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Volumn 62, Issue 6, 2013, Pages 1073-1082

Effects of interleukin-18 on natural killer cells: Costimulation of activation through Fc receptors for immunoglobulin

Author keywords

Cancer immunotherapy; Cytokines; Lymphoma; Monoclonal antibodies; Rituximab

Indexed keywords

CD16 ANTIGEN; FC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD16; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE SYK INHIBITOR; RECOMBINANT INTERLEUKIN 18; RITUXIMAB; UNCLASSIFIED DRUG;

EID: 84878830705     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1403-0     Document Type: Article
Times cited : (58)

References (39)
  • 1
    • 50949124847 scopus 로고    scopus 로고
    • Human natural killer cells
    • 18650461 10.1182/blood-2007-09-077438 1:CAS:528:DC%2BD1cXpsVajtb0%3D
    • Caligiuri MA (2008) Human natural killer cells. Blood 112(3):461-469
    • (2008) Blood , vol.112 , Issue.3 , pp. 461-469
    • Caligiuri, M.A.1
  • 2
    • 0025639142 scopus 로고
    • Biology and clinical relevance of human natural killer cells
    • 2265240 1:STN:280:DyaK3M%2FptFCkug%3D%3D
    • Robertson MJ, Ritz J (1990) Biology and clinical relevance of human natural killer cells. Blood 76:2421-2438
    • (1990) Blood , vol.76 , pp. 2421-2438
    • Robertson, M.J.1    Ritz, J.2
  • 3
    • 0030848994 scopus 로고    scopus 로고
    • Signal transduction during natural killer cell activation: Inside the mind of a killer
    • 9208838 10.1016/S1074-7613(00)80441-0 1:CAS:528:DyaK2sXktFCqs7Y%3D
    • Leibson P (1997) Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity 6:655-661
    • (1997) Immunity , vol.6 , pp. 655-661
    • Leibson, P.1
  • 4
    • 0034663931 scopus 로고    scopus 로고
    • Differential role of p38 and c-Jun N-terminal kinase 1 mitogen-activated protein kinases in NK cell cytotoxicity
    • 10925255 1:CAS:528:DC%2BD3cXls1Knu7g%3D
    • Trotta R, Fettucciari K, Azzoni L, Abebe B, Puorro KA, Eisenlohr LC, Perussia B (2000) Differential role of p38 and c-Jun N-terminal kinase 1 mitogen-activated protein kinases in NK cell cytotoxicity. J Immunol 165:1782-1789
    • (2000) J Immunol , vol.165 , pp. 1782-1789
    • Trotta, R.1    Fettucciari, K.2    Azzoni, L.3    Abebe, B.4    Puorro, K.A.5    Eisenlohr, L.C.6    Perussia, B.7
  • 5
    • 31544446098 scopus 로고    scopus 로고
    • Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated target cells
    • 16397268 10.1158/0008-5472.CAN-05-2429 1:CAS:528:DC%2BD28XhsFWksg%3D%3D
    • Roda JM, Parihar R, Magro C, Nuovo GJ, Tridandapani S, Carson WE (2006) Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated target cells. Cancer Res 66(1):517-526
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 517-526
    • Roda, J.M.1    Parihar, R.2    Magro, C.3    Nuovo, G.J.4    Tridandapani, S.5    Carson, W.E.6
  • 6
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
    • 11806974 10.1182/blood.V99.3.754 1:CAS:528:DC%2BD38XhtVals7k%3D
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H (2002) Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood 99:754-758
    • (2002) Blood , vol.99 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 7
    • 42949157368 scopus 로고    scopus 로고
    • Immunoglobulin G fragment c receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
    • 18347005 10.1200/JCO.2007.14.8957 1:CAS:528:DC%2BD1cXmsFemsLg%3D
    • Musolino A, Naldi N, Bortesi B, Pezzuolo D, Capelletti M, Missale G, Laccabue D, Zerbini A, Camisa R, Bisagni G, Neri TM, Ardizzoni A (2008) Immunoglobulin G fragment c receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 26(11):1789-1796
    • (2008) J Clin Oncol , vol.26 , Issue.11 , pp. 1789-1796
    • Musolino, A.1    Naldi, N.2    Bortesi, B.3    Pezzuolo, D.4    Capelletti, M.5    Missale, G.6    Laccabue, D.7    Zerbini, A.8    Camisa, R.9    Bisagni, G.10    Neri, T.M.11    Ardizzoni, A.12
  • 9
    • 0035059368 scopus 로고    scopus 로고
    • Interleukin-18 regulates both Th1 and Th2 responses
    • 10.1146/annurev.immunol.19.1.423 1:CAS:528:DC%2BD3MXivFKgurs%3D
    • Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 regulates both Th1 and Th2 responses. Ann Rev Immunol 19:423-474
    • (2001) Ann Rev Immunol , vol.19 , pp. 423-474
    • Nakanishi, K.1    Yoshimoto, T.2    Tsutsui, H.3    Okamura, H.4
  • 10
    • 2642674449 scopus 로고    scopus 로고
    • IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12-independent antitumor effects
    • 9469432 1:CAS:528:DyaK1cXhtVyksLo%3D
    • Osaki T, Peron J-M, Cai Q, Okamura H, Robbins PD, Kurimoto M, Lotze MT, Tahara H (1998) IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12-independent antitumor effects. J Immunol 160:1742-1749
    • (1998) J Immunol , vol.160 , pp. 1742-1749
    • Osaki, T.1    Peron, J.-M.2    Cai, Q.3    Okamura, H.4    Robbins, P.D.5    Kurimoto, M.6    Lotze, M.T.7    Tahara, H.8
  • 11
    • 0033565876 scopus 로고    scopus 로고
    • Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively
    • 10395644 1:CAS:528:DyaK1MXksVegt7Y%3D
    • Hashimoto W, Osaki T, Okamura H, Robbins PD, Kurimoto M, Nagata S, Peron J-M, Lotze MT, Tahara H (1999) Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively. J Immunol 163:583-589
    • (1999) J Immunol , vol.163 , pp. 583-589
    • Hashimoto, W.1    Osaki, T.2    Okamura, H.3    Robbins, P.D.4    Kurimoto, M.5    Nagata, S.6    Peron, J.-M.7    Lotze, M.T.8    Tahara, H.9
  • 13
    • 50349092728 scopus 로고    scopus 로고
    • A dose-escalation study of recombinant human interleukin-18 using two different schedules of administration in patients with cancer
    • 18519778 10.1158/1078-0432.CCR-07-4740 1:CAS:528:DC%2BD1cXmslygtr4%3D
    • Robertson MJ, Kirkwood JM, Logan TF, Koch KM, Kathman S, Kirby LC, Bell WN, Thurmond LM, Weisenbach J, Dar MM (2008) A dose-escalation study of recombinant human interleukin-18 using two different schedules of administration in patients with cancer. Clin Cancer Res 14(11):3462-3469
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3462-3469
    • Robertson, M.J.1    Kirkwood, J.M.2    Logan, T.F.3    Koch, K.M.4    Kathman, S.5    Kirby, L.C.6    Bell, W.N.7    Thurmond, L.M.8    Weisenbach, J.9    Dar, M.M.10
  • 14
    • 26944443695 scopus 로고    scopus 로고
    • Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma
    • 16194894 10.1080/10428190500158466 1:CAS:528:DC%2BD2MXhtV2gs7jO
    • Robertson MJ, Abonour R, Hromas R, Nelson RP, Fineberg NS, Cornetta K (2005) Augmented high-dose regimen of cyclophosphamide, carmustine, and etoposide with autologous hematopoietic stem cell transplantation for relapsed and refractory aggressive non-Hodgkin's lymphoma. Leuk Lymphoma 46:1477-1487
    • (2005) Leuk Lymphoma , vol.46 , pp. 1477-1487
    • Robertson, M.J.1    Abonour, R.2    Hromas, R.3    Nelson, R.P.4    Fineberg, N.S.5    Cornetta, K.6
  • 15
    • 0025196196 scopus 로고
    • Human natural killer cell adhesion molecules: Differential expression after activation and participation in cytolysis
    • 1700001 1:CAS:528:DyaK3MXnvF2hsw%3D%3D
    • Robertson MJ, Caligiuri MA, Manley TJ, Levine H, Ritz J (1990) Human natural killer cell adhesion molecules: differential expression after activation and participation in cytolysis. J Immunol 145:3194-3201
    • (1990) J Immunol , vol.145 , pp. 3194-3201
    • Robertson, M.J.1    Caligiuri, M.A.2    Manley, T.J.3    Levine, H.4    Ritz, J.5
  • 16
    • 67651097885 scopus 로고    scopus 로고
    • Impaired development of human Th1 cells in patients with deficient expression of STAT4
    • 19359411 10.1182/blood-2008-09-179820 1:CAS:528:DC%2BD1MXnsVSksbY%3D
    • Chang H-C, Han L, Goswami R, Nguyen ET, Pelloso D, Robertson MJ, Kaplan MH (2009) Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood 113(23):5887-5890
    • (2009) Blood , vol.113 , Issue.23 , pp. 5887-5890
    • Chang, H.-C.1    Han, L.2    Goswami, R.3    Nguyen, E.T.4    Pelloso, D.5    Robertson, M.J.6    Kaplan, M.H.7
  • 17
    • 0036791488 scopus 로고    scopus 로고
    • IL-12 enhances the natural killer cell cytokine response to Ab-coated target cells
    • 12370276 1:CAS:528:DC%2BD38XnslSksbc%3D
    • Parihar R, Dierksheide J, Hu Y, Carson WE (2002) IL-12 enhances the natural killer cell cytokine response to Ab-coated target cells. J Clin Invest 110(7):983-992
    • (2002) J Clin Invest , vol.110 , Issue.7 , pp. 983-992
    • Parihar, R.1    Dierksheide, J.2    Hu, Y.3    Carson, W.E.4
  • 18
    • 33745298650 scopus 로고    scopus 로고
    • Interleukin-21 enhances NK cell activation in response to antibody-coated targets
    • 16785506 1:CAS:528:DC%2BD28XlvV2ns7Y%3D
    • Roda JM, Parihar R, Lehman A, Mani A, Tridandapani S, Carson WE (2006) Interleukin-21 enhances NK cell activation in response to antibody-coated targets. J Immunol 177:120-129
    • (2006) J Immunol , vol.177 , pp. 120-129
    • Roda, J.M.1    Parihar, R.2    Lehman, A.3    Mani, A.4    Tridandapani, S.5    Carson, W.E.6
  • 19
    • 0033561762 scopus 로고    scopus 로고
    • Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
    • 10201989 1:CAS:528:DyaK1MXisFOms7Y%3D
    • Fehniger TA, Shah MH, Turner MJ, VanDeusen JB, Whitman SP, Cooper MA, Suzuki K, Wechser M, Goodsaid F, Caligiuri MA (1999) Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J Immunol 162:4511-4520
    • (1999) J Immunol , vol.162 , pp. 4511-4520
    • Fehniger, T.A.1    Shah, M.H.2    Turner, M.J.3    Vandeusen, J.B.4    Whitman, S.P.5    Cooper, M.A.6    Suzuki, K.7    Wechser, M.8    Goodsaid, F.9    Caligiuri, M.A.10
  • 20
    • 23044498580 scopus 로고    scopus 로고
    • Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma
    • 15817683 10.1182/blood-2005-01-0201 1:CAS:528:DC%2BD2MXntVSnu7g%3D
    • Robertson MJ, Chang H-C, Pelloso D, Kaplan MH (2005) Impaired interferon-γ production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood 106:963-970
    • (2005) Blood , vol.106 , pp. 963-970
    • Robertson, M.J.1    Chang, H.-C.2    Pelloso, D.3    Kaplan, M.H.4
  • 21
    • 0036847429 scopus 로고    scopus 로고
    • Interleukin-12 immunotherapy after autologous stem cell transplantation for hematologic malignancies
    • 12429625 1:CAS:528:DC%2BD38XpsVCgt78%3D
    • Robertson MJ, Pelloso D, Abonour R, Hromas RA, Nelson RP Jr, Wood L, Cornetta K (2002) Interleukin-12 immunotherapy after autologous stem cell transplantation for hematologic malignancies. Clin Cancer Res 8:3383-3393
    • (2002) Clin Cancer Res , vol.8 , pp. 3383-3393
    • Robertson, M.J.1    Pelloso, D.2    Abonour, R.3    Hromas, R.A.4    Nelson, Jr.R.P.5    Wood, L.6    Cornetta, K.7
  • 23
    • 0021223230 scopus 로고
    • The Fc receptor for IgG on human natural killer cells: Phenotypic, functional, and comparative studies with monoclonal antibodies
    • 6233371 1:CAS:528:DyaL2cXkslSksr0%3D
    • Perussia B, Trinchieri G, Jackson A, Warner NL, Faust J, Rumpold H, Kraft D, Lanier LL (1984) The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J Immunol 133(1):180-189
    • (1984) J Immunol , vol.133 , Issue.1 , pp. 180-189
    • Perussia, B.1    Trinchieri, G.2    Jackson, A.3    Warner, N.L.4    Faust, J.5    Rumpold, H.6    Kraft, D.7    Lanier, L.L.8
  • 24
    • 0032055812 scopus 로고    scopus 로고
    • Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcγRIIC gene
    • 9516136 1:CAS:528:DyaK1cXitF2hs70%3D
    • Metes D, Ernst LK, Chambers WH, Sulica A, Herberman RB, Morel PA (1998) Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcγRIIC gene. Blood 91(7):2369-2380
    • (1998) Blood , vol.91 , Issue.7 , pp. 2369-2380
    • Metes, D.1    Ernst, L.K.2    Chambers, W.H.3    Sulica, A.4    Herberman, R.B.5    Morel, P.A.6
  • 25
    • 18744432359 scopus 로고    scopus 로고
    • Ligand binding specificities and signal transduction pathways of Fcγ receptor IIc isoforms: The CD32 isoforms expressed by human NK cells
    • 10508259 10.1002/(SICI)1521-4141(199909)29:09<2842: AID-IMMU2842>3.0.CO;2-5 1:CAS:528:DyaK1MXlvFOqtLY%3D
    • Metes D, Manciulea M, Petrusca D, Rabinowich H, Ernst LK, Popescu I, Calugaru A, Sulica A, Chambers WH, Herberman RB, Morel PA (1999) Ligand binding specificities and signal transduction pathways of Fcγ receptor IIc isoforms: the CD32 isoforms expressed by human NK cells. Eur J Immunol 29:2842-2852
    • (1999) Eur J Immunol , vol.29 , pp. 2842-2852
    • Metes, D.1    Manciulea, M.2    Petrusca, D.3    Rabinowich, H.4    Ernst, L.K.5    Popescu, I.6    Calugaru, A.7    Sulica, A.8    Chambers, W.H.9    Herberman, R.B.10    Morel, P.A.11
  • 26
    • 0024561072 scopus 로고
    • Fcg R (CD16) interaction with ligand induces Ca2 + mobilization and phosphoinositide turnover in human natural killer cells: Role of Ca2 + in Fcγ R (CD16)-induced transcription and expression of lymphokine genes
    • 2536067 10.1084/jem.169.2.549 1:CAS:528:DyaL1MXhtFars7Y%3D
    • Cassatella MA, Anegon I, Cuturi MC, Griskey P, Trinchieri G, Perussia B (1989) Fcg R (CD16) interaction with ligand induces Ca2 + mobilization and phosphoinositide turnover in human natural killer cells: role of Ca2 + in Fcγ R (CD16)-induced transcription and expression of lymphokine genes. J Exp Med 169:549-567
    • (1989) J Exp Med , vol.169 , pp. 549-567
    • Cassatella, M.A.1    Anegon, I.2    Cuturi, M.C.3    Griskey, P.4    Trinchieri, G.5    Perussia, B.6
  • 28
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • 14525967 10.1189/jlb.0603252 1:CAS:528:DC%2BD2cXhsFKntrk%3D
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-γ: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163-189
    • (2004) J Leukoc Biol , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 29
    • 43249092876 scopus 로고    scopus 로고
    • Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-g
    • 18174382 10.1182/blood-2007-01-068908 1:CAS:528:DC%2BD1cXkvFeisLo%3D
    • Kondadasula SV, Roda JM, Parihar R, Yu J, Lehman A, Caligiuri MA, Tridandapani S, Burry RW, Carson WE (2008) Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-g. Blood 111(8):4173-4183
    • (2008) Blood , vol.111 , Issue.8 , pp. 4173-4183
    • Kondadasula, S.V.1    Roda, J.M.2    Parihar, R.3    Yu, J.4    Lehman, A.5    Caligiuri, M.A.6    Tridandapani, S.7    Burry, R.W.8    Carson, W.E.9
  • 30
    • 11144244014 scopus 로고    scopus 로고
    • Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells
    • 15345584 10.1182/blood-2004-07-2782
    • Mavropoulos A, Sully G, Cope AP, Clark A (2004) Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood 105:282-288
    • (2004) Blood , vol.105 , pp. 282-288
    • Mavropoulos, A.1    Sully, G.2    Cope, A.P.3    Clark, A.4
  • 31
    • 0036467440 scopus 로고    scopus 로고
    • Synergy of IL-12 and IL-18 for IFN-γ gene expression: IL-12-induced STAT4 contributes to IFN-γ promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1
    • 11801649 1:CAS:528:DC%2BD38XpsFenug%3D%3D
    • Nakahira M, Ahn H-J, Park W-R, Gao P, Tomura M, Park C-S, Hamaoka T, Ohta T, Kurimoto M, Fujiwara H (2002) Synergy of IL-12 and IL-18 for IFN-γ gene expression: IL-12-induced STAT4 contributes to IFN-γ promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1. J Immunol 168:1146-1153
    • (2002) J Immunol , vol.168 , pp. 1146-1153
    • Nakahira, M.1    Ahn, H.-J.2    Park, W.-R.3    Gao, P.4    Tomura, M.5    Park, C.-S.6    Hamaoka, T.7    Ohta, T.8    Kurimoto, M.9    Fujiwara, H.10
  • 32
    • 0034254177 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression
    • Zhang S, Kaplan MH (2000) The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-γ expression. J Immunol 165:1375-1380
    • (2000) J Immunol , vol.165 , pp. 1375-1380
    • Zhang, S.1    Kaplan, M.H.2
  • 33
    • 0036486763 scopus 로고    scopus 로고
    • Role of chemokines in the biology of natural killer cells
    • 11818437 1:CAS:528:DC%2BD38XhsVSntbs%3D
    • Robertson MJ (2002) Role of chemokines in the biology of natural killer cells. J Leukoc Biol 71:173-183
    • (2002) J Leukoc Biol , vol.71 , pp. 173-183
    • Robertson, M.J.1
  • 35
    • 37049008917 scopus 로고    scopus 로고
    • Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts
    • 17724141 10.1182/blood-2007-02-076075 1:CAS:528:DC%2BD2sXhtl2qsb%2FL
    • Daniel D, Yang B, Lawrence DA, Totpal K, Balter I, Lee WP, Gogineni A, Cole MJ, Yee SF, Ross S, Ashkenazi A (2007) Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts. Blood 110:4037-4046
    • (2007) Blood , vol.110 , pp. 4037-4046
    • Daniel, D.1    Yang, B.2    Lawrence, D.A.3    Totpal, K.4    Balter, I.5    Lee, W.P.6    Gogineni, A.7    Cole, M.J.8    Yee, S.F.9    Ross, S.10    Ashkenazi, A.11
  • 36
    • 23844435619 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model
    • 16115943 10.1158/1078-0432.CCR-05-0577 1:CAS:528:DC%2BD2MXos1Cis7k%3D
    • Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, Ottman E, Czuczman MS (2005) Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res 11(16):5984-5992
    • (2005) Clin Cancer Res , vol.11 , Issue.16 , pp. 5984-5992
    • Hernandez-Ilizaliturri, F.J.1    Reddy, N.2    Holkova, B.3    Ottman, E.4    Czuczman, M.S.5
  • 37
    • 0037108519 scopus 로고    scopus 로고
    • Syngergistic enhancement of ineffective endogenous antitumor immune response and induction of IFN-γ and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2
    • 12370382 1:CAS:528:DC%2BD38XnvFGmsr8%3D
    • Wigginton JM, Lee J-K, Wiltrout TA, Alvord WG, Hixon JA, Subleski J, Back TC, Wiltrout RH (2002) Syngergistic enhancement of ineffective endogenous antitumor immune response and induction of IFN-γ and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2. J Immunol 169:4467-4474
    • (2002) J Immunol , vol.169 , pp. 4467-4474
    • Wigginton, J.M.1    Lee, J.-K.2    Wiltrout, T.A.3    Alvord, W.G.4    Hixon, J.A.5    Subleski, J.6    Back, T.C.7    Wiltrout, R.H.8
  • 39
    • 84878859577 scopus 로고    scopus 로고
    • A phase i trial evaluating the safety and biological activity of iboctadekin (rhIL-18) in combination with rituximab in patients with CD20 + B cell non-Hodgkin's lymphoma
    • 10.1182/blood-2010-08-300343 (Abstract 3697)
    • Robertson MJ, Bauman J, Gardner O, Jonak Z, Struemper H, Germaschewski F, Koch KM, Murray S, Weisenbach J, Toso J (2011) A phase I trial evaluating the safety and biological activity of iboctadekin (rhIL-18) in combination with rituximab in patients with CD20 + B cell non-Hodgkin's lymphoma. Blood 118:1579-1580 (Abstract 3697)
    • (2011) Blood , vol.118 , pp. 1579-1580
    • Robertson, M.J.1    Bauman, J.2    Gardner, O.3    Jonak, Z.4    Struemper, H.5    Germaschewski, F.6    Koch, K.M.7    Murray, S.8    Weisenbach, J.9    Toso, J.10


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