Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis

Hepatology Research

Volumn 29, Issue 3, 2004, Pages 148-152

  Rai, Tsuyoshi ^a   Ohira, Hiromasa ^a   Tojo, Jun ^a   Abe, Kazumichi ^a   Yokokawa, Junko ^a   Takiguchi, Junko ^a   Shishido, Shoichiro ^a   Sato, Yukio ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Autoimmune hepatitis; Glucocorticoid receptor; Glucocorticoid resistance; Immunosuppressive drugs

Indexed keywords

ALANINE AMINOTRANSFERASE; BILIRUBIN; COMPLEMENTARY DNA; CORTICOSTEROID RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; PRIMER DNA; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; AUTOIMMUNE HEPATITIS; BILIRUBIN BLOOD LEVEL; CHRONIC HEPATITIS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN CELL; INCIDENCE; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; PEMPHIGUS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE RISK; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; STATISTICAL SIGNIFICANCE; SYSTEMIC LUPUS ERYTHEMATOSUS; TREATMENT OUTCOME; ULCERATIVE COLITIS; VIRUS HEPATITIS; VOLUNTEER;

EID: 2942639507     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2004.03.004     Document Type: Article

References (22)

1. Waldenstrom J.L. Blutprotein und Nahrungsweiss Deutsch Gesellschaft Z. Verdau. Stoffwechselkr 15 1950 1113-1119
2. Mackay I.R. Taft L.I. Cowling D.C. Lupoid hepatitis Lancet ii 1956 1323-1336
3. Mackay IR, Trit BD, The history of autoimmune hepatitis. In: Nishioka M, Toda G, Zeniya M, editors, Autoimmune hepatitis. Amsterdam: Elsevier; 1994. p. 3-23.
4. Hollenberg S.M. Weinberger C. Ong E.S. et al. Primary structure and expression of functional human glucocorticoid receptor cDNA Nature 315 1985 635-641
5. Bamberger C.M. Bamberger A.M. de Castro M. et al. Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans J. Clin. Invest. 95 1995 2435-2441
6. Jantzen H.M. Strahle U. Gloss B. Stewart F. et al. Cooperativity of glucocorticoid response element located far upstream of the tyrosine aminotransferase gene Cell 49 1987 29-38
7. Oakley R.H. Sar M. Cidlowski J.A. The human glucocorticoid receptor isoform: expression, biochemical properties, and putative function J. Biol. Chem. 271 1996 9550-9559
8. Bamberger C.M. Shulte H.M. Chrousos G.P. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids Endocr. Rev. 17 1996 245-261
9. Honda M. Orii F. Ayabe T. et al. Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis Gastroenterology 118 2000 859-866
10. Alvarez F. Berg P.A. Bianchi F.B. et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis J. Hepatol. 31 1999 929-938
11. Desmet V.J. Gerber M. Hoofnagle J.H. et al. Classification of Chronic Hepatitis: Diagnosis, Grading and Staging Hepatology 19 1994 1513-1520
12. de Castro M. Elliot S. Kino T. et al. The non-ligand binding β-isoform of the human glucocorticoid receptor (hGRβ): tissue levels, mechanism of action, and potential physiologic role Mol. Med. 2 1996 597-607
13. Webster JC, Oakey RH, Jewell CM, Cidlowski JA, Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci USA 2001;5:98(12):6885-70.
14. Korn S.H. Wouters E.F.M. Wesseling G. et al. In vitro and in vivo modulation of α- and β-glucocorticoid receptor mRNA in human bronchial epithelium Am. J. Respir. Crit. Care Med. 155 1997 1117-1122
15. Leung D.Y.M. Hamid Q. Votteri A. et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta J. Exp. Med. 186 1997 1567-1574
16. Hassen M.J. Mowat A.P. Mieli-Vergani G. et al. Circulating levels of interleukin-1α, tumor necrosis factor, interferon γ and soluble interleukin-2 receptor are high in children with autoimmune chronic liver disease Hepatology 12 1990 937
17. Manns M.P. Strassburg C.P. Autoimmune hepatitis: clinical challenges Gastroenterology 120 2001 1502-1517
18. Van Thiel D.H. Wright H. Carroll P. Starzl T.E. et al. Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial Am. J. Gastroenterol. 90 1995 771-776
19. Alvarez F. Ciocca M. Canero-Velasco C. et al. Short-term cyclosporine induces a remission of autoimmune hepatitis in children J. Hepatol. 94 1999 222-227
20. Pratt D.S. Flavin D.P. Kaplan M.M. et al. The successful treatment of autoimmune hepatitis with 6-mercaptopurine after failure with azathioprine Gastroenterology 110 1996 271-274
21. Kelly W.B. Stefan J.U. Mark G.S. Successful treatment of refractory type 1 autoimmune hepatitis with methotrexate J. Hepatol. 29 1998 990-993
22. Hamid Q.A. Wenzel S.E. Hauk P.J. et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma Am. J. Respir. Crit. Care Med. 159 1999 1600-1604