Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells

Biochemical and Biophysical Research Communications

Volumn 435, Issue 3, 2013, Pages 397-402

  He, Xin yao ^a   Liu, Xian jin ^b   Chen, Xiao ^a   Bian, Liu guan ^a   Zhao, Wei guo ^a   Shen, Jian kang ^a   Sun, Qing fang ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b Central Hospital of Zhumadian   (China)

Author keywords

Akt mTOR signaling and apoptosis; AMPK; EGFR; Gambogic acid; Glioma cell; LRIG1

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; CASPASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMBOGIC ACID; LEUCINE RICH REPEAT IG LIKE DOMANIN CONTAINING 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; GLIOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; MEMBRANE GLYCOPROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; TOR SERINE-THREONINE KINASES; TUMOR STEM CELL ASSAY; UP-REGULATION; XANTHONES;

EID: 84878976343     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.099     Document Type: Article

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