-
1
-
-
0001747786
-
Genetic contributions to understanding polyketide synthases
-
Hopwood D.A. Genetic contributions to understanding polyketide synthases. Chem Rev 97 (1997) 2465-2498
-
(1997)
Chem Rev
, vol.97
, pp. 2465-2498
-
-
Hopwood, D.A.1
-
2
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes J., Haydock S.F., Roberts G.A., Bevitt D.J., and Leadlay P.F. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 348 (1990) 176-178
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.F.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
3
-
-
0026559262
-
Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea
-
Donadio S., and Katz L. Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. Gene 111 (1992) 51-60
-
(1992)
Gene
, vol.111
, pp. 51-60
-
-
Donadio, S.1
Katz, L.2
-
4
-
-
0033574768
-
Dissecting and exploiting intermodular communication in polyketide synthases
-
Gokhale R.S., Tsuji S.Y., Cane D.E., and Khosla C. Dissecting and exploiting intermodular communication in polyketide synthases. Science 284 (1999) 482-485
-
(1999)
Science
, vol.284
, pp. 482-485
-
-
Gokhale, R.S.1
Tsuji, S.Y.2
Cane, D.E.3
Khosla, C.4
-
5
-
-
0027932534
-
Engineered biosynthesis of a complete macrolactone in a heterologous host
-
Kao C.M., Katz L., and Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 265 (1994) 509-512
-
(1994)
Science
, vol.265
, pp. 509-512
-
-
Kao, C.M.1
Katz, L.2
Khosla, C.3
-
7
-
-
34147098650
-
The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together
-
In this study, the crystal structure of yeast FAS reveals that this large, macromolecular assembly functions as a six-chambered reactor for fatty acid synthesis.
-
Lomakin I.B., Xiong Y., and Steitz T.A. The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell 129 (2007) 319-332. In this study, the crystal structure of yeast FAS reveals that this large, macromolecular assembly functions as a six-chambered reactor for fatty acid synthesis.
-
(2007)
Cell
, vol.129
, pp. 319-332
-
-
Lomakin, I.B.1
Xiong, Y.2
Steitz, T.A.3
-
8
-
-
34247353309
-
Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase
-
The structure of the yeast FAS complex presented here shows the direct interactions of ACP with one of the key catalytic centers in a multifunctional enzyme and suggests a model for substrate delivery.
-
Leibundgut M., Jenni S., Frick C., and Ban N. Structural basis for substrate delivery by acyl carrier protein in the yeast fatty acid synthase. Science 316 (2007) 288-290. The structure of the yeast FAS complex presented here shows the direct interactions of ACP with one of the key catalytic centers in a multifunctional enzyme and suggests a model for substrate delivery.
-
(2007)
Science
, vol.316
, pp. 288-290
-
-
Leibundgut, M.1
Jenni, S.2
Frick, C.3
Ban, N.4
-
9
-
-
33644697200
-
Architecture of mammalian fatty acid synthase at 4.5 Å resolution
-
A study on the homodimeric mammalian fatty acid synthase structure, each monomer consists of 270-kDa with seven functional domains. Large distances between active sites and conformational differences between the reaction chambers suggest mobility of acyl carrier protein and flexibility of multienzyme complex.
-
Maier T., Jenni S., and Ban N. Architecture of mammalian fatty acid synthase at 4.5 Å resolution. Science 311 (2006) 1258-1262. A study on the homodimeric mammalian fatty acid synthase structure, each monomer consists of 270-kDa with seven functional domains. Large distances between active sites and conformational differences between the reaction chambers suggest mobility of acyl carrier protein and flexibility of multienzyme complex.
-
(2006)
Science
, vol.311
, pp. 1258-1262
-
-
Maier, T.1
Jenni, S.2
Ban, N.3
-
10
-
-
33645962845
-
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases
-
A study on the structure that reveals a new folding domain that is essential for stabilization of the catalytic domain of KR.
-
Keatinge-Clay A.T., and Stroud R.M. The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure 14 (2006) 737-748. A study on the structure that reveals a new folding domain that is essential for stabilization of the catalytic domain of KR.
-
(2006)
Structure
, vol.14
, pp. 737-748
-
-
Keatinge-Clay, A.T.1
Stroud, R.M.2
-
11
-
-
34547930907
-
Structure and mechanism of the 6-deoxyerythronolide B synthase
-
This is a comprehensive review article that provides present structural perspective of PKSs.
-
Khosla C., Tang Y., Chen A.Y., Schnarr N.A., and Cane D.E. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annu Rev Biochem 76 (2007) 195-221. This is a comprehensive review article that provides present structural perspective of PKSs.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 195-221
-
-
Khosla, C.1
Tang, Y.2
Chen, A.Y.3
Schnarr, N.A.4
Cane, D.E.5
-
12
-
-
33746776204
-
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
-
A study on high-resolution structure of KS-AT didomain from PKSs. This structure reveals important role of KS-AT linker residues in orientation of KS and AT domains. This study also highlights previously identified N-terminal coiled-coil domain, which is involved in interactions between PKS proteins.
-
Tang Y., Kim C.Y., Mathews I.I., Cane D.E., and Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A 103 (2006) 11124-11129. A study on high-resolution structure of KS-AT didomain from PKSs. This structure reveals important role of KS-AT linker residues in orientation of KS and AT domains. This study also highlights previously identified N-terminal coiled-coil domain, which is involved in interactions between PKS proteins.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11124-11129
-
-
Tang, Y.1
Kim, C.Y.2
Mathews, I.I.3
Cane, D.E.4
Khosla, C.5
-
13
-
-
33947303415
-
Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases
-
Haynes S.W., and Challis G.L. Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases. Curr Opin Drug Discov Dev 10 (2007) 203-218
-
(2007)
Curr Opin Drug Discov Dev
, vol.10
, pp. 203-218
-
-
Haynes, S.W.1
Challis, G.L.2
-
14
-
-
25144510054
-
Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic
-
Wenzel S.C., and Muller R. Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from textbook biosynthetic logic. Curr Opin Chem Biol 9 (2005) 447-458
-
(2005)
Curr Opin Chem Biol
, vol.9
, pp. 447-458
-
-
Wenzel, S.C.1
Muller, R.2
-
15
-
-
21044447751
-
Functional analysis of the aureothin iterative type I polyketide synthase
-
He J., and Hertweck C. Functional analysis of the aureothin iterative type I polyketide synthase. Chembiochem 6 (2005) 908-912
-
(2005)
Chembiochem
, vol.6
, pp. 908-912
-
-
He, J.1
Hertweck, C.2
-
16
-
-
0344099408
-
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
-
Olano C., Wilkinson B., Moss S.J., Brana A.F., Mendez C., Leadlay P.F., and Salas J.A. Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun (Camb) 22 (2003) 2780-2782
-
(2003)
Chem Commun (Camb)
, vol.22
, pp. 2780-2782
-
-
Olano, C.1
Wilkinson, B.2
Moss, S.J.3
Brana, A.F.4
Mendez, C.5
Leadlay, P.F.6
Salas, J.A.7
-
17
-
-
1142293995
-
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase
-
Tang G.L., Cheng Y.Q., and Shen B. Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chem Biol 11 (2004) 33-45
-
(2004)
Chem Biol
, vol.11
, pp. 33-45
-
-
Tang, G.L.1
Cheng, Y.Q.2
Shen, B.3
-
18
-
-
14144253677
-
Cyclization mechanism for the synthesis of macrocyclic antibiotic lankacidin in Streptomyces rochei
-
Arakawa K., Sugino F., Kodama K., Ishii T., and Kinashi H. Cyclization mechanism for the synthesis of macrocyclic antibiotic lankacidin in Streptomyces rochei. Chem Biol 12 (2005) 249-256
-
(2005)
Chem Biol
, vol.12
, pp. 249-256
-
-
Arakawa, K.1
Sugino, F.2
Kodama, K.3
Ishii, T.4
Kinashi, H.5
-
19
-
-
34250790717
-
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
-
Cox R.J. Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem 5 (2007) 2010-2026
-
(2007)
Org Biomol Chem
, vol.5
, pp. 2010-2026
-
-
Cox, R.J.1
-
20
-
-
28844465191
-
An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation
-
This study reports heterologous expression of PKSN protein that shows complex utilization of auxiliary domains by a fungal Type I iterative PKS to produce alternapyrone.
-
Fujii I., Yoshida N., Shimomaki S., Oikawa H., and Ebizuka Y. An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation. Chem Biol 12 (2005) 1301-1309. This study reports heterologous expression of PKSN protein that shows complex utilization of auxiliary domains by a fungal Type I iterative PKS to produce alternapyrone.
-
(2005)
Chem Biol
, vol.12
, pp. 1301-1309
-
-
Fujii, I.1
Yoshida, N.2
Shimomaki, S.3
Oikawa, H.4
Ebizuka, Y.5
-
21
-
-
33947662068
-
Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids
-
This is a comprehensive review article that provides present understanding of mycobacterial PKSs in the biosynthesis of complex lipids.
-
Gokhale R.S., Saxena P., Chopra T., and Mohanty D. Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids. Nat Prod Rep 24 (2007) 267-277. This is a comprehensive review article that provides present understanding of mycobacterial PKSs in the biosynthesis of complex lipids.
-
(2007)
Nat Prod Rep
, vol.24
, pp. 267-277
-
-
Gokhale, R.S.1
Saxena, P.2
Chopra, T.3
Mohanty, D.4
-
22
-
-
1842577641
-
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
-
This is the first study of identification of a new family of proteins that activate fatty acids as acyl-adenylates, which are then used for biosynthesis of lipidic metabolites in mycobacteria.
-
Trivedi O.A., Arora P., Sridharan V., Tickoo R., Mohanty D., and Gokhale R.S. Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria. Nature 428 (2004) 441-445. This is the first study of identification of a new family of proteins that activate fatty acids as acyl-adenylates, which are then used for biosynthesis of lipidic metabolites in mycobacteria.
-
(2004)
Nature
, vol.428
, pp. 441-445
-
-
Trivedi, O.A.1
Arora, P.2
Sridharan, V.3
Tickoo, R.4
Mohanty, D.5
Gokhale, R.S.6
-
23
-
-
14644408803
-
Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid
-
Trivedi O.A., Arora P., Vats A., Ansari M.Z., Tickoo R., Sridharan V., Mohanty D., and Gokhale R.S. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Mol Cell 17 (2005) 631-643
-
(2005)
Mol Cell
, vol.17
, pp. 631-643
-
-
Trivedi, O.A.1
Arora, P.2
Vats, A.3
Ansari, M.Z.4
Tickoo, R.5
Sridharan, V.6
Mohanty, D.7
Gokhale, R.S.8
-
24
-
-
34347384411
-
Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis
-
Simeone R., Constant P., Guilhot C., Daffe M., and Chalut C. Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis. J Bacteriol 189 (2007) 4597-4602
-
(2007)
J Bacteriol
, vol.189
, pp. 4597-4602
-
-
Simeone, R.1
Constant, P.2
Guilhot, C.3
Daffe, M.4
Chalut, C.5
-
25
-
-
0347719360
-
A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
-
Portevin D., De Sousa-D'Auria C., Houssin C., Grimaldi C., Chami M., Daffe M., and Guilhot C. A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms. Proc Natl Acad Sci U S A 101 (2004) 314-319
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 314-319
-
-
Portevin, D.1
De Sousa-D'Auria, C.2
Houssin, C.3
Grimaldi, C.4
Chami, M.5
Daffe, M.6
Guilhot, C.7
-
26
-
-
34249675745
-
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
-
Lea-Smith D.J., Pyke J.S., Tull D., McConville M.J., Coppel R.L., and Crellin P.K. The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem 282 (2007) 11000-11008
-
(2007)
J Biol Chem
, vol.282
, pp. 11000-11008
-
-
Lea-Smith, D.J.1
Pyke, J.S.2
Tull, D.3
McConville, M.J.4
Coppel, R.L.5
Crellin, P.K.6
-
27
-
-
19944427295
-
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells
-
Matsunaga I., Bhatt A., Young D.C., Cheng T.Y., Eyles S.J., Besra G.S., Briken V., Porcelli S.A., Costello C.E., Jacobs Jr. W.R., et al. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. J Exp Med 200 (2004) 1559-1569
-
(2004)
J Exp Med
, vol.200
, pp. 1559-1569
-
-
Matsunaga, I.1
Bhatt, A.2
Young, D.C.3
Cheng, T.Y.4
Eyles, S.J.5
Besra, G.S.6
Briken, V.7
Porcelli, S.A.8
Costello, C.E.9
Jacobs Jr., W.R.10
-
28
-
-
0033982651
-
Role of linkers in communication between protein modules
-
Gokhale R.S., and Khosla C. Role of linkers in communication between protein modules. Curr Opin Chem Biol 4 (2000) 22-27
-
(2000)
Curr Opin Chem Biol
, vol.4
, pp. 22-27
-
-
Gokhale, R.S.1
Khosla, C.2
-
29
-
-
18344395923
-
The genome of the social amoeba Dictyostelium discoideum
-
The genome sequence of Dictyostelium revealed a large repertoire of PKS genes. This study also reports large number of other genes that could play a role in biosynthesis of small metabolites.
-
Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., et al. The genome of the social amoeba Dictyostelium discoideum. Nature 435 (2005) 43-57. The genome sequence of Dictyostelium revealed a large repertoire of PKS genes. This study also reports large number of other genes that could play a role in biosynthesis of small metabolites.
-
(2005)
Nature
, vol.435
, pp. 43-57
-
-
Eichinger, L.1
Pachebat, J.A.2
Glockner, G.3
Rajandream, M.A.4
Sucgang, R.5
Berriman, M.6
Song, J.7
Olsen, R.8
Szafranski, K.9
Xu, Q.10
-
30
-
-
33845962046
-
Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine
-
Kopp F., Mahlert C., Grunewald J., and Marahiel M.A. Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J Am Chem Soc 128 (2006) 16478-16479
-
(2006)
J Am Chem Soc
, vol.128
, pp. 16478-16479
-
-
Kopp, F.1
Mahlert, C.2
Grunewald, J.3
Marahiel, M.A.4
-
31
-
-
20444391730
-
Synthesis of linear gramicidin requires the cooperation of two independent reductases
-
Schracke N., Linne U., Mahlert C., and Marahiel M.A. Synthesis of linear gramicidin requires the cooperation of two independent reductases. Biochemistry 44 (2005) 8507-8513
-
(2005)
Biochemistry
, vol.44
, pp. 8507-8513
-
-
Schracke, N.1
Linne, U.2
Mahlert, C.3
Marahiel, M.A.4
-
32
-
-
33747598945
-
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase
-
Functional role of an unusual Type III PKS in the biosynthesis of differentiation inducing factor was demonstrated in this study.
-
Austin M.B., Saito T., Bowman M.E., Haydock S., Kato A., Moore B.S., Kay R.R., and Noel J.P. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol 2 (2006) 494-502. Functional role of an unusual Type III PKS in the biosynthesis of differentiation inducing factor was demonstrated in this study.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 494-502
-
-
Austin, M.B.1
Saito, T.2
Bowman, M.E.3
Haydock, S.4
Kato, A.5
Moore, B.S.6
Kay, R.R.7
Noel, J.P.8
-
33
-
-
33745527141
-
Identification of new differentiation inducing factors from Dictyostelium discoideum
-
Saito T., Taylor G.W., Yang J.C., Neuhaus D., Stetsenko D., Kato A., and Kay R.R. Identification of new differentiation inducing factors from Dictyostelium discoideum. Biochim Biophys Acta 1760 (2006) 754-761
-
(2006)
Biochim Biophys Acta
, vol.1760
, pp. 754-761
-
-
Saito, T.1
Taylor, G.W.2
Yang, J.C.3
Neuhaus, D.4
Stetsenko, D.5
Kato, A.6
Kay, R.R.7
-
34
-
-
0041620248
-
SEARCHPKS: a program for detection and analysis of polyketide synthase domains
-
Yadav G., Gokhale R.S., and Mohanty D. SEARCHPKS: a program for detection and analysis of polyketide synthase domains. Nucleic Acids Res 31 (2003) 3654-3658
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 3654-3658
-
-
Yadav, G.1
Gokhale, R.S.2
Mohanty, D.3
-
35
-
-
33751579141
-
Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2)
-
Tang Y., Lee H.Y., Kim C.Y., Mathews I., and Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry 45 (2006) 14085-14093
-
(2006)
Biochemistry
, vol.45
, pp. 14085-14093
-
-
Tang, Y.1
Lee, H.Y.2
Kim, C.Y.3
Mathews, I.4
Khosla, C.5
-
36
-
-
0037319699
-
The chalcone synthase superfamily of type III polyketide synthases
-
Austin M.B., and Noel J.P. The chalcone synthase superfamily of type III polyketide synthases. Nat Prod Rep 20 (2003) 79-110
-
(2003)
Nat Prod Rep
, vol.20
, pp. 79-110
-
-
Austin, M.B.1
Noel, J.P.2
-
37
-
-
0032805888
-
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis
-
Ferrer J.L., Jez J.M., Bowman M.E., Dixon R.A., and Noel J.P. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nat Struct Biol 6 (1999) 775-784
-
(1999)
Nat Struct Biol
, vol.6
, pp. 775-784
-
-
Ferrer, J.L.1
Jez, J.M.2
Bowman, M.E.3
Dixon, R.A.4
Noel, J.P.5
-
38
-
-
0242666130
-
A new family of type III polyketide synthases in Mycobacterium tuberculosis
-
This study revealed a new family of Type III PKSs that possess novel substrate specificity for long-chain acyl-CoAs.
-
Saxena P., Yadav G., Mohanty D., and Gokhale R.S. A new family of type III polyketide synthases in Mycobacterium tuberculosis. J Biol Chem 278 (2003) 44780-44790. This study revealed a new family of Type III PKSs that possess novel substrate specificity for long-chain acyl-CoAs.
-
(2003)
J Biol Chem
, vol.278
, pp. 44780-44790
-
-
Saxena, P.1
Yadav, G.2
Mohanty, D.3
Gokhale, R.S.4
-
39
-
-
4344585355
-
A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites
-
In this paper, a long hydrophobic acyl chain-binding tunnel was identified which has now been observed in other proteins as well. Mutational data showed that the tunnel volume dictated the specificity of acyl chain length for the starter substrates.
-
Sankaranarayanan R., Saxena P., Marathe U.B., Gokhale R.S., Shanmugam V.M., and Rukmini R. A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites. Nat Struct Mol Biol 11 (2004) 894-900. In this paper, a long hydrophobic acyl chain-binding tunnel was identified which has now been observed in other proteins as well. Mutational data showed that the tunnel volume dictated the specificity of acyl chain length for the starter substrates.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 894-900
-
-
Sankaranarayanan, R.1
Saxena, P.2
Marathe, U.B.3
Gokhale, R.S.4
Shanmugam, V.M.5
Rukmini, R.6
-
40
-
-
33646557702
-
Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii
-
This study for the first time showed that resorcinolic products could be biosynthesized by Type III PKSs. Functional significance on these phenolic lipids in Azotobacter was also demonstrated.
-
Funa N., Ozawa H., Hirata A., and Horinouchi S. Phenolic lipid synthesis by type III polyketide synthases is essential for cyst formation in Azotobacter vinelandii. Proc Natl Acad Sci U S A 103 (2006) 6356-6361. This study for the first time showed that resorcinolic products could be biosynthesized by Type III PKSs. Functional significance on these phenolic lipids in Azotobacter was also demonstrated.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6356-6361
-
-
Funa, N.1
Ozawa, H.2
Hirata, A.3
Horinouchi, S.4
-
41
-
-
34347255733
-
Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa
-
Funa N., Awakawa T., and Horinouchi S. Pentaketide resorcylic acid synthesis by type III polyketide synthase from Neurospora crassa. J Biol Chem 282 (2007) 14476-14481
-
(2007)
J Biol Chem
, vol.282
, pp. 14476-14481
-
-
Funa, N.1
Awakawa, T.2
Horinouchi, S.3
-
42
-
-
32644439876
-
Engineered biosynthesis of plant polyketides: manipulation of chalcone synthase
-
Abe I., Watanabe T., Morita H., Kohno T., and Noguchi H. Engineered biosynthesis of plant polyketides: manipulation of chalcone synthase. Org Lett 8 (2006) 499-502
-
(2006)
Org Lett
, vol.8
, pp. 499-502
-
-
Abe, I.1
Watanabe, T.2
Morita, H.3
Kohno, T.4
Noguchi, H.5
-
43
-
-
34547568170
-
High-throughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction
-
Kwon S.J., Lee M.Y., Ku B., Sherman D.H., and Dordick J.S. High-throughput, microarray-based synthesis of natural product analogues via in vitro metabolic pathway construction. ACS Chem Biol 2 (2007) 419-425
-
(2007)
ACS Chem Biol
, vol.2
, pp. 419-425
-
-
Kwon, S.J.1
Lee, M.Y.2
Ku, B.3
Sherman, D.H.4
Dordick, J.S.5
|