WD40-repeat proteins control the flow of Gβγ signaling for directional cell migration

Cell Adhesion and Migration

Volumn 7, Issue 2, 2013, Pages 214-218

  Runne, Caitlin ^a   Chen, Songhai ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Chemotaxis; G protein coupled receptors; G proteins; Signal transduction; Wd40 proteins

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; RECEPTOR FOR ACTIVATED C KINASE 1; UNCLASSIFIED DRUG; WD 40 PROTEIN;

CHEMOTAXIS; ENZYME ACTIVITY; HUMAN; LEUKOCYTE MIGRATION; NOTE; SIGNAL TRANSDUCTION;

EID: 84878751837     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.22940     Document Type: Note

References (38)

1. Swaney KF, Huang CH, Devreotes PN. Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 2010; 39:265-89; PMID:20192768; http://dx.doi.org/10.1146/annurev. biophys.093008.131228
2. Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol 2004; 1:95-104; PMID:16212895.
3. Weiner OD. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol 2002; 14:196-202; PMID:11891119; http://dx.doi.org/10.1016/S0955-0674(02)00310-1
4. Charest PG, Firtel RA. Feedback signaling controls leading-edge formation during chemotaxis. Curr Opin Genet Dev 2006; 16:339-47; PMID:16806895; http://dx.doi.org/10.1016/j.gde.2006.06.016
5. Wang F. The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol 2009; 1:a002980; PMID:20066099; http://dx.doi.org/10.1101/cshperspect.a002980
6. Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, et al. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 2003; 114:201-14; PMID:12887922; http://dx.doi.org/10.1016/ S0092-8674(03)00555-5
7. Chung CY, Potikyan G, Firtel RA. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 2001; 7:937-47; PMID:11389841; http://dx.doi.org/10.1016/S1097-2765(01)00247-7
8. Funamoto S, Meili R, Lee S, Parry L, Firtel RA. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 2002; 109:611-23; PMID:12062104; http://dx.doi.org/10.1016/S0092-8674(02) 00755-9
9. Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 2000; 287:1037-40; PMID:10669415; http://dx.doi.org/10.1126/science. 287.5455.1037
10. Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, et al. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol 2006; 174:647-52; PMID:16943182; http://dx.doi.org/10. 1083/jcb.200602142
11. Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, et al. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 2003; 114:215-27; PMID:12887923; http://dx.doi.org/10.1016/S0092-8674(03) 00559-2
12. Iijima M, Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 2002; 109:599-610; PMID:12062103; http://dx.doi.org/10.1016/S0092-8674(02)00745-6
13. Li Z, Dong X, Wang Z, Liu W, Deng N, Ding Y, et al. Regulation of PTEN by Rho small GTPases. Nat Cell Biol 2005; 7:399-404; PMID:15793569; http://dx.doi.org/10.1038/ncb1236
14. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HRA. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 2002; 4:509-13; PMID:12080346; http://dx.doi.org/10.1038/ncb811
15. Liu L, Das S, Losert W, Parent CA. mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell 2010; 19:845-57; PMID:21145500; http://dx.doi.org/10.1016/j.devcel.2010.11.004
16. Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, et al. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Dev Cell 2007; 12:603-14; PMID:17419997; http://dx.doi.org/10.1016/j.devcel.2007.03.005
17. Liu X, Ma B, Malik AB, Tang H, Yang T, Sun B, et al. Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol 2012; 13:457-64; PMID:22447027; http://dx.doi.org/10.1038/ni.2258
18. Tang W, Zhang Y, Xu W, Harden TK, Sondek J, Sun L, et al. A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Dev Cell 2011; 21:1038-50; PMID:22172670; http://dx.doi.org/10.1016/j.devcel.2011.10.023
19. Dong X, Mo Z, Bokoch G, Guo C, Li Z, Wu D. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 2005; 15:1874-9; PMID:16243036; http://dx.doi.org/10.1016/j.cub.2005.09.014
20. Welch HC, Condliffe AM, Milne LJ, Ferguson GJ, Hill K, Webb LM, et al. P-Rex1 regulates neutrophil function. Curr Biol 2005; 15:1867-73; PMID:16243035; http://dx.doi.org/10.1016/j.cub.2005.09.050
21. Smrcka AV. G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cell Mol Life Sci 2008; 65:2191-214; PMID:18488142; http://dx.doi.org/10.1007/s00018-008-8006-5
22. Gómez-Moutón C, Lacalle RA, Mira E, Jiménez-Baranda S, Barber DF, Carrera AC, et al. Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. J Cell Biol 2004; 164:759-68; PMID:14981096; http://dx.doi.org/10.1083/jcb.200309101
23. Jin T, Zhang N, Long Y, Parent CA, Devreotes PN. Localization of the G protein betagamma complex in living cells during chemotaxis. Science 2000; 287:1034-6; PMID:10669414; http://dx.doi.org/10.1126/science.287.5455.1034
24. Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, et al. The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. J Biol Chem 2002; 277:49888-95; PMID:12359736; http://dx.doi.org/10.1074/jbc.M202755200
25. Stirnimann CU, Petsalaki E, Russell RB, Müller CW. WD40 proteins propel cellular networks. Trends Biochem Sci 2010; 35:565-74; PMID:20451393; http://dx.doi.org/10.1016/j.tibs.2010.04.003
26. Adams DR, Ron D, Kiely PA. RACK1, A multifaceted scaffolding protein: Structure and function. Cell Commun Signal 2011; 9:22; PMID:21978545; http://dx.doi.org/10.1186/1478-811X-9-22
27. Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 2006; 8:1277-83; PMID:17041588; http://dx.doi.org/10. 1038/ncb1490
28. Whiteway MS, Wu C, Leeuw T, Clark K, Fourest-Lieuvin A, Thomas DY, et al. Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p. Science 1995; 269:1572-5; PMID:7667635; http://dx.doi.org/10.1126/science.7667635
29. Chen S, Dell EJ, Lin F, Sai J, Hamm HE. RACK1 regulates specific functions of Gbetagamma. J Biol Chem 2004; 279:17861-8; PMID:14963031; http://dx.doi.org/10.1074/jbc.M313727200
30. Chen S, Lin F, Hamm HE. RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation. J Biol Chem 2005; 280:33445-52; PMID:16051595; http://dx.doi.org/10.1074/jbc.M505422200
31. Chen S, Lin F, Shin ME, Wang F, Shen L, Hamm HE. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. Mol Biol Cell 2008; 19:3909-22; PMID:18596232; http://dx.doi.org/10.1091/mbc.E08-04-0433
32. Sun Z, Tang X, Lin F, Chen S. The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration. J Biol Chem 2011; 286:43902-12; PMID:22065575; http://dx.doi.org/10.1074/jbc.M111.301382
33. Ruiz Carrillo D, Chandrasekaran R, Nilsson M, Cornvik T, Liew CW, Tan SM, et al. Structure of human Rack1 protein at a resolution of 2.45Å. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012; 68:867-72; PMID:22869111; http://dx.doi.org/10.1107/S1744309112027480
34. Yuan C, Sato M, Lanier SM, Smrcka AV. Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8. J Biol Chem 2007; 282:19938-47; PMID:17446173; http://dx.doi.org/10.1074/jbc.M700396200
35. Tang X, Sun Z, Runne C, Madsen J, Domann F, Henry M, et al. A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer. J Biol Chem 2011; 286:13244-54; PMID:21349837; http://dx.doi.org/10.1074/jbc.M110.206615
36. Bookout AL, Finney AE, Guo R, Peppel K, Koch WJ, Daaka Y. Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. J Biol Chem 2003; 278:37569-73; PMID:12869546; http://dx.doi.org/10.1074/jbc.M306276200
37. Shi S, Deng YZ, Zhao JS, Ji XD, Shi J, Feng YX, et al. RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem 2012; 287:7845-58; PMID:22262830; http://dx.doi.org/10.1074/jbc.M111.315416
38. Deng YZ, Yao F, Li JJ, Mao ZF, Hu PT, Long LY, et al. RACK1 suppresses gastric tumorigenesis by stabilizing the β-catenin destruction complex. Gastroenterology 2012; 142:812-23, e15; PMID:22240482; http://dx.doi.org/10. 1053/j.gastro.2011.12.046