Oxcarbazepine accelerates cortisol elimination via cytochrome P450 3A4 induction

Archives of Disease in Childhood

Volumn 95, Issue 12, 2010, Pages 1065-1067

  Högler, Wolfgang ^a,b   Wudy, S A ^c   Luef, G ^b   Hartmann, M F ^c   Rauchenzauner, M ^b  

^a BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; ESTRADIOL; HYDROCORTISONE; OXCARBAZEPINE; PRASTERONE;

ADDISON DISEASE; ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; EPILEPSY; HUMAN; MALE; PRIORITY JOURNAL; URINALYSIS;

ADDISON DISEASE; ADOLESCENT; ADULT; ANTICONVULSANTS; CARBAMAZEPINE; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYME INDUCTION; EPILEPSY, TEMPORAL LOBE; HUMANS; HYDROCORTISONE; MALE; YOUNG ADULT;

EID: 78649853758     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2009.167361     Document Type: Article

References (5)

1. Andreasen AH, Brøsen K, Damkier P. A comparative pharmacokinetic study in healthy volunteers of the effect of carbamazepine and oxcarbazepine on cyp3a4. Epilepsia 2007;48:490-6.
2. May TW, Korn-Merker E, Rambeck B. Clinical pharmacokinetics of oxcarbazepine. Clin Pharmacokinet 2003;42:1023-42.
3. Wudy SA, Hartmann MF, Remer T. Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinary cortisol metabolite excretion rates during growth. Am J Physiol Endocrinol Metab 2007;293:E970-6.
4. Konishi H, Tanaka K, Minouchi T, et al. Urinary 6beta-hydroxycortisol/17- hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction. Ann Clin Biochem 2004;41:335-7.
5. Löfgren E, Tapanainen JS, Koivunen R, et al. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy. Epilepsia 2006;47:1441-6.