Role of helicity on the anticancer mechanism of action of cationic-helical peptides

International Journal of Molecular Sciences

Volumn 13, Issue 6, 2012, Pages 6849-6862

  Huang, Yi Bing ^a   He, Li Yan ^a   Jiang, Hong Yu ^a   Chen, Yu Xin ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Anticancer peptides; Helicity; Hydrophobicity; Mechanism of action; Specificity

Indexed keywords

ALPHA HELICAL PEPTIDE A12L; ALPHA HELICAL PEPTIDE A20L; AMINO ACID; DEXTRO AMINO ACID; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; ANTINEOPLASTIC AGENT; CATION; PEPTIDE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; DRUG EFFICACY; DRUG SPECIFICITY; HELA CELL; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; POLARIZATION; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; DRUG SCREENING; ERYTHROCYTE; HELA CELL LINE; IC50; MEDICINAL CHEMISTRY; MOLECULAR GENETICS; PROCEDURES; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; CATIONS; CHEMISTRY, PHARMACEUTICAL; CIRCULAR DICHROISM; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ERYTHROCYTES; HELA CELLS; HEMOLYSIS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84862489506     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13066849     Document Type: Article

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