Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats

Journal of Pain

Volumn 13, Issue 4, 2012, Pages 338-349

  Shih, Ming Hung ^a,b   Kao, Sheng Chin ^a,b   Wang, Wei ^a   Yaster, Myron ^a   Tao, Yuan Xiang ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

activation; cancer pain; dorsal horn; mTOR; NMDA receptors

Indexed keywords

ASCOMYCIN; MAMMALIAN TARGET OF RAPAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RAPAMYCIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE CANCER; CANCER CELL; CANCER PAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; HYPERALGESIA; LOCOMOTION; MALE; MECHANICAL STIMULATION; NERVE CELL; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; SPINAL GANGLION; THERMAL STIMULATION; TIBIA;

ANIMALS; BONE NEOPLASMS; DISEASE MODELS, ANIMAL; HYPERALGESIA; MALE; NEOPLASMS, EXPERIMENTAL; PAIN, INTRACTABLE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 84862785387     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2011.12.006     Document Type: Article

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