A suicidal poisoning due to tramadol. A metabolic approach to death investigation

Journal of Forensic and Legal Medicine

Volumn 20, Issue 5, 2013, Pages 555-558

  Barbera, Nunziata ^a   Fisichella, Marco ^a   Bosco, Andrea ^a   Indorato, Francesca ^a   Spadaro, Giorgio ^a   Romano, Guido ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Metabolic ratio; N desmethyltramadol; O desmethyltramadol; Postmortem; Tramadol

Indexed keywords

CARBAMAZEPINE; DRUG METABOLITE; N DESMETHYLTRAMADOL; N,N DIDESMETHYLTRAMADOL; N,O DIDESMETHYLTRAMADOL; O NORTRAMADOL; SCOPOLAMINE; TRAMADOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOPSY; BIOLOGICAL MONITORING; BLOOD SAMPLING; BRAIN; CASE REPORT; DEATH; DRUG BLOOD LEVEL; FEMALE; HAIR ANALYSIS; HUMAN; KIDNEY; LIVER; LUNG; MASS FRAGMENTOGRAPHY; MEDICAL HISTORY; MENTAL DISEASE; SUICIDE; VISCERA;

ANALGESICS, OPIOID; BILE; FEMALE; FORENSIC TOXICOLOGY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASTROINTESTINAL CONTENTS; HUMANS; MIDDLE AGED; SUICIDE; TRAMADOL;

EID: 84878904253     PISSN: 1752928X     EISSN: 18787487     Source Type: Journal    
DOI: 10.1016/j.jflm.2013.03.006     Document Type: Article

References (31)

1. M.J. Ellenhorn, S. Schonwald, G. Ordog, and J. Wasserberger The opiates Williams and Wilkins Ellenhorn's medical toxicology: diagnosis and treatment of human poisoning 1997 Williams and Wilkins Baltimore 445 446
2. T.A. Bamigbade, and R.M. Langford Tramadol hydrochloride: an overview of current use Hosp Med 59 1998 373 376
3. R.J. Leo, M.B. Narendran, and B. DeGuiseppe Methadone detoxification of tramadol dependence J Subst Abuse Treat 19 2000 297 299
4. W.N. Wu, L.A. Mckown, and S. Liao Metabolism of the analgesic drug ULTRAM (R) (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites Xenobiotica 32 2002 411 425
5. C.R. Lee, D. McTavish, and E.M. Sorkin Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states Drugs 46 1993 313 340
6. A.C. Moffat, M.D. Osselton, B. Widdop, and J. Watts Clarke's analysis of drugs and poisons 4th ed. 2011 Pharmaceutical Press London p. 2175-2177
7. K. De Decker, J. Cordonnier, W. Jacobs, V. Coucke, P. Schepens, and P.G. Jorens Fatal intoxication due to tramadol alone: case report and review of the literature Forensic Sci Int 175 2008 79 82
8. B. De Backer, F. Renardy, R. Denooz, and C. Charlier Quantification in postmortem blood and identification in urine of tramadol and its two main metabolites in two cases of lethal tramadol intoxication J Anal Toxicol 34 2010 599 604
9. K.E. Goeringer, B.K. Logan, and G.D. Christian Identification of tramadol and its metabolites in blood from drug-related deaths and drug-impaired drivers J Anal Toxicol 21 1997 529 537
10. B. Levine, V. Ramcharitar, and J. Smialek Tramadol distribution in four postmortem cases Forensic Sci Int 86 1997 43 48
11. K. Michaud, M. Augsburger, N. Romain, C. Giroud, and P. Mangin Fatal overdose of tramadol and Alprazolam Forensic Sci Int 105 1999 185 189
12. F. Clarot, J.P. Goullè, E. Vaz, and B. Proust Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality? Forensic Sci Int 134 2003 57 61
13. J.E. Clarkson, J.M. Lacy, C.L. Fligner, N. Thiersch, J. Howard, and R.C. Harruff Tramadol (UltramR) concentrations in death investigation and impaired driving cases and their significance J Forensic Sci 49 2004 1101 1105
14. M.G. Ripple, J.P. Pestaner, B.S. Levine, and J.E. Smialek Lethal combination of tramadol and multiple drugs affecting serotonin Am J Forensic Med Pathol 21 2000 370 374
15. N.D. Bynum, J.L. Poklis, M. Gaffney-Kraft, D. Garside, and J.D. Ropero-Miller Post-mortem distribution of tramadol, amitriptyline, and their metabolites in a suicidal overdose J Anal Toxicol 29 2005 401 406
16. J.L. Pilgrim, D. Gerostamoulos, and O.H. Drummer Deaths involving serotonergic drugs Forensic Sci Int 198 2010 110 117
17. J.L. Pilgrim, D. Gerostamoulos, and O.H. Drummer Deaths involving contraindicated and inappropriate combinations of serotonergic drugs Int J Leg Med 125 2011 803 815
18. D.J. Speed, S.J. Dickson, E.R. Cairns, and N.D. Kim Analysis of six anticonvulsant drugs using solid-phase extraction, deuterated internal standards, and gas chromatography-mass spectrometry J Anal Toxicol 24 2000 685 690
19. B. El-Haj, A. Al-Amri, and H. Ali Gas chromatography-mass spectrometry designation and prediction of metabolic dealkylation and hydroxylation reactions in xenobiotics exemplified by tramadol J Anal Toxicol 33 2009 34 40
20. K.A. Moore, S.J. Cina, R. Jones, D.M. Selby, B. Levine, and M.L. Smith Tissue distribution of tramadol and metabolites in an overdose fatality Am J Forensic Med Pathol 20 1999 98 100
21. K.J. Lusthof, and P.G. Zweipfenning Suicide by tramadol overdose J Anal Toxicol 22 1998 260
22. F. Musshoff, and B. Madea Fatality due to ingestion of tramadol alone Forensic Sci Int 116 2001 197 199
23. M.B. Loughrey, C.M. Loughrey, S. Johnston, and D. O'Rourke Fatal hepatic failure following accidental tramadol overdose Forensic Sci Int 134 2003 232 233
24. C. Gillen, M. Haurand, D.J. Kobelt, and S. Wnendt Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor Naunyn-Schmiedeberg's Arch Pharmacol 362 2000 116 121
25. L. Poulsen, L. Arendt-Nielsen, K. Brøsen, and S.H. Sindrup The hypoalgesic effect of tramadol in relation to CYP2D6 Clin Pharmacol Ther 60 1996 636 644
26. M.C. Frink, H.H. Hennies, W. Englberger, M. Haurand, and B. Wilffert Influence of tramadol on neurotransmitter systems of the rat brain Arzneim Forsch 46 1996 1029 1036
27. U.M. Stamer, F. Stüber, T. Muders, and F. Musshoff Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication Anesth Analg 107 2008 926 929
28. R.S. Pedersen, P. Damkier, and K. Brøsen Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers Eur J Clin Pharmacol 62 2006 513 521
29. F. Fliegert, B. Kurth, and K. Gohler The effects of tramadol on static and dynamic pupillometry in healthy subjects - the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status Eur J Clin Pharmacol 61 2005 257 266
30. W. Högler, S.A. Wudy, G. Luef, M.F. Hartmann, and M. Rauchenzauner Oxcarbazepine accelerates cortisol elimination via cytochrome P450 3A4 induction Arch Dis Child 95 2010 1065
31. A. Shahzadi, I. Javed, B. Aslam, F. Muhammad, M.R. Asi, and M.Y. Ashraf Therapeutic effects of ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers Pak J Pharm Sci 24 2011 63 68