Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis

Toxicology Letters

Volumn 220, Issue 2, 2013, Pages 109-117

  Hwang, Sung Jun ^a   Hwang, You Jung ^a   Yun, Mi Ok ^a   Kim, Jong Hee ^b   Oh, Gap Soo ^a   Park, Joo Hung ^a  

^a Changwon National University   (South Korea)

^b Kyungnam University   (South Korea)

Author keywords

AhR; C Src; EAE; Indoxyl 3 sulfate; STAT3; Th17

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; AROMATIC HYDROCARBON RECEPTOR; INDOXYL 3 SULFATE; INTERLEUKIN 17; INTERLEUKIN 6; PROTEIN TYROSINE KINASE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; UNCLASSIFIED DRUG; UREMIC TOXIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; ENZYME ACTIVITY; IMMUNOMODULATION; IN VITRO STUDY; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH17 CELL;

ANIMALS; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INDICAN; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHORYLATION; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; TETRACHLORODIBENZODIOXIN; TH17 CELLS;

EID: 84878970050     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.04.016     Document Type: Article

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