Phospholipase Cβ1 is linked to RNA interference of specific genes through translin-associated factor X

FASEB Journal

Volumn 26, Issue 12, 2012, Pages 4903-4913

  Philip, Finly ^a   Guo, Yuanjian ^a   Aisiku, Omoz ^a,b   Scarlata, Suzanne ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

G protein signaling; Histone H2B; RNA transcription

Indexed keywords

BINDING PROTEIN; CALCIUM ION; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; LACTATE DEHYDROGENASE; PHOSPHOLIPASE C BETA1; TRANSLIN ASSOCIATED FACTOR X; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM SIGNALING; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INDUCTION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE;

ACTIVE TRANSPORT, CELL NUCLEUS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL NUCLEUS; DNA-BINDING PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HELA CELLS; HISTONES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; L-LACTATE DEHYDROGENASE; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; PHOSPHOLIPASE C BETA; PROTEIN BINDING; RNA INTERFERENCE; TRANSFECTION;

EID: 84870340939     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-213934     Document Type: Article

References (33)

1. Suh, P., Park, J., Manzoli, L., Cocco, L., Peak, J., Katan, M., Fukami, K., Kataoka, T., Yun, S., and Ryu, S. (2008) Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Reports 41, 415-434 (Pubitemid 351914885)
2. Rebecchi, M. J., and Pentyala, S. N. (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291-1335
3. Dowal, L., Provitera, P., and Scarlata, S. (2006) Stable association between G alpha(q) and phospholipase C beta 1 in living cells. J. Biol. Chem. 281, 23999-24014 (Pubitemid 44274174)
4. Cocco, L., Faenza, I., Fiume, R. M., Gilmour, S. R., and Manzoli, F. A. (2006) Phosphoinositide-specific phospholipase C (PIPLC) β1 and nuclear lipid-dependent signaling. Biochim. Biophys. Acta 1761, 509-521 (Pubitemid 43928864)
5. Cocco, L., Martelli, A. M., Gilmour, R. S., Rhee, S. G., and Manzoli, F. A. (2001) Nuclear phospholipase C and signaling. Biochim. Biophys. Acta 1530, 1-14 (Pubitemid 32121879)
6. Xu, A., Suh, P. G., Marmy-Conus, N., Pearson, R. B., Seok, O. Y., Cocco, L., and Gilmour, R. (2001) Phosphorylation of nuclear phospholipase Cb1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor 1. Mol. Cell. Biol. 21, 2981-2990 (Pubitemid 32298366)
7. Aisiku, O. R., Runnels, L. W., and Scarlata, S. (2010) Identification of a novel binding partner of phospholipase Cβ1: translin-associated factor X. PLoS ONE 5, e15001
8. Yang, S., Cho, Y. S., Chennathukuzhi, V. M., Underkoffler, L. A., Loomes, K., and Hecht, N. B. (2004) Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation. J. Biol. Chem. 279, 12605-12614 (Pubitemid 38445832)
9. Wang, J., Boja, E. S., Oubrahim, H., and Chock, P. B. (2004) Testis brain ribonucleic acid-binding protein/translin possesses both single-stranded and double-stranded ribonuclease activities. Biochemistry 43, 13424-13431 (Pubitemid 39391143)
10. Jaendling, A., and McFarlane, R. J. (2010) Biological roles of translin and translin-associated factor-X: RNA metabolism comes to the fore. Biochem. J. 429, 225-234
11. Cho, Y. S., Chennathukuzhi, V. M., Handel, M. A., Eppig, J., and Hecht, N. B. (2004) The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells. J. Biol. Chem. 279, 31514-31523 (Pubitemid 39037820)
12. Ye, X., Huang, N., Liu, Y., Paroo, Z., Huerta, C., Li, P., Chen, S., Liu, Q., and Zhang, H. (2011) Structure of C3PO and mechanism of human RISC activation. Nat. Struct. Mol. Biol. 18, 650-657
13. Tian, Y., Simanshu, D. K., Ascano, M., Diaz-Avalos, R., Park, A. Y., Juranek, S. A., Rice, W. J., Yin, Q., Robinson, C. V., Tuschl, T., and Patel, D. J. (2011) Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex. Nat. Struct. Mol. Biol. 18, 658-664
14. Liu, Y., Ye, X., Jiang, F., Liang, C., Chen, D., Peng, J., Kinch, L. N., Grishin, N. V., and Liu, Q. (2009) C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 325, 750-753
15. Kawamata, T., and Tomari, Y. (2010) Making RISC. Trends Biochem. Sci. 35, 368-376
16. McOmish, C. E., Burrows, E. L., Howard, M., and Hannan, A. J. (2008) PLC-β1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus 18, 824-834
17. Chennathukuzhi, V., Stein, J. M., Abel, T., Donlon, S., Yang, S., Miller, J. P., Allman, D. M., Simmons, R. A., and Hecht, N. B. (2003) Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Mol. Cell. Biol. 23, 6419-6434 (Pubitemid 37075755)
18. Stein, J. M., Bergman, W., Fang, Y., Davison, L., Brensinger, C., Robinson, M. B., Hecht, N. B., and Abel, T. (2006) Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J. Neurosci. 26, 2184-2196 (Pubitemid 44699027)
19. Li, Z., Wu, Y., and Baraban, J. M. (2008) The Translin/Trax RNA binding complex: clues to function in the nervous system. Biochim. Biophys. Acta 1779, 479-485
20. Zheng, L., Roeder, R. G., and Luo, Y. (2003) S Phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 114, 255-266 (Pubitemid 36936918)
21. Dai, R.-P., Yu, F.-X., Goh, S.-R., Chng, H.-W., Tan, Y.-L., Fu, J.-L., Zheng, L., and Luo, Y. (2008) Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status. J. Biol. Chem. 283, 26894-26901
22. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) DNA transfection by electroporation. In Molecular Cloning: A Laboratory Manual (Irwin, N., ed) Chap. 16.54, Cold Spring Harbor Press, Plainview, New York, USA
23. Guo, Y., Golebiewska, U., and Scarlata, S. (2011) Modulation of Ca2+ activity in cardiomyocytes through caveolae-gαq interactions. Biophys. J. 100, 1599-1607
24. Guo, Y., Rebecchi, M., and Scarlata, S. (2005) Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1. J. Biol. Chem. 280, 1438-1447
25. Livak, K. J., and Schmittgen, T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25, 402-408 (Pubitemid 34164012)
26. Hughes, T. E., Zhang, H., Logothetis, D., and Berlot, C. H. (2001) Visualization of a functional Gaq-green fluorescent protein fusion in living cells. J. Biol. Chem. 276, 4227-4235
27. Lee, Y. H., Kim, S.-Y., Kim, J.-R., Yoh, K.-T., Baek, S.-H., Kim, M. J., Ryu, S. H., Suh, P.-G., and Kim, J.-H. (2000) Overexpression of phospholipase Cβ-1 protects NIH3T3 cells from oxidative stress-induced cell death. Life Sci. 67, 827-837 (Pubitemid 30482751)
28. Cocco, L., Martelli, A. M., Vitale, M., Falconi, M., Barnabei, O., Stewart Gilmour, R., and Manzoli, F. A. (2002) Inositides in the nucleus: regulation of nuclear PI-PLCbeta1. Adv. Enzyme Regul. 42, 181-193 (Pubitemid 35033538)
29. Lamond, A. I., and Spector, D. L. (2003) Nuclear speckles: a model for nuclear organelles. Nat. Rev. Mol. Cell Biol. 4, 605-612 (Pubitemid 36934962)
30. Faenza, I., Matteucci, A., Bavelloni, A., Marmiroli, S., Martelli, A. M., Gilmour, R. S., Suh, P. G., Manzoli, L., and Cocco, L. (2002) Nuclear PLCbeta(1) acts as a negative regulator of p45/NF-E2 expression levels in friend erythroleukemia cells. Biochim. Biophys. Acta 1589, 305-310 (Pubitemid 34603301)
31. Singer, A., Waldo, G., Harden, T. K., and Sondek, J. (2002) A unique fold of phospholipase C-beta mediates dimerization and interaction with GalphaQ. Nat. Struc. Biol. 9, 32-36 (Pubitemid 34049176)
32. Follo, M. Y., Finelli, C., Clissa, C., Mongiorgi, S., Bosi, C., Martinelli, G., Baccarani, M., Manzoli, L., Martelli, A. M., and Cocco, L. (2009) Phosphoinositide-phospholipase C β1 monoallelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. J. Clin. Oncol. 27, 782-790
33. Siomi, H., and Siomi, M. C. (2009) RISC hitches onto endosome trafficking. Nat. Cell Biol. 11, 1049-1051