메뉴 건너뛰기




Volumn 19, Issue 17, 2013, Pages 3094-3106

The role of niacin in lipid-lowering treatment: Are we aiming too high?

Author keywords

Laropiprant; Lipid lowering drugs; Lipids; Lipoproteins; Niacin; Nicotinic acid; Statins

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANTILIPEMIC AGENT; C REACTIVE PROTEIN; G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LAROPIPRANT PLUS NICOTINIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID;

EID: 84878642566     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319170017     Document Type: Article
Times cited : (16)

References (128)
  • 1
    • 51249095156 scopus 로고    scopus 로고
    • Hypercholesterolaemia and its management
    • Bhatnagar D, Soran H, Durrington PN. Hypercholesterolaemia and its management. BMJ 2008; 337: a993.
    • (2008) BMJ , vol.337
    • Bhatnagar, D.1    Soran, H.2    Durrington, P.N.3
  • 2
    • 77952955394 scopus 로고    scopus 로고
    • Niacin and fibrates in atherogenic dyslipidemia: Pharmacotherapy to reduce cardiovascular risk
    • Chapman MJ, Redfern JS, McGovern ME, Giral P. Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk. Pharmacol Ther 2010; 126: 314-45.
    • (2010) Pharmacol Ther , vol.126 , pp. 314-345
    • Chapman, M.J.1    Redfern, J.S.2    McGovern, M.E.3    Giral, P.4
  • 3
    • 84877748791 scopus 로고    scopus 로고
    • How to control residual cardiovascular risk despite statin treatment: Focusing on HDLcholesterol
    • Lim S, Park YM, Sakuma I, Koh KK. How to control residual cardiovascular risk despite statin treatment: Focusing on HDLcholesterol. Int J Cardiol 2012.
    • (2012) Int J Cardiol
    • Lim, S.1    Park, Y.M.2    Sakuma, I.3    Koh, K.K.4
  • 4
    • 84858756420 scopus 로고    scopus 로고
    • Targeting HDL-cholesterol to reduce residual cardiovascular risk
    • Iacob AO, Choudhury RP. Targeting HDL-cholesterol to reduce residual cardiovascular risk. Curr Opin Lipidol 2012; 23: 172-4.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 172-174
    • Iacob, A.O.1    Choudhury, R.P.2
  • 5
    • 77955712458 scopus 로고    scopus 로고
    • HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: An analysis from the JUPITER trial
    • Ridker PM, Genest J, Boekholdt SM, et al. HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet 2010; 376: 333-9.
    • (2010) Lancet , vol.376 , pp. 333-339
    • Ridker, P.M.1    Genest, J.2    Boekholdt, S.M.3
  • 6
    • 84861372936 scopus 로고    scopus 로고
    • Extended-release niacin with laropiprant: A review on efficacy, clinical effectiveness and safety
    • Yadav R, France M, Younis N, et al. Extended-release niacin with laropiprant: a review on efficacy, clinical effectiveness and safety. Expert Opin Pharmacother 2012; 13: 1345-62.
    • (2012) Expert Opin Pharmacother , vol.13 , pp. 1345-1362
    • Yadav, R.1    France, M.2    Younis, N.3
  • 7
    • 84861697885 scopus 로고    scopus 로고
    • Niacin: Chemical forms, bioavailability, and health effects
    • MacKay D, Hathcock J, Guarneri E. Niacin: chemical forms, bioavailability, and health effects. Nutr Rev 2012; 70: 357-66.
    • (2012) Nutr Rev , vol.70 , pp. 357-366
    • McKay, D.1    Hathcock, J.2    Guarneri, E.3
  • 8
    • 64249122748 scopus 로고    scopus 로고
    • A comparison of the pharmacokinetics of two different formulations of extended-release niacin
    • Lauring B, Rosko K, Luo WL, et al. A comparison of the pharmacokinetics of two different formulations of extended-release niacin. Curr Med Res Opin 2009; 25: 15-22.
    • (2009) Curr Med Res Opin , vol.25 , pp. 15-22
    • Lauring, B.1    Rosko, K.2    Luo, W.L.3
  • 9
    • 84865583102 scopus 로고    scopus 로고
    • Role of HCA(2) (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin
    • Hanson J, Gille A, Offermanns S. Role of HCA(2) (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin. Pharmacol Ther 2012; 136: 1-7.
    • (2012) Pharmacol Ther , vol.136 , pp. 1-7
    • Hanson, J.1    Gille, A.2    Offermanns, S.3
  • 11
    • 0035666867 scopus 로고    scopus 로고
    • PUMA-G, an IFN-gammainducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily
    • Schaub A, Futterer A, Pfeffer K. PUMA-G, an IFN-gammainducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Eur J Immunol 2001; 31: 3714-25.
    • (2001) Eur J Immunol , vol.31 , pp. 3714-3725
    • Schaub, A.1    Futterer, A.2    Pfeffer, K.3
  • 12
    • 77955300428 scopus 로고    scopus 로고
    • Nicotinic acid-and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
    • Hanson J, Gille A, Zwykiel S, et al. Nicotinic acid-and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J Clin Invest 2010; 120: 2910-9.
    • (2010) J Clin Invest , vol.120 , pp. 2910-2919
    • Hanson, J.1    Gille, A.2    Zwykiel, S.3
  • 13
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru S, Kero J, Schaub A, et al. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 2003; 9: 352-5.
    • (2003) Nat Med , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3
  • 14
    • 84865330824 scopus 로고    scopus 로고
    • Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression
    • Lauring B, Taggart AK, Tata JR, et al. Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression. Sci Transl Med 2012; 4: 148ra115.
    • (2012) Sci Transl Med , vol.4
    • Lauring, B.1    Taggart, A.K.2    Tata, J.R.3
  • 15
    • 80053530578 scopus 로고    scopus 로고
    • Effects of nicotinic acid on gene expression: Potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug
    • Kang I, Kim SW, Youn JH. Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab 2011; 96: 3048-55.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3048-3055
    • Kang, I.1    Kim, S.W.2    Youn, J.H.3
  • 16
    • 0020567318 scopus 로고
    • Growth hormone, cortisol, and glucagon concentrations during plasma free fatty acid depression: Different effects of nicotinic acid and an adenosine derivative (BM 11.189)
    • Quabbe HJ, Luyckx AS, L'age M, Schwarz C. Growth hormone, cortisol, and glucagon concentrations during plasma free fatty acid depression: different effects of nicotinic acid and an adenosine derivative (BM 11.189). J Clin Endocrinol Metab 1983; 57: 410-4.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 410-414
    • Quabbe, H.J.1    Luyckx, A.S.2    L'age, M.3    Schwarz, C.4
  • 17
    • 3042786319 scopus 로고    scopus 로고
    • Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle
    • Watt MJ, Holmes AG, Steinberg GR, et al. Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab 2004; 287: E120-E127.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Watt, M.J.1    Holmes, A.G.2    Steinberg, G.R.3
  • 18
    • 7044274320 scopus 로고    scopus 로고
    • Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise
    • O'Neill M, Watt MJ, Heigenhauser GJ, Spriet LL. Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise. J Appl Physiol 2004; 97: 1938-45.
    • (2004) J Appl Physiol , vol.97 , pp. 1938-1945
    • O'Neill, M.1    Watt, M.J.2    Heigenhauser, G.J.3    Spriet, L.L.4
  • 19
    • 0014086435 scopus 로고
    • The plasma free fatty acid rebound induced by nicotinic acid
    • Pereira JN. The plasma free fatty acid rebound induced by nicotinic acid. J Lipid Res 1967; 8: 239-44.
    • (1967) J Lipid Res , vol.8 , pp. 239-244
    • Pereira, J.N.1
  • 21
    • 38749110451 scopus 로고    scopus 로고
    • Increased total and high-molecular weight adiponectin after extended-release niacin
    • Plaisance EP, Grandjean PW, Brunson BL, Judd RL. Increased total and high-molecular weight adiponectin after extended-release niacin. Metabolism 2008; 57: 404-9.
    • (2008) Metabolism , vol.57 , pp. 404-409
    • Plaisance, E.P.1    Grandjean, P.W.2    Brunson, B.L.3    Judd, R.L.4
  • 22
    • 77954896506 scopus 로고    scopus 로고
    • Nicotinic acid decreases apolipoprotein B100-containing lipoprotein levels by reducing hepatic very low density lipoprotein secretion through a possible diacylglycerol acyltransferase 2 inhibition in obese dogs
    • Le BJ, Leray V, Chetiveaux M, et al. Nicotinic acid decreases apolipoprotein B100-containing lipoprotein levels by reducing hepatic very low density lipoprotein secretion through a possible diacylglycerol acyltransferase 2 inhibition in obese dogs. J Pharmacol Exp Ther 2010; 334: 583-9.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 583-589
    • Le, B.J.1    Leray, V.2    Chetiveaux, M.3
  • 23
    • 79957637411 scopus 로고    scopus 로고
    • Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue
    • Oh YT, Oh KS, Choi YM, et al. Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab 2011; 300: E1012-E1021.
    • (2011) Am J Physiol Endocrinol Metab , vol.300
    • Oh, Y.T.1    Oh, K.S.2    Choi, Y.M.3
  • 25
    • 84857657538 scopus 로고    scopus 로고
    • Niacin in cardiovascular disease: Recent preclinical and clinical developments
    • Digby JE, Ruparelia N, Choudhury RP. Niacin in cardiovascular disease: recent preclinical and clinical developments. Arterioscler Thromb Vasc Biol 2012; 32: 582-8.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 582-588
    • Digby, J.E.1    Ruparelia, N.2    Choudhury, R.P.3
  • 26
    • 55449091198 scopus 로고    scopus 로고
    • Of mice and men: Blowing away the cobwebs from the mechanism of action of niacin on HDL metabolism
    • Watts GF, Chan DC. Of mice and men: blowing away the cobwebs from the mechanism of action of niacin on HDL metabolism. Arterioscler Thromb Vasc Biol 2008; 28: 1892-5.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1892-1895
    • Watts, G.F.1    Chan, D.C.2
  • 27
    • 55449114841 scopus 로고    scopus 로고
    • Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
    • van der Hoorn JW, de HW, Berbee JF, et al. Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice. Arterioscler Thromb Vasc Biol 2008; 28: 2016-22.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2016-2022
    • van der Hoorn, J.W.1    de, H.W.2    Berbee, J.F.3
  • 28
    • 51649127816 scopus 로고    scopus 로고
    • Extendedrelease niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    • Lamon-Fava S, Diffenderfer MR, Barrett PH, et al. Extendedrelease niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins. Arterioscler Thromb Vasc Biol 2008; 28: 1672-8.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1672-1678
    • Lamon-Fava, S.1    Diffenderfer, M.R.2    Barrett, P.H.3
  • 29
    • 0031442321 scopus 로고    scopus 로고
    • Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G2 cells. Implication for reverse cholesterol transport
    • Jin FY, Kamanna VS, Kashyap ML. Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G2 cells. Implication for reverse cholesterol transport. Arterioscler Thromb Vasc Biol 1997; 17: 2020-8.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2020-2028
    • Jin, F.Y.1    Kamanna, V.S.2    Kashyap, M.L.3
  • 30
    • 0037413638 scopus 로고    scopus 로고
    • Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis
    • Martinez LO, Jacquet S, Esteve JP, et al. Ectopic beta-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis. Nature 2003; 421: 75-9.
    • (2003) Nature , vol.421 , pp. 75-79
    • Martinez, L.O.1    Jacquet, S.2    Esteve, J.P.3
  • 31
    • 79953192995 scopus 로고    scopus 로고
    • HDL and cardiovascular disease: Atherogenic and atheroprotective mechanisms
    • Navab M, Reddy ST, Van Lenten BJ, Fogelman AM. HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nat Rev Cardiol 2011; 8: 222-32.
    • (2011) Nat Rev Cardiol , vol.8 , pp. 222-232
    • Navab, M.1    Reddy, S.T.2    van Lenten, B.J.3    Fogelman, A.M.4
  • 32
    • 70349595967 scopus 로고    scopus 로고
    • Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes
    • Wu ZH, Zhao SP. Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes. Pharmacology 2009; 84: 282-7.
    • (2009) Pharmacology , vol.84 , pp. 282-287
    • Wu, Z.H.1    Zhao, S.P.2
  • 33
    • 80053972733 scopus 로고    scopus 로고
    • Adipose tissue ATP binding cassette transporter A1 contributes to highdensity lipoprotein biogenesis in vivo
    • Chung S, Sawyer JK, Gebre AK, Maeda N, Parks JS. Adipose tissue ATP binding cassette transporter A1 contributes to highdensity lipoprotein biogenesis in vivo. Circulation 2011; 124: 1663-72.
    • (2011) Circulation , vol.124 , pp. 1663-1672
    • Chung, S.1    Sawyer, J.K.2    Gebre, A.K.3    Maeda, N.4    Parks, J.S.5
  • 34
    • 33744517651 scopus 로고    scopus 로고
    • Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: Effects of niacin treatment
    • Benjo AM, Maranhao RC, Coimbra SR, et al. Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: effects of niacin treatment. Atherosclerosis 2006; 187: 116-22.
    • (2006) Atherosclerosis , vol.187 , pp. 116-122
    • Benjo, A.M.1    Maranhao, R.C.2    Coimbra, S.R.3
  • 35
    • 79551717222 scopus 로고    scopus 로고
    • Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients
    • Hamilton SJ, Chew GT, Davis TM, Watts GF. Niacin improves small artery vasodilatory function and compliance in statin-treated type 2 diabetic patients. Diab Vasc Dis Res 2010; 7: 296-9.
    • (2010) Diab Vasc Dis Res , vol.7 , pp. 296-299
    • Hamilton, S.J.1    Chew, G.T.2    Davis, T.M.3    Watts, G.F.4
  • 36
    • 67349209273 scopus 로고    scopus 로고
    • Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: Results of the randomized, double-blind, placebo-controlled INEF study
    • Warnholtz A, Wild P, Ostad MA, et al. Effects of oral niacin on endothelial dysfunction in patients with coronary artery disease: results of the randomized, double-blind, placebo-controlled INEF study. Atherosclerosis 2009; 204: 216-21.
    • (2009) Atherosclerosis , vol.204 , pp. 216-221
    • Warnholtz, A.1    Wild, P.2    Ostad, M.A.3
  • 37
    • 0028834278 scopus 로고
    • Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress
    • Pandolfi PP, Sonati F, Rivi R, et al. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J 1995; 14: 5209-15.
    • (1995) EMBO J , vol.14 , pp. 5209-5215
    • Pandolfi, P.P.1    Sonati, F.2    Rivi, R.3
  • 38
    • 0030022523 scopus 로고    scopus 로고
    • Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta
    • Ito Y, Pagano PJ, Tornheim K, Brecher P, Cohen RA. Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta. Am J Physiol 1996; 270: H81-H87.
    • (1996) Am J Physiol , vol.270
    • Ito, Y.1    Pagano, P.J.2    Tornheim, K.3    Brecher, P.4    Cohen, R.A.5
  • 39
    • 0033524854 scopus 로고    scopus 로고
    • The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells
    • Yan Q, Briehl M, Crowley CL, et al. The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells. Biochem Biophys Res Commun 1999; 255: 133-6.
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 133-136
    • Yan, Q.1    Briehl, M.2    Crowley, C.L.3
  • 40
    • 0036297295 scopus 로고    scopus 로고
    • Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells
    • Cao Z, Li Y. Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells. Biochem Biophys Res Commun 2002; 292: 50-7.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 50-57
    • Cao, Z.1    Li, Y.2
  • 41
    • 57649219453 scopus 로고    scopus 로고
    • Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells
    • Ganji SH, Qin S, Zhang L, Kamanna VS, Kashyap ML. Niacin inhibits vascular oxidative stress, redox-sensitive genes, and monocyte adhesion to human aortic endothelial cells. Atherosclerosis 2009; 202: 68-75.
    • (2009) Atherosclerosis , vol.202 , pp. 68-75
    • Ganji, S.H.1    Qin, S.2    Zhang, L.3    Kamanna, V.S.4    Kashyap, M.L.5
  • 42
    • 0032951101 scopus 로고    scopus 로고
    • Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells
    • Jin FY, Kamanna VS, Kashyap ML. Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells. Arterioscler Thromb Vasc Biol 1999; 19: 1051-9.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 1051-1059
    • Jin, F.Y.1    Kamanna, V.S.2    Kashyap, M.L.3
  • 43
    • 77049084050 scopus 로고    scopus 로고
    • Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin
    • Digby JE, McNeill E, Dyar OJ, et al. Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. Atherosclerosis 2010; 209: 89-95.
    • (2010) Atherosclerosis , vol.209 , pp. 89-95
    • Digby, J.E.1    McNeill, E.2    Dyar, O.J.3
  • 44
    • 79952240405 scopus 로고    scopus 로고
    • Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • Lukasova M, Malaval C, Gille A, Kero J, Offermanns S. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 2011; 121: 1163-73.
    • (2011) J Clin Invest , vol.121 , pp. 1163-1173
    • Lukasova, M.1    Malaval, C.2    Gille, A.3    Kero, J.4    Offermanns, S.5
  • 45
    • 33748038025 scopus 로고    scopus 로고
    • Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease
    • Kuvin JT, Dave DM, Sliney KA, et al. Effects of extended-release niacin on lipoprotein particle size, distribution, and inflammatory markers in patients with coronary artery disease. Am J Cardiol 2006; 98: 743-5.
    • (2006) Am J Cardiol , vol.98 , pp. 743-745
    • Kuvin, J.T.1    Dave, D.M.2    Sliney, K.A.3
  • 47
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001; 345: 1583-92.
    • (2001) N Engl J Med , vol.345 , pp. 1583-1592
    • Brown, B.G.1    Zhao, X.Q.2    Chait, A.3
  • 48
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown G, Albers JJ, Fisher LD, et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 1990; 323: 1289-98.
    • (1990) N Engl J Med , vol.323 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3
  • 49
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
    • Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986; 8: 1245-55.
    • (1986) J Am Coll Cardiol , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 50
    • 0001632634 scopus 로고    scopus 로고
    • Treatment Effect of Niaspan, a Controlled-release Niacin, in Patients With Hypercholesterolemia: A Placebo-controlled Trial
    • Morgan JM, Capuzzi DM, Guyton JR, et al. Treatment Effect of Niaspan, a Controlled-release Niacin, in Patients With Hypercholesterolemia: A Placebo-controlled Trial. J Cardiovasc Pharmacol Ther 1996; 1: 195-202.
    • (1996) J Cardiovasc Pharmacol Ther , vol.1 , pp. 195-202
    • Morgan, J.M.1    Capuzzi, D.M.2    Guyton, J.R.3
  • 51
    • 2442425776 scopus 로고    scopus 로고
    • Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia
    • Knopp RH, Alagona P, Davidson M, et al. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 1998; 47: 1097-104.
    • (1998) Metabolism , vol.47 , pp. 1097-1104
    • Knopp, R.H.1    Alagona, P.2    Davidson, M.3
  • 52
    • 0034191863 scopus 로고    scopus 로고
    • Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia
    • Goldberg A, Alagona P, Jr., Capuzzi DM, et al. Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. Am J Cardiol 2000; 85: 1100-5.
    • (2000) Am J Cardiol , vol.85 , pp. 1100-1105
    • Goldberg, A.1    Alagona Jr., P.2    Capuzzi, D.M.3
  • 53
    • 2442520797 scopus 로고    scopus 로고
    • Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: Assessing all reasonable doses with innovative surface graph analysis
    • Insull W, Jr., McGovern ME, Schrott H, et al. Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: assessing all reasonable doses with innovative surface graph analysis. Arch Intern Med 2004; 164: 1121-7.
    • (2004) Arch Intern Med , vol.164 , pp. 1121-1127
    • Insull Jr., W.1    McGovern, M.E.2    Schrott, H.3
  • 54
    • 0037343026 scopus 로고    scopus 로고
    • A dose-ranging study of a new, once-daily, dual-component drug product containing niacin extended-release and lovastatin
    • Hunninghake DB, McGovern ME, Koren M, et al. A dose-ranging study of a new, once-daily, dual-component drug product containing niacin extended-release and lovastatin. Clin Cardiol 2003; 26: 112-8.
    • (2003) Clin Cardiol , vol.26 , pp. 112-118
    • Hunninghake, D.B.1    McGovern, M.E.2    Koren, M.3
  • 55
    • 0032542302 scopus 로고    scopus 로고
    • Efficacy and safety of an extended-release niacin (Niaspan): A long-term study
    • Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998; 82: 74U-81U.
    • (1998) Am J Cardiol , vol.82
    • Capuzzi, D.M.1    Guyton, J.R.2    Morgan, J.M.3
  • 56
    • 62549110921 scopus 로고    scopus 로고
    • Efficacy and safety of combination therapy with niacin extended-release and simvastatin versus atorvastatin in patients with dyslipidemia: The SUPREME Study
    • Insull W, Jr., Basile JN, Vo AN, et al. Efficacy and safety of combination therapy with niacin extended-release and simvastatin versus atorvastatin in patients with dyslipidemia: The SUPREME Study. J Clin Lipidol 2009; 3: 109-18.
    • (2009) J Clin Lipidol , vol.3 , pp. 109-118
    • Insull Jr., W.1    Basile, J.N.2    Vo, A.N.3
  • 57
    • 80051882497 scopus 로고    scopus 로고
    • Combination of niacin extended-release and simvastatin results in a less atherogenic lipid profile than atorvastatin monotherapy
    • Insull W, Jr., Toth PP, Superko HR, et al. Combination of niacin extended-release and simvastatin results in a less atherogenic lipid profile than atorvastatin monotherapy. Vasc Health Risk Manag 2010; 6: 1065-75.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 1065-1075
    • Insull Jr., W.1    Toth, P.P.2    Superko, H.R.3
  • 58
    • 84856942270 scopus 로고    scopus 로고
    • Combination treatment with atorvastatin plus niacin provides effective control of complex dyslipidemias: A literature review
    • McKenney JM. Combination treatment with atorvastatin plus niacin provides effective control of complex dyslipidemias: a literature review. Postgrad Med 2012; 124: 7-20.
    • (2012) Postgrad Med , vol.124 , pp. 7-20
    • McKenney, J.M.1
  • 59
    • 0037158150 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: Results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial
    • Grundy SM, Vega GL, McGovern ME, et al. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial. Arch Intern Med 2002; 162: 1568-76.
    • (2002) Arch Intern Med , vol.162 , pp. 1568-1576
    • Grundy, S.M.1    Vega, G.L.2    McGovern, M.E.3
  • 60
    • 78349281108 scopus 로고    scopus 로고
    • Should we measure routinely oxidised and atherogenic dense low-density lipoproteins in subjects with type 2 diabetes?
    • Rizzo M, Berneis K, Koulouris S, et al. Should we measure routinely oxidised and atherogenic dense low-density lipoproteins in subjects with type 2 diabetes? Int J Clin Pract 2010; 64: 1632-42.
    • (2010) Int J Clin Pract , vol.64 , pp. 1632-1642
    • Rizzo, M.1    Berneis, K.2    Koulouris, S.3
  • 61
    • 0033751381 scopus 로고    scopus 로고
    • Mechanism of action of niacin on lipoprotein metabolism
    • Kamanna VS, Kashyap ML. Mechanism of action of niacin on lipoprotein metabolism. Curr Atheroscler Rep 2000; 2: 36-46.
    • (2000) Curr Atheroscler Rep , vol.2 , pp. 36-46
    • Kamanna, V.S.1    Kashyap, M.L.2
  • 62
    • 0038201868 scopus 로고    scopus 로고
    • Effects of extendedrelease niacin on lipoprotein subclass distribution
    • Morgan JM, Capuzzi DM, Baksh RI, et al. Effects of extendedrelease niacin on lipoprotein subclass distribution. Am J Cardiol 2003; 91: 1432-6.
    • (2003) Am J Cardiol , vol.91 , pp. 1432-1436
    • Morgan, J.M.1    Capuzzi, D.M.2    Baksh, R.I.3
  • 63
    • 31044448925 scopus 로고    scopus 로고
    • GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
    • Benyo Z, Gille A, Kero J, et al. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 2005; 115: 3634-40.
    • (2005) J Clin Invest , vol.115 , pp. 3634-3640
    • Benyo, Z.1    Gille, A.2    Kero, J.3
  • 64
    • 33751087034 scopus 로고    scopus 로고
    • Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells
    • Benyo Z, Gille A, Bennett CL, Clausen BE, Offermanns S. Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells. Mol Pharmacol 2006; 70: 1844-9.
    • (2006) Mol Pharmacol , vol.70 , pp. 1844-1849
    • Benyo, Z.1    Gille, A.2    Bennett, C.L.3    Clausen, B.E.4    Offermanns, S.5
  • 66
    • 31944438344 scopus 로고    scopus 로고
    • Benefits of niacin in patients with versus without the metabolic syndrome and healed myocardial infarction (from the Coronary Drug Project)
    • Canner PL, Furberg CD, McGovern ME. Benefits of niacin in patients with versus without the metabolic syndrome and healed myocardial infarction (from the Coronary Drug Project). Am J Cardiol 2006; 97: 477-9.
    • (2006) Am J Cardiol , vol.97 , pp. 477-479
    • Canner, P.L.1    Furberg, C.D.2    McGovern, M.E.3
  • 67
    • 60449103180 scopus 로고    scopus 로고
    • Blood pressurelowering effects of extended-release niacin alone and extendedrelease niacin/laropiprant combination: A post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients
    • Bays HE, Maccubbin D, Meehan AG, et al. Blood pressurelowering effects of extended-release niacin alone and extendedrelease niacin/laropiprant combination: a post hoc analysis of a 24-week, placebo-controlled trial in dyslipidemic patients. Clin Ther 2009; 31: 115-22.
    • (2009) Clin Ther , vol.31 , pp. 115-122
    • Bays, H.E.1    McCubbin, D.2    Meehan, A.G.3
  • 68
    • 84862862264 scopus 로고    scopus 로고
    • Add-on-Statin Extended Release Nicotinic Acid/Laropiprant but Not the Switch to High-Dose Rosuvastatin Lowers Blood Pressure: An Open-Label Randomized Study
    • Kei A, Elisaf M, Moutzouri E, Tsiara S, Liberopoulos E. Add-on-Statin Extended Release Nicotinic Acid/Laropiprant but Not the Switch to High-Dose Rosuvastatin Lowers Blood Pressure: An Open-Label Randomized Study. Int J Hypertens 2011; 2011: 830434.
    • (2011) Int J Hypertens , vol.2011 , pp. 830434
    • Kei, A.1    Elisaf, M.2    Moutzouri, E.3    Tsiara, S.4    Liberopoulos, E.5
  • 69
    • 46449105753 scopus 로고    scopus 로고
    • Dosage, titration, and gaps in treatment with extended release niacin in clinical practice
    • Kamal-Bahl SJ, Burke TA, Watson DJ, Wentworth CE. Dosage, titration, and gaps in treatment with extended release niacin in clinical practice. Curr Med Res Opin 2008; 24: 1817-21.
    • (2008) Curr Med Res Opin , vol.24 , pp. 1817-1821
    • Kamal-Bahl, S.J.1    Burke, T.A.2    Watson, D.J.3    Wentworth, C.E.4
  • 70
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials
    • Birjmohun RS, Hutten BA, Kastelein JJ, Stroes ES. Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials. J Am Coll Cardiol 2005; 45: 185-97.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 185-197
    • Birjmohun, R.S.1    Hutten, B.A.2    Kastelein, J.J.3    Stroes, E.S.4
  • 71
    • 48549100919 scopus 로고    scopus 로고
    • Flushing and the HDL-C response to extended-release niacin
    • Taylor AJ, Stanek EJ. Flushing and the HDL-C response to extended-release niacin. J Clin Lipidol 2008; 2: 285-8.
    • (2008) J Clin Lipidol , vol.2 , pp. 285-288
    • Taylor, A.J.1    Stanek, E.J.2
  • 72
    • 34548755161 scopus 로고    scopus 로고
    • The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet
    • Menon R, Tolbert D, Cefali E. The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet. Biopharm Drug Dispos 2007; 28: 297-306.
    • (2007) Biopharm Drug Dispos , vol.28 , pp. 297-306
    • Menon, R.1    Tolbert, D.2    Cefali, E.3
  • 73
    • 33846838863 scopus 로고    scopus 로고
    • Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice
    • Kamal-Bahl SJ, Burke T, Watson D, Wentworth C. Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice. Am J Cardiol 2007; 99: 530-4.
    • (2007) Am J Cardiol , vol.99 , pp. 530-534
    • Kamal-Bahl, S.J.1    Burke, T.2    Watson, D.3    Wentworth, C.4
  • 74
    • 33751090692 scopus 로고    scopus 로고
    • Langerhans cells release prostaglandin D2 in response to nicotinic acid
    • Maciejewski-Lenoir D, Richman JG, Hakak Y, et al. Langerhans cells release prostaglandin D2 in response to nicotinic acid. J Invest Dermatol 2006; 126: 2637-46.
    • (2006) J Invest Dermatol , vol.126 , pp. 2637-2646
    • McIejewski-Lenoir, D.1    Richman, J.G.2    Hakak, Y.3
  • 75
    • 68949083513 scopus 로고    scopus 로고
    • Extended-release niacin (nicotinic acid)/laropiprant
    • Perry CM. Extended-release niacin (nicotinic acid)/laropiprant. Drugs 2009; 69: 1665-79.
    • (2009) Drugs , vol.69 , pp. 1665-1679
    • Perry, C.M.1
  • 76
    • 84865447632 scopus 로고    scopus 로고
    • Effectiveness and safety of laropiprant on niacin-induced flushing
    • Maccubbin DL, Chen F, Anderson JW, et al. Effectiveness and safety of laropiprant on niacin-induced flushing. Am J Cardiol 2012; 110: 817-22.
    • (2012) Am J Cardiol , vol.110 , pp. 817-822
    • McCubbin, D.L.1    Chen, F.2    Anderson, J.W.3
  • 77
    • 77951265584 scopus 로고    scopus 로고
    • Effects of extended release niacin/laropiprant, laropiprant, extended release niacin and placebo on platelet aggregation and bleeding time in healthy subjects
    • Lai E, Schwartz JI, Dallob A, et al. Effects of extended release niacin/laropiprant, laropiprant, extended release niacin and placebo on platelet aggregation and bleeding time in healthy subjects. Platelets 2010; 21: 191-8.
    • (2010) Platelets , vol.21 , pp. 191-198
    • Lai, E.1    Schwartz, J.I.2    Dallob, A.3
  • 78
    • 80053638774 scopus 로고    scopus 로고
    • The effects of laropiprant, a selective prostaglandin D(2) receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin
    • Dallob A, Luo WL, Luk JM, et al. The effects of laropiprant, a selective prostaglandin D(2) receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin. Platelets 2011; 22: 495-503.
    • (2011) Platelets , vol.22 , pp. 495-503
    • Dallob, A.1    Luo, W.L.2    Luk, J.M.3
  • 79
    • 67249129221 scopus 로고    scopus 로고
    • Influence of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, on the pharmacokinetics and pharmacodynamics of warfarin
    • Schwartz JI, Liu F, Stroh M, et al. Influence of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, on the pharmacokinetics and pharmacodynamics of warfarin. Am J Ther 2009; 16: 215-23.
    • (2009) Am J Ther , vol.16 , pp. 215-223
    • Schwartz, J.I.1    Liu, F.2    Stroh, M.3
  • 80
    • 43949145969 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist
    • Lai E, Wenning LA, Crumley TM, et al. Pharmacokinetics, pharmacodynamics, and safety of a prostaglandin D2 receptor antagonist. Clin Pharmacol Ther 2008; 83: 840-7.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 840-847
    • Lai, E.1    Wenning, L.A.2    Crumley, T.M.3
  • 81
    • 79953808335 scopus 로고    scopus 로고
    • Pharmacokinetics of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, in patients with moderate hepatic impairment
    • Wang YH, Liu F, Luk JA, et al. Pharmacokinetics of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, in patients with moderate hepatic impairment. J Clin Pharmacol 2011; 51: 406-12.
    • (2011) J Clin Pharmacol , vol.51 , pp. 406-412
    • Wang, Y.H.1    Liu, F.2    Luk, J.A.3
  • 82
    • 68949107831 scopus 로고    scopus 로고
    • Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency
    • Stroh M, Wenning L, Luo WL, et al. Pharmacokinetics of laropiprant and glucuronide metabolite in patients with severe renal insufficiency. Am J Ther 2009; 16: 379-84.
    • (2009) Am J Ther , vol.16 , pp. 379-384
    • Stroh, M.1    Wenning, L.2    Luo, W.L.3
  • 83
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • Maccubbin D, Bays HE, Olsson AG, et al. Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2008; 62: 1959-70.
    • (2008) Int J Clin Pract , vol.62 , pp. 1959-1970
    • McCubbin, D.1    Bays, H.E.2    Olsson, A.G.3
  • 84
    • 33947118734 scopus 로고    scopus 로고
    • Safety considerations with niacin therapy
    • Guyton JR, Bays HE. Safety considerations with niacin therapy. Am J Cardiol 2007; 99: 22C-31C.
    • (2007) Am J Cardiol , vol.99
    • Guyton, J.R.1    Bays, H.E.2
  • 85
    • 84555190235 scopus 로고    scopus 로고
    • Safety and tolerability of extended-release niacin with laropiprant
    • Yadav R, Kwok S, Ammori BJ, Issa B, Soran H. Safety and tolerability of extended-release niacin with laropiprant. Expert Opin Drug Saf 2012; 11: 151-9.
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 151-159
    • Yadav, R.1    Kwok, S.2    Ammori, B.J.3    Issa, B.4    Soran, H.5
  • 86
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubbin D, Koren MJ, Davidson M, et al. Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 2009; 104: 74-81.
    • (2009) Am J Cardiol , vol.104 , pp. 74-81
    • McCubbin, D.1    Koren, M.J.2    Davidson, M.3
  • 87
    • 65249130554 scopus 로고    scopus 로고
    • Efficacy and safety profile of co-administered ER niacin/laropiprant and simvastatin in dyslipidaemia
    • Gleim G, Ballantyne CM, Liu N, et al. Efficacy and safety profile of co-administered ER niacin/laropiprant and simvastatin in dyslipidaemia. Br J Cardiol 2009; 16: 90-107.
    • (2009) Br J Cardiol , vol.16 , pp. 90-107
    • Gleim, G.1    Ballantyne, C.M.2    Liu, N.3
  • 88
    • 77950641140 scopus 로고    scopus 로고
    • Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • Shah S, Ceska R, Gil-Extremera B, et al. Efficacy and safety of extended-release niacin/laropiprant plus statin vs. doubling the dose of statin in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2010; 64: 727-38.
    • (2010) Int J Clin Pract , vol.64 , pp. 727-738
    • Shah, S.1    Ceska, R.2    Gil-Extremera, B.3
  • 89
    • 79952747843 scopus 로고    scopus 로고
    • Efficacy and safety of extended-release niacin/laropiprant in patients with type 2 diabetes mellitus
    • MacLean A, McKenney J, Scott R, et al. Efficacy and safety of extended-release niacin/laropiprant in patients with type 2 diabetes mellitus. Br J Cardiol 2011; 18: 37-45.
    • (2011) Br J Cardiol , vol.18 , pp. 37-45
    • McLean, A.1    McKenney, J.2    Scott, R.3
  • 90
    • 0023749951 scopus 로고
    • Nicotinic acid-induced fulminant hepatic failure
    • Clementz GL, Holmes AW. Nicotinic acid-induced fulminant hepatic failure. J Clin Gastroenterol 1987; 9: 582-4.
    • (1987) J Clin Gastroenterol , vol.9 , pp. 582-584
    • Clementz, G.L.1    Holmes, A.W.2
  • 91
    • 85047692711 scopus 로고
    • Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia
    • Keenan JM, Fontaine PL, Wenz JB, et al. Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia. Arch Intern Med 1991; 151: 1424-32.
    • (1991) Arch Intern Med , vol.151 , pp. 1424-1432
    • Keenan, J.M.1    Fontaine, P.L.2    Wenz, J.B.3
  • 92
    • 0028057319 scopus 로고
    • A comparison of the efficacy and toxic effects of sustained-vs immediate-release niacin in hypercholesterolemic patients
    • McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained-vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994; 271: 672-7.
    • (1994) JAMA , vol.271 , pp. 672-677
    • McKenney, J.M.1    Proctor, J.D.2    Harris, S.3    Chinchili, V.M.4
  • 93
    • 0034700644 scopus 로고    scopus 로고
    • Evaluating niacin in its various forms
    • Knopp RH. Evaluating niacin in its various forms. Am J Cardiol 2000; 86: 51L-6L.
    • (2000) Am J Cardiol , vol.86
    • Knopp, R.H.1
  • 94
    • 4344592577 scopus 로고    scopus 로고
    • Niaspan, the prolonged release preparation of nicotinic acid (niacin), the broad-spectrum lipid drug
    • Carlson LA. Niaspan, the prolonged release preparation of nicotinic acid (niacin), the broad-spectrum lipid drug. Int J Clin Pract 2004; 58: 706-13.
    • (2004) Int J Clin Pract , vol.58 , pp. 706-713
    • Carlson, L.A.1
  • 95
    • 84862865263 scopus 로고    scopus 로고
    • Nicotinic acid: Clinical considerations
    • Kei A, Elisaf MS. Nicotinic acid: clinical considerations. Expert Opin Drug Saf 2012; 11: 551-64.
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 551-564
    • Kei, A.1    Elisaf, M.S.2
  • 96
    • 22644437126 scopus 로고    scopus 로고
    • Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review
    • Carlson LA. Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J Intern Med 2005; 258: 94-114.
    • (2005) J Intern Med , vol.258 , pp. 94-114
    • Carlson, L.A.1
  • 99
    • 50949133756 scopus 로고    scopus 로고
    • Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study)
    • Ballantyne CM, Davidson MH, McKenney J, et al. Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study). Am J Cardiol 2008; 101: 1428-36.
    • (2008) Am J Cardiol , vol.101 , pp. 1428-1436
    • Ballantyne, C.M.1    Davidson, M.H.2    McKenney, J.3
  • 100
    • 44949180810 scopus 로고    scopus 로고
    • Managing dyslipidemia in chronic kidney disease
    • Harper CR, Jacobson TA. Managing dyslipidemia in chronic kidney disease. J Am Coll Cardiol 2008; 51: 2375-84.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2375-2384
    • Harper, C.R.1    Jacobson, T.A.2
  • 101
    • 0027325530 scopus 로고
    • Severe reversible hyperglycemia as a consequence of niacin therapy
    • Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med 1993; 153: 2050-2.
    • (1993) Arch Intern Med , vol.153 , pp. 2050-2052
    • Schwartz, M.L.1
  • 102
    • 0025148561 scopus 로고
    • Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus
    • Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990; 264: 723-6.
    • (1990) JAMA , vol.264 , pp. 723-726
    • Garg, A.1    Grundy, S.M.2
  • 103
    • 11844304073 scopus 로고    scopus 로고
    • Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project)
    • Canner PL, Furberg CD, Terrin ML, McGovern ME. Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project). Am J Cardiol 2005; 95: 254-7.
    • (2005) Am J Cardiol , vol.95 , pp. 254-257
    • Canner, P.L.1    Furberg, C.D.2    Terrin, M.L.3    McGovern, M.E.4
  • 104
    • 71649101609 scopus 로고    scopus 로고
    • Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: A combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
    • Zhao XQ, Krasuski RA, Baer J, et al. Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS). Am J Cardiol 2009; 104: 1457-64.
    • (2009) Am J Cardiol , vol.104 , pp. 1457-1464
    • Zhao, X.Q.1    Krasuski, R.A.2    Baer, J.3
  • 105
    • 34447328718 scopus 로고    scopus 로고
    • Niacin plus Simvastatin Reduces Coronary Stenosis Progression Among Patients with Metabolic Syndrome Despite a Modest Increase in Insulin Resistance: A Subgroup Analysis of the HDL-Atherosclerosis Treatment Study (HATS)
    • Vittone F, Chait A, Morse JS, et al. Niacin plus Simvastatin Reduces Coronary Stenosis Progression Among Patients with Metabolic Syndrome Despite a Modest Increase in Insulin Resistance: A Subgroup Analysis of the HDL-Atherosclerosis Treatment Study (HATS). J Clin Lipidol 2007; 1: 203-10.
    • (2007) J Clin Lipidol , vol.1 , pp. 203-210
    • Vittone, F.1    Chait, A.2    Morse, J.S.3
  • 106
    • 42149136762 scopus 로고    scopus 로고
    • Effects of niacin on glucose control in patients with dyslipidemia
    • Goldberg RB, Jacobson TA. Effects of niacin on glucose control in patients with dyslipidemia. Mayo Clin Proc 2008; 83: 470-8.
    • (2008) Mayo Clin Proc , vol.83 , pp. 470-478
    • Goldberg, R.B.1    Jacobson, T.A.2
  • 108
    • 79956358444 scopus 로고    scopus 로고
    • Sustained hypophosphatemic effect of once-daily niacin/laropiprant in dyslipidemic CKD stage 3 patients
    • Ix JH, Ganjoo P, Tipping D, Tershakovec AM, Bostom AG. Sustained hypophosphatemic effect of once-daily niacin/laropiprant in dyslipidemic CKD stage 3 patients. Am J Kidney Dis 2011; 57: 963-5.
    • (2011) Am J Kidney Dis , vol.57 , pp. 963-965
    • Ix, J.H.1    Ganjoo, P.2    Tipping, D.3    Tershakovec, A.M.4    Bostom, A.G.5
  • 109
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson LA, Rosenhamer G. Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 1988; 223: 405-18.
    • (1988) Acta Med Scand , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 110
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • Blankenhorn DH, Nessim SA, Johnson RL, et al. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 1987; 257: 3233-40.
    • (1987) JAMA , vol.257 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3
  • 111
    • 0025678697 scopus 로고
    • Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year followup
    • Cashin-Hemphill L, Mack WJ, Pogoda JM, et al. Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year followup. JAMA 1990; 264: 3013-7.
    • (1990) JAMA , vol.264 , pp. 3013-3017
    • Cashin-Hemphill, L.1    Mack, W.J.2    Pogoda, J.M.3
  • 112
    • 19944426989 scopus 로고    scopus 로고
    • A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: Effects on progression of coronary heart disease and clinical events
    • Whitney EJ, Krasuski RA, Personius BE, et al. A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. Ann Intern Med 2005; 142: 95-104.
    • (2005) Ann Intern Med , vol.142 , pp. 95-104
    • Whitney, E.J.1    Krasuski, R.A.2    Personius, B.E.3
  • 113
    • 0025685469 scopus 로고
    • Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens
    • Kane JP, Malloy MJ, Ports TA, et al. Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. JAMA 1990; 264: 3007-12.
    • (1990) JAMA , vol.264 , pp. 3007-3012
    • Kane, J.P.1    Malloy, M.J.2    Ports, T.A.3
  • 114
    • 35348902493 scopus 로고    scopus 로고
    • The effects of extendedrelease niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome
    • Thoenes M, Oguchi A, Nagamia S, et al. The effects of extendedrelease niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. Int J Clin Pract 2007; 61: 1942-8.
    • (2007) Int J Clin Pract , vol.61 , pp. 1942-1948
    • Thoenes, M.1    Oguchi, A.2    Nagamia, S.3
  • 115
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: A double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor AJ, Sullenberger LE, Lee HJ, Lee JK, Grace KA. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double-blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation 2004; 110: 3512-7.
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 116
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intimamedia thickness: ARBITER 3
    • Taylor AJ, Lee HJ, Sullenberger LE. The effect of 24 months of combination statin and extended-release niacin on carotid intimamedia thickness: ARBITER 3. Curr Med Res Opin 2006; 22: 2243-50.
    • (2006) Curr Med Res Opin , vol.22 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 117
    • 72049129430 scopus 로고    scopus 로고
    • Extended-release niacin or ezetimibe and carotid intima-media thickness
    • Taylor AJ, Villines TC, Stanek EJ, et al. Extended-release niacin or ezetimibe and carotid intima-media thickness. N Engl J Med 2009; 361: 2113-22.
    • (2009) N Engl J Med , vol.361 , pp. 2113-2122
    • Taylor, A.J.1    Villines, T.C.2    Stanek, E.J.3
  • 118
    • 84861606700 scopus 로고    scopus 로고
    • Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: Reconciling the AIMHIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial with previous surrogate endpoint trials
    • Michos ED, Sibley CT, Baer JT, Blaha MJ, Blumenthal RS. Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIMHIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial with previous surrogate endpoint trials. J Am Coll Cardiol 2012; 59: 2058-64.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2058-2064
    • Michos, E.D.1    Sibley, C.T.2    Baer, J.T.3    Blaha, M.J.4    Blumenthal, R.S.5
  • 119
    • 77953121328 scopus 로고    scopus 로고
    • The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): Final results and the impact of medication adherence, dose, and treatment duration
    • Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration. J Am Coll Cardiol 2010; 55: 2721-6.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2721-2726
    • Villines, T.C.1    Stanek, E.J.2    Devine, P.J.3
  • 120
    • 70350516769 scopus 로고    scopus 로고
    • Effects of high-dose modifiedrelease nicotinic acid on atherosclerosis and vascular function: A randomized, placebo-controlled, magnetic resonance imaging study
    • Lee JM, Robson MD, Yu LM, et al. Effects of high-dose modifiedrelease nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. J Am Coll Cardiol 2009; 54: 1787-94.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1787-1794
    • Lee, J.M.1    Robson, M.D.2    Yu, L.M.3
  • 121
    • 77952397461 scopus 로고    scopus 로고
    • Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis
    • Bruckert E, Labreuche J, Amarenco P. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis 2010; 210: 353-61.
    • (2010) Atherosclerosis , vol.210 , pp. 353-361
    • Bruckert, E.1    Labreuche, J.2    Amarenco, P.3
  • 122
    • 77951928738 scopus 로고    scopus 로고
    • Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease
    • Duggal JK, Singh M, Attri N, et al. Effect of niacin therapy on cardiovascular outcomes in patients with coronary artery disease. J Cardiovasc Pharmacol Ther 2010; 15: 158-66.
    • (2010) J Cardiovasc Pharmacol Ther , vol.15 , pp. 158-166
    • Duggal, J.K.1    Singh, M.2    Attri, N.3
  • 123
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 2011; 365: 2255-67.
    • (2011) N Engl J Med , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2    Anderson, T.3
  • 124
    • 84861115793 scopus 로고    scopus 로고
    • Hyperlipidaemia and cardiovascular disease: HDL, inflammation and surprising results of AIM-HIGH study
    • Nofer JR. Hyperlipidaemia and cardiovascular disease: HDL, inflammation and surprising results of AIM-HIGH study. Curr Opin Lipidol 2012; 23: 260-2.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 260-262
    • Nofer, J.R.1
  • 125
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002; 106: 3143-421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 126
    • 0035423283 scopus 로고    scopus 로고
    • Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia
    • McKenney JM, McCormick LS, Schaefer EJ, Black DM, Watkins ML. Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia. Am J Cardiol 2001; 88: 270-4.
    • (2001) Am J Cardiol , vol.88 , pp. 270-274
    • McKenney, J.M.1    McCormick, L.S.2    Schaefer, E.J.3    Black, D.M.4    Watkins, M.L.5
  • 127
    • 0034609562 scopus 로고    scopus 로고
    • Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies
    • Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 2000; 102: 1082-5.
    • (2000) Circulation , vol.102 , pp. 1082-1085
    • Danesh, J.1    Collins, R.2    Peto, R.3
  • 128
    • 77955861123 scopus 로고    scopus 로고
    • Shifting views on lipid lowering therapy
    • Krumholz HM, Hayward RA. Shifting views on lipid lowering therapy. BMJ 2010; 341: c3531.
    • (2010) BMJ , vol.341
    • Krumholz, H.M.1    Hayward, R.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.