Thyroid Hormone Reverses Aging-Induced Myocardial Fatty Acid Oxidation Defects and Improves the Response to Acutely Increased Afterload

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Ledee, Dolena ^a   Portman, Michael A ^a,b   Kajimoto, Masaki ^a   Isern, Nancy ^c   Olson, Aaron K ^a,b  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CARBON 13; CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; GLUCOSE; INSULIN; LACTIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRUVIC ACID; THYROID HORMONE;

AEROBIC METABOLISM; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CARNITINE PALMITOYLTRANSFERASE I GENE; CD36 GENE; CITRIC ACID CYCLE; DIASTOLIC DYSFUNCTION; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; HEART AFTERLOAD; HEART FUNCTION; HEART MUSCLE; HORMONAL REGULATION; ISOLATED HEART; ISOTOPE LABELING; LONG CHAIN FATTY ACID COENZYME A LIGASE GENE; MOUSE; NONHUMAN; OXIDATION KINETICS; PHENOTYPE; PROTEIN EXPRESSION;

ACETYL COENZYME A; AGING; ANIMALS; CITRIC ACID CYCLE; FATTY ACIDS; HEART FUNCTION TESTS; HEART VENTRICLES; MICE; MICE, INBRED C57BL; MYOCARDIUM; OXIDATION-REDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBSTRATE SPECIFICITY; THYROID HORMONES;

MUS;

EID: 84878746872     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065532     Document Type: Article

References (31)

1. Biondi B, Cooper DS, (2008) The clinical significance of subclinical thyroid dysfunction. Endocr Rev 29: 76-131.
2. Gencer B, Collet TH, Virgini V, Bauer DC, Gussekloo J, et al. (2012) Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts. Circulation 126: 1040-1049.
3. Hyland KA, Arnold AM, Lee JS, Cappola AR (2012) Persistent Subclinical Hypothyroidism and Cardiovascular Risk in the Elderly: The Cardiovascular Health Study. J Clin Endocrinol Metab.
4. Biondi B, Palmieri EA, Lombardi G, Fazio S, (2002) Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med 137: 904-914.
5. Monzani F, Di Bello V, Caraccio N, Bertini A, Giorgi D, et al. (2001) Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, placebo-controlled study. J Clin Endocrinol Metab 86: 1110-1115.
6. Fazio S, Palmieri EA, Lombardi G, Biondi B, (2004) Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res 59: 31-50.
7. Klein I, Danzi S, (2007) Thyroid disease and the heart. Circulation 116: 1725-1735.
8. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, et al. (2003) A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A 100: 1226-1231.
9. Lehman JJ, Kelly DP, (2002) Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. Clin Exp Pharmacol Physiol 29: 339-345.
10. Abu-Erreish GM, Neely JR, Whitmer JT, Whitman V, Sanadi DR, (1977) Fatty acid oxidation by isolated perfused working hearts of aged rats. Am J Physiol 232: E258-262.
11. Kates AM, Herrero P, Dence C, Soto P, Srinivasan M, et al. (2003) Impact of aging on substrate metabolism by the human heart. J Am Coll Cardiol 41: 293-299.
12. Koonen DP, Febbraio M, Bonnet S, Nagendran J, Young ME, et al. (2007) CD36 expression contributes to age-induced cardiomyopathy in mice. Circulation 116: 2139-2147.
13. McMillin JB, Taffet GE, Taegtmeyer H, Hudson EK, Tate CA, (1993) Mitochondrial metabolism and substrate competition in the aging Fischer rat heart. Cardiovasc Res 27: 2222-2228.
14. Hyyti OM, Ledee D, Ning XH, Ge M, Portman MA, (2010) Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice. Am J Physiol Heart Circ Physiol 299: H868-875.
15. Pantos C, Mourouzis I, Tsagoulis N, Markakis K, Galanopoulos G, et al. (2009) Thyroid hormone at supra-physiological dose optimizes cardiac geometry and improves cardiac function in rats with old myocardial infarction. J Physiol Pharmacol 60: 49-56.
16. Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, et al. (2012) C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle. J Mol Cell Cardiol.
17. Lloyd S, Brocks C, Chatham JC, (2003) Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. Am J Physiol Heart Circ Physiol 285: H163-172.
18. Hyyti OM, Olson AK, Ge M, Ning XH, Buroker NE, et al. (2008) Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency. Am J Physiol Endocrinol Metab 295: E420-427.
19. Malloy CR, Jones JG, Jeffrey FM, Jessen ME, Sherry AD, (1996) Contribution of various substrates to total citric acid cycle flux and anaplerosis as determined by 13C isotopomer analysis and O2 consumption in the heart. MAGMA 4: 35-46.
20. Jeffrey FM, Storey CJ, Sherry AD, Malloy CR, (1996) 13C isotopomer model for estimation of anaplerotic substrate oxidation via acetyl-CoA. Am J Physiol 271: E788-799.
21. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034.
22. Biondi B, (2012) Mechanisms in endocrinology: Heart failure and thyroid dysfunction. Eur J Endocrinol 167: 609-618.
23. Shirani J, Barron MM, Pierre-Louis ML, Roberts WC, (1993) Congestive heart failure, dilated cardiac ventricles, and sudden death in hyperthyroidism. Am J Cardiol 72: 365-368.
24. Chen YF, Kobayashi S, Chen J, Redetzke RA, Said S, et al. (2008) Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. J Mol Cell Cardiol 44: 180-187.
25. Lakatta EG, Levy D, (2003) Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation 107: 139-146.
26. Rohrer D, Dillmann WH, (1988) Thyroid hormone markedly increases the mRNA coding for sarcoplasmic reticulum Ca2+-ATPase in the rat heart. J Biol Chem 263: 6941-6944.
27. Hyyti OM, Ning XH, Buroker NE, Ge M, Portman MA, (2006) Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms. Am J Physiol Endocrinol Metab 290: E372-379.
28. Krueger JJ, Ning XH, Argo BM, Hyyti O, Portman MA, (2001) Triidothyronine and epinephrine rapidly modify myocardial substrate selection: a (13)C isotopomer analysis. Am J Physiol Endocrinol Metab 281: E983-990.
29. Kolwicz SC Jr, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, et al. (2012) Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res 111: 728-738.
30. Neubauer S, (2007) The failing heart-an engine out of fuel. N Engl J Med 356: 1140-1151.
31. Stanley WC, Recchia FA, Lopaschuk GD, (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129.