Ligand binding specificities and signal transduction pathways of Fcγ receptor IIc isoforms: The CD32 isoforms expressed by human NK cells

European Journal of Immunology

Volumn 29, Issue 9, 1999, Pages 2842-2852

  Metes, Diana ^a,b   Manciulea, Mioara ^b   Pretrusca, Daniela ^b   Rabinowich, Hannah ^c,d   Ernst, Linda K ^c,d   Popescu, Iulia ^b   Calugaru, Ana ^b   Sulica, Andrei ^b   Chambers, William H ^c,d   Herberman, Ronald B ^c,d   Morel, Penelope A ^c,d,e  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b STEFAN S NICOLAU INSTITUTE OF VIROLOGY   (Romania)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Fc receptor; Human; NK cell

Indexed keywords

CALCIUM ION; CD3 ANTIGEN; CD32 ANTIGEN; FC RECEPTOR; IMMUNOGLOBULIN G; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; LIGAND BINDING; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD; CROSS-LINKING REAGENTS; ENZYME ACTIVATION; EPITOPES; HUMANS; JURKAT CELLS; K562 CELLS; KILLER CELLS, NATURAL; LIGANDS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TYROSINE; U937 CELLS;

EID: 18744432359     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199909)29:09<2842::AID-IMMU2842>3.0.CO;2-5     Document Type: Article

References (38)

1. Van de Winkel, J. G. J. and Capel, P. J. A., Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 1993. 14: 215-221.
2. Ravetch, J. V. and Kinet, J.-P., Fc receptors. Annu. Rev. Immunol. 1991. 9: 457-492.
3. Brooks, D. G., Qiu, W. Q., Luster, A. D. and Ravetch, J. V., Structure and expression of human IgG FcγRII (CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. J. Exp. Med. 1989. 170: 1369-1385.
4. Qiu, W. Q., de Bruin, D., Brownstein, B. H., Pearse, R. and Ravetch, J. V., Organization of the human and mouse low-affinity FcγR genes: evidence for duplication and recombination. Science 1990. 248: 732-735.
5. Van den Herik-Oudijk, I. E., Westerdall, N. A. C., Henriquez, N. V., Capel, P. J. A. and van de Winkel, J. G. J., Functional analysis of human FcγRII (CD32) isoforms expressed in B cells. J. Immunol. 1994. 152: 574-585.
6. Van den Herik-Oudjik, I. E., Capel, P. J. A., van der Bruggen, T. and van de Winkel, J. G. J., Identification of signaling motifs within human FcγRIIa and FcγRIIb isoforms. Blood 1995. 85: 2202-2211.
7. Daeron, M., Fc receptor biology. Annu. Rev. Immunol. 1997. 15: 203-234.
8. Ghazizadeh, S., Bolen, J. B. and Fleit, H. B., Physical and functional association of src-related protein kinases with FcγRII in monocytic THP-1 cells. J. Biol. Chem. 1994. 269: 8878-8884.
9. 2+]; flux by distinct regions of an Fc receptor. Science 1991. 254: 1785-1788.
10. Reth, M., Antigen receptor tail clue. Nature 1989. 338: 383-384.
11. Van den Herik-Oudjik, I. E., Ter Bekke, M. W. H., Tempelman, M. J., Capel, P. J. A. and van de Winkel, J. G. J., Functional differences between two Fc receptor ITAM signaling motifs. Blood 1995. 86: 3302-3307.
12. Amigorena, S., Bonnerot, C., Drake, J. R., Choquet, D., Hunziker, W., Guillet, J.-G., Wester, P., Sautes, C., Mellman, I. and Fridman, W. H., Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science 1992. 256: 1808-1812.
13. Daeron, M., Latour, S., Malbec, O., Espinosa, E., Pina, P., Pasmans, S. and Fridman, W. H., The same tyrosine-based inhibition motif, in the intracytoplasmic domain of FcγRIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 1995, 3: 635-646.
14. Muta, T., Kurosaki, T., Misulovin, Z., Sanchez, M., Nussenzweig, M. C. and Ravetch, J. V., A 13 amino acid motif in the cytoplasmic domain of FcγRIIB modulates B cell receptor signaling. Nature 1994. 368: 70-73.
15. Warmerdan, P. A. M., Nabben, N. M. J. M., van de Graaf, S. A. R., van de Winkel, J. G. J. and Capet, P. J. A., The human low-affinity immunoglobulin G Fc receptor IIC is a result of an unequal crossover event. J. Biol. Chem. 1993. 268: 7346-7349.
16. Metes, D., Galatiuc, C., Moldovan, I., Morel, P. A., Chambers, W. H., DeLeo, A. B., Rabinowich, H., Schall, R., Whiteside, T. L., Sulica, A. and Herberman, R. B., Expression and function of FcγRII on human natural killer cells. Nat. Immun. 1994. 13: 289-300.
17. Metes, D., Ernst, L. K., Chambers, W. H., Sulica, A., Herberman, R. B. and Morel, P. A., Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcγRIIC gene. Blood 1998. 91: 2369-2380.
18. Van den Herik-Oudijk, I. E., Wasterdaal, N. A. C., de Haas, M., Kemper, L., Capel, P. J. A., von dem Borne, A. E. G. and van de Winkel, J. G. J., Binding heterogeneity within the CD32 panel of mAb. In Schlossman, S. F., Boumsell, L., Gilks, W., Harlan, J. M., Kishimoto, T., Morimoto, C., Ritz, J., Shaw, S., Silverstein, R., Springer, T., Tedder, T. E. and Todd, R. F. (Eds.), Leukocyte typing V: white cell differentiation antigens. Oxford University Press, Oxford 1995, pp 832-835.
19. Hulett, M. D. and Hogarth, P. M., Molecular basis of Fc receptor function. Adv. Immunol. 1994. 57: 1-127.
20. Warmerdan, P. A. M., van den Winkel, J. G. J., Gosselin, E. J. and Capel, P. J. A., Molecular basis for a polymorphism of human FCγ receptor II (CD32). J. Exp. Med. 1990. 172: 19-25.
21. Warmerdan, P. A. M., van de Winkel, J. G. J., Vlug, A. et al., A single amino acid in the second Ig-like domain of the human Fcγ receptor II is critical for human IgG2 binding. J. Immunol. 1991. 147: 1338-1343.
22. Bolen, J., Protein tyrosine kinases in the initiation of antigen receptor signaling. Curr. Opin. Immunol. 1995. 8: 306-312.
23. Chan, A. C. and Shaw, A. S., Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 1995. 8: 394-400.
24. 2+], flux in FcγRIIA signaling. J. Immunol. 1994. 152: 3017-3023.
25. Lanier, L. L., Yu, G. and Phillips, J. H., Analysis of FcγRIII (CD16) membrane expression and association with CD3ζ and FcεRI-γ by site-directed mutation. J. Immunol. 1991. 146: 1571-1576.
26. Farber, D. L. and Sears, D. W., Functional activities of Fc receptors on NK cells. In Lotzova, E. and Herberman, R. B. (Eds.), NK cell mediated cytotoxicity: receptors, signaling and mechanisms. CRC, Boca Raton, 1992, pp 207-229.
27. Warmerdam, P. A. M., van den Herik-Oudjik, I. E., Parren, P. W. H. I., Westerdaal, N. A. C., van de Winkel, J. G. J. and Capel, P. J. A., Interaction of a human FcγRIIb1 (CD32) isoform with murine and human IgG subclasses. Int. Immunol. 1993. 5: 239-247.
28. Trinchieri, G., Biology of natural killer cells. Adv. Immunol. 1989. 47: 187-376.
29. Tuijnman, W. B., Capel, P. J. A. and van den Winkel, J. G. J., Human low-affinity IgG receptor FcγRIIa (CD32) introduced into mouse fibroblasts mediates phagocytosis of sentisized eryhtrocytes. Blood 1992. 79: 1651-1656.
30. Huizinga, T. W. J., Kerst, M., Nuyens, J. H., Vlug, A., von dem Borne, A. E. G. K., Roos, D. and Tetteroo, P. A. T., Binding characteristics of dimeric IgG subclass complexes to human neutrophils. J. Immunol. 1989. 142: 2359-2364.
31. Leibson, P. J., Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity 1997. 6: 655-661.
32. Wirthmueller, U., Kurosaki, T., Murakami, M. S. and Ravetch, J. V., Signal transduction by FcγRIII (CD16) is mediated through the y chain. J. Exp. Med. 1992. 175: 1381-1390.
33. Masuda, M. and Roos, D., Association of all three types of FcγR (CD64, CD32, and CD16) with a γ-chain homodimer in cultured human monocytes. J. Immunol. 1993. 151: 7188-7195.
34. Naziduddin, B., Duffy, B. F., Tucker, J. and Mohanakumar, T., Evidence for cross-regulation of FcgammaRIIB (CD16) receptor-mediated signaling by FcgammaRII (CD32) expressed on PMN. J. Immunol. 1992. 149: 3701-3712.
35. Boot, J. H. A., Geerts, M. E. J. and Aarden, L. A., Functional polymorphism of Fc receptors in human monocyte-mediated cytotoxicity toward erythrocytes induced by murine isotype switch variants. J. Immunol. 1989. 142: 1217-1223.
36. Porges, A. J., Redecha, P. B., Doebele, R., Pan, L. C., Salmon, J. E. and Kimberly, R. B., Novel Fcγ receptor I family gene products in human mononuclear cells. J. Clin. Invest. 1992, 90: 2102-2109.
37. Altin, J. G., Pagler, E. B., Kinnear, B. F. and Warren, H. S., Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells. Immunol. Cell Biol. 1994. 72: 87-96.
38. Rabinowich, H., Lin, W. C., Herberman, R. B. and Whiteside, T. L., Signaling via CD7 molecules on human NK cells. Induction of tyrosine phosphorylation and beta 1 integrin-mediated adhesion to fibronectin. J. Immunol. 1994. 153: 3504-3513.