Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice

Pain

Volumn 152, Issue 11, 2011, Pages 2582-2595

  Obara, Ilona ^a,b   Tochiki, Keri K ^a   Géranton, Sandrine M ^a   Carr, Fiona B ^a   Lumb, Bridget M ^c   Liu, Qingsong ^d,e   Hunt, Stephen P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Inflammatory pain; Local translation; mTOR; Neuropathic pain; Temsirolimus (CCI 779); Torin1

Indexed keywords

ADENOSINE TRIPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; TEMSIROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD SENSITIVITY; CONTROLLED STUDY; DRUG INHIBITION; MALE; MECHANICAL STIMULATION; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SPINAL CORD INJURY; STIMULUS RESPONSE;

ANIMALS; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; NEURAL INHIBITION; NEURALGIA; NOCICEPTORS; POSTERIOR HORN CELLS; PROTEIN KINASE INHIBITORS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 80054991423     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.07.025     Document Type: Article

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