DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5639-5649

  Kelong, Ma ^a,b   He, Yinghua ^b   Zhang, Hongyu ^b   Fei, Qi ^b   Niu, Dandan ^b   Wang, Dongmei ^c   Ding, Xia ^c   Xu, Hua ^d   Chen, Xiaoping ^d   Zhu, Jingde ^b,e  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^e ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5-FLUOROURACIL; 5-FLUOROURACIL (5-FU); ANTIAPOPTOTIC; CANCER THERAPY; CASPASES; CELL LINES; CELL-CYCLE PROGRESSION; CHEMORESISTANCE; CLINICAL SAMPLES; DNA METHYLATION; HEPATOCELLULAR CARCINOMA; MECHANISTIC STUDIES; MICRORNAS; NEW MECHANISMS; NUDE MICE; PHENOTYPIC FEATURES; RESISTANT CELLS; SPLICING FACTORS;

AMINO ACIDS; CELL CULTURE; CELL PROLIFERATION; GENE THERAPY;

GENE EXPRESSION;

CASPASE 2; CELL PROTEIN; CISPLATIN; DOCETAXEL; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; IRINOTECAN; MICRORNA; MICRORNA 193A 3P; MITOMYCIN; NAVELBINE; PACLITAXEL; SERINE ARGININE RICH SPLICING FACTOR 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DNA METHYLATION; ENZYME INDUCTION; GENE EXPRESSION; GENETIC REGULATION; GENOMICS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA SPLICING;

ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE SILENCING; GENOMICS; HUMANS; LIVER NEOPLASMS; MICE; MICRORNAS; NUCLEAR PROTEINS; RIBONUCLEOPROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84863142634     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.291229     Document Type: Article

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