-
1
-
-
62049083420
-
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
-
10.1038/nm.1912, 2838375, 19198615
-
Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009, 15(3):331-337. 10.1038/nm.1912, 2838375, 19198615.
-
(2009)
Nat Med
, vol.15
, Issue.3
, pp. 331-337
-
-
Nagahara, A.H.1
Merrill, D.A.2
Coppola, G.3
Tsukada, S.4
Schroeder, B.E.5
Shaked, G.M.6
Wang, L.7
Blesch, A.8
Kim, A.9
Conner, J.M.10
-
2
-
-
84934444350
-
Selecting a mouse model of Alzheimer's disease
-
Chin J. Selecting a mouse model of Alzheimer's disease. Methods Mol Biol 2011, 670:169-189.
-
(2011)
Methods Mol Biol
, vol.670
, pp. 169-189
-
-
Chin, J.1
-
3
-
-
77955454185
-
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways
-
10.1073/pnas.0914257107, 2906579, 20616000
-
Miller JA, Horvath S, Geschwind DH. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proc Natl Acad Sci USA 2010, 107(28):12698-12703. 10.1073/pnas.0914257107, 2906579, 20616000.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.28
, pp. 12698-12703
-
-
Miller, J.A.1
Horvath, S.2
Geschwind, D.H.3
-
4
-
-
34047146046
-
A conditional mouse model of synovial sarcoma: insights into a myogenic origin
-
10.1016/j.ccr.2007.01.016, 17418413
-
Haldar M, Hancock JD, Coffin CM, Lessnick SL, Capecchi MR. A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell 2007, 11(4):375-388. 10.1016/j.ccr.2007.01.016, 17418413.
-
(2007)
Cancer Cell
, vol.11
, Issue.4
, pp. 375-388
-
-
Haldar, M.1
Hancock, J.D.2
Coffin, C.M.3
Lessnick, S.L.4
Capecchi, M.R.5
-
5
-
-
76549117990
-
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
-
10.1073/pnas.0908682107, 2824379, 20080688
-
Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R. Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment. Proc Natl Acad Sci U S A 2010, 107:1565-1570. 10.1073/pnas.0908682107, 2824379, 20080688.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1565-1570
-
-
Hung, K.E.1
Maricevich, M.A.2
Richard, L.G.3
Chen, W.Y.4
Richardson, M.P.5
Kunin, A.6
Bronson, R.T.7
Mahmood, U.8
Kucherlapati, R.9
-
6
-
-
79960580428
-
Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
-
3144583, 21772266
-
Raab M, Kappel S, Kramer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, et al. Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells. Nat Commun 2011, 2:395. 3144583, 21772266.
-
(2011)
Nat Commun
, vol.2
, pp. 395
-
-
Raab, M.1
Kappel, S.2
Kramer, A.3
Sanhaji, M.4
Matthess, Y.5
Kurunci-Csacsko, E.6
Calzada-Wack, J.7
Rathkolb, B.8
Rozman, J.9
Adler, T.10
-
7
-
-
65549123510
-
Zebrafish: a complete animal model for in vivo drug discovery and development
-
10.2174/138920009787522197, 19275547
-
Chakraborty C, Hsu CH, Wen ZH, Lin CS, Agoramoorthy G. Zebrafish: a complete animal model for in vivo drug discovery and development. Curr Drug Metab 2009, 10(2):116-124. 10.2174/138920009787522197, 19275547.
-
(2009)
Curr Drug Metab
, vol.10
, Issue.2
, pp. 116-124
-
-
Chakraborty, C.1
Hsu, C.H.2
Wen, Z.H.3
Lin, C.S.4
Agoramoorthy, G.5
-
8
-
-
12144273121
-
In vivo drug discovery in the zebrafish
-
10.1038/nrd1606, 15688071
-
Zon LI, Peterson RT. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 2005, 4(1):35-44. 10.1038/nrd1606, 15688071.
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.1
, pp. 35-44
-
-
Zon, L.I.1
Peterson, R.T.2
-
9
-
-
34250685667
-
Zebrafish: an emerging model system for human disease and drug discovery
-
10.1038/sj.clpt.6100223, 17495877
-
Kari G, Rodeck U, Dicker AP. Zebrafish: an emerging model system for human disease and drug discovery. Clin Pharmacol Ther 2007, 82(1):70-80. 10.1038/sj.clpt.6100223, 17495877.
-
(2007)
Clin Pharmacol Ther
, vol.82
, Issue.1
, pp. 70-80
-
-
Kari, G.1
Rodeck, U.2
Dicker, A.P.3
-
10
-
-
33749334697
-
Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective
-
10.1158/1078-0432.CCR-06-0437, 17000664
-
Singh M, Johnson L. Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective. Clinical Cancer Research 2006, 12(18):5312-5328. 10.1158/1078-0432.CCR-06-0437, 17000664.
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.18
, pp. 5312-5328
-
-
Singh, M.1
Johnson, L.2
-
11
-
-
33748331308
-
The mighty mouse: genetically engineered mouse models in cancer drug development
-
10.1038/nrd2110, 16915232
-
Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 2006, 5(9):741-754. 10.1038/nrd2110, 16915232.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.9
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
12
-
-
0033771951
-
Concordance of the toxicity of pharmaceuticals in humans and in animals
-
10.1006/rtph.2000.1399, 11029269
-
Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, Lilly P, Sanders J, Sipes G, Bracken W, et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul Toxicol Pharmacol 2000, 32(1):56-67. 10.1006/rtph.2000.1399, 11029269.
-
(2000)
Regul Toxicol Pharmacol
, vol.32
, Issue.1
, pp. 56-67
-
-
Olson, H.1
Betton, G.2
Robinson, D.3
Thomas, K.4
Monro, A.5
Kolaja, G.6
Lilly, P.7
Sanders, J.8
Sipes, G.9
Bracken, W.10
-
13
-
-
34247554428
-
Conservation of regional gene expression in mouse and human brain
-
10.1371/journal.pgen.0030059, 1853119, 17447843
-
Strand AD, Aragaki AK, Baquet ZC, Hodges A, Cunningham P, Holmans P, Jones KR, Jones L, Kooperberg C, Olson JM. Conservation of regional gene expression in mouse and human brain. PLoS Genet 2007, 3(4):e59. 10.1371/journal.pgen.0030059, 1853119, 17447843.
-
(2007)
PLoS Genet
, vol.3
, Issue.4
-
-
Strand, A.D.1
Aragaki, A.K.2
Baquet, Z.C.3
Hodges, A.4
Cunningham, P.5
Holmans, P.6
Jones, K.R.7
Jones, L.8
Kooperberg, C.9
Olson, J.M.10
-
14
-
-
79251638359
-
The similarity of gene expression between human and mouse tissues
-
10.1186/gb-2011-12-1-101, 3091293, 21241524
-
Dowell RD. The similarity of gene expression between human and mouse tissues. Genome Biol 2011, 12(1):101. 10.1186/gb-2011-12-1-101, 3091293, 21241524.
-
(2011)
Genome Biol
, vol.12
, Issue.1
, pp. 101
-
-
Dowell, R.D.1
-
15
-
-
78650371571
-
Large scale comparison of global gene expression patterns in human and mouse
-
10.1186/gb-2010-11-12-r124, 3046484, 21182765
-
Zheng-Bradley X, Rung J, Parkinson H, Brazma A. Large scale comparison of global gene expression patterns in human and mouse. Genome Biol 2010, 11(12):R124. 10.1186/gb-2010-11-12-r124, 3046484, 21182765.
-
(2010)
Genome Biol
, vol.11
, Issue.12
-
-
Zheng-Bradley, X.1
Rung, J.2
Parkinson, H.3
Brazma, A.4
-
16
-
-
65349162170
-
Conservation of core gene expression in vertebrate tissues
-
10.1186/jbiol130, 2689434, 19371447
-
Chan ET, Quon GT, Chua G, Babak T, Trochesset M, Zirngibl RA, Aubin J, Ratcliffe MJ, Wilde A, Brudno M, et al. Conservation of core gene expression in vertebrate tissues. J Biol 2009, 8(3):33. 10.1186/jbiol130, 2689434, 19371447.
-
(2009)
J Biol
, vol.8
, Issue.3
, pp. 33
-
-
Chan, E.T.1
Quon, G.T.2
Chua, G.3
Babak, T.4
Trochesset, M.5
Zirngibl, R.A.6
Aubin, J.7
Ratcliffe, M.J.8
Wilde, A.9
Brudno, M.10
-
17
-
-
33749335282
-
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
-
10.1126/science.1132939, 17008526
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006, 313(5795):1929-1935. 10.1126/science.1132939, 17008526.
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.P.8
Subramanian, A.9
Ross, K.N.10
-
18
-
-
33747817416
-
Roundup: a multi-genome repository of orthologs and evolutionary distances
-
10.1093/bioinformatics/btl286, 16777906
-
Deluca TF, Wu IH, Pu J, Monaghan T, Peshkin L, Singh S, Wall DP. Roundup: a multi-genome repository of orthologs and evolutionary distances. Bioinformatics 2006, 22(16):2044-2046. 10.1093/bioinformatics/btl286, 16777906.
-
(2006)
Bioinformatics
, vol.22
, Issue.16
, pp. 2044-2046
-
-
Deluca, T.F.1
Wu, I.H.2
Pu, J.3
Monaghan, T.4
Peshkin, L.5
Singh, S.6
Wall, D.P.7
-
19
-
-
56649116111
-
Gene expression module-based chemical function similarity search
-
10.1093/nar/gkn610, 2582597, 18842630
-
Li Y, Hao P, Zheng S, Tu K, Fan H, Zhu R, Ding G, Dong C, Wang C, Li X, et al. Gene expression module-based chemical function similarity search. Nucleic Acids Res 2008, 36(20):e137. 10.1093/nar/gkn610, 2582597, 18842630.
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.20
-
-
Li, Y.1
Hao, P.2
Zheng, S.3
Tu, K.4
Fan, H.5
Zhu, R.6
Ding, G.7
Dong, C.8
Wang, C.9
Li, X.10
-
20
-
-
62149139389
-
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS)
-
10.1016/j.exphem.2008.12.002, 2693256, 19217201
-
Dowdell KC, Pesnicak L, Hoffmann V, Steadman K, Remaley AT, Cohen JI, Straus SE, Rao VK. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS). Exp Hematol 2009, 37(4):487-494. 10.1016/j.exphem.2008.12.002, 2693256, 19217201.
-
(2009)
Exp Hematol
, vol.37
, Issue.4
, pp. 487-494
-
-
Dowdell, K.C.1
Pesnicak, L.2
Hoffmann, V.3
Steadman, K.4
Remaley, A.T.5
Cohen, J.I.6
Straus, S.E.7
Rao, V.K.8
-
21
-
-
77951237809
-
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
-
10.1186/1476-4598-9-49, 2843655, 20202195
-
Hrzenjak A, Moinfar F, Kremser ML, Strohmeier B, Petru E, Zatloukal K, Denk H. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer 2010, 9:49. 10.1186/1476-4598-9-49, 2843655, 20202195.
-
(2010)
Mol Cancer
, vol.9
, pp. 49
-
-
Hrzenjak, A.1
Moinfar, F.2
Kremser, M.L.3
Strohmeier, B.4
Petru, E.5
Zatloukal, K.6
Denk, H.7
-
22
-
-
0036691495
-
Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi
-
10.1128/EC.1.4.538-547.2002, 118000, 12456002
-
Baidyaroy D, Brosch G, Graessle S, Trojer P, Walton JD. Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi. Eukaryot Cell 2002, 1(4):538-547. 10.1128/EC.1.4.538-547.2002, 118000, 12456002.
-
(2002)
Eukaryot Cell
, vol.1
, Issue.4
, pp. 538-547
-
-
Baidyaroy, D.1
Brosch, G.2
Graessle, S.3
Trojer, P.4
Walton, J.D.5
-
23
-
-
70349330786
-
Disease signatures are robust across tissues and experiments
-
2758720, 19756046
-
Dudley JT, Tibshirani R, Deshpande T, Butte AJ. Disease signatures are robust across tissues and experiments. Mol Syst Biol 2009, 5:307. 2758720, 19756046.
-
(2009)
Mol Syst Biol
, vol.5
, pp. 307
-
-
Dudley, J.T.1
Tibshirani, R.2
Deshpande, T.3
Butte, A.J.4
-
24
-
-
69049087456
-
The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma
-
10.1093/toxsci/kfp213, 2794330, 19812364
-
Laifenfeld D, Gilchrist A, Drubin D, Jorge M, Eddy SF, Frushour BP, Ladd B, Obert LA, Gosink MM, Cook JC, et al. The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma. Toxicol Sci 2010, 113(1):254-266. 10.1093/toxsci/kfp213, 2794330, 19812364.
-
(2010)
Toxicol Sci
, vol.113
, Issue.1
, pp. 254-266
-
-
Laifenfeld, D.1
Gilchrist, A.2
Drubin, D.3
Jorge, M.4
Eddy, S.F.5
Frushour, B.P.6
Ladd, B.7
Obert, L.A.8
Gosink, M.M.9
Cook, J.C.10
-
25
-
-
27644508837
-
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
-
10.1158/1535-7163.MCT-05-0198, 16227395
-
Zhang Q, Tang X, Lu QY, Zhang ZF, Brown J, Le AD. Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol Cancer Ther 2005, 4(10):1465-1474. 10.1158/1535-7163.MCT-05-0198, 16227395.
-
(2005)
Mol Cancer Ther
, vol.4
, Issue.10
, pp. 1465-1474
-
-
Zhang, Q.1
Tang, X.2
Lu, Q.Y.3
Zhang, Z.F.4
Brown, J.5
Le, A.D.6
-
26
-
-
66749091184
-
The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells
-
10.1038/aps.2009.29, 19349965
-
Li Y, Zhang JF, Zhang YM, Ma XB. The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells. Acta Pharmacol Sin 2009, 30(5):576-581. 10.1038/aps.2009.29, 19349965.
-
(2009)
Acta Pharmacol Sin
, vol.30
, Issue.5
, pp. 576-581
-
-
Li, Y.1
Zhang, J.F.2
Zhang, Y.M.3
Ma, X.B.4
-
27
-
-
41949097208
-
Nitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration
-
10.1128/JB.01857-07, 2293237, 18296525
-
Sohaskey CD. Nitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration. J Bacteriol 2008, 190(8):2981-2986. 10.1128/JB.01857-07, 2293237, 18296525.
-
(2008)
J Bacteriol
, vol.190
, Issue.8
, pp. 2981-2986
-
-
Sohaskey, C.D.1
-
28
-
-
25144472027
-
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells
-
10.1152/physiolgenomics.00045.2004, 15942021
-
Vengellur A, Phillips JM, Hogenesch JB, LaPres JJ. Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. Physiol Genomics 2005, 22(3):308-318. 10.1152/physiolgenomics.00045.2004, 15942021.
-
(2005)
Physiol Genomics
, vol.22
, Issue.3
, pp. 308-318
-
-
Vengellur, A.1
Phillips, J.M.2
Hogenesch, J.B.3
LaPres, J.J.4
-
29
-
-
0031019187
-
Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro
-
Yamamoto S, Tanaka E, Higashi H. Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J Neurophysiol 1997, 77(1):386-392.
-
(1997)
J Neurophysiol
, vol.77
, Issue.1
, pp. 386-392
-
-
Yamamoto, S.1
Tanaka, E.2
Higashi, H.3
-
30
-
-
0029845844
-
Modulation of hypoxia-induced calpain activity in rat renal proximal tubules
-
10.1038/ki.1996.422, 8887272
-
Edelstein CL, Yaqoob MM, Alkhunaizi AM, Gengaro PE, Nemenoff RA, Wang KK, Schrier RW. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Kidney Int 1996, 50(4):1150-1157. 10.1038/ki.1996.422, 8887272.
-
(1996)
Kidney Int
, vol.50
, Issue.4
, pp. 1150-1157
-
-
Edelstein, C.L.1
Yaqoob, M.M.2
Alkhunaizi, A.M.3
Gengaro, P.E.4
Nemenoff, R.A.5
Wang, K.K.6
Schrier, R.W.7
-
31
-
-
35948951072
-
Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione
-
10.1165/rcmb.2006-0289SM, 1994227, 17541013
-
Carver DJ, Gaston B, Deronde K, Palmer LA. Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione. Am J Respir Cell Mol Biol 2007, 37(3):255-263. 10.1165/rcmb.2006-0289SM, 1994227, 17541013.
-
(2007)
Am J Respir Cell Mol Biol
, vol.37
, Issue.3
, pp. 255-263
-
-
Carver, D.J.1
Gaston, B.2
Deronde, K.3
Palmer, L.A.4
-
32
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
10.1128/MCB.22.20.7004-7014.2002, 139825, 12242281
-
Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002, 22(20):7004-7014. 10.1128/MCB.22.20.7004-7014.2002, 139825, 12242281.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.20
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
33
-
-
0034329304
-
Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer
-
Kambe T, Tada-Kambe J, Kuge Y, Yamaguchi-Iwai Y, Nagao M, Sasaki R. Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer. Blood 2000, 96(9):3265-3271.
-
(2000)
Blood
, vol.96
, Issue.9
, pp. 3265-3271
-
-
Kambe, T.1
Tada-Kambe, J.2
Kuge, Y.3
Yamaguchi-Iwai, Y.4
Nagao, M.5
Sasaki, R.6
-
34
-
-
69549096508
-
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling
-
10.1124/mol.109.057430, 19528198
-
Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol 2009, 76(3):588-595. 10.1124/mol.109.057430, 19528198.
-
(2009)
Mol Pharmacol
, vol.76
, Issue.3
, pp. 588-595
-
-
Tuller, E.R.1
Beavers, C.T.2
Lou, J.R.3
Ihnat, M.A.4
Benbrook, D.M.5
Ding, W.Q.6
-
35
-
-
34748886158
-
In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia
-
10.1016/j.cbpa.2007.08.020, 2083261, 17884646
-
Schlenker EH. In hamsters dopamine D2 receptors affect ventilation during and following intermittent hypoxia. Comp Biochem Physiol A Mol Integr Physiol 2007, 148(3):674-680. 10.1016/j.cbpa.2007.08.020, 2083261, 17884646.
-
(2007)
Comp Biochem Physiol A Mol Integr Physiol
, vol.148
, Issue.3
, pp. 674-680
-
-
Schlenker, E.H.1
-
36
-
-
0037211301
-
Role of ERK and calcium in the hypoxia-induced activation of HIF-1
-
10.1002/jcp.10176, 12447987
-
Mottet D, Michel G, Renard P, Ninane N, Raes M, Michiels C. Role of ERK and calcium in the hypoxia-induced activation of HIF-1. J Cell Physiol 2003, 194(1):30-44. 10.1002/jcp.10176, 12447987.
-
(2003)
J Cell Physiol
, vol.194
, Issue.1
, pp. 30-44
-
-
Mottet, D.1
Michel, G.2
Renard, P.3
Ninane, N.4
Raes, M.5
Michiels, C.6
-
37
-
-
0035107345
-
Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells
-
10.1016/S0898-6568(00)00128-5, 11257444
-
Beitner-Johnson D, Rust RT, Hsieh TC, Millhorn DE. Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signal 2001, 13(1):23-27. 10.1016/S0898-6568(00)00128-5, 11257444.
-
(2001)
Cell Signal
, vol.13
, Issue.1
, pp. 23-27
-
-
Beitner-Johnson, D.1
Rust, R.T.2
Hsieh, T.C.3
Millhorn, D.E.4
-
38
-
-
77952403264
-
Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model
-
10.1161/CIRCRESAHA.109.213447, 2882633, 20466987
-
Ramasamy R, Goldberg IJ. Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model. Circ Res 2010, 106(9):1449-1458. 10.1161/CIRCRESAHA.109.213447, 2882633, 20466987.
-
(2010)
Circ Res
, vol.106
, Issue.9
, pp. 1449-1458
-
-
Ramasamy, R.1
Goldberg, I.J.2
-
39
-
-
0028972025
-
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
-
10.1016/0092-8674(95)90193-0, 8521497
-
Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995, 83(5):803-812. 10.1016/0092-8674(95)90193-0, 8521497.
-
(1995)
Cell
, vol.83
, Issue.5
, pp. 803-812
-
-
Forman, B.M.1
Tontonoz, P.2
Chen, J.3
Brun, R.P.4
Spiegelman, B.M.5
Evans, R.M.6
-
40
-
-
0034406481
-
PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer
-
10.1016/S0165-6147(00)01559-5, 11121836
-
Murphy GJ, Holder JC. PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 2000, 21(12):469-474. 10.1016/S0165-6147(00)01559-5, 11121836.
-
(2000)
Trends Pharmacol Sci
, vol.21
, Issue.12
, pp. 469-474
-
-
Murphy, G.J.1
Holder, J.C.2
-
41
-
-
0036772687
-
Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation
-
10.1210/en.2002-220259, 12239100
-
Kayali AG, Austin DA, Webster NJ. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology 2002, 143(10):3884-3896. 10.1210/en.2002-220259, 12239100.
-
(2002)
Endocrinology
, vol.143
, Issue.10
, pp. 3884-3896
-
-
Kayali, A.G.1
Austin, D.A.2
Webster, N.J.3
-
42
-
-
78149471440
-
Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way
-
10.1007/s12192-010-0202-1, 3024068, 20480272
-
Zhang D, Xu L, Cao F, Wei T, Yang C, Uzan G, Peng B. Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. Cell Stress Chaperones 2010, 15(6):939-946. 10.1007/s12192-010-0202-1, 3024068, 20480272.
-
(2010)
Cell Stress Chaperones
, vol.15
, Issue.6
, pp. 939-946
-
-
Zhang, D.1
Xu, L.2
Cao, F.3
Wei, T.4
Yang, C.5
Uzan, G.6
Peng, B.7
-
43
-
-
67149115541
-
Towards retinoid therapy for Alzheimer's disease
-
10.2174/156720509788486581, 2765081, 19519313
-
Shudo K, Fukasawa H, Nakagomi M, Yamagata N. Towards retinoid therapy for Alzheimer's disease. Curr Alzheimer Res 2009, 6(3):302-311. 10.2174/156720509788486581, 2765081, 19519313.
-
(2009)
Curr Alzheimer Res
, vol.6
, Issue.3
, pp. 302-311
-
-
Shudo, K.1
Fukasawa, H.2
Nakagomi, M.3
Yamagata, N.4
-
44
-
-
73649131216
-
Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes
-
Valles SL, Dolz-Gaiton P, Gambini J, Borras C, Lloret A, Pallardo FV, Vina J. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. Brain Res 2010, 1312:138-144.
-
(2010)
Brain Res
, vol.1312
, pp. 138-144
-
-
Valles, S.L.1
Dolz-Gaiton, P.2
Gambini, J.3
Borras, C.4
Lloret, A.5
Pallardo, F.V.6
Vina, J.7
-
45
-
-
57449113371
-
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
-
10.1186/1471-2202-9-S2-S7, 2604885, 19091004
-
Luo W, Rodina A, Chiosis G. Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?. BMC Neurosci 2008, 9(Suppl 2):S7. 10.1186/1471-2202-9-S2-S7, 2604885, 19091004.
-
(2008)
BMC Neurosci
, vol.9
, Issue.SUPPL. 2
-
-
Luo, W.1
Rodina, A.2
Chiosis, G.3
-
46
-
-
66049094854
-
Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase
-
10.1021/bi802070j, 3021459, 19236051
-
Shineman DW, Dain AS, Kim ML, Lee VM. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. Biochemistry 2009, 48(17):3787-3794. 10.1021/bi802070j, 3021459, 19236051.
-
(2009)
Biochemistry
, vol.48
, Issue.17
, pp. 3787-3794
-
-
Shineman, D.W.1
Dain, A.S.2
Kim, M.L.3
Lee, V.M.4
-
47
-
-
69449092485
-
Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
-
10.1097/JGP.0b013e3181ab8c61, 2842091, 19700947
-
Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, Raskind MA, Peskind ER. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry 2009, 17(9):744-751. 10.1097/JGP.0b013e3181ab8c61, 2842091, 19700947.
-
(2009)
Am J Geriatr Psychiatry
, vol.17
, Issue.9
, pp. 744-751
-
-
Wang, L.Y.1
Shofer, J.B.2
Rohde, K.3
Hart, K.L.4
Hoff, D.J.5
McFall, Y.H.6
Raskind, M.A.7
Peskind, E.R.8
-
48
-
-
66749168924
-
Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle
-
10.1124/jpet.108.149112, 2683768, 19293389
-
Han G, Ma H, Chintala R, Fulton DJ, Barman SA, White RE. Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle. J Pharmacol Exp Ther 2009, 329(3):850-855. 10.1124/jpet.108.149112, 2683768, 19293389.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, Issue.3
, pp. 850-855
-
-
Han, G.1
Ma, H.2
Chintala, R.3
Fulton, D.J.4
Barman, S.A.5
White, R.E.6
-
49
-
-
77957044703
-
Discovery of drug mode of action and drug repositioning from transcriptional responses
-
10.1073/pnas.1000138107, 2930479, 20679242
-
Iorio F, Bosotti R, Scacheri E, Belcastro V, Mithbaokar P, Ferriero R, Murino L, Tagliaferri R, Brunetti-Pierri N, Isacchi A, et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc Natl Acad Sci USA 2010, 107(33):14621-14626. 10.1073/pnas.1000138107, 2930479, 20679242.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.33
, pp. 14621-14626
-
-
Iorio, F.1
Bosotti, R.2
Scacheri, E.3
Belcastro, V.4
Mithbaokar, P.5
Ferriero, R.6
Murino, L.7
Tagliaferri, R.8
Brunetti-Pierri, N.9
Isacchi, A.10
-
50
-
-
0034177385
-
Control of estrogen receptor ligand binding by Hsp90
-
10.1016/S0960-0760(00)00037-6, 10822011
-
Fliss AE, Benzeno S, Rao J, Caplan AJ. Control of estrogen receptor ligand binding by Hsp90. J Steroid Biochem Mol Biol 2000, 72(5):223-230. 10.1016/S0960-0760(00)00037-6, 10822011.
-
(2000)
J Steroid Biochem Mol Biol
, vol.72
, Issue.5
, pp. 223-230
-
-
Fliss, A.E.1
Benzeno, S.2
Rao, J.3
Caplan, A.J.4
-
51
-
-
0037023687
-
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis
-
10.1074/jbc.M110009200, 11823458
-
Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem 2002, 277(14):12128-12136. 10.1074/jbc.M110009200, 11823458.
-
(2002)
J Biol Chem
, vol.277
, Issue.14
, pp. 12128-12136
-
-
Greenfield, J.P.1
Leung, L.W.2
Cai, D.3
Kaasik, K.4
Gross, R.S.5
Rodriguez-Boulan, E.6
Greengard, P.7
Xu, H.8
-
52
-
-
80055017153
-
New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models
-
10.1093/bfgp/elr031, 3189694, 21987712
-
Schofield PN, Sundberg JP, Hoehndorf R, Gkoutos GV. New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models. Brief Funct Genomics 2011, 10(5):258-265. 10.1093/bfgp/elr031, 3189694, 21987712.
-
(2011)
Brief Funct Genomics
, vol.10
, Issue.5
, pp. 258-265
-
-
Schofield, P.N.1
Sundberg, J.P.2
Hoehndorf, R.3
Gkoutos, G.V.4
-
53
-
-
0141626909
-
Detecting putative orthologs
-
10.1093/bioinformatics/btg213, 15593400
-
Wall DP, Fraser HB, Hirsh AE. Detecting putative orthologs. Bioinformatics 2003, 19(13):1710-1711. 10.1093/bioinformatics/btg213, 15593400.
-
(2003)
Bioinformatics
, vol.19
, Issue.13
, pp. 1710-1711
-
-
Wall, D.P.1
Fraser, H.B.2
Hirsh, A.E.3
|