VEGF-releasing biodegradable nanospheres administered by craniotomy: A novel therapeutic approach in the APP/Ps1 mouse model of Alzheimer's disease

Journal of Controlled Release

Volumn 170, Issue 1, 2013, Pages 111-119

  Herrán, Enara ^a,b   Pérez González, Rocio ^c,d   Igartua, Manoli ^a,b   Pedraz, José Luis ^a,b   Carro, Eva ^c,d   Hernández, Rosa María ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c Universidad Complutense   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Alzheimer's disease; Animal model; Nanoparticles; PLGA; VEGF

Indexed keywords

BIOACTIVITY; CELL CULTURE; MAMMALS; NANOPARTICLES; NANOSPHERES; NEURONS; PARTICLE SIZE;

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; ANIMAL MODEL; NEURODEGENERATIVE DISORDERS; PLGA; POLY(LACTIC-CO-GLYCOLIC ACID); VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF;

NEURODEGENERATIVE DISEASES;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; LIPOPOLYSACCHARIDE; NANOSPHERE; POLYGLACTIN; PRESENILIN 1; VASCULOTROPIN;

ALZHEIMER DISEASE; ANGIOGENESIS; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BIODEGRADABILITY; BIOLOGICAL ACTIVITY; BRAIN CELL CULTURE; CELL LOSS; CELL PROLIFERATION; CELL VIABILITY; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CRANIOTOMY; DRUG RELEASE; EMBRYO; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MAZE TEST; MENTAL TEST; MINIMALLY INVASIVE SURGERY; MOUSE; NANOENCAPSULATION; NANOTECHNOLOGY; NERVE CELL; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OPEN FIELD TEST; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RECOGNITION; TRANSGENIC MOUSE; ZETA POTENTIAL;

EID: 84878738008     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.04.028     Document Type: Article

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