Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance

Redox Biology

Volumn 1, Issue 1, 2013, Pages 115-124

  Maciag, Anna E ^a   Holland, Ryan J ^b   Cheng, Y S Robert ^c   Rodriguez, Luis G ^a   Saavedra, Joseph E ^a   Anderson, Lucy M ^b   Keefer, Larry K ^b  

^a SAIC FREDERICK INC   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Arylated diazeniumdiolate; Glutathione; Leukemia; Nitric oxide

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSFER RNA LIGASE; ANTINEOPLASTIC AGENT; COMPLEMENT COMPONENT C5A; DIACYLGLYCEROL ACYLTRANSFERASE; DIAZENIUMDIOLATE NITRIC OXIDE RELEASING PRODRUG; DIPEPTIDYL PEPTIDASE; EARLY GROWTH RESPONSE FACTOR 3; FATTY ACID BINDING PROTEIN 4; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A4; HEME OXYGENASE 1; IMMEDIATE EARLY PROTEIN; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; KRUPPEL LIKE FACTOR 6; NITRIC OXIDE; PLECKSTRIN; PROTEIN V FOS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RNA POLYMERASE; TRANSCRIPTION FACTOR NRF2; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TRYPTOPHAN 2,3 DIOXYGENASE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; AZO COMPOUND; NITRIC OXIDE DONOR; O(2)-(2,4-DINITROPHENYL) 1-((4-ETHOXYCARBONYL)PIPERAZIN-1-YL)DIAZEN-1-IUM-1,2-DIOLATE; PIPERAZINE DERIVATIVE; PRODRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL REACTION; CYTOTOXICITY; DOWN REGULATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOBLOTTING; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOPHILICITY; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; RNA EXTRACTION; SIGNAL TRANSDUCTION; UPREGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; LEUKEMIA; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

ACETYLCYSTEINE; AZO COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; HUMANS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; NITRIC OXIDE DONORS; OXIDATION-REDUCTION; PIPERAZINES; PRODRUGS; REACTIVE NITROGEN SPECIES;

EID: 84878770969     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2012.12.002     Document Type: Article

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