Effects of extended release niacin/laropiprant, laropiprant, extended release niacin and placebo on platelet aggregation and bleeding time in healthy subjects

Platelets

Volumn 21, Issue 3, 2010, Pages 191-198

  Lai, Eseng ^a   Schwartz, Jules I ^a   Dallob, Aimee ^a   Jumes, Patricia ^a   Liu, Fang ^a   Kraft, Walter K ^b   Royalty, Jane ^c   Chodakewitz, Jeffrey A ^a   McCrary Sisk, Christine ^a   Radziszewski, Waldemar ^a   Wagner, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c D/b/a Covance GFI Research   (United States)

Author keywords

Bleeding time; Extended release niacin; Laropiprant; Platelet aggregation

Indexed keywords

ADENOSINE DIPHOSPHATE; COLLAGEN; LAROPIPRANT; NICOTINIC ACID; PLACEBO;

ADULT; ARTICLE; BLEEDING TIME; CELL ASSAY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ERUPTION; DRUG WITHDRAWAL; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; MULTICENTER STUDY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; SUSTAINED DRUG RELEASE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; VASODILATATION;

ADOLESCENT; ADULT; AGED; BLEEDING TIME; COLLAGEN; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INDOLES; MALE; MIDDLE AGED; NIACIN; PLACEBOS; PLATELET AGGREGATION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 77951265584     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537100903521611     Document Type: Article

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