Gα12 Drives Invasion of Oral Squamous Cell Carcinoma through Up-Regulation of Proinflammatory Cytokines

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Jian, Shiou Ling ^a,b   Hsieh, Hsin Yi ^b   Liao, Chun Ta ^c   Yen, Tzu Chen ^c   Nien, Shu Wei ^b   Cheng, Ann Joy ^d   Juang, Jyh Lyh ^a,b,e  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT 12; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; UNCLASSIFIED DRUG; AUTACOID;

ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR PATHOLOGY; MOUTH SQUAMOUS CELL CARCINOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; CELL MOTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUTH TUMOR; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; INTERLEUKIN-8; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; UP-REGULATION;

EID: 84878746553     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066133     Document Type: Article

References (50)

1. Ramqvist T, Dalianis T, (2010) Oropharyngeal cancer epidemic and human papillomavirus. Emerging infectious diseases 16: 1671-1677.
2. Leemans CR, Braakhuis BJM, Brakenhoff R, (2011) The molecular biology of head and neck cancer. Nature Reviews Cancer 11: 9-22.
3. Pai SI, Westra WH, (2009) Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol 4: 49-70.
4. Chen Y-J, Chang J, Liao C-T, Wang H-M, Yen T-C, et al. (2008) Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci 99: 1507-1514.
5. Chung C, Gillison M, (2009) Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clinical cancer research 15: 6758-6762.
6. Wang F, Arun P, Friedman J, Chen Z, Van Waes C, (2009) Current and potential inflammation targeted therapies in head and neck cancer. Curr Opin Pharmacol 9: 389-395.
7. Mantovani A, Allavena P, Sica A, Balkwill F, (2008) Cancer-related inflammation. Nature 454: 436-444.
8. Chen Z, Malhotra PS, Thomas GR, Ondrey FG, Duffey DC, et al. (1999) Expression of proinflammatory and proangiogenic cytokines in patients with head and neck cancer. Clinical cancer research 5: 1369-1379.
9. Pries R, Nitsch S, Wollenberg B, (2006) Role of cytokines in head and neck squamous cell carcinoma. Expert review of anticancer therapy 6: 1195-1203.
10. St John MAR, Li Y, Zhou X, Denny P, Ho C-M, et al. (2004) Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 130: 929-935.
11. Duffy S, Taylor JMG, Terrell J, Islam M, Li Y, et al. (2008) Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer 113: 750-757.
12. Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, et al. (2010) Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem 285: 32512-32521.
13. Chen C-J, Sung W-W, Lin Y-M, Chen M-K, Lee C-H, et al. (2012) Gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma. PLoS ONE 7: e50104-e50104.
14. Culig Z, (2013) Interleukin-6 as a therapy target in oral squamous carcinoma. Expert opinion on therapeutic targets 17: 53-59.
15. Gokhale A, Haddad R, Cavacini L, Wirth L, Weeks L, et al. (2005) Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck. Oral Oncol 41: 70-76.
16. Riedel F, Zaiss I, Herzog D, Gatte K, Naim R, et al. (2005) Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma. Anticancer research 25: 2761-2765.
17. SahebJamee M, Eslami M, AtarbashiMoghadam F, Sarafnejad A, (2008) Salivary concentration of TNFalpha, IL1 alpha, IL6, and IL8 in oral squamous cell carcinoma. Medicina oral, patología oral y cirugía bucal 13: E292-E295.
18. de Oliveira MV, Fraga CA, Gomez RS, Paula AM, (2009) Immunohistochemical expression of interleukin-4,-6,-8, and-12 in inflammatory cells in surrounding invasive front of oral squamous cell carcinoma. Head Neck 31: 1439-1446.
19. Wu JY, Yi C, Chung HR, Wang DJ, Chang WC, et al. (2010) Potential biomarkers in saliva for oral squamous cell carcinoma. Oral Oncol 46: 226-231.
20. Dorsam RT, Gutkind JS, (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7: 79-94.
21. Li S, Huang S, Peng S-B, (2005) Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int J Oncol 27: 1329-1339.
22. Spiegelberg B, Hamm H, (2007) Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. Current opinion in genetics & development 17: 40-44.
23. Fraser C, (2008) G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer. International reviews of immunology 27: 320-350.
24. Neves SR, Ram PT, Iyengar R, (2002) G protein pathways. Science 296: 1636-1639.
25. Cotton M, Claing A, (2009) G protein-coupled receptors stimulation and the control of cell migration. Cellular signalling 21: 1045-1053.
26. Juneja J, Casey P, (2009) Role of G12 proteins in oncogenesis and metastasis. British Journal of Pharmacology 158: 32-40.
27. Liu SC, Jen YM, Jiang SS, Chang JL, Hsiung CA, et al. (2009) G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization. Cancer Res 69: 6122-6130.
28. Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, et al. (2006) The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 103: 8173-8178.
29. Kelly P, Stemmle LN, Madden JF, Fields TA, Daaka Y, et al. (2006) A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem 281: 26483-26490.
30. Ki SH, Choi MJ, Lee CH, Kim SG, (2007) Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. J Biol Chem 282: 1938-1947.
31. Peng C-H, Liao C-T, Peng S-C, Chen Y-J, Cheng A-J, et al. (2011) A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. PLoS ONE 6: e23452-e23452.
32. Lin S-C, Liu C-J, Chiu C-P, Chang S-M, Lu S-Y, et al. (2004) Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract. Journal of oral pathology & medicine 33: 79-86.
33. Lu Y-C, Chen Y-J, Wang H-M, Tsai C-Y, Chen W-H, et al. (2012) Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling. Cancer prevention research 5: 665-674.
34. Greenberg JS, Fowler R, Gomez J, Mo V, Roberts D, et al. (2003) Extent of extracapsular spread: a critical prognosticator in oral tongue cancer. Cancer 97: 1464-1470.
35. Wenzel S, Sagowski C, Kehrl W, Metternich FU, (2004) The prognostic impact of metastatic pattern of lymph nodes in patients with oral and oropharyngeal squamous cell carcinomas. European archives of oto-rhino-laryngology 261: 270-275.
36. Shaw RJ, Lowe D, Woolgar JA, Brown JS, Vaughan ED, et al. (2010) Extracapsular spread in oral squamous cell carcinoma. Head Neck 32: 714-722.
37. Liao CT, Lee LY, Huang SF, Chen IH, Kang CJ, et al. (2011) Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes. Int J Radiat Oncol Biol Phys 81: 930-937.
38. Tung CL, Lin ST, Chou HC, Chen YW, Lin HC, et al. (2013) Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma. J Pharm Biomed Anal 75: 7-17.
39. Bian D, Mahanivong C, Yu J, Frisch SM, Pan ZK, et al. (2006) The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration. Oncogene 25: 2234-2244.
40. Radhika V, Hee Ha J, Jayaraman M, Tsim S-T, Dhanasekaran N, (2005) Mitogenic signaling by lysophosphatidic acid (LPA) involves Galpha12. Oncogene 24: 4597-4603.
41. Aki Y, Kondo A, Nakamura H, Togari A, (2008) Lysophosphatidic acid-stimulated interleukin-6 and-8 synthesis through LPA1 receptors on human osteoblasts. Archives of oral biology 53: 207-213.
42. Chen SU, Chou CH, Lee H, Ho CH, Lin CW, et al. (2008) Lysophosphatidic acid up-regulates expression of interleukin-8 and-6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome. J Clin Endocrinol Metab 93: 935-943.
43. Hwang YS, Lee SK, Park KK, Chung WY, (2012) Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. Oral Oncol 48: 40-48.
44. Ho MKC, Su Y, Yeung WWS, Wong YH, (2009) Regulation of transcription factors by heterotrimeric G proteins. Current Molecular Pharmacology 2: 19-31.
45. Facchinetti MM, Gandini NA, Fermento ME, Sterin-Speziale NB, Ji Y, et al. (2010) The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs 192: 314-324.
46. Penson RT, Kronish K, Duan Z, Feller AJ, Stark P, et al. (2000) Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. International journal of gynecological cancer 10: 33-41.
47. Waugh DJJ, Wilson C, (2008) The interleukin-8 pathway in cancer. Clinical cancer research 14: 6735-6741.
48. Wang Y, Niu X, Qu Y, Wu J, Zhu Y, et al. (2010) Autocrine production of interleukin-6 confers cisplatin and paclitaxel resistance in ovarian cancer cells. Cancer Lett 295: 110-123.
49. Freier K, Engel M, Lindel K, Flechtenmacher C, Mahling J, et al. (2008) Neoadjuvant concurrent radiochemotherapy followed by surgery in advanced oral squamous cell carcinoma (OSCC): a retrospective analysis of 207 patients. Oral Oncol 44: 116-123.
50. Lebman D, Spiegel S, (2008) Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. Journal of lipid research 49: 1388-1394.