-
1
-
-
0034661820
-
Neuropathology of synuclein aggregates
-
Duda, J. E., Lee, V. M., and Trojanowski, J. Q. (2000) Neuropathology of synuclein aggregates J. Neurosci. Res. 61, 121-127
-
(2000)
J. Neurosci. Res.
, vol.61
, pp. 121-127
-
-
Duda, J.E.1
Lee, V.M.2
Trojanowski, J.Q.3
-
2
-
-
15544371311
-
Pathogenic effects of α-synuclein aggregation
-
Lundvig, D., Lindersson, E., and Jensen, P. H. (2005) Pathogenic effects of α-synuclein aggregation Mol. Brain Res. 134, 3-17
-
(2005)
Mol. Brain Res.
, vol.134
, pp. 3-17
-
-
Lundvig, D.1
Lindersson, E.2
Jensen, P.H.3
-
3
-
-
0036150971
-
The synucleins
-
George, J. M. (2002) The synucleins Genome Biol. 3, 3002.3001-3002.3006
-
(2002)
Genome Biol.
, vol.3
, pp. 30023001-30023006
-
-
George, J.M.1
-
4
-
-
0035928748
-
Membrane binding and self-association of alpha-synuclein
-
Narayanan, V. and Scarlata, S. (2001) Membrane binding and self-association of alpha-synuclein Biochemistry 40, 9927-9934
-
(2001)
Biochemistry
, vol.40
, pp. 9927-9934
-
-
Narayanan, V.1
Scarlata, S.2
-
5
-
-
80052398365
-
[agr]-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) [agr]-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation Nature 477, 107-110
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T.1
Choi, J.G.2
Selkoe, D.J.3
-
6
-
-
80055078029
-
A soluble α-synuclein construct forms a dynamic tetramer
-
Wang, W., Perovic, I., Chittuluru, J., Kaganovich, A., Nguyen, L. T. T., Liao, J., Auclair, J. R., Johnson, D., Landeru, A., Simorellis, A. K., Ju, S., Cookson, M. R., Asturias, F. J., Agar, J. N., Webb, B. N., Kang, C., Ringe, D., Petsko, G. A., Pochapsky, T. C., and Hoang, Q. Q. (2011) A soluble α-synuclein construct forms a dynamic tetramer Proc. Natl. Acad. Sci. U.S.A. 108, 17797-17802
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 17797-17802
-
-
Wang, W.1
Perovic, I.2
Chittuluru, J.3
Kaganovich, A.4
Nguyen, L.T.T.5
Liao, J.6
Auclair, J.R.7
Johnson, D.8
Landeru, A.9
Simorellis, A.K.10
Ju, S.11
Cookson, M.R.12
Asturias, F.J.13
Agar, J.N.14
Webb, B.N.15
Kang, C.16
Ringe, D.17
Petsko, G.A.18
Pochapsky, T.C.19
Hoang, Q.Q.20
more..
-
7
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury Jr., P.T.6
-
8
-
-
0031678048
-
Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease
-
Parsian, A., Racette, B., Zhang, Z. H., Chakraverty, S., Rundle, M., Goate, A., and Perlmutter, J. S. (1998) Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease Neurology 51, 1757-1759
-
(1998)
Neurology
, vol.51
, pp. 1757-1759
-
-
Parsian, A.1
Racette, B.2
Zhang, Z.H.3
Chakraverty, S.4
Rundle, M.5
Goate, A.6
Perlmutter, J.S.7
-
9
-
-
15744405993
-
Synuclein, dopamine and oxidative stress: Co-conspirators in Parkinson's disease?
-
Maguire-Zeiss, K. A., Short, D. W., and Federoff, H. J. (2005) Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Mol. Brain Res. 134, 18-23
-
(2005)
Mol. Brain Res.
, vol.134
, pp. 18-23
-
-
Maguire-Zeiss, K.A.1
Short, D.W.2
Federoff, H.J.3
-
10
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha- synuclein nitration in synucleinopathy lesions [In Process Citation]
-
Giasson, B. I., Duda, J. E., Murray, I. V., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M. (2000) Oxidative damage linked to neurodegeneration by selective alpha- synuclein nitration in synucleinopathy lesions [In Process Citation] Science 290, 985-989
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, B.I.1
Duda, J.E.2
Murray, I.V.3
Chen, Q.4
Souza, J.M.5
Hurtig, H.I.6
Ischiropoulos, H.7
Trojanowski, J.Q.8
Lee, V.M.9
-
11
-
-
0034674652
-
Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
-
Souza, J. M., Giasson, B. I., Chen, Q., Lee, V. M., and Ischiropoulos, H. (2000) Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies J. Biol. Chem. 275, 18344-18349
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18344-18349
-
-
Souza, J.M.1
Giasson, B.I.2
Chen, Q.3
Lee, V.M.4
Ischiropoulos, H.5
-
12
-
-
0034640160
-
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr- alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells
-
Ancolio, K., Alves da Costa, C., Ueda, K., and Checler, F. (2000) Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr- alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells Neurosci. Lett. 285, 79-82
-
(2000)
Neurosci. Lett.
, vol.285
, pp. 79-82
-
-
Ancolio, K.1
Alves Da Costa, C.2
Ueda, K.3
Checler, F.4
-
13
-
-
4344659685
-
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
-
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., and Sulzer, D. (2004) Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy Science 305, 1292-1295
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
14
-
-
0035066885
-
Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
-
Lee, F. J. and al., e. (2001) Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis FASEB J. 15, 916-926
-
(2001)
FASEB J.
, vol.15
, pp. 916-926
-
-
Lee, F.J.1
-
15
-
-
12144267004
-
Fluorescence studies suggest a role for a-synuclein in the phosphatdiylinositol lipid signaling pathway
-
Narayanan, V., Guo, Y., and Scarlata, S. (2005) Fluorescence studies suggest a role for a-synuclein in the phosphatdiylinositol lipid signaling pathway Biochemistry 44, 462-470
-
(2005)
Biochemistry
, vol.44
, pp. 462-470
-
-
Narayanan, V.1
Guo, Y.2
Scarlata, S.3
-
16
-
-
84862808235
-
α-synuclein increases the cellular level of phospholipase Cβ1
-
Guo, Y., Rosati, B., and Scarlata, S. (2012) α-synuclein increases the cellular level of phospholipase Cβ1 Cell. Signalling 24, 1109-1114
-
(2012)
Cell. Signalling
, vol.24
, pp. 1109-1114
-
-
Guo, Y.1
Rosati, B.2
Scarlata, S.3
-
17
-
-
46249091922
-
Multiple roles of phosphoinositide-specific phospholipase C isozymes
-
Suh, P., Park, J., Manzoli, L., Cocco, L., Peak, J., Katan, M., Fukami, K., Kataoka, T., Yun, S., and Ryu, S. (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes BMB Rep. 41, 415-434
-
(2008)
BMB Rep.
, vol.41
, pp. 415-434
-
-
Suh, P.1
Park, J.2
Manzoli, L.3
Cocco, L.4
Peak, J.5
Katan, M.6
Fukami, K.7
Kataoka, T.8
Yun, S.9
Ryu, S.10
-
18
-
-
0033779101
-
Structure, function and control of phosphoinositide-specific phospholipase C
-
Rebecchi, M. and Pentylana, S. (2000) Structure, function and control of phosphoinositide-specific phospholipase C Phys. Rev. 80, 1291-1335
-
(2000)
Phys. Rev.
, vol.80
, pp. 1291-1335
-
-
Rebecchi, M.1
Pentylana, S.2
-
19
-
-
84870340939
-
Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X
-
Philip, F., Guo, Y., Aisiku, O., and Scarlata, S. (2012) Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X FASEB J. 26, 4903-13
-
(2012)
FASEB J.
, vol.26
, pp. 4903-13
-
-
Philip, F.1
Guo, Y.2
Aisiku, O.3
Scarlata, S.4
-
20
-
-
0033514304
-
Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C- b effectors
-
Runnels, L. W. and Scarlata, S. (1999) Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C- b effectors Biochemistry 38, 1488-1496
-
(1999)
Biochemistry
, vol.38
, pp. 1488-1496
-
-
Runnels, L.W.1
Scarlata, S.2
-
21
-
-
33747668837
-
Stable association between G alpha(q) and phospholipase C beta 1 in living cells
-
Dowal, L., Provitera, P., and Scarlata, S. (2006) Stable association between G alpha(q) and phospholipase C beta 1 in living cells J. Biol. Chem. 281, 23999-24014
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 23999-24014
-
-
Dowal, L.1
Provitera, P.2
Scarlata, S.3
-
22
-
-
79953713263
-
Differential Response to Morphine of the Oligomeric State of μ-Opioid in the Presence of δ-Opioid Receptors
-
Golebiewska, U., Johnston, J. M., Devi, L., Filizola, M., and Scarlata, S. (2011) Differential Response to Morphine of the Oligomeric State of μ-Opioid in the Presence of δ-Opioid Receptors Biochemistry 50, 2829-2837
-
(2011)
Biochemistry
, vol.50
, pp. 2829-2837
-
-
Golebiewska, U.1
Johnston, J.M.2
Devi, L.3
Filizola, M.4
Scarlata, S.5
-
23
-
-
0035895355
-
Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1
-
Dowal, L., Elliott, J., Popov, S., Wilkie, T. M., and Scarlata, S. (2001) Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1 Biochemistry 40, 414-421
-
(2001)
Biochemistry
, vol.40
, pp. 414-421
-
-
Dowal, L.1
Elliott, J.2
Popov, S.3
Wilkie, T.M.4
Scarlata, S.5
-
24
-
-
55249086973
-
Histone 2B (H2B) Expression Is Confined to a Proper NAD+/NADH Redox Status
-
Dai, R.-P., Yu, F.-X., Goh, S.-R., Chng, H.-W., Tan, Y.-L., Fu, J.-L., Zheng, L., and Luo, Y. (2008) Histone 2B (H2B) Expression Is Confined to a Proper NAD+/NADH Redox Status J. Biol. Chem. 283, 26894-26901
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26894-26901
-
-
Dai, R.-P.1
Yu, F.-X.2
Goh, S.-R.3
Chng, H.-W.4
Tan, Y.-L.5
Fu, J.-L.6
Zheng, L.7
Luo, Y.8
-
25
-
-
10744227740
-
Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications
-
Farrer, M., Kachergus, J., Forno, L., Lincoln, S., Wang, D.-S., Hulihan, M., Maraganore, D., Gwinn-Hardy, K., Wszolek, Z., Dickson, D., and Langston, J. W. (2004) Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications Ann. Neurol. 55, 174-179
-
(2004)
Ann. Neurol.
, vol.55
, pp. 174-179
-
-
Farrer, M.1
Kachergus, J.2
Forno, L.3
Lincoln, S.4
Wang, D.-S.5
Hulihan, M.6
Maraganore, D.7
Gwinn-Hardy, K.8
Wszolek, Z.9
Dickson, D.10
Langston, J.W.11
-
26
-
-
0242300619
-
A-Synuclein locus triplication casues Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Baptista, M., Miller, D., Blancate, J., Hardy, J., and Gwinn-Hardy, K. (2003) a-Synuclein locus triplication casues Parkinson's disease Science 302, 841
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Baptista, M.14
Miller, D.15
Blancate, J.16
Hardy, J.17
Gwinn-Hardy, K.18
-
27
-
-
0033564726
-
Copper(II)-induced self-oligomerization of alpha-synuclein
-
Paik, S. R., Shin, H. J., Lee, J. H., Chang, C. S., and Kim, J. (1999) Copper(II)-induced self-oligomerization of alpha-synuclein Biochem. J. 340, 821-828
-
(1999)
Biochem. J.
, vol.340
, pp. 821-828
-
-
Paik, S.R.1
Shin, H.J.2
Lee, J.H.3
Chang, C.S.4
Kim, J.5
-
28
-
-
80055078029
-
A soluble α-synuclein construct forms a dynamic tetramer
-
Wang, W., Perovic, I., Chittuluru, J., Kaganovich, A., Nguyen, L. T. T., Liao, J., Auclair, J. R., Johnson, D., Landeru, A., Simorellis, A. K., Ju, S., Cookson, M. R., Asturias, F. J., Agar, J. N., Webb, B. N., Kang, C., Ringe, D., Petsko, G. A., Pochapsky, T. C., and Hoang, Q. Q. (2011) A soluble α-synuclein construct forms a dynamic tetramer Proc. Natl. Acad. Sci. U.S.A. 108, 17797-802
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 17797-802
-
-
Wang, W.1
Perovic, I.2
Chittuluru, J.3
Kaganovich, A.4
Nguyen, L.T.T.5
Liao, J.6
Auclair, J.R.7
Johnson, D.8
Landeru, A.9
Simorellis, A.K.10
Ju, S.11
Cookson, M.R.12
Asturias, F.J.13
Agar, J.N.14
Webb, B.N.15
Kang, C.16
Ringe, D.17
Petsko, G.A.18
Pochapsky, T.C.19
Hoang, Q.Q.20
more..
-
29
-
-
84860172516
-
N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein
-
Trexler, A. J. and Rhoades, E. (2012) N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein Protein Sci. 21, 601-605
-
(2012)
Protein Sci.
, vol.21
, pp. 601-605
-
-
Trexler, A.J.1
Rhoades, E.2
-
30
-
-
0034193399
-
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons
-
Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., and Lee, V. M. (2000) Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons J. Neurosci. 20, 3214-3220
-
(2000)
J. Neurosci.
, vol.20
, pp. 3214-3220
-
-
Murphy, D.D.1
Rueter, S.M.2
Trojanowski, J.Q.3
Lee, V.M.4
-
31
-
-
33947280424
-
α-Synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids
-
Golovko, M. Y., Rosenberger, T. A., Feddersen, S., Færgeman, N. J., and Murphy, E. J. (2007) α-Synuclein gene ablation increases docosahexaenoic acid incorporation and turnover in brain phospholipids J. Neurochem. 101, 201-211
-
(2007)
J. Neurochem.
, vol.101
, pp. 201-211
-
-
Golovko, M.Y.1
Rosenberger, T.A.2
Feddersen, S.3
Færgeman, N.J.4
Murphy, E.J.5
-
32
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich, A., Schmitz, Y., Farinas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., and Rosenthal, A. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system Neuron 25, 239-252
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
33
-
-
0035958973
-
Muscarininc receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicles fraction in cytoplasm
-
Leng, Y., Chase, T. N., and Bennett, M. C. (2001) Muscarininc receptor stimulation induces translocation of an alpha-synuclein oligomer from plasma membrane to a light vesicles fraction in cytoplasm J. Biol. Chem. 276, 28212-28218
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28212-28218
-
-
Leng, Y.1
Chase, T.N.2
Bennett, M.C.3
-
34
-
-
0034595728
-
Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
-
Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., and Freed, C. R. (2000) Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells Brain Res. 866, 33-43
-
(2000)
Brain Res.
, vol.866
, pp. 33-43
-
-
Zhou, W.1
Hurlbert, M.S.2
Schaack, J.3
Prasad, K.N.4
Freed, C.R.5
|