scopus 로고    scopus 로고
    • An automated learning and memroy model in mice: Pharmacological and behavioral evaluation of an autoshpaed response
    • Vanover KE, Barrett JE. An automated learning and memory model in mice: pharmacological and behavioral evaluation of an autoshaped response. Behav Pharmacol 1998;9:273-83. (Pubitemid 28273113)
    • (1998) Behavioural Pharmacology , vol.9 , Issue.3 , pp. 273-283
    • Vanover, K.E.1    Barrett, J.E.2
  • 24
    • 43149113698 scopus 로고    scopus 로고
    • Assessment of learning and memory using the autoshaping of operant responding in mice
    • Chapter 8:Unit 8.5F
    • Barrett JE, Vanover KE. Assessment of learning and memory using the autoshaping of operant responding in mice. Curr Protoc Neurosci 2004;Chapter 8:Unit 8.5F.
    • (2004) Curr Protoc Neurosci
    • Barrett, J.E.1    Vanover, K.E.2
  • 25
    • 8844281576 scopus 로고    scopus 로고
    • An overview of the tasks used to test working memory in rodents
    • DOI 10.1016/j.neubiorev.2004.09.002, PII S0149763404000909, Neurobiology of Cognition in Laboratory Animals
    • Dudchenko PA. An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 2004;28:699-709. (Pubitemid 39535867)
    • (2004) Neuroscience and Biobehavioral Reviews , vol.28 , Issue.7 , pp. 699-709
    • Dudchenko, P.A.1
  • 26
    • 12344316918 scopus 로고    scopus 로고
    • Attenuation of d-amphetamine-induced disruption of conditional discrimination performance by α-flupenthixol
    • DOI 10.1007/s00213-004-1954-z
    • Dunn MJ, Futter D, Bonardi C, Killcross S. Attenuation of d-amphetamine-induced disruption of conditional discrimination performance by α-flupenthixol. Psychopharmacology (Berl) 2005;177:296-306. (Pubitemid 40137290)
    • (2005) Psychopharmacology , vol.177 , Issue.3 , pp. 296-306
    • Dunn, M.J.1    Futter, D.2    Bonardi, C.3    Killcross, S.4
  • 28
    • 77954086949 scopus 로고    scopus 로고
    • The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
    • Klinkenberg I, Blokland A. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 2010;34:1307-50.
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 1307-1350
    • Klinkenberg, I.1    Blokland, A.2
  • 29
    • 0038069379 scopus 로고    scopus 로고
    • Risk-taking behavior in adolescent mice: Psychobiological determinants and early epigenetic influence
    • DOI 10.1016/S0149-7634(03)00006-X
    • Laviola G, Macri S, Morley-Fletcher S, Adriani W. Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence. Neurosci Biobehav Rev 2003;27:19-31. (Pubitemid 36535388)
    • (2003) Neuroscience and Biobehavioral Reviews , vol.27 , Issue.1-2 , pp. 19-31
    • Laviola, G.1    Macri, S.2    Morley-Fletcher, S.3    Adriani, W.4
  • 30
    • 0019974098 scopus 로고
    • Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics
    • DOI 10.1007/BF01062336
    • Boxenbaum H. Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics. J Pharmacokinet Biopharm 1982;10:201-27. (Pubitemid 12044187)
    • (1982) Journal of Pharmacokinetics and Biopharmaceutics , vol.10 , Issue.2 , pp. 201-227
    • Boxenbaum, H.1
  • 31
    • 23944496599 scopus 로고    scopus 로고
    • A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance
    • DOI 10.1124/dmd.105.004135
    • Tang H, Mayersohn M. A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance. Drug Metab Dispos 2005;33:1294-6. (Pubitemid 41196971)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.9 , pp. 1294-1296
    • Tang, H.1    Mayersohn, M.2
  • 32
    • 0345281999 scopus 로고
    • Combined autoshaping-operant (AO) training: CSUCS interval in rats
    • Davenport JW. Combined autoshaping-operant (AO) training: CSUCS interval in rats. Bull Psychomonic Soc 1974;3:383-5.
    • (1974) Bull Psychomonic Soc , vol.3 , pp. 383-385
    • Davenport, J.W.1
  • 33
    • 0344945595 scopus 로고    scopus 로고
    • Performance of different mouse strains in an object recognition task
    • DOI 10.1016/S0166-4328(03)00117-7
    • Sik A, van Nieuwehuyzen P, Prickaerts J, Blokland A. Performance of different mouse strains in an object recognition task. Behav Brain Res 2003;147:49-54. (Pubitemid 37491412)
    • (2003) Behavioural Brain Research , vol.147 , Issue.1-2 , pp. 49-54
    • Sik, A.1    Van Nieuwehuyzen, P.2    Prickaerts, J.3    Blokland, A.4
  • 34
    • 77953841496 scopus 로고    scopus 로고
    • Novel object recognition in the rat: A facile assay for cognitive function
    • Chapter 5: Unit 5.59
    • Mathiasen JR, Dicamillo A. Novel object recognition in the rat: a facile assay for cognitive function. Curr Protoc Pharmacol 2010;Chapter 5: Unit 5.59.
    • (2010) Curr Protoc Pharmacol
    • Mathiasen, J.R.1    Dicamillo, A.2
  • 35
    • 77957335007 scopus 로고    scopus 로고
    • A within-subject cognitive battery in the rat: Differential effects of NMDA receptor antagonists
    • Berl
    • Dix S, Gilmour G, Potts S, Smith JW, Tricklebank M. A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists. Psychopharmacology (Berl) 2010;212:227-42.
    • (2010) Psychopharmacology , vol.212 , pp. 227-242
    • Dix, S.1    Gilmour, G.2    Potts, S.3    Smith, J.W.4    Tricklebank, M.5
  • 37
    • 77957583781 scopus 로고    scopus 로고
    • Attention and working memory abilities in children treated for acute lymphoblastic leukemia
    • Ashford J, Schoffstall C, Reddick WE, Leone C, Laningham FH, Glass JO, et al. Attention and working memory abilities in children treated for acute lymphoblastic leukemia. Cancer 2010;116:4638-45.
    • (2010) Cancer , vol.116 , pp. 4638-4645
    • Ashford, J.1    Schoffstall, C.2    Reddick, W.E.3    Leone, C.4    Laningham, F.H.5    Glass, J.O.6
  • 38
    • 0033797954 scopus 로고    scopus 로고
    • Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia
    • Moleski M. Neuropsychological, neuroanatomical, and neurophysiological consequences of CNS chemotherapy for acute lymphoblastic leukemia. Arch Clin Neuropsych 2000;15:603-630.
    • (2000) Arch Clin Neuropsych , vol.15 , pp. 603-630
    • Moleski, M.1
  • 39
    • 84878966706 scopus 로고    scopus 로고
    • Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models
    • Bisen-Hersh EB, Hineline PN, Walker EA. Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models. J Cancer 2011;2:292-301.
    • (2011) J Cancer , vol.2 , pp. 292-301
    • Bisen-Hersh, E.B.1    Hineline, P.N.2    Walker, E.A.3
  • 40
    • 84878964902 scopus 로고    scopus 로고
    • Animal models of chemotherapy-induced learning and memory deficits
    • Raffa RB, Tallarida RJ, editors. Austin (TX): RG Landes Bioscience, Inc.
    • Walker EA. Animal models of chemotherapy-induced learning and memory deficits. In: Raffa RB, Tallarida RJ, editors. 'Chemofog': cognitive deficits associated with cancer chemotherapy. Austin (TX): RG Landes Bioscience, Inc.; 2010.
    • (2010) 'Chemofog': Cognitive Deficits Associated with Cancer Chemotherapy
    • Walker, E.A.1
  • 41
    • 82955233935 scopus 로고    scopus 로고
    • Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice
    • Berl
    • Walker EA, Foley JJ, Clark-Vetri R, Raffa RB. Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice. Psychopharmacology (Berl) 2011;217:539-48.
    • (2011) Psychopharmacology , vol.217 , pp. 539-548
    • Walker, E.A.1    Foley, J.J.2    Clark-Vetri, R.3    Raffa, R.B.4
  • 42
    • 33751307914 scopus 로고    scopus 로고
    • The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice
    • DOI 10.1016/j.pbb.2006.07.010, PII S0091305706002206
    • Winocur G, Vardy J, Binns MA, Kerr L, Tannock I. The effects of the anticancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice. Pharmacol Biochem Behav 2006;85:66-75. (Pubitemid 44802737)
    • (2006) Pharmacology Biochemistry and Behavior , vol.85 , Issue.1 , pp. 66-75
    • Winocur, G.1    Vardy, J.2    Binns, M.A.3    Kerr, L.4    Tannock, I.5
  • 44
    • 0017753231 scopus 로고
    • Neurobehavioral and systemic effects of longterm blood lead-elevation in rats. I. Discrimination learning and open field-behavior
    • Winneke G, Brockhaus A, Baltissen R. Neurobehavioral and systemic effects of longterm blood lead-elevation in rats. I. Discrimination learning and open field-behavior. Arch Toxicol 1977;37:247-63. (Pubitemid 8245973)
    • (1977) Archives of Toxicology , vol.37 , Issue.4 , pp. 247-263
    • Winneke, G.1    Brockhaus, A.2    Baltissen, R.3
  • 45
    • 0344505736 scopus 로고    scopus 로고
    • Unilateral hippocampal lesions in newborn and adult rats: Effects on spatial memory and BDNF gene expression
    • DOI 10.1016/S0166-4328(97)00117-4, PII S0166432897001174
    • van Praag H, Mei Qu P, Elliott RC, Wu H, Dreyfus CF, Black IB. Unilateral hippocampal lesions in newborn and adult rats: effects on spatial memory and BDNF gene expression. Behav Brain Res 1998;92:21-30. (Pubitemid 28179604)
    • (1998) Behavioural Brain Research , vol.92 , Issue.1 , pp. 21-30
    • Van Praag, H.1    Qu, P.M.2    Elliott, R.C.3    Wu, H.4    Dreyfus, C.F.5    Black, I.B.6
  • 46
    • 80052381901 scopus 로고    scopus 로고
    • Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence
    • Rayen I, van den Hove DL, Prickaerts J, Steinbusch HW, Pawluski JL. Fluoxetine during development reverses the effects of prenatal stress on depressive-like behavior and hippocampal neurogenesis in adolescence. PLoS ONE 2011;6:e24003.
    • (2011) PLoS ONE , vol.6
    • Rayen, I.1    Van Den Hove, D.L.2    Prickaerts, J.3    Steinbusch, H.W.4    Pawluski, J.L.5
  • 47
    • 61849176458 scopus 로고    scopus 로고
    • Differential effects of paclitaxel treatment on cognitive functioning and mechanical sensitivity
    • Boyette-Davis JA, FuchsPN. Differential effects of paclitaxel treatment on cognitive functioning and mechanical sensitivity. Neurosci Lett 2009;453:170-4.
    • (2009) Neurosci Lett , vol.453 , pp. 170-174
    • Boyette-Davis, J.A.1    Fuchs, P.N.2
  • 48
    • 0031823864 scopus 로고    scopus 로고
    • Attentional processes and their remediation in childhood cancer
    • Butler RW. Attentional processes and their remediation in childhood cancer. Med Pediatr Oncol 1998;Suppl 1:75-8.
    • (1998) Med Pediatr Oncol , Issue.SUPPL. 1 , pp. 75-78
    • Butler, R.W.1
  • 49
    • 0036159352 scopus 로고    scopus 로고
    • Attentional processes and their remediation in children treated for cancer: A literature review and the development of a therapeutic approach
    • DOI 10.1017/S1355617702811110
    • Butler RW, Copeland DR. Attentional processes and their remediation in children treated for cancer: a literature review and the development of a therapeutic approach. J Int Neuropsychol Soc 2002;8:115-24. (Pubitemid 34130479)
    • (2002) Journal of the International Neuropsychological Society , vol.8 , Issue.1 , pp. 115-124
    • Butler, R.W.1    Copeland, D.R.2
  • 51
    • 0001364464 scopus 로고
    • The development of non-continuity behavior through continuity learning
    • Reid LS. The development of non-continuity behavior through continuity learning. J Exp Psychol 1953;46:107-12.
    • (1953) J Exp Psychol , vol.46 , pp. 107-112
    • Reid, L.S.1
  • 52
    • 34548759797 scopus 로고    scopus 로고
    • Optimizing combination chemotherapy by controlling drug ratios
    • DOI 10.1124/mi.7.4.8
    • Mayer LD, Janoff AS. Optimizing combination chemotherapy by controlling drug ratios. Mol Interv 2007;7:216-23. (Pubitemid 47437268)
    • (2007) Molecular Interventions , vol.7 , Issue.4 , pp. 216-223
    • Mayer, L.D.1    Janoff, A.S.2
  • 53
    • 84858225214 scopus 로고    scopus 로고
    • Identification of hepatic niche harboring human acute lymphoblastic leukemia cells via the SDF-1/CXCR4 axis
    • Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, et al. Identification of hepatic niche harboring human acute lymphoblastic leukemia cells via the SDF-1/CXCR4 axis. PLoS ONE 2011;6:e27042.
    • (2011) PLoS ONE , vol.6
    • Kato, I.1    Niwa, A.2    Heike, T.3    Fujino, H.4    Saito, M.K.5    Umeda, K.6


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