Mass spectrometry reveals changes in MHC I antigen presentation after lentivector expression of a gene regulation system

Molecular Therapy Nucleic Acids

Volumn 2, Issue , 2013, Pages e75-

  Vogel, Roland ^a   Al Daccak, Reem ^b   Drews, Oliver ^c   Alonzeau, Jessy ^a   Mester, Gabor ^c   Charron, Dominique ^b   Stevanovic, Stefan ^c   Mallet, Jacques ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SAINT LOUIS HOSPITAL   (France)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Gene therapy; Genotoxicity; HLA antigens; Immune responses

Indexed keywords

LENTIVIRUS VECTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RAPAMYCIN;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; GENE CONTROL; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSGENE;

EID: 84878878644     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.3     Document Type: Article

References (33)

1. Fussenegger, M (2001). The impact of mammalian gene regulation concepts on functional genomic research, metabolic engineering, and advanced gene therapies. Biotechnol Prog 17: 1-51. (Pubitemid 32145373)
2. Baron, U and Bujard, H (2000). Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Meth Enzymol 327: 401-421. (Pubitemid 34193323)
3. Zhu, Z, Zheng, T, Lee, CG, Homer, RJ and Elias, JA (2002). Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Semin Cell Dev Biol 13: 121-128. (Pubitemid 35300824)
4. Latta-Mahieu, M, Rolland, M, Caillet, C, Wang, M, Kennel, P, Mahfouz, I et al. (2002). Gene transfer of a chimeric trans-activator is immunogenic and results in short-lived transgene expression. Hum Gene Ther 13: 1611-1620. (Pubitemid 35034681)
5. Ginhoux, F, Turbant, S, Gross, DA, Poupiot, J, Marais, T, Lone, Y et al. (2004). HLAA 0201-restricted cytolytic responses to the rtTA transactivator dominant and cryptic epitopes compromise transgene expression induced by the tetracycline on system. Mol Ther 10: 279-289. (Pubitemid 39127368)
6. Rivera, VM, Clackson, T, Natesan, S, Pollock, R, Amara, JF, Keenan, T et al. (1996). A humanized system for pharmacologic control of gene expression. Nat Med 2: 1028-1032. (Pubitemid 26306843)
7. Rivera, VM, Wang, X, Wardwell, S, Courage, NL, Volchuk, A, Keenan, T et al. (2000). Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287: 826-830. (Pubitemid 30084319)
8. Pollock, R, Issner, R, Zoller, K, Natesan, S, Rivera, VM and Clackson, T (2000). Delivery of a stringent dimerizer-regulated gene expression system in a single retroviral vector.Proc Natl Acad Sci USA 97: 13221-13226.
9. Vogel, R, Mammeri, H and Mallet, J (2008). Lentiviral vectors mediate nonimmunosuppressive rapamycin analog-induced production of secreted therapeutic factors in the brain: regulation at the level of transcription and exocytosis. Hum Gene Ther 19: 167-178. (Pubitemid 351271511)
10. Nielsen, M, Lundegaard, C, Lund, O and Kesmir, C (2005). The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage. Immunogenetics 57: 33-41. (Pubitemid 40591245)
11. Nielsen, M, Lundegaard, C, Blicher, T, Lamberth, K, Harndahl, M, Justesen, S et al. (2007). NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence. PLoS ONE 2: e796.
12. Lemmel, C, Weik, S, Eberle, U, Dengjel, J, Kratt, T, Becker, HD et al. (2004). Differential quantitative analysis of MHC ligands by mass spectrometry using stable isotope labeling. Nat Biotechnol 22: 450-454. (Pubitemid 38451377)
13. Davis, AA, Bernstein, PS, Bok, D, Turner, J, Nachtigal, M and Hunt, RC (1995). A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture. Invest Ophthalmol Vis Sci 36: 955-964.
14. Fallaux, FJ, Kranenburg, O, Cramer, SJ, Houweling, A, Van Ormondt, H, Hoeben, RC et al. (1996). Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther 7: 215-222. (Pubitemid 26044840)
15. Weinzierl, AO, Rudolf, D, Hillen, N, Tenzer, S, van Endert, P, Schild, H et al. (2008). Features of TAP-independent MHC class I ligands revealed by quantitative mass spectrometry. Eur J Immunol 38: 1503-1510.
16. Falk, K, Rötzschke, O, Takiguchi, M, Gnau, V, Stevanovic, S, Jung, G et al. (1995). Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease. Int Immunol 7: 223-228.
17. Weinzierl, AO, Lemmel, C, Schoor, O, Müller, M, Krüger, T, Wernet, D et al. (2007).Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface. Mol Cell Proteomics 6: 102-113. (Pubitemid 46152695)
18. Thommen, DS, Schuster, H, Keller, M, Kapoor, S, Weinzierl, AO, Chennakesava, CS et al. (2012). Two preferentially expressed proteins protect vascular endothelial cells from an attack by peptide-specific CTL. J Immunol 188: 5283-5292.
19. Wölk, B, Trautwein, C, Büchele, B, Kersting, N, Blum, HE, Rammensee, HG et al. (2012). Identification of naturally processed hepatitis C virus-derived major histocompatibility complex class I ligands. PLoS ONE 7: e29286.
20. Seliger, B, Dressler, SP, Massa, C, Recktenwald, CV, Altenberend, F, Bukur, J et al. (2011). Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells. Proteomics 11: 2528-2541.
21. Meyer, VS, Drews, O, Günder, M, Hennenlotter, J, Rammensee, HG and Stevanovic, S (2009). Identification of natural MHC class II presented phosphopeptides and tumorderived MHC class I phospholigands. J Proteome Res 8: 3666-3674.
22. Meyer, VS, Kastenmuller, W, Gasteiger, G, Franz-Wachtel, M, Lamkemeyer, T, Rammensee, HG et al. (2008). Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling. J Immunol 181: 6371-6383.
23. Hacein-Bey-Abina, S, von Kalle, C, Schmidt, M, Le Deist, F, Wulffraat, N, McIntyre, E et al. (2003). A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348: 255-256. (Pubitemid 36077924)
24. Oh, WJ, Rishi, V, Pelech, S and Vinson, C (2007). Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin. Carcinogenesis 28: 2244-2252. (Pubitemid 47543387)
25. di Marzo Veronese, F, Arnott, D, Barnaba, V, Loftus, DJ, Sakaguchi, K, Thompson, CB et al. (1996). Autoreactive cytotoxic T lymphocytes in human immunodeficiency virus type 1-infected subjects. J Exp Med 183: 2509-2516. (Pubitemid 26192360)
26. Kane, NM, Nowrouzi, A, Mukherjee, S, Blundell, MP, Greig, JA, Lee, WK et al. (2010). Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Mol Ther 18: 2139-2145.
27. Klionsky, DJ (2005). The molecular machinery of autophagy: unanswered questions. J Cell Sci 118(Pt 1): 7-18. (Pubitemid 40277100)
28. English, L, Chemali, M, Duron, J, Rondeau, C, Laplante, A, Gingras, D et al. (2009). Autophagy enhances the presentation of endogenous viral antigens on MHC class Imolecules during HSV-1 infection. Nat Immunol 10: 480-487.
29. Dengjel, J, Schoor, O, Fischer, R, Reich, M, Kraus, M, Müller, M et al. (2005). Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci USA 102: 7922-7927. (Pubitemid 40781039)
30. Malarkannan, S, Horng, T, Shih, PP, Schwab, S and Shastri, N (1999). Presentation ofout-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. Immunity 10: 681-690. (Pubitemid 29302921)
31. Cavazzana-Calvo, M, Payen, E, Negre, O, Wang, G, Hehir, K, Fusil, F et al. (2010). Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia. Nature 467: 318-322.
32. Humphries, W, Wei, J, Sampson, JH and Heimberger, AB (2010). The role of Tregs in glioma-mediated immunosuppression: potential target for intervention. Neurosurg Clin NAm 21: 125-137.
33. Weinzierl, AO, Maurer, D, Altenberend, F, Schneiderhan-Marra, N, Klingel, K, Schoor, O et al. (2008). A cryptic vascular endothelial growth factor T-cell epitope: identification and characterization by mass spectrometry and T-cell assays. Cancer Res 68: 2447-2454. (Pubitemid 351521820)