Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones

Journal of Biological Chemistry

Volumn 288, Issue 23, 2013, Pages 16484-16494

  Gokulan, Kuppan ^a   O'Leary, Seán E ^a   Russell, William K ^a   Russell, David H ^a   Lalgondar, Mallikarjun ^a   Begley, Tadhg P ^a   Ioerger, Thomas R ^b   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Texas AandM University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; COCRYSTALLIZATION; HYDROPHOBIC TUNNEL; KINETIC ANALYSIS; M. TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; OPTIMAL ACTIVITY; POLYKETIDE SYNTHASES;

MASS SPECTROMETRY; PLANTS (BOTANY); SUBSTRATES;

TUBES (COMPONENTS);

ALKYLPYRONE; BACTERIAL ENZYME; COENZYME A; CYSTEINE; MALONYL COENZYME A; METHYLMALONYLCOENZYME A; PALMITIC ACID; POLYKETIDE SYNTHASE 11; PYRONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROPHOBICITY; LACTONIZATION; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALKYLPYRONES; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; LIPID SYNTHESIS; LIPIDS; MYCOBACTERIUM TUBERCULOSIS; PKS11; POLYKETIDES; TUBERCULOSIS;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; MALONYL COENZYME A; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; POLYKETIDE SYNTHASES; PYRONES;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84878756904     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.468892     Document Type: Article

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