Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 295, Issue 6, 2008, Pages

  Kamiyama, Koki ^a   Matsuda, Naoyuki ^a   Yamamoto, Seiji ^a   Takano, Ken Ichi ^a   Takano, Yasuo ^a   Yamazaki, Hiromi ^a   Kageyama, Shun Ichiro ^a   Yokoo, Hiroki ^a   Nagata, Takuya ^a   Hatakeyama, Noboru ^a   Tsukada, Kazuhiro ^a   Hattori, Yuichi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Lung inflammation; Nuclear factor B

Indexed keywords

CASPASE 3; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LUNG LAVAGE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE; CASPASE 3; CELL NUCLEUS; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; GUINEA PIGS; HUMANS; LIPOPOLYSACCHARIDES; LUNG; METHYLPREDNISOLONE; PNEUMONIA; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SHOCK, SEPTIC; SPLEEN;

EID: 57149099973     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00459.2007     Document Type: Article

References (60)

1. Adcock IM, Gilobey T, Colin M, Gelder CM, Chung KF, Barnes PJ. Glucocorticoid receptor localization in normal and asthmatic lung. Am J Respir Crit Care Med 154: 771-782, 1996.
2. Annane D, Sébille V, Charpentier C, Bollaert PE, François B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troché G, Chaumet-Riffaut P, Bellissant E. Effect of treatment low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288: 862-871, 2002.
3. Bamberger CM, Bamberger AM, de Castro M, Chrousons GP. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid actions in humans. J Clin Invest 95: 2435-2441, 1995.
4. Bambergar CM, Schultze HM, Chrousons GP. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17: 245-261, 1996.
5. Beato M, Herrlich P, Schütz G. Steroid hormone receptors: many actions in search of a pilot. Cell 83: 851-857, 1995.
6. Bhattacharyya S, Brown DE, Brewer JA, Vogt SK, Muglia LJ. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood 109: 4313-4319, 2007.
7. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26: 645-650, 1998.
8. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, Peter K. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 27: 723-732, 1999.
9. Briegel J, Schelling G, Haller M, Mraz W, Forst H, Peter K. A comparison of the adrenocortical response during septic shock after complete recovery. Intensive Care Med 22: 894-899, 1996.
10. Britt RC, Devine A, Swallen KC, Weireter LJ, Collins JN, Cole FJ, Britt LD. Corticosteroid use in the intensive care unit. At what cost? Arch Surg 141: 145-149, 2006.
11. Burnstein KL, Bellingham DL, Jewell CM, Powell-Oliver FE, Cidlowski JA. Autoregulation of glucocorticoid receptor gene expression. Steroids 56: 52-58, 1991.
12. Caamano CA, Morano ML, Dalman FC, Pratt WB, Akil H. A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling. J Biol Chem 273: 20473-20480, 1998.
13. Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A, Hotchkiss RS. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J 21: 708-719, 2007.
14. Charmandari F, Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T. The human glucocorticoid receptor (hGR) β isoform suppresses the transcriptional activity of hGRα by interfering with formation of active coactivator complexes. Mol Endocrinol 19: 52-64, 2005.
15. Cidlowski JA, Cidlowski NB. Regulation of glucocorticoid receptors by glucocorticoids in cultured HeLa S3 cells. Endocrinology 109: 1975-1982, 1981.
16. Da J, Chen L, Hedenstierna G. Nitric oxide up-regulates the glucocorticoid receptor and blunts the inflammatory reaction in porcine endotoxin sepsis. Crit Care Med 35: 26-32, 2007.
17. Dostert A, Heinzel T. Negative glucocorticoid receptor response elements and their role in glucocorticoid actions. Curr Pharm Des 10: 2807-2816, 2004.
18. Encio IJ, Detera-Wadleigh SD. The genemic structure of the human glucocorticoid receptor. J Biol Chem 266: 7182-7188, 1991.
19. Goecke A, Guerreno J. Glucocorticoid receptor β in acute and chronic inflammatory conditions: clinical implications. Immunobiology 211: 85-96, 2006.
20. Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, Edwards CK 3rd, Schuchman EH, Fuks Z, Kolesnick R. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med 186: 1831-1841, 1997.
21. Hall-Angerås M, Angerås U, Hasselgren PO, Fischer JE. Corticosterone alone does not explain increased muscle proteolysis in septic rats. J Surg Res 48: 368-372, 1990.
22. Hall-Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE. Effect of the glucocorticoid receptor antagonist RU38486 on muscle protein breakdown in sepsis. Surgery 109: 468-473, 1991.
23. Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, Wallaert B, Lafitte JJ, Chrousos GP, Szefler SJ, Leung DY. Increased glucocorticoid receptor β in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med 159: 1600-1604, 1999.
24. Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, Kohgo Y. Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid resistant ulcerative colitis. Gastroenterology 118: 859-866, 2000.
25. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchyma cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25: 1298-1307, 1997.
26. Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ, Karl IE. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162: 4148-4156, 1999.
27. Lefering R, Neugebauer EA. Steroid controversy in sepsis and septic shock: a meta-analysis. Crit Care Med 23: 1294-1303, 1995.
28. Leung DY, Hamid Q, Vottero A, Szefler SJ, Surs W, Minshall E, Chrousos GP, Klemm DJ. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor β. J Exp Med 186: 1567-1574, 1997.
29. Li F, Xu RB. Changes in canine leukocyte glucocorticoid receptors during endotoxin shock. Circ Shock 26: 99-105, 1988.
30. Liu SF, Malik AB. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290: L622-L645, 2006.
31. Lu NZ, Cidlowski JA. The origin and functions of multiple human glucocorticoid receptor isoforms. Ann NY Acad Sci 1024: 102-123, 2004.
32. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM. The nuclear receptor superfamily: the second decade. Cell 83: 835-839, 1995.
33. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554, 2003.
34. Matsuda N, Hattori Y, Takahashi Y, Nishihira J, Jesmin S, Kobayashi M, Gando S. Therapeutic effect of in vivo transfection of transcription factor decoy to NF-κB on septic lung in mice. Am J Physiol Lung Cell Mol Physiol 287: L1248-L1255, 2004.
35. Matsuda N, Hayashi Y, Takahashi Y, Hattori Y. Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319: 1348-1354, 2006.
36. 2 receptor gene and protein levels differentially expressed in the hearts of rodents and humans. J Pharmacol Exp Ther 309: 786-795, 2004.
37. Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, Hattori Y. Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res 76: 132-140, 2007.
38. Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R. Methylprednisolone infusion in early severe ARDS. Results of a randomized controlled trial. Chest 131: 954-963, 2007.
39. Minnecci PC, Deans KJ, Banks SM, Eichacker PQ, Natanson C. Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 141: 47-56, 2004.
40. Oakley RH, Jewell CM, Yudt MR, Bofetiado DM, Cidlowski JA. The dominant negative activity of the human glucocorticoid receptor β isoform. Specificity and mechanisms of action. J Biol Chem 274: 27857-27866, 1999.
41. Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor β isoform. Expression, biochemical properties, and putative function. J Biol Chem 271: 9550-9559, 1996.
42. Oberholzer C, Obertholzer A, Clare-Salzler M, Moldawer LL. Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J 15: 879-892, 2001.
43. Okret S, Poellinger L, Dong Y, Gustafsson JÅ. Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone. Proc Natl Acad Sci USA 83: 5899-5903, 1986.
44. Peter JV, John P, Graham PL, Moran JL, George IA, Bersten A. Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ 336: 1006-1009, 2008.
45. Riccardi C, Cifone G, Migliorati G. Glucocrticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ 6: 1182-1189, 1999.
46. Riedemann NC, Guo RF, Ward PA. The enigma of sepsis. J Clin Invest 112: 460-467, 2003.
47. Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD. Mechanism of glucocorticoid receptor down-regulation by glucocorticoids. J Biol Chem 263: 2581-2584, 1988.
48. Rothwell PM, Udwadia ZF, Lawler PG. Cortisol response to corticotrophin and survival in septic shock. Lancet 337: 582-583, 1991.
49. Shackleford GM, Hart SF, Berry LJ. Endotoxin treatment inhibits glucocorticoid induction of hepatic enzymes at a late induction step. Am J Physiol Endocrinol Metab 250: E218-E225, 1986.
50. Soni A, Pepper GM, Wyrwinski PM, Ramirez NE, Simon R, Pina T, Gruenspan H, Vaca CE. Adrenal insufficiency occurring during septic shock: incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 98: 266-271, 1998.
51. Steinberg KP, Hudson LD, Goodman RB, Hough CL, Lanken PN, Hyzy R, Thompson BT, Ancukiewicz M; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 354: 1671-1684, 2006.
52. Stith RD, McCallum RE. Down regulation of hepatic glucocorticoid receptors after endotoxin treatment. Infect Immun 40: 613-621, 1983.
53. Stith RD, McCallum RE. General effect of endotoxin on glucocorticoid receptors in mammalian tissues. Circ Shock 18: 301-309, 1986.
54. Sun X, Fischer DR, Pritts TA, Wray CJ, Hasselgren PO. Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am J Physiol Regul Integr Comp Physiol 282: R509-R518, 2002.
55. Svec F, Rudis M. Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cells. J Biol Chem 256: 5984-5987, 1981.
56. Truss M, Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr Rev 14: 459-479, 1993.
57. Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood 106: 2295-2301, 2005.
58. Yudt MR, Jewell CM, Bienstock RJ, Cidolowski JA. Molecular origins for the dominant negative function of human glucocorticoid receptor β. Mol Cell Biol 23: 4319-4330, 2003.
59. Zeni F, Freeman B, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 25: 1095-1100, 1997.
60. Zhou M, Simms HH, Wang P. Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial apoptosis in sepsis. Ann Surg 240: 321-330, 2004.